{"id":"https://openalex.org/W2898081463","doi":"https://doi.org/10.1155/2018/5651989","title":"The Herb\u2010Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet by Modulation of the Pharmacodynamics and Liver Carboxylesterase 1A Metabolism","display_name":"The Herb\u2010Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet by Modulation of the Pharmacodynamics and Liver Carboxylesterase 1A Metabolism","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2898081463","doi":"https://doi.org/10.1155/2018/5651989","mag":"2898081463","pmid":"https://pubmed.ncbi.nlm.nih.gov/30498515","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6220743"},"language":"en","primary_location":{"id":"doi:10.1155/2018/5651989","doi":"https://doi.org/10.1155/2018/5651989","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/5651989","pdf_url":"https://downloads.hindawi.com/journals/ecam/2018/5651989.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2018/5651989.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100675092","display_name":"Shitang Ma","orcid":"https://orcid.org/0000-0002-7216-2979","observed_orcids":["https://orcid.org/0000-0002-7216-2979"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210109416","display_name":"Anhui Science and Technology University","ror":"https://ror.org/01pn91c28","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210109416"]},{"id":"https://openalex.org/I4405277203","display_name":"Institute of Biomedical Engineering, Chinese Academy of Medical Sciences","ror":"https://ror.org/01vagp983","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4405277203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shitang Ma","raw_affiliation_strings":["Institute of Bio-Medical Engineering, Chinese Academy of Medical Sciences, China","Life and Health College, Anhui Science and Technology University, China"],"raw_orcid":"https://orcid.org/0000-0002-7216-2979","affiliations":[{"raw_affiliation_string":"Institute of Bio-Medical Engineering, Chinese Academy of Medical Sciences, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4405277203"]},{"raw_affiliation_string":"Life and Health College, Anhui Science and Technology University, China","institution_ids":["https://openalex.org/I184681353","https://openalex.org/I4210109416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084923912","display_name":"Guoliang Dai","orcid":"https://orcid.org/0000-0001-8319-9374","observed_orcids":["https://orcid.org/0000-0001-8319-9374"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoliang Dai","raw_affiliation_strings":["Nanjing University of Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing University of Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077832164","display_name":"Xiaolin Bi","orcid":"https://orcid.org/0000-0002-6558-7768","observed_orcids":["https://orcid.org/0000-0002-6558-7768"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolin Bi","raw_affiliation_strings":["Nanjing University of Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing University of Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007450993","display_name":"Meirong Gong","orcid":"https://orcid.org/0000-0002-1497-5971","observed_orcids":["https://orcid.org/0000-0002-1497-5971"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meirong Gong","raw_affiliation_strings":["Nanjing University of Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing University of Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086144154","display_name":"Chenggui Miao","orcid":"https://orcid.org/0000-0001-7862-4524","observed_orcids":["https://orcid.org/0000-0001-7862-4524"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]},{"id":"https://openalex.org/I4210109416","display_name":"Anhui Science and Technology University","ror":"https://ror.org/01pn91c28","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210109416"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenggui Miao","raw_affiliation_strings":["Life and Health College, Anhui Science and Technology University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life and Health College, Anhui Science and Technology University, China","institution_ids":["https://openalex.org/I184681353","https://openalex.org/I4210109416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353465","display_name":"Hao Chen","orcid":"https://orcid.org/0000-0001-5246-4868","observed_orcids":["https://orcid.org/0000-0001-5246-4868"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]},{"id":"https://openalex.org/I4210109416","display_name":"Anhui Science and Technology University","ror":"https://ror.org/01pn91c28","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210109416"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Chen","raw_affiliation_strings":["Life and Health College, Anhui Science and Technology University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life and Health College, Anhui Science and Technology University, China","institution_ids":["https://openalex.org/I184681353","https://openalex.org/I4210109416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075790757","display_name":"Liang-Liang