{"id":"https://openalex.org/W2897488461","doi":"https://doi.org/10.1158/1078-0432.ccr-18-1469","title":"Enhancing Abiraterone Acetate Efficacy in Androgen Receptor\u2013positive Triple-negative Breast Cancer: Chk1 as a Potential Target","display_name":"Enhancing Abiraterone Acetate Efficacy in Androgen Receptor\u2013positive Triple-negative Breast Cancer: Chk1 as a Potential Target","publication_year":2018,"publication_date":"2018-10-23","ids":{"openalex":"https://openalex.org/W2897488461","doi":"https://doi.org/10.1158/1078-0432.ccr-18-1469","mag":"2897488461","pmid":"https://pubmed.ncbi.nlm.nih.gov/30352905"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-18-1469","doi":"https://doi.org/10.1158/1078-0432.ccr-18-1469","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-18-1469","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051527051","display_name":"Thomas Grellety","orcid":"https://orcid.org/0000-0001-5316-1420","observed_orcids":["https://orcid.org/0000-0001-5316-1420"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Thomas Grellety","raw_affiliation_strings":["1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","2University of Bordeaux, Bordeaux, France","3Department of Medical Oncology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134409"]},{"raw_affiliation_string":"2University of Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530"]},{"raw_affiliation_string":"3Department of Medical Oncology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France","institution_ids":["https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027696743","display_name":"C\u00e9line Callens","orcid":"https://orcid.org/0000-0003-3377-4937","observed_orcids":["https://orcid.org/0000-0003-3377-4937","https://orcid.org/0009-0008-1382-7230"]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Celine Callens","raw_affiliation_strings":["4Pharmacogenomic Unit, Genetics Laboratory, Institut Curie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pharmacogenomic Unit, Genetics Laboratory, Institut Curie, Paris, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091732504","display_name":"\u00c9lodie Richard","orcid":"https://orcid.org/0000-0003-3778-1210","observed_orcids":["https://orcid.org/0000-0003-3778-1210"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Richard","raw_affiliation_strings":["1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020848251","display_name":"Adrien Briaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Adrien Briaux","raw_affiliation_strings":["4Pharmacogenomic Unit, Genetics Laboratory, Institut Curie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pharmacogenomic Unit, Genetics Laboratory, Institut Curie, Paris, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028257477","display_name":"Val\u00e9rie Velasco","orcid":"https://orcid.org/0009-0005-6182-864X","observed_orcids":["https://orcid.org/0009-0005-6182-864X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie V\u00e9lasco","raw_affiliation_strings":["1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","5Department of Pathology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134409"]},{"raw_affiliation_string":"5Department of Pathology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France","institution_ids":["https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045959","display_name":"Marina Pulido","orcid":"https://orcid.org/0009-0004-3851-6157","observed_orcids":["https://orcid.org/0009-0004-3851-6157"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]},{"id":"https://openalex.org/I4387155924","display_name":"Centre d'Investigation Clinique Plurith\u00e9matique de Bordeaux","ror":"https://ror.org/000bbyx17","country_code":"FR","type":"other","lineage":["https://openalex.org/I15057530","https://openalex.org/I3018323443","https://openalex.org/I4210134409","https://openalex.org/I4387155924"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marina Pulido","raw_affiliation_strings":["6Clinical and Epidemiological Research Unit, Institut Bergoni\u00e9, INSERM CIC1401, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Clinical and Epidemiological Research Unit, Institut Bergoni\u00e9, INSERM CIC1401, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134409","https://openalex.org/I4387155924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006642161","display_name":"Anthony Gon\u00e7alv\u00e8s","orcid":"https://orcid.org/0000-0001-7570-7439","observed_orcids":["https://orcid.org/0000-0001-7570-7439"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anthony Gon\u00e7alves","raw_affiliation_strings":["7Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Department of Medical Oncology, CRCM, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Department of Medical Oncology, CRCM, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019420341","display_name":"Pierre Gestraud","orcid":"https://orcid.org/0000-0002-3893-9879","observed_orcids":["https://orcid.org/0000-0002-3893-9879"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Gestraud","raw_affiliation_strings":["8Institut Curie, PSL Research University, Mines Paris Tech, Bioinformatics and Computational Systems Biology of Cancer, INSERM U900, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-3893-9879","affiliations":[{"raw_affiliation_string":"8Institut