{"id":"https://openalex.org/W2898246781","doi":"https://doi.org/10.1186/s13046-018-0931-z","title":"The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation","display_name":"The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation","publication_year":2018,"publication_date":"2018-10-25","ids":{"openalex":"https://openalex.org/W2898246781","doi":"https://doi.org/10.1186/s13046-018-0931-z","mag":"2898246781","pmid":"https://pubmed.ncbi.nlm.nih.gov/30359286"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-018-0931-z","doi":"https://doi.org/10.1186/s13046-018-0931-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-018-0931-z","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-018-0931-z","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-018-0931-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089096739","display_name":"Yuting Gu","orcid":"https://orcid.org/0000-0001-5891-0101","observed_orcids":["https://orcid.org/0000-0001-5891-0101"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Gu","raw_affiliation_strings":["Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","Department of Stomatology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]},{"raw_affiliation_string":"Department of Stomatology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102871702","display_name":"Fan Lv","orcid":"https://orcid.org/0000-0002-0988-6958","observed_orcids":["https://orcid.org/0000-0002-0988-6958"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Lv","raw_affiliation_strings":["Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068070422","display_name":"Mingxing Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxing Xue","raw_affiliation_strings":["Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004747587","display_name":"Kai Chen","orcid":"https://orcid.org/0000-0002-8845-1820","observed_orcids":["https://orcid.org/0000-0002-8845-1820"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Chen","raw_affiliation_strings":["Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349405","display_name":"Cheng Cheng","orcid":"https://orcid.org/0000-0002-5367-3618","observed_orcids":["https://orcid.org/0000-0002-5367-3618"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Cheng","raw_affiliation_strings":["Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063126731","display_name":"Xinyuan Ding","orcid":"https://orcid.org/0000-0002-8982-6807","observed_orcids":["https://orcid.org/0000-0002-8982-6807"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyuan Ding","raw_affiliation_strings":["Department of Pharmacy, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492599","display_name":"Min Jin","orcid":"https://orcid.org/0000-0003-0073-4816","observed_orcids":["https://orcid.org/0000-0003-0073-4816"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Jin","raw_affiliation_strings":["Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100750617","display_name":"Guofeng Xu","orcid":"https://orcid.org/0000-0002-5104-5386","observed_orcids":["https://orcid.org/0000-0002-5104-5386"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guofeng Xu","raw_affiliation_strings":["Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101474457","display_name":"Yanyun Zhang","orcid":"https://orcid.org/0000-0002-8990-8220","observed_orcids":["https://orcid.org/0000-0002-8990-8220"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyun Zhang","raw_affiliation_strings":["Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053566490","display_name":"Zhixiang Wu","orcid":"https://orcid.org/0000-0002-3947-2035","observed_orcids":["https://orcid.org/0000-0002-3947-2035","https://orcid.org/0000-0001-6557-0184"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhixiang Wu","raw_affiliation_strings":["Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, China. wuzhixiang@xinhuamed.com.cn","Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. wuzhixiang@xinhuamed.com.cn","Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China. wuzhixiang@xinhuamed.com.cn","Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, China. wuzhixiang@xinhuamed.com.cn","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]},{"raw_affiliation_string":"Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. wuzhixiang@xinhuamed.com.cn","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China. wuzhixiang@xinhuamed.com.cn","institution_ids":[]},{"raw_affiliation_string":"Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101997469","display_name":"Leizhen Zheng","orcid":"https://orcid.org/0000-0003-1309-3755","observed_orcids":["https://orcid.org/0000-0003-1309-3755"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Leizhen Zheng","raw_affiliation_strings":["Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. zhengleizhen2006@126.com","Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. zhengleizhen2006@126.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]},{"raw_affiliation_string":"Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100761133","display_name":"Yeming Wu","orcid":"https://orcid.org/0000-0003-3559-4817","observed_orcids":["https://orcid.org/0000-0003-3559-4817"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yeming Wu","raw_affiliation_strings":["Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, China. wuyeming@xinhuamed.com.cn","Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. wuyeming@xinhuamed.com.cn","Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China. wuyeming@xinhuamed.com.cn","Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, China. wuyeming@xinhuamed.com.cn","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]},{"raw_affiliation_string":"Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. wuyeming@xinhuamed.com.cn","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China. wuyeming@xinhuamed.com.cn","institution_ids":[]},{"raw_affiliation_string":"Division