{"id":"https://openalex.org/W2898695740","doi":"https://doi.org/10.1182/blood-2018-99-115163","title":"Imetelstat Is Effective Treatment for Patients with Intermediate-2 or High-Risk Myelofibrosis Who Have Relapsed on or Are Refractory to Janus Kinase Inhibitor Therapy: Results of a Phase 2 Randomized Study of Two Dose Levels","display_name":"Imetelstat Is Effective Treatment for Patients with Intermediate-2 or High-Risk Myelofibrosis Who Have Relapsed on or Are Refractory to Janus Kinase Inhibitor Therapy: Results of a Phase 2 Randomized Study of Two Dose Levels","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2898695740","doi":"https://doi.org/10.1182/blood-2018-99-115163","mag":"2898695740"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-115163","doi":"https://doi.org/10.1182/blood-2018-99-115163","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-115163","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072336042","display_name":"John O Mascarenhas","orcid":"https://orcid.org/0000-0002-8400-0483","observed_orcids":["https://orcid.org/0000-0002-8400-0483"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Mascarenhas","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010075752","display_name":"Rami S. Komrokji","orcid":"https://orcid.org/0000-0002-1876-5269","observed_orcids":["https://orcid.org/0000-0002-1876-5269"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rami S. Komrokji","raw_affiliation_strings":["Department of Malignant Hematology, H Lee Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, H Lee Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071926851","display_name":"Mich\u00e8le Cavo","orcid":"https://orcid.org/0000-0003-4514-3227","observed_orcids":["https://orcid.org/0000-0003-4514-3227"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Cavo","raw_affiliation_strings":["\"Ser\u00e0gnoli\" Institute of Hematology Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"Ser\u00e0gnoli\" Institute of Hematology Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111559933","display_name":"Bruno Martino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098397","display_name":"Azienda ospedaliera \"Bianchi-Melacrino-Morelli\"","ror":"https://ror.org/00z28d984","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210098397"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Bruno Martino","raw_affiliation_strings":["Hematology Department, Grande Ospedale Metropolitano-G.O.M. Bianchi-Melacrino-Morelli, Reggio Calabria, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Grande Ospedale Metropolitano-G.O.M. Bianchi-Melacrino-Morelli, Reggio Calabria, Italy","institution_ids":["https://openalex.org/I4210098397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042734609","display_name":"Dietger W. Niederwieser","orcid":"https://orcid.org/0000-0002-4737-1103","observed_orcids":["https://orcid.org/0000-0002-4737-1103"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietger Niederwieser","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021124944","display_name":"Andreas Reiter","orcid":"https://orcid.org/0000-0002-7718-6507","observed_orcids":["https://orcid.org/0000-0002-7718-6507"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Reiter","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074629157","display_name":"Bart Lee Scott","orcid":"https://orcid.org/0000-0001-9620-7839","observed_orcids":["https://orcid.org/0000-0001-9620-7839"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bart L Scott","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049910941","display_name":"Maria R. Baer","orcid":"https://orcid.org/0000-0002-9499-1348","observed_orcids":["https://orcid.org/0000-0002-9499-1348"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria R. Baer","raw_affiliation_strings":["University of Maryland Greenebaum Cancer Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland Greenebaum Cancer Center, Baltimore, MD","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006372952","display_name":"Ronald