{"id":"https://openalex.org/W2898338401","doi":null,"title":"CELLULAR PATHWAY DEREGULATION AND POTENTIAL TARGETED THERAPY FOR ADULT T-CELL LEUKEMIA","display_name":"CELLULAR PATHWAY DEREGULATION AND POTENTIAL TARGETED THERAPY FOR ADULT T-CELL LEUKEMIA","publication_year":2017,"publication_date":"2017-12-31","ids":{"openalex":"https://openalex.org/W2898338401","mag":"2898338401"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/27030","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/27030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054449057","display_name":"Ramona Moles","orcid":"https://orcid.org/0000-0001-8576-2394","observed_orcids":["https://orcid.org/0000-0001-8576-2394"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ramona Moles","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8576-2394","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054449057"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-t-cell-leukemia-lymphoma","display_name":"adult T-cell leukemia/lymphoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8880000114440918},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/helicase-inhibitors","display_name":"helicase inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/viral-transformation","display_name":"viral transformation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C78780426","wikidata":"https://www.wikidata.org/wiki/Q902410","display_name":"Deregulation","level":2,"score":0.7950390577316284},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5338196754455566},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4470142424106598},{"id":"https://openalex.org/C2776913467","wikidata":"https://www.wikidata.org/wiki/Q7667895","display_name":"T-cell leukemia","level":3,"score":0.4201522767543793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3757442831993103},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.32164162397384644},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2598784565925598},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.2262314260005951},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.14173623919487}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/27030","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/27030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2898338401","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/27030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2140987681","https://openalex.org/W2799730024","https://openalex.org/W7097516883","https://openalex.org/W158470133","https://openalex.org/W1976897726","https://openalex.org/W2979380346","https://openalex.org/W4280507449","https://openalex.org/W2045016873","https://openalex.org/W2041531155","https://openalex.org/W1597869075"],"abstract_inverted_index":{"Human":[0],"T-cell":[1,13],"leukemia":[2],"virus":[3,45],"type":[4],"1":[5],"(HTLV-1)":[6],"is":[7,50,87,134,141,158],"the":[8,40,44,98,110,156,159],"etiologic":[9],"agent":[10],"of":[11,27,37,63,71,84,100,112,121,161,166],"Adult":[12],"Leukemia":[14],"(ATL),":[15],"a":[16,20,60,148],"lymphoproliferative":[17],"disorder":[18],"with":[19,30],"very":[21],"poor":[22],"prognosis.":[23],"While":[24],"approximatively":[25],"5%":[26],"individuals":[28],"infected":[29],"HTLV-1":[31],"develop":[32],"ATL":[33,49,107,174],"within":[34],"twenty":[35],"years":[36],"first":[38],"infection,":[39],"molecular":[41],"mechanism":[42],"that":[43,131],"uses":[46],"to":[47,77,88,119],"induce":[48],"not":[51],"entirely":[52],"understood.":[53],"microRNAs":[54],"are":[55],"posttranscriptional":[56],"regulators":[57],"involved":[58],"in":[59,91,97,104,136,152,171],"wide":[61],"range":[62],"biological":[64,68],"processes.":[65],"Based":[66],"on":[67,143],"functions,":[69],"alteration":[70],"their":[72,95],"expression":[73,93],"can":[74],"potentially":[75],"contribute":[76],"tumor":[78],"initiation":[79],"and":[80,94,106,164,168,173],"progression.":[81],"The":[82],"purpose":[83],"this":[85,139],"thesis":[86,140],"study":[89,160],"changes":[90],"miRNA":[92],"role":[96],"deregulation":[99],"cellular":[101],"pathways":[102],"essential":[103],"HTLV-1-transformed":[105,137,172],"cells.":[108,175],"Moreover,":[109],"absence":[111],"an":[113],"effective":[114],"treatment":[115],"for":[116,125],"patients":[117],"led":[118],"investigation":[120],"potential":[122],"therapeutic":[123,150],"strategies":[124],"ATL.":[126,153],"Since":[127],"previous":[128],"findings":[129],"show":[130],"DNA":[132,145],"repair":[133,146],"impaired":[135],"cells,":[138],"focused":[142],"targeting":[144],"as":[147],"new":[149],"option":[151],"More":[154],"specifically,":[155],"aim":[157],"antiproliferative":[162],"effects":[163],"cytotoxicity":[165],"PARP":[167],"helicase":[169],"inhibitors":[170]},"counts_by_year":[],"updated_date":"2026-09-18T07:38:42.748307","created_date":"2018-11-02T00:00:00"}