{"id":"https://openalex.org/W2897512901","doi":"https://doi.org/10.1371/journal.pbio.2005924","title":"Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic","display_name":"Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic","publication_year":2018,"publication_date":"2018-10-18","ids":{"openalex":"https://openalex.org/W2897512901","doi":"https://doi.org/10.1371/journal.pbio.2005924","mag":"2897512901","pmid":"https://pubmed.ncbi.nlm.nih.gov/30335746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6193608"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pbio.2005924","doi":"https://doi.org/10.1371/journal.pbio.2005924","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.2005924","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005924&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005924&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112530126","display_name":"Jason B. Boehme","orcid":"https://orcid.org/0000-0003-4908-9934","observed_orcids":["https://orcid.org/0000-0003-4908-9934"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Boehme","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012959704","display_name":"Natacha Le Moan","orcid":"https://orcid.org/0000-0002-1674-4720","observed_orcids":["https://orcid.org/0000-0002-1674-4720"]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natacha Le Moan","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065846921","display_name":"Rebecca Johnson Kameny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca J. Kameny","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014751776","display_name":"Alexandra Loucks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Loucks","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060057152","display_name":"Michael J. Johengen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Johengen","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057328443","display_name":"Amy L. Lesneski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy L. Lesneski","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101113567","display_name":"Wenhui Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenhui Gong","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089678161","display_name":"Brian D. Goudy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Goudy","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tina Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Davis","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045830945","display_name":"Kevin Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Tanaka","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Davis","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102451660","display_name":"Youping He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youping He","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062929622","display_name":"Janel Renee Long-Boyle","orcid":"https://orcid.org/0009-0002-5545-2808","observed_orcids":["https://orcid.org/0009-0002-5545-2808"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janel Long-Boyle","raw_affiliation_strings":["Department of Clinical Pharmacology, University of California, San Francisco, San Francisco, California, United States of America","Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000044132","display_name":"Vijay D. Ivaturi","orcid":"https://orcid.org/0000-0002-6433-1154","observed_orcids":["https://orcid.org/0000-0002-6433-1154"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Ivaturi","raw_affiliation_strings":["Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America","School of Pharmacy, University of Maryland, Baltimore, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, University of Maryland, Baltimore, United States of America","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083885025","display_name":"Jogarao V. S. Gobburu","orcid":"https://orcid.org/0000-0002-8348-4295","observed_orcids":["https://orcid.org/0000-0002-8348-4295"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jogarao V. S. Gobburu","raw_affiliation_strings":["Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America","School of Pharmacy, University of Maryland, Baltimore, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, University of Maryland, Baltimore, United States of America","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033050158","display_name":"Jonathan A. Winger","orcid":"https://orcid.org/0000-0003-1413-3384","observed_orcids":["https://orcid.org/0000-0003-1413-3384"]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Winger","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112070179","display_name":"Stephen P. Cary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen P. Cary","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076697089","display_name":"Sanjeev A. Datar","orcid":"https://orcid.org/0009-0003-6986-2821","observed_orcids":["https://orcid.org/0009-0003-6986-2821"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjeev A. Datar","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112239097","display_name":"Jeffrey R. Fineman","orcid":"https://orcid.org/0000-0001-9740-405X","observed_orcids":["https://orcid.org/0000-0001-9740-405X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Fineman","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010037572","display_name":"Ana Krtolica","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099232","display_name":"Omniox (United States)","ror":"https://ror.org/011cheg80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099232"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana Krtolica","raw_affiliation_strings":["Omniox, Inc., San