Gao","orcid":"https://orcid.org/0000-0002-0704-9371","observed_orcids":["https://orcid.org/0000-0002-0704-9371"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]},{"id":"https://openalex.org/I4210109416","display_name":"Anhui Science and Technology University","ror":"https://ror.org/01pn91c28","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210109416"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangliang Gao","raw_affiliation_strings":["Life and Health College, Anhui Science and Technology University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life and Health College, Anhui Science and Technology University, China","institution_ids":["https://openalex.org/I184681353","https://openalex.org/I4210109416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110743347","display_name":"Weiman Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150172","display_name":"First Affiliated Hospital of Bengbu Medical College","ror":"https://ror.org/04v043n92","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150172"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiman Zhao","raw_affiliation_strings":["The First Affiliated Hospital of Bengbu Medical College, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Bengbu Medical College, China","institution_ids":["https://openalex.org/I4210150172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103239052","display_name":"Tianjun Liu","orcid":"https://orcid.org/0000-0002-4661-4417","observed_orcids":["https://orcid.org/0000-0002-4661-4417"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4405277203","display_name":"Institute of Biomedical Engineering, Chinese Academy of Medical Sciences","ror":"https://ror.org/01vagp983","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4405277203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianjun Liu","raw_affiliation_strings":["Institute of Bio-Medical Engineering, Chinese Academy of Medical Sciences, China"],"raw_orcid":"https://orcid.org/0000-0002-4661-4417","affiliations":[{"raw_affiliation_string":"Institute of Bio-Medical Engineering, Chinese Academy of Medical Sciences, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4405277203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015276515","display_name":"Ningru Zhang","orcid":"https://orcid.org/0000-0002-2681-8850","observed_orcids":["https://orcid.org/0000-0002-2681-8850"]},"institutions":[{"id":"https://openalex.org/I4210150172","display_name":"First Affiliated Hospital of Bengbu Medical College","ror":"https://ror.org/04v043n92","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150172"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ningru Zhang","raw_affiliation_strings":["The First Affiliated Hospital of Bengbu Medical College, China"],"raw_orcid":"https://orcid.org/0000-0002-2681-8850","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Bengbu Medical College, China","institution_ids":["https://openalex.org/I4210150172"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015276515","https://openalex.org/A5103239052"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210150172","https://openalex.org/I4405277203"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.881,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65337289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"2018","issue":"1","first_page":"5651989","last_page":"5651989"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.8769999742507935},{"id":"https://openalex.org/keywords/herb-drug-interactions","display_name":"herb-drug interactions","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hepatic-drug-metabolism","display_name":"hepatic drug metabolism","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cardio-cerebrovascular-disease","display_name":"cardio-cerebrovascular disease","score":0.7269999980926514},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.8410260677337646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7836347222328186},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7388919591903687},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6854701638221741},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.5217027068138123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5183175802230835},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.48050129413604736},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.45767849683761597},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.44140374660491943},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.35845306515693665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3195183277130127},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13746190071105957},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.11288666725158691}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2018/5651989","doi":"https://doi.org/10.1155/2018/5651989","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/5651989","pdf_url":"https://downloads.hindawi.com/journals/ecam/2018/5651989.