{"id":"https://openalex.org/W2897572043","doi":"https://doi.org/10.1002/chem.201804368","title":"A Dimeric 2,9\u2010Diamino\u20101,10\u2010phenanthroline Derivative Improves Alternative Splicing in Myotonic Dystrophy Type 1 Cell and Mouse Models","display_name":"A Dimeric 2,9\u2010Diamino\u20101,10\u2010phenanthroline Derivative Improves Alternative Splicing in Myotonic Dystrophy Type 1 Cell and Mouse Models","publication_year":2018,"publication_date":"2018-10-10","ids":{"openalex":"https://openalex.org/W2897572043","doi":"https://doi.org/10.1002/chem.201804368","mag":"2897572043","pmid":"https://pubmed.ncbi.nlm.nih.gov/30302858"},"language":"en","primary_location":{"id":"doi:10.1002/chem.201804368","doi":"https://doi.org/10.1002/chem.201804368","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201804368","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104280001","display_name":"Jinxing Li","orcid":"https://orcid.org/0000-0002-5888-342X","observed_orcids":["https://orcid.org/0000-0002-5888-342X"]},"institutions":[{"id":"https://openalex.org/I4405287424","display_name":"The Institute of Scientific and Industrial Research, The University of Osaka","ror":"https://ror.org/053t3hh85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287424","https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jinxing Li","raw_affiliation_strings":["Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan","institution_ids":["https://openalex.org/I4405287424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013419903","display_name":"Masayuki Nakamori","orcid":"https://orcid.org/0000-0003-4714-3044","observed_orcids":["https://orcid.org/0000-0003-4714-3044"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Nakamori","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, 565-0871 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, 565-0871 Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102858804","display_name":"Jun Matsumoto","orcid":"https://orcid.org/0000-0001-6696-0459","observed_orcids":["https://orcid.org/0000-0001-6696-0459"]},"institutions":[{"id":"https://openalex.org/I4405287424","display_name":"The Institute of Scientific and Industrial Research, The University of Osaka","ror":"https://ror.org/053t3hh85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287424","https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Matsumoto","raw_affiliation_strings":["Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan","institution_ids":["https://openalex.org/I4405287424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078916199","display_name":"Asako Murata","orcid":"https://orcid.org/0000-0003-2073-7272","observed_orcids":["https://orcid.org/0000-0003-2073-7272"]},"institutions":[{"id":"https://openalex.org/I4405287424","display_name":"The Institute of Scientific and Industrial Research, The University of Osaka","ror":"https://ror.org/053t3hh85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287424","https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asako Murata","raw_affiliation_strings":["Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan","institution_ids":["https://openalex.org/I4405287424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052423494","display_name":"Chikara Dohno","orcid":"https://orcid.org/0000-0003-3698-8738","observed_orcids":["https://orcid.org/0000-0003-3698-8738"]},"institutions":[{"id":"https://openalex.org/I4405287424","display_name":"The Institute of Scientific and Industrial Research, The University of Osaka","ror":"https://ror.org/053t3hh85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287424","https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikara Dohno","raw_affiliation_strings":["Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan","institution_ids":["https://openalex.org/I4405287424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021788512","display_name":"Agnieszka Kiliszek","orcid":"https://orcid.org/0000-0002-2871-7535","observed_orcids":["https://orcid.org/0000-0002-2871-7535"]},"institutions":[{"id":"https://openalex.org/I4210152414","display_name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences","ror":"https://ror.org/04ejdtr48","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agnieszka Kiliszek","raw_affiliation_strings":["Department of Structure and Function of Biomolecules, The Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structure and Function of Biomolecules, The Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznan, Poland","institution_ids":["https://openalex.org/I4210152414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016112564","display_name":"Katarzyna Taylor","orcid":"https://orcid.org/0000-0003-3219-6872","observed_orcids":["https://orcid.org/0000-0003-3219-6872"]},"institutions":[{"id":"https://openalex.org/I59411706","display_name":"Adam Mickiewicz University in Pozna\u0144","ror":"https://ror.org/04g6bbq64","country_code":"PL","type":"education","lineage":["https://openalex.org/I59411706"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna Taylor","raw_affiliation_strings":["Department of Gene Expression Laboratory of Gene Therapy Institute of Molecular Biology and Biotechnology Adam Mickiewicz University  Umultowska 89 61-614 Pozna\u0144 Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Expression Laboratory of Gene Therapy Institute of Molecular Biology and Biotechnology Adam Mickiewicz University  Umultowska 89 61-614 Pozna\u0144 Poland","institution_ids":["https://openalex.org/I59411706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066841557","display_name":"Krzysztof Sobczak","orcid":"https://orcid.org/0000-0001-8352-9812","observed_orcids":["https://orcid.org/0000-0001-8352-9812"]},"institutions":[{"id":"https://openalex.org/I59411706","display_name":"Adam Mickiewicz University in Pozna\u0144","ror":"https://ror.org/04g6bbq64","country_code":"PL","type":"education","lineage":["https://openalex.org/I59411706"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof Sobczak","raw_affiliation_strings":["Department of Gene Expression Laboratory of Gene Therapy Institute of Molecular Biology and Biotechnology Adam Mickiewicz University  Umultowska 89 61-614 Pozna\u0144 Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Expression Laboratory of Gene Therapy Institute of Molecular Biology and Biotechnology Adam Mickiewicz University  Umultowska 89 61-614 Pozna\u0144 Poland","institution_ids":["https://openalex.org/I59411706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004710853","display_name":"Kazuhiko Nakatani","orcid":"https://orcid.org/0000-0002-1705-5265","observed_orcids":["https://orcid.org/0000-0002-1705-5265"]},"institutions":[{"id":"https://openalex.org/I4405287424","display_name":"The Institute of Scientific and Industrial Research, The University of Osaka","ror":"https://ror.org/053t3hh85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287424","https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiko Nakatani","raw_affiliation_strings":["Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan"],"raw_orcid":"https://orcid.org/0000-0002-1705-5265","affiliations":[{"raw_affiliation_string":"Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, 567-0047 Japan","institution_ids":["https://openalex.org/I4405287424"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004710853"],"corresponding_institution_ids":["https://openalex.org/I4405287424"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":2.1607,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.87616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"68","first_page":"18115","last_page":"18122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myotonic-dystrophy-type-1","display_name":"myotonic dystrophy type 1","score":1.0},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cug-repeat-expansion","display_name":"CUG repeat expansion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mbnl1","display_name":"MBNL1","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C2778063965","wikidata":"https://www.wikidata.org/wiki/Q1860507","display_name":"Myotonic dystrophy","level":2,"score":0.909317135810852},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.8501666188240051},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6408061981201172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5342622995376587},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.47525927424430847},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.44510552287101746},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42418578267097473},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41877537965774536},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.4116094410419464},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3619314730167389},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34245169162750244},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3264477849006653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30277085304260254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2793688178062439}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010618","descriptor_name":"Phenanthrolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010618","descriptor_name":"Phenanthrolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/chem.201804368","doi":"https://doi.org/10.1002/chem.201804368","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201804368","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},{"id":"pmid:30302858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30302858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1253731539","display_name":"Small-molecule induced &#8211;1 ribosomal frameshifting and its application to the control of protein transport and localization","funder_award_id":"18K05355","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2874261889","display_name":"Chemical Biology Studies on Trinucleotide Repeat Disease using Repeat-Binding Molecules","funder_award_id":"26000007","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G405246219","display_name":"RNA-based