Carlos, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omniox, Inc., San Carlos, California, United States of America","institution_ids":["https://openalex.org/I4210099232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074203964","display_name":"Emin Maltepe","orcid":"https://orcid.org/0000-0002-1271-7565","observed_orcids":["https://orcid.org/0000-0002-1271-7565"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emin Maltepe","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1271-7565","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Initiative for Pediatric Drug and Device Development (iPD3), San Francisco, California, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010037572","https://openalex.org/A5074203964"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210099232"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":0.6546,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.59909696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"10","first_page":"e2005924","last_page":"e2005924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.765999972820282},{"id":"https://openalex.org/keywords/acute-hypoxia","display_name":"acute hypoxia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myocardial-oxygenation","display_name":"myocardial oxygenation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hemoglobin-based-oxygen-carriers","display_name":"hemoglobin-based oxygen carriers","score":0.7540000081062317},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cardiac-contractile-function","display_name":"cardiac contractile function","score":0.5730000138282776},{"id":"https://openalex.org/keywords/lambs","display_name":"lambs","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5883104205131531},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.5138347744941711},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5103809237480164},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4659484624862671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4591277539730072},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.44959959387779236},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.43350598216056824},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.428882896900177},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.32350680232048035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29775285720825195},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2820824086666107},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26081231236457825},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.1654517650604248},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001691","descriptor_name":"Biological Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pbio.2005924","doi":"https://doi.org/10.1371/journal.pbio.2005924","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.2005924","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005924&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5162884","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6193608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6193608","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6193608","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biol","raw_type":"Text"},{"id":"pmid:30335746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30335746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS biology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7fw5603w","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7fw5603w","pdf_url":"https://escholarship.org/content/qt7fw5603w/qt7fw5603w.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Biology, vol 16, iss 10","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e13aa0d7d62a4167b657b0418bb3eb3f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e13aa0d7d62a4167b657b0418bb3eb3f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, Vol 16, Iss 10, p e2005924 (2018)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7fw5603w","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7fw5603w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS biology, vol 16, iss 10","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pbio.2005924","doi":"https://doi.org/10.1371/journal.pbio.2005924","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.2005924","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005924&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3001856454","display_name":"Perinatal Pulmonary Hypertension: Developmental Mediators","funder_award_id":"R01HL061284","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3106260107","display_name":"Integrating Environmental Cues at the Maternal-Fetal Vascular Interface","funder_award_id":"R01HD072455","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000912419","display_name":"Altered Lymphatic Function and Development in Congenital Heart Disease","funder_award_id":"R01HL133034","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000920828","display_name":"Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass","funder_award_id":"R44HD094414","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2897512901.pdf","grobid_xml":"https://content.openalex.org/works/W2897512901.