of Pediatric Oncology, Shanghai Institute of Pediatric Research, Shanghai, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5053566490","https://openalex.org/A5100761133","https://openalex.org/A5101997469"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579","https://openalex.org/I3923682","https://openalex.org/I4210151382"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":3.2701,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.92315113,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"37","issue":"1","first_page":"258","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/uchl1","display_name":"UCHL1","score":1.0},{"id":"https://openalex.org/keywords/deubiquitinase","display_name":"deubiquitinase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ganglioneuroblastoma","display_name":"ganglioneuroblastoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ganglioneuroma","display_name":"ganglioneuroma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":1.0},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.49799999594688416},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C102658986","wikidata":"https://www.wikidata.org/wiki/Q5266092","display_name":"Deubiquitinating enzyme","level":4,"score":0.8131558299064636},{"id":"https://openalex.org/C2780582931","wikidata":"https://www.wikidata.org/wiki/Q5521151","display_name":"Ganglioneuroblastoma","level":5,"score":0.7452195286750793},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.6541347503662109},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.6199187636375427},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.6079807281494141},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5776375532150269},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.566148042678833},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5572905540466309},{"id":"https://openalex.org/C2779102060","wikidata":"https://www.wikidata.org/wiki/Q1124606","display_name":"Ganglioneuroma","level":4,"score":0.5315487384796143},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5079613327980042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5018942356109619},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47327399253845215},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.46586015820503235},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4612938165664673},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3755279779434204},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.357617050409317},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3364650011062622},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.26084741950035095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2204599380493164},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1863783597946167},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.181892991065979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17729991674423218},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17520391941070557},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15841427445411682},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10823479294776917},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018305","descriptor_name":"Ganglioneuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018305","descriptor_name":"Ganglioneuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018305","descriptor_name":"Ganglioneuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13046-018-0931-z","doi":"https://doi.org/10.1186/s13046-018-0931-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-018-0931-z","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-018-0931-z","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:30359286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30359286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5160113","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6203192","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6203192","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6203192","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bf0e065139524a9b89ffe4a239ef650f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bf0e065139524a9b89ffe4a239ef650f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-14 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13046-018-0931-z","doi":"https://doi.org/10.1186/s13046-018-0931-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-018-0931-z","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-018-0931-z","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1102425948","display_name":null,"funder_award_id":"No. 81572918","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2983280289","display_name":null,"funder_award_id":"16QA1402900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3365060708","display_name":null,"funder_award_id":"81672488","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3600822611","display_name":null,"funder_award_id":"2015CB943303","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G4775654616","display_name":null,"funder_award_id":"2014CB94330","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G4800030306","display_name":null,"funder_award_id":"2015CB943303, 2014CB94330","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G6424353240","display_name":null,"funder_award_id":"No. 81402478","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6915249461","display_name":null,"funder_award_id":"16QA1402900","funder_id":"https://openalex.org/F4320327803","funder_display_name":"Shanghai Rising-Star Program"},{"id":"https://openalex.org/G7574632262","display_name":null,"funder_award_id":"2015CB943303","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8014372221","display_name":null,"funder_award_id":"81402478","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G987193725","display_name":null,"funder_award_id":"81572918","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320327803","display_name":"Shanghai Rising-Star Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2898246781.pdf","grobid_xml":"https://content.openalex.org/works/W2898246781.