{"id":"https://openalex.org/W2898544102","doi":"https://doi.org/10.1038/s41598-018-34345-3","title":"Phosphoinositide 3-kinase-delta could be a biomarker for eosinophilic nasal polyps","display_name":"Phosphoinositide 3-kinase-delta could be a biomarker for eosinophilic nasal polyps","publication_year":2018,"publication_date":"2018-10-24","ids":{"openalex":"https://openalex.org/W2898544102","doi":"https://doi.org/10.1038/s41598-018-34345-3","mag":"2898544102","pmid":"https://pubmed.ncbi.nlm.nih.gov/30375439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6207677"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-34345-3","doi":"https://doi.org/10.1038/s41598-018-34345-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-34345-3","pdf_url":"https://www.nature.com/articles/s41598-018-34345-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-34345-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100737773","display_name":"Jong Seung Kim","orcid":"https://orcid.org/0000-0003-3477-1172","observed_orcids":["https://orcid.org/0000-0003-3477-1172","https://orcid.org/0000-0002-1384-6799"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Seung Kim","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, South Korea","Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"raw_affiliation_string":"Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026683668","display_name":"Jae Seok Jeong","orcid":"https://orcid.org/0000-0002-4635-8302","observed_orcids":["https://orcid.org/0000-0002-4635-8302"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Seok Jeong","raw_affiliation_strings":["Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015822976","display_name":"Kyung-Bae Lee","orcid":"https://orcid.org/0000-0002-4442-7896","observed_orcids":["https://orcid.org/0000-0002-4442-7896"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung Bae Lee","raw_affiliation_strings":["Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073854525","display_name":"So Ri Kim","orcid":"https://orcid.org/0000-0002-6074-9158","observed_orcids":["https://orcid.org/0000-0002-6074-9158"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So Ri Kim","raw_affiliation_strings":["Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea","Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-6074-9158","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"raw_affiliation_string":"Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104066600","display_name":"Yeong Hun Choe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeong Hun Choe","raw_affiliation_strings":["Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074559284","display_name":"Sam Hyun Kwon","orcid":"https://orcid.org/0000-0001-5261-6155","observed_orcids":["https://orcid.org/0000-0001-5261-6155"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sam Hyun Kwon","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, South Korea","Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"raw_affiliation_string":"Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049245305","display_name":"Seong Cho","orcid":"https://orcid.org/0000-0003-0933-953X","observed_orcids":["https://orcid.org/0000-0003-0933-953X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong Ho Cho","raw_affiliation_strings":["Division of Allergy and Immunology, Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057454247","display_name":"Yong Chul Lee","orcid":"https://orcid.org/0000-0002-0433-509X","observed_orcids":["https://orcid.org/0000-0002-0433-509X"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong Chul Lee","raw_affiliation_strings":["Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea. leeyc@jbnu.ac.kr","Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea. leeyc@jbnu.ac.kr","Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea. leeyc@jbnu.ac.kr","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"raw_affiliation_string":"Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea. leeyc@jbnu.ac.kr","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"raw_affiliation_string":"Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057454247"],"corresponding_institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"1","first_page":"15990","last_page":"15990"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphoinositide-3-kinase-delta","display_name":"phosphoinositide 3-kinase delta","score":0.9520000219345093},{"id":"https://openalex.org/keywords/eosinophilic-nasal-polyps","display_name":"eosinophilic nasal polyps","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-rhinosinusitis","display_name":"chronic rhinosinusitis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nasal-inflammation","display_name":"nasal