{"id":"https://openalex.org/W2897793376","doi":"https://doi.org/10.1042/bsr20181515","title":"Efficacy comparisons of enteral nutrition and parenteral nutrition in patients with severe acute pancreatitis: a meta-analysis from randomized controlled trials","display_name":"Efficacy comparisons of enteral nutrition and parenteral nutrition in patients with severe acute pancreatitis: a meta-analysis from randomized controlled trials","publication_year":2018,"publication_date":"2018-10-17","ids":{"openalex":"https://openalex.org/W2897793376","doi":"https://doi.org/10.1042/bsr20181515","mag":"2897793376","pmid":"https://pubmed.ncbi.nlm.nih.gov/30333259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6239262"},"language":"en","primary_location":{"id":"doi:10.1042/bsr20181515","doi":"https://doi.org/10.1042/bsr20181515","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bsr20181515","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1042/bsr20181515","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002772001","display_name":"Ping Wu","orcid":"https://orcid.org/0000-0001-5718-9922","observed_orcids":["https://orcid.org/0000-0001-5718-9922"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I198959115","display_name":"Changzhi Medical College","ror":"https://ror.org/0340wst14","country_code":"CN","type":"education","lineage":["https://openalex.org/I198959115"]},{"id":"https://openalex.org/I4210146183","display_name":"Changzhi Medical College Peace Hospital","ror":"https://ror.org/05cnf4c39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146183"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Wu","raw_affiliation_strings":["Department of Science and Education, Peace Hospital of Changzhi Medical College, Changzhi, Shanxi Province 046000, China","Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, Hunan Province 410078 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Education, Peace Hospital of Changzhi Medical College, Changzhi, Shanxi Province 046000, China","institution_ids":["https://openalex.org/I198959115","https://openalex.org/I4210146183"]},{"raw_affiliation_string":"Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, Hunan Province 410078 China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420635","display_name":"Liang Li","orcid":"https://orcid.org/0000-0001-9086-7422","observed_orcids":["https://orcid.org/0000-0001-9086-7422"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Li","raw_affiliation_strings":["Department of Medical Services, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Services, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":null,"display_name":"Weijia Sun","orcid":"https://orcid.org/0000-0001-6147-390X","observed_orcids":["https://orcid.org/0000-0001-6147-390X"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weijia Sun","raw_affiliation_strings":["Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China"],"raw_orcid":"https://orcid.org/0000-0001-6147-390X","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":1960,"currency":"USD","value_usd":1960},"apc_paid":{"value":1960,"currency":"USD","value_usd":1960},"fwci":0.4751,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.41880342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"38","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.19910000264644623,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enteral-nutrition","display_name":"enteral nutrition","score":0.8370000123977661},{"id":"https://openalex.org/keywords/parenteral-nutrition","display_name":"parenteral nutrition","score":1.0},{"id":"https://openalex.org/keywords/severe-acute-pancreatitis","display_name":"severe acute pancreatitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.949999988079071},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.628000020980835},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.8650000095367432},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.8960000276565552},{"id":"https://openalex.org/keywords/surgical-treatment","display_name":"surgical treatment","score":0.7459999918937683},{"id":"https://openalex.org/keywords/nutritional-support","display_name":"nutritional support","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C78722104","wikidata":"https://www.wikidata.org/wiki/Q21653202","display_name":"Parenteral nutrition","level":2,"score":0.8851548433303833},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.8287832736968994},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7309694886207581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6669290661811829},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.5792281627655029},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5673165917396545},{"id":"https://openalex.org/C44315111","wikidata":"https://www.wikidata.org/wiki/Q1344580","display_name":"Enteral administration","level":3,"score":0.5571950078010559},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5453739166259766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41426557302474976}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004750","descriptor_name":"Enteral Nutrition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010288","descriptor_name":"Parenteral