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W87779505","https://openalex.org/W109843434","https://openalex.org/W255996521","https://openalex.org/W1546234696","https://openalex.org/W1557750025","https://openalex.org/W1574760821","https://openalex.org/W1868102229","https://openalex.org/W1956277079","https://openalex.org/W1970487866","https://openalex.org/W1973976410","https://openalex.org/W1974787320","https://openalex.org/W1976850638","https://openalex.org/W1976964821","https://openalex.org/W1978291922","https://openalex.org/W1978941397","https://openalex.org/W1979759472","https://openalex.org/W1981840935","https://openalex.org/W1987775947","https://openalex.org/W2001977326","https://openalex.org/W2002161071","https://openalex.org/W2008784714","https://openalex.org/W2009527638","https://openalex.org/W2011034634","https://openalex.org/W2018533096","https://openalex.org/W2021946180","https://openalex.org/W2034091457","https://openalex.org/W2035845726","https://openalex.org/W2047757955","https://openalex.org/W2051382343","https://openalex.org/W2055835375","https://openalex.org/W2056557320","https://openalex.org/W2058238481","https://openalex.org/W2058660100","https://openalex.org/W2062976153","https://openalex.org/W2063062764","https://openalex.org/W2069753164","https://openalex.org/W2077461414","https://openalex.org/W2078075091","https://openalex.org/W2078546046","https://openalex.org/W2084238656","https://openalex.org/W2086630647","https://openalex.org/W2090650515","https://openalex.org/W2102026933","https://openalex.org/W2102448742","https://openalex.org/W2119991169","https://openalex.org/W2125570845","https://openalex.org/W2126965875","https://openalex.org/W2129429230","https://openalex.org/W2131364104","https://openalex.org/W2136489607","https://openalex.org/W2137930751","https://openalex.org/W2145950740","https://openalex.org/W2156125520","https://openalex.org/W2161491970","https://openalex.org/W2162950588","https://openalex.org/W2163493236","https://openalex.org/W2229381132","https://openalex.org/W2259009562","https://openalex.org/W2279668863","https://openalex.org/W2325915282","https://openalex.org/W2336038108","https://openalex.org/W2412106294","https://openalex.org/W2417537637","https://openalex.org/W2537118017","https://openalex.org/W2571840819","https://openalex.org/W2581605534","https://openalex.org/W2607661676"],"related_works":["https://openalex.org/W2808330277","https://openalex.org/W2601068662","https://openalex.org/W2058758311","https://openalex.org/W2470635553","https://openalex.org/W1978315953","https://openalex.org/W7100904191","https://openalex.org/W2039598018","https://openalex.org/W2062716749","https://openalex.org/W4214487220","https://openalex.org/W4395449134"],"abstract_inverted_index":{"The":[0],"heart":[1,51,192],"exhibits":[2],"the":[3,16,33,50,61,70,88,175,268,274],"highest":[4],"basal":[5],"oxygen":[6],"(O2)":[7],"consumption":[8],"per":[9],"tissue":[10],"mass":[11],"of":[12,63,77,92,173,270,276],"any":[13],"organ":[14],"in":[15,40,191,219,224,273],"body":[17,34],"and":[18,55,145,199,215,237,242,262],"is":[19,119,259],"uniquely":[20],"dependent":[21],"on":[22],"aerobic":[23],"metabolism":[24],"to":[25,52,102,147,156],"sustain":[26],"contractile":[27,221,246],"function.":[28,222],"During":[29],"acute":[30,277],"hypoxic":[31,89,103],"states,":[32],"responds":[35],"with":[36,123,167,179],"a":[37,64,129,216,260],"compensatory":[38],"increase":[39],"cardiac":[41],"output":[42],"that":[43,118,257],"further":[44],"increases":[45,190],"myocardial":[46,56,227,271],"O2":[47,82,101,110,122,136,264],"demand,":[48],"predisposing":[49],"ischemic":[53],"stress":[54],"dysfunction.":[57],"Here,":[58],"we":[59],"test":[60],"utility":[62],"novel":[65],"engineered":[66],"protein":[67],"derived":[68],"from":[69],"heme-based":[71],"nitric":[72],"oxide":[73],"(NO)/oxygen":[74],"(H-NOX)":[75],"family":[76],"bacterial":[78],"proteins":[79],"as":[80],"an":[81],"delivery":[83,265],"biotherapeutic":[84,266],"(Omniox-cardiovascular":[85],"[OMX-CV])":[86],"for":[87,121,267],"myocardium.":[90],"Because":[91],"their":[93],"unique":[94],"binding":[95,117],"characteristics,":[96],"H-NOX-based":[97,113],"variants":[98,114],"effectively":[99],"deliver":[100],"tissues,":[104],"but":[105],"not":[106],"those":[107],"at":[108,250],"physiologic":[109],"tension.":[111],"Additionally,":[112],"exhibit":[115],"tunable":[116],"specific":[120],"subphysiologic":[124],"reactivity":[125],"towards":[126],"NO,":[127],"circumventing":[128],"significant":[130,189,217],"toxicity":[131],"exhibited":[132,212],"by":[133,165],"hemoglobin":[134],"(Hb)-based":[135],"carriers":[137],"(HBOCs).":[138],"Juvenile":[139],"lambs":[140,176,211],"were":[141,154,177,248],"sedated,":[142],"mechanically":[143],"ventilated,":[144],"instrumented":[146],"measure":[148],"cardiovascular":[149],"parameters.":[150],"Biventricular":[151],"admittance":[152],"catheters":[153],"inserted":[155],"perform":[157],"pressure-volume":[158],"(PV)":[159],"analyses.":[160],"Systemic":[161],"hypoxia":[162,187,214],"was":[163,229],"induced":[164,188],"ventilation":[166],"10%":[168],"O2.":[169],"Following":[170],"15":[171],"minutes":[172],"hypoxia,":[174],"treated":[178],"OMX-CV":[180,258],"(200":[181],"mg/kg":[182],"IV)":[183],"or":[184,235],"vehicle.":[185],"Acute":[186],"rate":[193],"(HR),":[194],"pulmonary":[195,200],"blood":[196],"flow":[197],"(PBF),":[198],"vascular":[201],"resistance":[202],"(PVR)":[203],"(p":[204],"<":[205],"0.05).":[206],"At":[207],"1":[208],"hour,":[209],"vehicle-treated":[210],"severe":[213],"decrease":[218],"biventricular":[220],"However,":[223],"OMX-CV-treated":[225],"animals,":[226],"oxygenation":[228],"improved":[230],"without":[231],"negatively":[232],"impacting":[233],"systemic":[234],"PVR,":[236],"both":[238],"right":[239],"ventricle":[240,244],"(RV)":[241],"left":[243],"(LV)":[245],"function":[247],"maintained":[249],"pre-hypoxic":[251],"baseline":[252],"levels.":[253],"These":[254],"data":[255],"suggest":[256],"promising":[261],"safe":[263],"preservation":[269],"contractility":[272],"setting":[275],"hypoxia.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-10-26T00:00:00"}