{"id":"https://openalex.org/W2897476973","doi":"https://doi.org/10.1101/444265","title":"Electron Microscopy Analysis of hAPP-Induced Neurodegeneration in the Glomerular Network","display_name":"Electron Microscopy Analysis of hAPP-Induced Neurodegeneration in the Glomerular Network","publication_year":2018,"publication_date":"2018-10-16","ids":{"openalex":"https://openalex.org/W2897476973","doi":"https://doi.org/10.1101/444265","mag":"2897476973"},"language":"en","primary_location":{"id":"doi:10.1101/444265","doi":"https://doi.org/10.1101/444265","is_oa":true,"landing_page_url":"https://doi.org/10.1101/444265","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/10/16/444265.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2018/10/16/444265.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110439820","display_name":"A. Robbins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia E. Robbins","raw_affiliation_strings":["Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051754148","display_name":"Katherine S. Lehmann","orcid":"https://orcid.org/0000-0002-0323-879X","observed_orcids":["https://orcid.org/0000-0002-0323-879X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine S. Lehmann","raw_affiliation_strings":["Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0000-0002-0323-879X","affiliations":[{"raw_affiliation_string":"Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076482584","display_name":"Li Bai","orcid":"https://orcid.org/0000-0002-7169-1334","observed_orcids":["https://orcid.org/0000-0002-7169-1334"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Bai","raw_affiliation_strings":["Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034925988","display_name":"Leonardo Belluscio","orcid":"https://orcid.org/0000-0003-3227-8747","observed_orcids":["https://orcid.org/0000-0003-3227-8747"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonardo Belluscio","raw_affiliation_strings":["Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0000-0003-3227-8747","affiliations":[{"raw_affiliation_string":"Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9580000042915344},{"id":"https://openalex.org/keywords/olfactory-bulb-glomeruli","display_name":"olfactory bulb glomeruli","score":0.8019999861717224},{"id":"https://openalex.org/keywords/olfactory-receptor-neurons","display_name":"olfactory sensory neurons","score":0.9509999752044678},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.6970000267028809},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.878000020980835},{"id":"https://openalex.org/keywords/anosmia","display_name":"anosmia","score":0.699999988079071},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease-mutations","display_name":"familial Alzheimer's disease mutations","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.9022669196128845},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8060504198074341},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6403255462646484},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.5695021748542786},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5558915734291077},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.47026902437210083},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.45882344245910645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4512644112110138},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.43816766142845154},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3321942687034607},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3266092538833618},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3222324550151825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29575225710868835},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.28748607635498047},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2528684139251709},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/444265","doi":"https://doi.org/10.1101/444265","is_oa":true,"landing_page_url":"https://doi.org/10.1101/444265","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/10/16/444265.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/444265","doi":"https://doi.org/10.1101/444265","is_oa":true,"landing_page_url":"https://doi.org/10.1101/444265","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/10/16/444265.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3428485866","display_name":"Restoration of olfactory neural circuitry following disruption.","funder_award_id":"ZIANS003116","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2897476973.pdf","grobid_xml":"https://content.openalex.org/works/W2897476973.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1524477382","https://openalex.org/W1552780924","https://openalex.org/W1743419595","https://openalex.org/W1961943243","https://openalex.org/W1976775751","https://openalex.org/W1977752615","https://openalex.org/W1982237245","https://openalex.org/W1988816781","https://openalex.org/W2013399937","https://openalex.org/W2014780231","https://openalex.org/W2027771004","https://openalex.org/W2038394514","https://openalex.org/W2059212904","https://openalex.org/W2064958479","https://openalex.org/W2068775337","https://openalex.org/W2071847392","https://openalex.org/W2072369612","https://openalex.org/W2085572937","https://openalex.org/W2096410114","https://openalex.org/W2101846435","https://openalex.org/W2104494178","https://openalex.org/W2105371361","https://openalex.org/W2130310231","https://openalex.org/W2151283457","https://openalex.org/W2152864425","https://openalex.org/W2171463275","https://openalex.org/W2189027870","https://openalex.org/W2318563828","https://openalex.org/W2487348324","https://openalex.org/W2512178358","https://openalex.org/W2528055324","https://openalex.org/W2766620055","https://openalex.org/W2767476280"],"related_works":["https://openalex.org/W2105371361","https://openalex.org/W2130310231","https://openalex.org/W2135509206","https://openalex.org/W2157457668","https://openalex.org/W2050757082","https://openalex.org/W382531454","https://openalex.org/W4229031062","https://openalex.org/W2038832555","https://openalex.org/W4229671101","https://openalex.org/W2102053742"],"abstract_inverted_index":{"Abstract":[0],"Loss":[1],"of":[2,8,23,36,42,52,119,135,144,168],"smell":[3],"is":[4,58,179],"an":[5,16,151,164],"early":[6],"indicator":[7],"Alzheimer\u2019s":[9],"disease":[10],"(AD),":[11],"making":[12],"the":[13,21,37,49,67,133,158],"olfactory":[14,84,93,169],"system":[15,38],"accessible":[17],"model":[18],"to":[19,138,156],"study":[20,71],"effect":[22],"AD":[24,80,173],"related":[25],"proteins":[26],"such":[27],"as":[28],"Amyloid":[29],"Precursor":[30],"Protein":[31],"(APP).":[32],"The":[33],"regenerative":[34],"capacity":[35,134],"further":[39],"enables":[40],"studies":[41],"circuit":[43,177],"recovery":[44,178],"after":[45],"APP-induced":[46,187],"degeneration.":[47],"While":[48],"cellular":[50],"effects":[51,62],"APP":[53,77],"are":[54],"well":[55],"documented,":[56],"little":[57],"known":[59],"about":[60],"its":[61],"on":[63,92],"brain":[64,182],"circuits":[65,137],"at":[66],"ultrastructural":[68,166],"level.":[69,160],"To":[70],"circuitry":[72],"changes,":[73],"we":[74,131],"overexpressed":[75],"humanized":[76],"with":[78,116,172],"familial":[79],"mutations":[81],"(hAPP)":[82],"in":[83,112,153,181],"sensory":[85],"neurons":[86],"and":[87,99,140,147,174],"performed":[88],"serial":[89],"electron":[90],"microscopy":[91],"bulb":[94],"glomeruli":[95],"from":[96],"both":[97,145],"control":[98,159],"hAPP":[100,126],"expressing":[101],"mice.":[102],"We":[103],"found":[104,141],"that":[105,176,184],"hAPP-expressing":[106],"mice":[107],"showed":[108],"a":[109],"striking":[110],"decrease":[111],"glomerular":[113,136],"connectivity":[114,146],"along":[115],"widespread":[117],"changes":[118],"subcellular":[120,148],"structures.":[121],"By":[122],"then":[123],"turning":[124],"off":[125],"expression":[127],"for":[128],"6":[129],"weeks":[130],"tested":[132],"recover":[139],"clear":[142],"restoration":[143],"features,":[149],"including":[150],"increase":[152],"post-synaptic":[154],"density":[155],"above":[157],"These":[161],"data":[162],"provide":[163],"important":[165],"view":[167],"regions":[170],"associated":[171],"suggest":[175],"possible":[180],"tissue":[183],"has":[185],"experienced":[186],"neurodegeneration.":[188]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2018-10-26T00:00:00"}