Hoffman","orcid":"https://orcid.org/0000-0001-6564-6732","observed_orcids":["https://orcid.org/0000-0001-6564-6732","https://orcid.org/0000-0002-0091-9573"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Hoffman","raw_affiliation_strings":["Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060015628","display_name":"Olatoyosi M. Odenike","orcid":"https://orcid.org/0000-0002-4027-4124","observed_orcids":["https://orcid.org/0000-0002-4027-4124"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olatoyosi Odenike","raw_affiliation_strings":["Section of Hematology/Oncology, University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058116249","display_name":"Jacqueline Bussolari","orcid":"https://orcid.org/0009-0005-9705-0913","observed_orcids":["https://orcid.org/0009-0005-9705-0913"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Bussolari","raw_affiliation_strings":["Janssen Research & Development, LLC, Raritan, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Raritan, NJ","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109451502","display_name":"Eugene Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugene Zhu","raw_affiliation_strings":["Janssen Research & Development, LLC, Raritan, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Raritan, NJ","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062094994","display_name":"Fei Huang","orcid":"https://orcid.org/0000-0003-3263-0675","observed_orcids":["https://orcid.org/0000-0003-3263-0675"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fei Huang","raw_affiliation_strings":["Janssen Research & Development, LLC, Spring House, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Spring House, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004071908","display_name":"Esther H. Rose","orcid":"https://orcid.org/0000-0002-7572-1596","observed_orcids":["https://orcid.org/0000-0002-7572-1596"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Esther Rose","raw_affiliation_strings":["Janssen Research & Development, LLC, Raritan, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Raritan, NJ","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062937325","display_name":"Laurie Jill Sherman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie Sherman","raw_affiliation_strings":["Janssen Research & Development, LLC, Spring House, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Spring House, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078437962","display_name":"Souria Dougherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Souria Dougherty","raw_affiliation_strings":["Janssen Research & Development, LLC, Spring House, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Spring House, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030798486","display_name":"Faye M. Feller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faye M. Feller","raw_affiliation_strings":["Janssen Research & Development, LLC, Raritan, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, Raritan, NJ","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008609620","display_name":"Jean\u2010Jacques Kiladjian","orcid":"https://orcid.org/0000-0002-8121-438X","observed_orcids":["https://orcid.org/0000-0002-8121-438X"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Jacques Kiladjian","raw_affiliation_strings":["Centre d'Investigations Cliniques, H\u00f4pital Saint-Louis, Universit\u00e9 Paris Diderot, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre d'Investigations Cliniques, H\u00f4pital Saint-Louis, Universit\u00e9 Paris Diderot, Paris, France","institution_ids":["https://openalex.org/I4210144610","https://openalex.org/I4387154366"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5004071908","https://openalex.org/A5021124944","https://openalex.org/A5062094994","https://openalex.org/A5071926851","https://openalex.org/A5109451502","https://openalex.org/A5111559933"],"corresponding_institution_ids":["https://openalex.org/I4210098397","https://openalex.org/I4210156450","https://openalex.org/I4405282460","https://openalex.org/I9360294"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"685","last_page":"685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imetelstat","display_name":"imetelstat","score":0.996999979019165},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/telomerase-inhibition","display_name":"telomerase