inflammation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9440000057220459},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.871999979019165},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.7866443395614624},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6505401134490967},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.5233991742134094},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.4539484977722168},{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.4452134072780609},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39100348949432373},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38330626487731934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36139142513275146},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33858972787857056},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33778780698776245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31422579288482666},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2603837847709656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20173874497413635},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19212689995765686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17097830772399902},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-018-34345-3","doi":"https://doi.org/10.1038/s41598-018-34345-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-34345-3","pdf_url":"https://www.nature.com/articles/s41598-018-34345-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5161135","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6207677","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30375439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30375439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6207677","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6207677/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5dead888040841d8bb0eff3e11f7deae","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5dead888040841d8bb0eff3e11f7deae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-34345-3","doi":"https://doi.org/10.1038/s41598-018-34345-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-34345-3","pdf_url":"https://www.nature.com/articles/s41598-018-34345-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3864252158","display_name":null,"funder_award_id":"NRF2014R1A2A1A01002823","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321194","display_name":"Chonbuk National University","ror":"https://ror.org/05q92br09"},{"id":"https://openalex.org/F4320321549","display_name":"Chonbuk National University Hospital","ror":"https://ror.org/03by16w37"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2898544102.pdf","grobid_xml":"https://content.openalex.org/works/W2898544102.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W91108901","https://openalex.org/W1552927675","https://openalex.org/W1585743408","https://openalex.org/W1594031697","https://openalex.org/W1686386964","https://openalex.org/W1762605472","https://openalex.org/W1968080521","https://openalex.org/W1972104377","https://openalex.org/W1977544966","https://openalex.org/W1978596588","https://openalex.org/W1979484887","https://openalex.org/W1990235568","https://openalex.org/W2014302714","https://openalex.org/W2021701428","https://openalex.org/W2026583845","https://openalex.org/W2028152664","https://openalex.org/W2039533506","https://openalex.org/W2097637220","https://openalex.org/W2101624295","https://openalex.org/W2136853405","https://openalex.org/W2142554389","https://openalex.org/W2163577434","https://openalex.org/W2209714275","https://openalex.org/W2264831043","https://openalex.org/W2282773014","https://openalex.org/W2312821981","https://openalex.org/W2593852904","https://openalex.org/W2740528188","https://openalex.org/W2744377419","https://openalex.org/W2753338558","https://openalex.org/W2771768541","https://openalex.org/W2784912488","https://openalex.org/W2796115420","https://openalex.org/W2884288527"],"related_works":["https://openalex.org/W54658314","https://openalex.org/W1978570564","https://openalex.org/W3009558940","https://openalex.org/W7221181196","https://openalex.org/W2074897148","https://openalex.org/W2922519953","https://openalex.org/W2905942367","https://openalex.org/W2136853405","https://openalex.org/W2990990842","https://openalex.org/W2010145759"],"abstract_inverted_index":{"Nasal":[0],"polyps":[1],"(NP)":[2],"cause":[3],"diverse":[4],"clinical":[5,94,146],"symptoms":[6],"of":[7,13,30,52,57,96,118,127,137],"chronic":[8],"rhinosinusitis":[9],"(CRS).":[10],"Chronic":[11],"inflammation":[12,36],"sinonasal":[14],"mucosa":[15],"is":[16],"known":[17],"to":[18,26,65,91,134],"be":[19],"crucial":[20],"in":[21,34,59,84,111,120],"NP":[22,39,42,60,103,112,121,141],"formation.":[23],"We":[24],"aimed":[25],"define":[27],"the":[28,97,128,135],"implications":[29],"phosphoinositide":[31],"3-kinase":[32],"(PI3K)-\u03b4":[33],"nasal":[35],"associated":[37,142],"with":[38,74,104,143],"by":[40],"analyzing":[41],"tissue":[43,61,113],"obtained":[44],"from":[45],"CRS":[46,77,100],"patients.":[47],"Results":[48],"showed":[49],"that":[50],"expression":[51,70,81,107],"p110\u03b4,":[53],"a":[54],"regulatory":[55],"subunit":[56],"PI3K-\u03b4,":[58],"was":[62,71,82],"increased":[63,83],"compared":[64],"control":[66],"tissue.":[67],"Increased":[68],"p110\u03b4":[69,80,106],"closely":[72,89],"correlated":[73],"more":[75,92,109,124,144],"severe":[76,125,145],"features.":[78,150],"Interestingly,":[79],"eosinophilic":[85,140],"NP,":[86,138],"which":[87],"are":[88],"related":[90],"complicated":[93],"courses":[95],"disease.":[98,129],"Furthermore,":[99],"patients":[101],"possessing":[102],"higher":[105,116],"displayed":[108],"eosinophils":[110],"and":[114,123,148],"blood,":[115],"levels":[117],"IL-5":[119],"tissue,":[122],"features":[126],"Therefore,":[130],"PI3K-\u03b4":[131],"may":[132],"contribute":[133],"formation":[136],"especially":[139],"presentations":[147],"radiological":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-11-02T00:00:00"}