Curie, PSL Research University, Mines Paris Tech, Bioinformatics and Computational Systems Biology of Cancer, INSERM U900, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I70768539","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038698814","display_name":"Ga\u00ebtan Marie MacGrogan","orcid":"https://orcid.org/0000-0002-3483-9758","observed_orcids":["https://orcid.org/0000-0002-3483-9758"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gaetan MacGrogan","raw_affiliation_strings":["1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","5Department of Pathology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134409"]},{"raw_affiliation_string":"5Department of Pathology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France","institution_ids":["https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056811246","display_name":"Herve R. Bonnefoi","orcid":"https://orcid.org/0000-0003-4293-9748","observed_orcids":["https://orcid.org/0000-0003-4293-9748"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Bonnefoi","raw_affiliation_strings":["1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","2University of Bordeaux, Bordeaux, France","3Department of Medical Oncology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134409"]},{"raw_affiliation_string":"2University of Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530"]},{"raw_affiliation_string":"3Department of Medical Oncology, Institut Bergoni\u00e9, Comprehensive Cancer Centre Bordeaux, France","institution_ids":["https://openalex.org/I4210134409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086620418","display_name":"Bruno Cardinaud","orcid":"https://orcid.org/0000-0002-6510-2599","observed_orcids":["https://orcid.org/0000-0002-6510-2599"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]},{"id":"https://openalex.org/I4210160189","display_name":"Institut Polytechnique de Bordeaux","ror":"https://ror.org/054qv7y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210160189"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Cardinaud","raw_affiliation_strings":["1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","9Bordeaux Institut National Polytechnique, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UNIT U1218, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134409"]},{"raw_affiliation_string":"9Bordeaux Institut National Polytechnique, Bordeaux, France","institution_ids":["https://openalex.org/I4210160189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5051527051"],"corresponding_institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210134409"],"apc_list":null,"apc_paid":null,"fwci":0.7554,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.62999513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"25","issue":"2","first_page":"856","last_page":"867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.12620000541210175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/androgen-receptor-positive-breast-cancer","display_name":"androgen receptor-positive breast cancer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/apocrine-breast-cancer","display_name":"apocrine breast cancer","score":0.7200000286102295},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.875},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4490000009536743},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/azd7762","display_name":"AZD7762","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-transcriptome","display_name":"tumor transcriptome","score":0.6299999952316284},{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2775832370","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone acetate","level":5,"score":0.7857030630111694},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7240497469902039},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5913199782371521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5547705888748169},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4995310306549072},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.48833319544792175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4457828104496002},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4269311726093292},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.42457252740859985},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32196134328842163},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.31742483377456665},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.11872300505638123},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.08136457204818726}],"mesh":[{"descriptor_ui":"D000069501","descriptor_name":"Abiraterone Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069501","descriptor_name":"Abiraterone Acetate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-18-1469","doi":"https://doi.org/10.1158/1078-0432.ccr-18-1469","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-18-1469","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:30352905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30352905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1420609810","display_name":null,"funder_award_id":"R00 CA1440138","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1699089933","display_name":"Development of a Novel Peptide Platform for  Targeted PET Imaging