inhibition","score":0.7590000033378601},{"id":"https://openalex.org/keywords/spleen-volume-reduction","display_name":"spleen volume reduction","score":0.7760000228881836},{"id":"https://openalex.org/keywords/symptomatic-response","display_name":"symptom response","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.6019999980926514},{"id":"https://openalex.org/keywords/dipss-risk-stratification","display_name":"DIPSS risk stratification","score":0.6399999856948853},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6269999742507935},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.421999990940094},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.6190000176429749},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.3889999985694885},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.42500001192092896},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7798495292663574},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.739458441734314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6292240619659424},{"id":"https://openalex.org/C2776233030","wikidata":"https://www.wikidata.org/wiki/Q17149812","display_name":"Janus kinase inhibitor","level":4,"score":0.5267181992530823},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5213854908943176},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5096230506896973},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4634556472301483},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.43023034930229187},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3790609538555145},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3308963179588318},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2207966148853302},{"id":"https://openalex.org/C2778886723","wikidata":"https://www.wikidata.org/wiki/Q3530324","display_name":"Tofacitinib","level":3,"score":0.18507739901542664},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-115163","doi":"https://doi.org/10.1182/blood-2018-99-115163","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-115163","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3165929791","https://openalex.org/W2891562335","https://openalex.org/W4405048120","https://openalex.org/W1653629301","https://openalex.org/W1612798501","https://openalex.org/W4310127292","https://openalex.org/W4200584238","https://openalex.org/W2950818829","https://openalex.org/W4283325206","https://openalex.org/W4229009918"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Imetelstat,":[2],"a":[3,16,41,61,78,325,331,367,400,693],"13-mer":[4],"oligonucleotide":[5],"that":[6,126],"specifically":[7],"targets":[8],"the":[9,75,149,264,316,346,354,362,376,386,395,412,427,440,470],"RNA":[10],"template":[11],"of":[12,20,54,77,83,102,105,151,155,288,295,309,318,335,454,650,727,741,757,794,806,818,831,843,855,871,887,940,952,964,979,991,1004,1068,1081,1092],"human":[13],"telomerase,":[14],"is":[15,692],"potent":[17],"competitive":[18],"inhibitor":[19,64],"telomerase":[21],"enzymatic":[22],"activity":[23,32,617],"(Asai":[24],"Cancer":[25],"Res":[26],"2003;":[27],"Herbert":[28],"Oncogene":[29],"2005).":[30],"Clinical":[31],"and":[33,180,202,238,240,275,297,390,437,443,483,494,536,539,550,556,565,572,700],"an":[34,474,597,724,738,754,791,803,815,828,840,852,868,884,937,949,961,976,988,1001,1065,1078,1089],"acceptable":[35,679],"safety":[36,673],"profile":[37,674],"were":[38,188,246,299,322,435,481,529,543,558,585,602,653],"reported":[39,638,660],"in":[40,45,89,118,137,211,263,361,385,394,411,426,506,587,618,630,704],"33-patient":[42],"pilot":[43],"study":[44,82,101,636],"intermediate-2":[46],"(int-2)":[47],"or":[48,109,123,142,159,291,313,461,515,620,729,743,759,796,808,820,833,845,857,873,889,942,954,966,981,993,1006,1070,1083,1094],"high-risk":[49,124,621],"myelofibrosis":[50],"(MF),":[51],"where":[52],"48%":[53],"patients":[55,90,245,296,321,360,384,393,451,479,493,507,589,623,641,651,699],"had":[56,366,399],"been":[57,418,489,659],"previously":[58,654],