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5236571","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6220743","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30498515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30498515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6220743","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6220743/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2018/5651989","doi":"https://doi.org/10.1155/2018/5651989","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/5651989","pdf_url":"https://downloads.hindawi.com/journals/ecam/2018/5651989.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2244793800","display_name":null,"funder_award_id":"81403268","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5016893632","display_name":null,"funder_award_id":"81403114","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323708","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80"},{"id":"https://openalex.org/F4320324804","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2898081463.pdf","grobid_xml":"https://content.openalex.org/works/W2898081463.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W20146419","https://openalex.org/W859682856","https://openalex.org/W1688653807","https://openalex.org/W1947736790","https://openalex.org/W1992751298","https://openalex.org/W1995821598","https://openalex.org/W2011729383","https://openalex.org/W2020393005","https://openalex.org/W2037879477","https://openalex.org/W2053638988","https://openalex.org/W2053972879","https://openalex.org/W2060405446","https://openalex.org/W2063256053","https://openalex.org/W2063552863","https://openalex.org/W2080373987","https://openalex.org/W2090489816","https://openalex.org/W2114992089","https://openalex.org/W2119726460","https://openalex.org/W2134843898","https://openalex.org/W2138877709","https://openalex.org/W2172474070","https://openalex.org/W2296051397","https://openalex.org/W2303858329","https://openalex.org/W2309744964","https://openalex.org/W2331680518","https://openalex.org/W2350544828","https://openalex.org/W2411470723","https://openalex.org/W2593860539","https://openalex.org/W2596579164","https://openalex.org/W2610665772"],"related_works":["https://openalex.org/W2138877709","https://openalex.org/W4376872822","https://openalex.org/W2580689538","https://openalex.org/W2948529851","https://openalex.org/W2051025045","https://openalex.org/W4386592525","https://openalex.org/W3209666725","https://openalex.org/W2331493699","https://openalex.org/W3016710384","https://openalex.org/W2970284930"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Clopidogrel":[1,28,169],"and":[2,29,36,70,75,80,95,107,158,170,178,217,228,242,257],"Xuesaitong":[3],"dispersible":[4],"tablet":[5],"(XST)":[6],"have":[7],"been":[8],"clinically":[9],"proven":[10],"to":[11,22,144,163,265],"be":[12],"effective":[13],"for":[14,59,90,104,109,126],"treating":[15],"cardiocerebrovascular":[16],"disease.":[17],"The":[18,93,113,129,155,211],"present":[19],"study":[20,213],"was":[21,122,134,142,188],"investigate":[23,145],"the":[24,34,110,146,152,165,175,183,195,204,252,258,261,266,273],"herb-drug":[25,166,222],"interaction":[26,202],"of":[27,33,55,131,149,180,185,236,248,268,275],"XST":[30,150,171,199,218],"by":[31,124,208],"modulation":[32],"pharmacodynamics":[35,157],"liver":[37],"Carboxylesterase":[38],"1A(CES1A)":[39],"metabolism.":[40],"METHODS:":[41],"30":[42,68,79,91],"male":[43],"SD":[44],"rats":[45,58],"were":[46,161,263],"randomly":[47],"divided":[48],"into":[49],"a":[50,62,71],"control":[51],"group":[52,64,73,85,97],"(equal":[53],"volumes":[54],"saline,":[56],"6":[57,102,108],"mRNA":[60,105,133,187,255],"analysis),":[61],"clopidogrel":[63,94,117,216],"(clopidogrel":[65,74],"with":[66,77,101,136,203],"dose":[67,78,235],"mg/kg),":[69],"combination":[72,96,267],"XST,":[76,269],"50":[81],"mg/kg":[82],"respectively,":[83],"each":[84],"continuous":[86],"administration":[87],"once":[88],"daily":[89],"days).":[92],"comprised":[98],"12":[99],"rats,":[100],"designated":[103],"analysis":[106],"pharmacokinetic":[111,227],"study.":[112],"2-bromo-3'-methoxyacetophenone-":[114],"(MPB-)":[115],"derivatized":[116],"active":[118,225,249,277],"thiol":[119],"metabolite":[120],"(CAMD)":[121],"measured":[123],"UHPLC-MS/MS":[125],"pharmacokinetics":[127,274],"(n=6).":[128,139],"expression":[130,184,256],"CES1A":[132,153,159,186,205,229,240,254],"examined":[135],"real-time":[137],"RT-PCR":[138],"Molecular":[140],"simulation":[141],"used":[143],"inhibition":[147,259],"effect":[148],"on":[151,260],"protein.":[154],"CAMD":[156,226],"metabolism":[160,206],"investigated":[162],"evaluated":[164],"interaction.":[167],"RESULTS:":[168],"coadministration":[172,219,237],"appreciably":[173],"increased":[174],"Cmax,":[176],"AUC,":[177],"MRT":[179],"CAMD.":[181,250,278],"However,":[182],"decreased":[189,253],"accordingly.":[190],"It":[191],"also":[192],"indicated":[193,214],"that":[194,215],"bioactive":[196],"components":[197],"in":[198,244],"had":[200],"good":[201],"target":[207],"molecular":[209],"simulation.":[210],"animal":[212],"produced":[220],"significant":[221],"interactions":[223],"at":[224],"metabolic":[230],"enzyme":[231],"aspect.":[232],"CONCLUSION:":[233],"30-days":[234],"altered":[238],"hepatic":[239],"protein":[241,262],"resulted":[243],"reduced":[245],"plasma":[246,276],"levels":[247],"both":[251],"due":[264],"which":[270],"accordingly":[271],"upregulated":[272]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2018-10-26T00:00:00"}