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1653631888","https://openalex.org/W1894057315","https://openalex.org/W1926885922","https://openalex.org/W1964520872","https://openalex.org/W1967098715","https://openalex.org/W1977889350","https://openalex.org/W1986441249","https://openalex.org/W2000577272","https://openalex.org/W2002156115","https://openalex.org/W2015751107","https://openalex.org/W2018393684","https://openalex.org/W2047200931","https://openalex.org/W2051556946","https://openalex.org/W2057527139","https://openalex.org/W2059531568","https://openalex.org/W2063960043","https://openalex.org/W2068931555","https://openalex.org/W2071793574","https://openalex.org/W2082232396","https://openalex.org/W2089505157","https://openalex.org/W2091910580","https://openalex.org/W2095849686","https://openalex.org/W2096600031","https://openalex.org/W2101362932","https://openalex.org/W2106713259","https://openalex.org/W2114720222","https://openalex.org/W2118071133","https://openalex.org/W2126352399","https://openalex.org/W2126882311","https://openalex.org/W2130925781","https://openalex.org/W2132855064","https://openalex.org/W2137092630","https://openalex.org/W2139752108","https://openalex.org/W2144488343","https://openalex.org/W2151115238","https://openalex.org/W2152420890","https://openalex.org/W2165256106","https://openalex.org/W2168919863","https://openalex.org/W2220838850","https://openalex.org/W2519390626","https://openalex.org/W2744683708","https://openalex.org/W2750470970","https://openalex.org/W2766223190"],"related_works":["https://openalex.org/W2092504554","https://openalex.org/W2098500401","https://openalex.org/W1974301777","https://openalex.org/W2005031632","https://openalex.org/W3169193529","https://openalex.org/W2626302075","https://openalex.org/W2469154422","https://openalex.org/W2154081118","https://openalex.org/W2089214172","https://openalex.org/W1966003801"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuroblastoma":[1],"(NB)":[2],"is":[3],"the":[4,57,65,71,88,133,139,154,165,240],"most":[5],"common":[6],"pediatric":[7],"solid":[8],"tumor":[9,34,102,186,264],"that":[10,18,200,216],"originates":[11],"from":[12],"neural":[13,260,272],"crest-derived":[14],"sympathoadrenal":[15],"precursor":[16],"cells":[17,35],"are":[19],"committed":[20],"to":[21,297],"development":[22],"of":[23,32,67,75,116,156,262,277,293,308],"sympathetic":[24],"nervous":[25],"system.":[26],"The":[27,81,113],"well":[28],"differentiated":[29,140,237],"histological":[30],"phenotype":[31],"NB":[33,50,122,159,223,234,263,311],"has":[36],"been":[37],"reportedly":[38],"associated":[39,221,280],"with":[40,222,281,323],"favorable":[41],"patient":[42,111,151],"outcome.":[43],"Retinoic":[44],"acid":[45],"(RA)":[46],"can":[47],"effectively":[48],"induce":[49],"cell":[51,160,312],"differentiation,":[52,224],"thereby":[53],"being":[54],"used":[55],"in":[56,108,118,148,158,179,211,230,310,321],"clinic":[58],"as":[59,203,315],"a":[60,100,204,305,316,327],"treatment":[61],"agent":[62],"for":[63,207,319,331],"inducing":[64],"differentiation":[66,77,161,246,261,273,313],"high-risk":[68],"NB.":[69,212,332],"However,":[70],"underlying":[72,166],"molecular":[73],"mechanisms":[74,167],"regulating":[76,283],"remain":[78],"elusive.":[79],"METHODS:":[80],"correlation":[82,134,242],"between":[83,135,243],"clinical":[84,209],"characteristics,":[85],"survival":[86,320],"and":[87,105,121,129,132,138,162,164,175,189,196,232,239,245,271,286,314],"deubiquitinating":[89],"enzyme":[90],"ubiquitin":[91],"C-terminal":[92],"hydrolase":[93],"1":[94],"(UCHL1)":[95],"expression":[96,115,137,219,229],"were":[97,168],"assessed":[98],"using":[99,171],"neuroblastic":[101,185],"tissue":[103,187],"microarray,":[104],"then":[106],"validated":[107,147],"three":[109,149,190],"independent":[110,150,191],"datasets.":[112,152],"different":[114],"UCHL1":[117,136,157,201,218,228,244,251,278,294,309],"ganglioneuroblastoma,":[119],"ganglioneuroma":[120],"was":[123,142,145,220,279],"detected":[124],"by":[125,170,226,252,267],"immunohistochemistry,":[126],"mass":[127],"spectra":[128],"immunoblotting":[130],"analysis,":[131],"histology":[141],"analyzed,":[143],"which":[144],"also":[146],"Furthermore,":[153],"roles":[155],"proliferation":[163],"studied":[169],"short":[172],"hairpin":[173],"RNA":[174],"its":[176],"inhibitor":[177],"LDN57444":[178,255],"vitro.":[180],"RESULTS:":[181],"Based":[182],"on":[183],"our":[184],"microarrays":[188],"validation":[192],"datasets":[193],"(Oberthuer,":[194],"Versteeg":[195],"Seeger),":[197],"we":[198],"identified":[199],"served":[202],"prognostic":[205,317],"marker":[206,318],"better":[208],"outcome":[210],"We":[213],"further":[214],"demonstrated":[215],"high":[217],"indicated":[225],"higher":[227],"ganglioneuroblastomas/ganglioneuromas":[231],"well-differentiated":[233],"than":[235],"poorly":[236],"NB,":[238,324],"positive":[241],"markers.":[247,274],"As":[248],"expected,":[249],"inhibiting":[250],"knockdown":[253,292],"or":[254],"could":[256],"significantly":[257],"inhibit":[258],"RA-induced":[259,284,298],"cells,":[265],"characterized":[266],"decreased":[268],"neurite":[269],"outgrowth":[270],"This":[275],"effect":[276],"positively":[282],"AKT":[285],"ERK1/2":[287],"signaling":[288],"activation.":[289],"What's":[290],"more,":[291],"conferred":[295],"resistance":[296],"growth":[299],"arrest.":[300],"CONCLUSION:":[301],"Our":[302],"findings":[303],"identify":[304],"pivotal":[306],"role":[307],"patients":[322],"potentially":[325],"providing":[326],"novel":[328],"therapeutic":[329],"target":[330]},"counts_by_year":[{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}