"treated":[59,655],"with":[60,91,120,372,508,561,656],"Janus":[62],"Kinase":[63],"(JAKi)":[65],"(Tefferi":[66],"N":[67],"Engl":[68],"J":[69],"Med":[70],"2015).":[71],"Here,":[72],"we":[73],"report":[74],"results":[76],"phase":[79,99],"2":[80,100],"clinical":[81,319,616,705],"imetelstat":[84,106,676],"at":[85,145,223,248,452,526,540,607,685],"two":[86,103],"dose":[87,455],"levels":[88],"MF":[92,125,162,622,698],"(MYF2001,":[93],"NCT02426086).":[94],"Methods:":[95],"A":[96],"randomized,":[97],"multicenter,":[98],"doses":[104],"(9.4":[107],"mg/kg":[108,111,348,356,364,378,388,397,414,429,442,445,472,528,542,563,570,609,687],"4.7":[110,253,355,377,396,428,444,541,569],"IV,":[112],"every":[113,611,689],"3":[114,391,612,690],"weeks)":[115],"was":[116,127,163,271,279,343,423,476,495,504,677],"performed":[117],"adults":[119],"DIPSS":[121],"int-2":[122,619],"relapsed/refractory":[128,626,645],"to":[129,627,646,661],"prior":[130],"JAKi":[131,152,270,459,657],"therapy":[132,460],"(ie,":[133],"either":[134],"no":[135,286,373,634],"reduction":[136,198,210,404],"splenomegaly":[138,144,170],"after":[139,148],"12":[140],"weeks":[141,613,691],"worsening":[143],"any":[146],"time":[147,268,317,453],"start":[150],"therapy).":[153],"Diagnosis":[154],"primary,":[156],"post-essential":[157],"thrombocythemia,":[158],"post-polycythemia":[160],"vera":[161],"required;":[164],"other":[165],"eligibility":[166],"criteria":[167],"included":[168,229],"measurable":[169],"(by":[171],"magnetic":[172],"resonance":[173],"imaging":[174],"[MRI]),":[175],"active":[176],"MF-related":[177],"systemic":[178],"symptoms":[179],"platelet":[181,277],"count":[182,278],"\u226575":[183],"x":[184,281],"109/L.":[185,282],"Primary":[186],"endpoints":[187,228],"spleen":[189,196,368],"response":[190,204,369,402,502],"rate":[191,205,503],"(%":[192,206],"achieving":[193,207],"\u2265":[194,208,306,405],"35%":[195],"volume":[197],"[SVR]":[199],"by":[200,596],"MRI)":[201],"symptom":[203,213,401],"50%":[209],"total":[212],"score":[214],"[TSS]":[215],"per":[216,370],"Myelofibrosis":[217],"Symptom":[218],"Assessment":[219],"Form":[220],"(MFSAF)":[221],"v2":[222],"week":[224],"24.":[225],"Key":[226],"secondary":[227],"safety,":[230],"overall":[231],"survival":[232,433,639],"(OS),":[233],"treatment":[234,333,342,523],"response,":[235,237],"molecular":[236,302],"pharmacokinetic":[239],"pharmacodynamic":[241],"relationships.":[242],"Results:":[243],"107":[244],"enrolled":[247],"55":[249],"institutions":[250],"(48":[251],"on":[252,256,269,341,345,353,375,522,590,723,737,753,790,802,814,827,839,851,867,883,936,948,960,975,987,1000,1064,1077,1088],"mg/kg;":[254],"59":[255],"9.4":[257,347,363,387,413,441,471,527,562,608,686],"mg/kg).":[258],"Baseline":[259],"characteristics":[260],"are":[261,625,643],"shown":[262],"Table.":[265],"Additionally,":[266],"median":[267,276,326,332,421,648],"23":[272],"(0.9-89.7)":[273],"mo,":[274,329],"147":[280],"Triple-negative":[283],"(TN;":[284],"ie,":[285,305],"mutations":[287],"JAK2,":[289],"MPL,":[290],"CALR)":[292],"comprised":[293],"24.8%":[294],"67.6%":[298],"considered":[300,678],"high":[301],"risk":[303],"(HMR;":[304],"1":[307,509],"mutation":[308,511],"ASXL1,":[310],"EZH2,":[311,513],"SRSF2,":[312,514],"IDH1/2).":[314],"At":[315],"cutoff,":[320],"followed":[323],"for":[324,439,457,491,498,640,675,680,696],"22.6":[327],"(0.2-27.4)":[328],"including":[330],"duration":[334,340],"6.2":[336],"(0.0-27.2)":[337],"mo.":[338],"Median":[339,409],"longer":[344],"arm":[349,365,379,389,398,415],"(7.7":[350],"mo)":[351],"than":[352,568],"arm.":[357,430],"Six":[358],"(10.2%)":[359],"MRI,":[371],"responses":[374],"(Figure":[380,407],"1).":[381],"Nineteen":[382],"(32%)":[383],"(6%)":[392],"(TSS":[403],"50%)":[406],"2).":[408],"OS":[410,422,484,486,649],"has":[416,487,614,637,658],"not":[417,488,603],"reached,":[419],"while":[420],"19.9":[424],"mo":[425,497,664],"The":[431,517,672],"18-mo":[432],"rates":[434],"76.7%":[436],"62.9%":[438],"arms,":[446],"respectively.":[447],"Sensitivity":[448],"analyses":[449],"censoring":[450],"escalation":[456],"subsequent":[458],"allogeneic":[462],"stem":[463],"cell":[464],"transplant":[465],"generated":[466],"similar":[467],"results.":[468],"In":[469],"arm,":[473],"association":[475],"observed":[477,586,631],"between":[478],"who":[480,624,642,652],"TN":[482,492],"(median":[485],"reached":[490],"23.6":[496],"non-TN":[499],"patients).":[500],"Spleen":[501],"higher":[505],"HMR":[510],"(ASXL1,":[512],"IDH1/2.":[516],"most":[518,575],"common":[519],"adverse":[520],"events":[521],"(all":[524],"grades)":[525],"thrombocytopenia":[530,551,557],"(49%),":[531],"anemia":[532,548],"(44%),":[533],"neutropenia":[534,555],"(36%),":[535],"nausea":[537,546],"(34%)":[538],"diarrhea":[544],"(38%),":[545],"(31%),":[547,549],"(23%).":[552],"Grade":[553,581],"3/4":[554,582],"more":[559],"frequent":[560],"(34%":[564],"42%,":[566],"respectively)":[567],"(13%":[571],"29%,":[573],"respectively);":[574],"cytopenias":[576],"resolved":[577],"within":[578],"4":[579],"weeks.":[580],"LFT":[583],"elevations":[584],"7":[588],"study.":[591],"Imetelstat-related":[592],"hepatic":[593],"toxicities,":[594],"confirmed":[595],"independent":[598],"Hepatic":[599],"Review":[600],"Committee,":[601],"observed.":[604],"Conclusions:":[605],"Imetelstat":[606,684],"IV":[610,688],"demonstrated":[615],"JAKi,":[628,647],"notably":[629],"OS.":[632],"Though":[633],"formal":[635],"truly":[644],"be":[662],"12-14":[663],"(Kuykendall":[665],"Ann":[666],"Hematol":[667],"2018;":[668],"Newberry":[669],"Blood":[670],"2017).":[671],"this":[681],"poor-prognosis":[682],"population.":[683],"promising":[694],"agent":[695],"JAKi-pretreated":[697],"warrants":[701],"further":[702],"testing":[703],"trials.":[706],"Disclosures":[707],"Mascarenhas:":[708],"Roche:":[709],"Research":[710,713,716,719,732,746,749,780,784,860,876,893,903,910,913,916,919,923,927,931,969,1011,1014,1017,1021,1024,1027,1031,1073,1097],"Funding;":[711,714,717,720,733,747,750,781,894,904,914,917,920,924,932,970,1012,1015,1018,1022,1025,1028,1074],"Merck:":[712],"Novartis:":[715,766,770,774,909,1086],"Promedior:":[718],"Incyte:":[721,918,984],"Membership":[722,736,752,789,801,813,826,838,850,866,882,935,947,959,974,986,999,1063,1076,1087],"entity's":[725,739,755,792,804,816,829,841,853,869,885,938,950,962,977,989,1002,1066,1079,1090],"Board":[726,740,756,793,805,817,830,842,854,870,886,939,951,963,978,990,1003,1067,1080,1091],"Directors":[728,742,758,795,807,819,832,844,856,872,888,941,953,965,980,992,1005,1069,1082,1093],"advisory":[730,744,760,797,809,821,834,846,858,874,890,943,955,967,982,994,1007,1071,1084,1095],"committees,":[731,745,859,875,968,1072,1096],"CTI":[734],"Biopharma:":[735],"Janssen:":[748,848,1023],"Celgene:":[751,778,782,864,945,1016,1075],"committees.":[761,891],"Komrokji:Novartis:":[762],"Honoraria,":[763,767,771,775,779,783,788,800,812,825,837,849,865,881,930],"Speakers":[764,768,772,776,862,878,896],"Bureau;":[765,769,773,777,863,879],"Funding.":[785,911,928,1032,1098],"Cavo:Adaptive":[786],"Biotechnologies:":[787],"committees;":[798,810,822,835,847,944,956,983,995,1008,1085],"GlaxoSmithKline:":[799],"AbbVie:":[811],"Bristol-Myers":[823],"Squibb:":[824],"Takeda:":[836],"Funding,":[861,877],"Amgen:":[880],"Niederwieser:Novartis:":[892],"Miltenyi:":[895],"Bureau.":[897],"Reiter:Incyte:":[898],"Consultancy,":[899,902,934,946,958,973,985,998],"Honoraria.":[900],"Scott:Celgene:":[901],"Agios:":[905,1013],"Consultancy;":[906,908],"Alexion:":[907],"Hoffman:Janssen:":[912],"Merus:":[915],"Summer":[921],"Road:":[922],"Formation":[925],"Biologics:":[926],"Odenike:ABBVIE:":[929],"Pfizer:":[933],"CTI/Baxalta:":[957],"Dava":[971],"Oncology:":[972],"Jazz":[996],"Pharmaceuticals:":[997],"Oncotherapy":[1009],"Science:":[1010],"NS":[1019],"Pharma:":[1020],"Astex:":[1026],"Gilead":[1029],"Sciences:":[1030],"Bussolari:Janssen:":[1033],"Employment,":[1034,1038,1042,1046,1050,1054,1058],"Equity":[1035,1039,1043,1047,1051,1055,1059],"Ownership.":[1036,1040,1044,1048,1052,1056,1060],"Zhu:Janssen:":[1037],"Huang:Janssen:":[1041],"Rose:Janssen:":[1045],"Sherman:Janssen:":[1049],"Dougherty:Janssen:":[1053],"Feller:Janssen:":[1057],"Kiladjian:AOP":[1061],"Orphan:":[1062]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-11-09T00:00:00"}