genetic switch using synthetic small molecular ligands that control RNA structure and function","funder_award_id":"18H02107","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4083992200","display_name":"Allele specific inhibition of mutant mRNA expression for repeat expansion disorders","funder_award_id":"15K15339","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7918942628","display_name":"Therapeutic developemt for myotonic dystrophy","funder_award_id":"16H05321","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1555409852","https://openalex.org/W1965975446","https://openalex.org/W1966858416","https://openalex.org/W1969813445","https://openalex.org/W1973843771","https://openalex.org/W1981891547","https://openalex.org/W1986262235","https://openalex.org/W1988117352","https://openalex.org/W1988283896","https://openalex.org/W1999617545","https://openalex.org/W2001607290","https://openalex.org/W2003543791","https://openalex.org/W2012195419","https://openalex.org/W2013963839","https://openalex.org/W2020334159","https://openalex.org/W2033121956","https://openalex.org/W2035235725","https://openalex.org/W2036345369","https://openalex.org/W2038306358","https://openalex.org/W2057269517","https://openalex.org/W2061812354","https://openalex.org/W2075336126","https://openalex.org/W2076133587","https://openalex.org/W2076368535","https://openalex.org/W2076655665","https://openalex.org/W2076848698","https://openalex.org/W2081280332","https://openalex.org/W2081748748","https://openalex.org/W2083636372","https://openalex.org/W2087505473","https://openalex.org/W2088201490","https://openalex.org/W2090309798","https://openalex.org/W2090893194","https://openalex.org/W2099643329","https://openalex.org/W2102145465","https://openalex.org/W2103116226","https://openalex.org/W2108570063","https://openalex.org/W2109436341","https://openalex.org/W2112760828","https://openalex.org/W2125442413","https://openalex.org/W2131173813","https://openalex.org/W2131447660","https://openalex.org/W2139912474","https://openalex.org/W2139919925","https://openalex.org/W2141124826","https://openalex.org/W2141427674","https://openalex.org/W2146308704","https://openalex.org/W2147017969","https://openalex.org/W2162947452","https://openalex.org/W2168137891","https://openalex.org/W2175696527","https://openalex.org/W2191269878","https://openalex.org/W2339718724","https://openalex.org/W2347060969","https://openalex.org/W2415805387","https://openalex.org/W2508330908","https://openalex.org/W2514552612","https://openalex.org/W2530837351","https://openalex.org/W2563585356","https://openalex.org/W2765760205","https://openalex.org/W2949983130","https://openalex.org/W4231135783"],"related_works":["https://openalex.org/W7130641736","https://openalex.org/W2076848698","https://openalex.org/W3027158079","https://openalex.org/W2147895384","https://openalex.org/W3168210481","https://openalex.org/W7134263039","https://openalex.org/W2514552612","https://openalex.org/W2413337828","https://openalex.org/W2076133587","https://openalex.org/W2069571644"],"abstract_inverted_index":{"Abstract":[0],"Expanded":[1],"r(CUG)":[2,29,51,84,168],"repeats":[3,52,169],"are":[4,94],"the":[5,8,22,33,39,50,61,66,74,90,110,135,138,163],"cause":[6],"of":[7,19,24,41,63,68,73,92,112,137,165],"neurological":[9],"disorder":[10],"myotonic":[11],"dystrophy":[12],"type":[13],"1":[14],"(DM1).":[15],"The":[16,96,142],"pathological":[17],"features":[18],"DM1":[20,120,125],"include":[21],"formation":[23],"ribonuclear":[25],"foci":[26],"containing":[27],"expanded":[28],"repeats,":[30,85],"which":[31],"sequester":[32],"MBNL1":[34,166],"protein":[35],"and":[36,53,86,104,123,156],"lead":[37],"to":[38,49,83,114,167],"misregulation":[40,91],"alternative":[42,55],"pre\u2010mRNA":[43,139],"splicing.":[44],"Small":[45],"molecules":[46],"that":[47,129,158],"bind":[48],"improve":[54],"splicing":[56,93,140],"have":[57],"therapeutic":[58],"potential":[59],"in":[60,134,149,170],"treatment":[62],"DM1.":[64],"Herein,":[65],"synthesis":[67],"DDAP":[69,113,130,159],"(a":[70],"dimeric":[71],"form":[72],"CUG\u2010binding":[75],"molecule":[76],"DAP":[77],"reported":[78],"previously),":[79],"its":[80,87],"binding":[81,111,154,164],"properties":[82],"effect":[88],"on":[89,118],"reported.":[95],"surface":[97],"plasmon":[98],"resonance":[99],"assay,":[100,155],"circular":[101],"dichroism":[102],"spectra,":[103],"ESI\u2010TOF":[105],"mass":[106],"spectrometry":[107],"results":[108],"confirmed":[109],"r(CUG)9":[115],"repeats.":[116],"Studies":[117],"a":[119,124,152,171],"cell":[121],"model":[122,127],"mouse":[126],"revealed":[128],"was":[131,147],"partially":[132],"effective":[133],"recovery":[136,146],"defects.":[141],"mechanism":[143],"underlying":[144],"this":[145],"studied":[148],"vitro":[150],"through":[151],"competitive":[153],"suggested":[157],"could":[160],"interfere":[161],"with":[162],"concentration\u2010dependent":[172],"manner.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-26T00:00:00"}