Nutrition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015596","descriptor_name":"Nutrition Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bsr20181515","doi":"https://doi.org/10.1042/bsr20181515","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bsr20181515","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5221836","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6239262","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6239262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6239262","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosci Rep","raw_type":"Text"},{"id":"pmid:30333259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30333259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bsr20181515","doi":"https://doi.org/10.1042/bsr20181515","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bsr20181515","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335740","display_name":"Xiangya Hospital, Central South University","ror":"https://ror.org/05akvb491"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W174296664","https://openalex.org/W1608400507","https://openalex.org/W1883482717","https://openalex.org/W1964435302","https://openalex.org/W1974847663","https://openalex.org/W1985462234","https://openalex.org/W1991921053","https://openalex.org/W2018665232","https://openalex.org/W2020069799","https://openalex.org/W2032244195","https://openalex.org/W2077661614","https://openalex.org/W2085546839","https://openalex.org/W2092391192","https://openalex.org/W2098923148","https://openalex.org/W2101707914","https://openalex.org/W2125435699","https://openalex.org/W2125857498","https://openalex.org/W2128487155","https://openalex.org/W2137833300","https://openalex.org/W2147621134","https://openalex.org/W2147848555","https://openalex.org/W2157823046","https://openalex.org/W2161374186","https://openalex.org/W2195148034","https://openalex.org/W2232303330","https://openalex.org/W2293743168","https://openalex.org/W2339974486","https://openalex.org/W2374507512","https://openalex.org/W2419107692","https://openalex.org/W2583763176","https://openalex.org/W2588296676","https://openalex.org/W2588681363","https://openalex.org/W2810649598","https://openalex.org/W3029060632","https://openalex.org/W4249270402","https://openalex.org/W6636330541"],"related_works":["https://openalex.org/W2756475758","https://openalex.org/W2358744487","https://openalex.org/W3029808985","https://openalex.org/W2374840576","https://openalex.org/W2365167743","https://openalex.org/W2349347868","https://openalex.org/W1991921053","https://openalex.org/W2368337239","https://openalex.org/W2030703059","https://openalex.org/W3032789260"],"abstract_inverted_index":{"We":[0,40],"conducted":[1,41],"a":[2,29,37,42,88,153],"comprehensive":[3],"analysis":[4],"to":[5,27,62,68,81,180],"evaluate":[6],"the":[7,47,74,115,131,163,209,224],"treatment":[8,237],"efficacy":[9],"and":[10,16,26,53,83,96,129,135,214,228],"safety":[11],"of":[12,46,50,90,133,156,175,211,226],"enteral":[13],"nutrition":[14,18],"(EN)":[15],"parenteral":[17],"(PN)":[19],"in":[20,36],"severe":[21],"acute":[22],"pancreatitis":[23],"(SAP)":[24],"patients,":[25],"provide":[28],"basis":[30],"for":[31,94,98,216,239],"their":[32,60],"evidence":[33],"based":[34],"application":[35],"clinical":[38],"setting.":[39],"systematic":[43],"online":[44],"search":[45],"PubMed,":[48],"Web":[49],"Science,":[51],"Wanfang,":[52],"China":[54],"National":[55],"Knowledge":[56],"Infrastructure":[57],"databases,":[58],"from":[59],"inception":[61],"November":[63],"2017.":[64],"Studies":[65],"were":[66,79],"subjected":[67,80],"further":[69],"screening":[70],"if":[71],"they":[72],"met":[73],"inclusion/exclusion":[75],"criteria.":[76],"Eleven":[77],"studies":[78,104],"qualitative":[82],"quantitative":[84],"synthesis;":[85],"these":[86],"included":[87],"total":[89],"562":[91],"patients":[92,217,240],"(281":[93],"EN":[95,111,150,176,220,231],"281":[97],"PN).":[99],"No":[100,194],"significant":[101],"heterogeneity":[102],"across":[103],"was":[105,177,197],"found.":[106,198],"The":[107,149,173],"results":[108],"indicated":[109],"that":[110,202],"can":[112],"significantly":[113,181,207],"decrease":[114],"mortality":[116],"rate":[117,225],"(relative":[118],"risk":[119,132,155,210],"[RR]":[120],"=":[121,138,167,188],"0.43,":[122],"95%":[123,140,169,190],"confidence":[124],"interval":[125],"[CI]:":[126],"0.23\u20130.78,":[127],"P=0.006),":[128],"lowers":[130],"infection":[134],"complications":[136,215],"(RR":[137,166],"0.53,":[139],"CI:":[141,170,191],"0.39\u20130.71,":[142],"P=0.000)":[143],"more":[144],"so":[145],"than":[146],"does":[147],"PN.":[148],"group":[151,165],"had":[152],"similar":[154],"multiple":[157],"organ":[158],"failure":[159],"(MOF)":[160],"compared":[161],"with":[162,218,241],"PN":[164],"0.63,":[168],"0.39\u20131.02,":[171],"P=0.059).":[172],"use":[174],"also":[178,222],"found":[179],"reduce":[182],"mean":[183],"hospitalization":[184],"time":[185],"(mean":[186],"difference":[187],"\u22122.93,":[189],"\u22124.52\u20131.34,":[192],"P=0.000).":[193],"publication":[195],"bias":[196],"Our":[199],"meta-analysis":[200],"suggested":[201],"EN,":[203],"but":[204],"not":[205],"PN,":[206],"reduced":[208],"mortality,":[212],"infection,":[213],"SAP.":[219,242],"support":[221],"decreased":[223],"MOF":[227],"surgical":[229],"intervention.":[230],"is":[232],"recommended":[233],"as":[234],"an":[235],"initial":[236],"option":[238]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-26T00:00:00"}