and Radiotherapy of Breast Cancer","funder_award_id":"F32EB025050","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G649770369","display_name":"Pretargeted Clinical Imaging of CA19.9 in Pancreatic Cancer","funder_award_id":"U01CA221046","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1795244573","https://openalex.org/W1912234690","https://openalex.org/W1970336739","https://openalex.org/W1989689178","https://openalex.org/W1995830102","https://openalex.org/W2013147142","https://openalex.org/W2025676301","https://openalex.org/W2028768684","https://openalex.org/W2035921832","https://openalex.org/W2043152591","https://openalex.org/W2043179716","https://openalex.org/W2073049760","https://openalex.org/W2077945404","https://openalex.org/W2084845237","https://openalex.org/W2088190208","https://openalex.org/W2088318211","https://openalex.org/W2095514878","https://openalex.org/W2097381426","https://openalex.org/W2098804778","https://openalex.org/W2107617686","https://openalex.org/W2110065044","https://openalex.org/W2114031931","https://openalex.org/W2114505219","https://openalex.org/W2114843025","https://openalex.org/W2116964110","https://openalex.org/W2131702935","https://openalex.org/W2134539328","https://openalex.org/W2135088554","https://openalex.org/W2147343434","https://openalex.org/W2162143298","https://openalex.org/W2170551349","https://openalex.org/W2253928581","https://openalex.org/W2280399394","https://openalex.org/W2291507155","https://openalex.org/W2472035483","https://openalex.org/W2500951036","https://openalex.org/W2502131840","https://openalex.org/W2518784337","https://openalex.org/W2589771973","https://openalex.org/W2610242496","https://openalex.org/W2614443510","https://openalex.org/W2761448817","https://openalex.org/W2784775153","https://openalex.org/W2786371182","https://openalex.org/W2789717902","https://openalex.org/W2794018125"],"related_works":["https://openalex.org/W2944020944","https://openalex.org/W4392763554","https://openalex.org/W2015815514","https://openalex.org/W6912093233","https://openalex.org/W6968167848","https://openalex.org/W6930731080","https://openalex.org/W4408657362","https://openalex.org/W6968077879","https://openalex.org/W6911919845","https://openalex.org/W2280399394"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Our":[2],"aim":[3],"was":[4,163],"to":[5,151],"identify":[6],"predictive":[7],"factors":[8],"of":[9,147,158,168,187,210,221,238],"abiraterone":[10,36,84,123,191,239],"acetate":[11,37,85,192],"efficacy":[12,220],"and":[13,55,76,86,90,104,116,125,153,193,208],"putative":[14,246],"new":[15],"druggable":[16],"targets":[17],"in":[18,27,96,102,105,142,166,235,249],"androgen":[19],"receptor":[20],"(AR)-positive":[21],"triple-negative":[22],"breast":[23,56],"cancer":[24],"(TNBC)":[25],"treated":[26],"the":[28,60,68,143,159,164,185,219,236],"UCBG":[29],"2012-1":[30],"trial.":[31],"Experimental":[32],"Design:":[33],"We":[34,51,64,82,241],"defined":[35],"response":[38],"as":[39,244],"either":[40,93],"complete":[41],"or":[42,45,95],"partial":[43],"response,":[44],"stable":[46],"disease":[47],"at":[48,198],"6":[49],"months.":[50],"sequenced":[52],"91":[53],"general":[54],"cancer\u2013associated":[57],"genes":[58,138],"from":[59,67,118],"tumor":[61],"DNA":[62,154,211],"samples.":[63],"analyzed":[65],"transcriptomes":[66],"extracted":[69],"RNA":[70],"samples":[71],"on":[72,98,202],"a":[73,170,174,245],"NanoString":[74],"platform":[75],"performed":[77],"IHC":[78,109],"using":[79],"tissue":[80],"microarrays.":[81],"assessed":[83],"Chk1":[87,194,243],"inhibitors":[88],"(GDC-0575":[89],"AZD7762)":[91],"efficacies,":[92],"alone":[94],"combination,":[97],"cell":[99,188,203,205],"lines":[100],"grown":[101],"vitro":[103],"vivo.":[106],"Results:":[107],"Classic":[108],"apocrine":[110,131,230],"markers":[111],"including":[112],"AR,":[113],"FOXA1,":[114],"GGT1,":[115],"GCDFP15,":[117],"patients'":[119],"tumors":[120],"allowed":[121],"identifying":[122],"acetate-responders":[124],"nonresponders.":[126],"All":[127],"responders":[128],"had":[129],"clear":[130],"features.":[132],"Transcriptome":[133],"analysis":[134],"revealed":[135],"that":[136,177,229],"31":[137],"were":[139],"differentially":[140],"expressed":[141],"two":[144],"subgroups,":[145],"9":[146],"them":[148],"being":[149],"linked":[150],"proliferation":[152],"damage":[155],"repair.":[156],"One":[157],"most":[160],"significant":[161],"differences":[162],"overexpression,":[165],"nonresponders,":[167],"CHEK1,":[169],"gene":[171],"encoding":[172],"Chk1,":[173],"protein":[175],"kinase":[176],"can":[178,232],"be":[179,233],"blocked":[180],"by":[181],"specific":[182],"inhibitors.":[183],"On":[184],"basis":[186],"line":[189],"experiments,":[190],"inhibitor":[195],"combination":[196,223],"showed":[197],"least":[199],"additive":[200],"effect":[201],"viability,":[204],"cycle,":[206],"apoptosis,":[207],"accumulation":[209],"damages.":[212],"In":[213],"vivo,":[214],"orthotopic":[215],"xenograft":[216],"experiments":[217],"confirmed":[218],"this":[222],"therapy.":[224],"Conclusions:":[225],"This":[226],"study":[227],"suggests":[228],"features":[231],"helpful":[234],"identification":[237],"acetate-responders.":[240],"identified":[242],"drug":[247],"target":[248],"AR-positive":[250],"TNBCs.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-10-26T00:00:00"}
