{"id":"https://openalex.org/W2897475413","doi":"https://doi.org/10.1146/annurev-cellbio-100616-060701","title":"Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly","display_name":"Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly","publication_year":2018,"publication_date":"2018-10-06","ids":{"openalex":"https://openalex.org/W2897475413","doi":"https://doi.org/10.1146/annurev-cellbio-100616-060701","mag":"2897475413","pmid":"https://pubmed.ncbi.nlm.nih.gov/30296392"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-cellbio-100616-060701","doi":"https://doi.org/10.1146/annurev-cellbio-100616-060701","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-100616-060701","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080524672","display_name":"George Mountoufaris","orcid":"https://orcid.org/0000-0002-0240-9745","observed_orcids":["https://orcid.org/0000-0002-0240-9745"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I4405270606","display_name":"Mortimer B. Zuckerman Mind Brain Behavior Institute","ror":"https://ror.org/0110mmp98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270606"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Mountoufaris","raw_affiliation_strings":["Current address: Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA","Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","Current address: Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Current address: Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I4405270606","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052916249","display_name":"Daniele Canzio","orcid":"https://orcid.org/0000-0002-2592-2269","observed_orcids":["https://orcid.org/0000-0002-2592-2269"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4405270606","display_name":"Mortimer B. Zuckerman Mind Brain Behavior Institute","ror":"https://ror.org/0110mmp98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270606"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniele Canzio","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4405270606","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063168240","display_name":"Chiamaka L. Nwakeze","orcid":"https://orcid.org/0000-0001-5243-8491","observed_orcids":["https://orcid.org/0000-0001-5243-8491"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4405270606","display_name":"Mortimer B. Zuckerman Mind Brain Behavior Institute","ror":"https://ror.org/0110mmp98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270606"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiamaka L. Nwakeze","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4405270606","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067230615","display_name":"Weisheng V. Chen","orcid":"https://orcid.org/0000-0002-5546-8933","observed_orcids":["https://orcid.org/0000-0002-5546-8933"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4405270606","display_name":"Mortimer B. Zuckerman Mind Brain Behavior Institute","ror":"https://ror.org/0110mmp98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270606"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weisheng V. Chen","raw_affiliation_strings":["Current address: Leveragen, Inc., Cambridge, Massachusetts 02139, USA","Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Leveragen, Inc., Cambridge, Massachusetts 02139, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4405270606","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091116725","display_name":"Tom Maniatis","orcid":"https://orcid.org/0000-0002-2722-8633","observed_orcids":["https://orcid.org/0000-0002-2722-8633"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4405270606","display_name":"Mortimer B. Zuckerman Mind Brain Behavior Institute","ror":"https://ror.org/0110mmp98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270606"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Maniatis","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA;","institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email: tm2472@cumc.columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4405270606","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3608,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.80430712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"34","issue":"1","first_page":"471","last_page":"493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clustered-protocadherins","display_name":"clustered protocadherins","score":0.996999979019165},{"id":"https://openalex.org/keywords/homophilic-interactions","display_name":"homophilic interactions","score":0.8119999766349792},{"id":"https://openalex.org/keywords/self-avoidance","display_name":"self-avoidance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tiling","display_name":"tiling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/neural-circuit-assembly","display_name":"neural circuit assembly","score":0.9620000123977661},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C163911330","wikidata":"https://www.wikidata.org/wiki/Q7251899","display_name":"Protocadherin","level":4,"score":0.8828064203262329},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.7558727264404297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6778662204742432},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5866842865943909},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.5671866536140442},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5270046591758728},{"id":"https://openalex.org/C2992459734","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neural cell","level":3,"score":0.47393542528152466},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32815295457839966},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.32782232761383057},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2656845450401306},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1938909888267517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19129857420921326},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev-cellbio-100616-060701","doi":"https://doi.org/10.1146/annurev-cellbio-100616-060701","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-100616-060701","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:30296392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30296392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:90364","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/90364/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/4","score":0.8500000238418579,"display_name":"Quality education"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W84988101","https://openalex.org/W133424498","https://openalex.org/W1481885984","https://openalex.org/W1548344655","https://openalex.org/W1828538530","https://openalex.org/W1902978248","https://openalex.org/W1941076503","https://openalex.org/W1972985327","https://openalex.org/W1973062929","https://openalex.org/W1974594271","https://openalex.org/W1974637131","https://openalex.org/W1977559278","https://openalex.org/W1983845889","https://openalex.org/W1985445026","https://openalex.org/W1987429832","https://openalex.org/W1987449934","https://openalex.org/W1988276587","https://openalex.org/W1988394934","https://openalex.org/W1990545433","https://openalex.org/W2005611301","https://openalex.org/W2007981920","https://openalex.org/W2013934108","https://openalex.org/W2014327040","https://openalex.org/W2018210971","https://openalex.org/W2018979418","https://openalex.org/W2020869819","https://openalex.org/W2026754734","https://openalex.org/W2028807389","https://openalex.org/W2030292651","https://openalex.org/W2031627559","https://openalex.org/W2038587881","https://openalex.org/W2042531021","https://openalex.org/W2046466208","https://openalex.org/W2047969260","https://openalex.org/W2049862483","https://openalex.org/W2051036306","https://openalex.org/W2060876619","https://openalex.org/W2068391384","https://openalex.org/W2069186336","https://openalex.org/W2069638671","https://openalex.org/W2070372326","https://openalex.org/W2071759249","https://openalex.org/W2077096793","https://openalex.org/W2080141091","https://openalex.org/W2081237481","https://openalex.org/W2081451150","https://openalex.org/W2084805548","https://openalex.org/W2089483026","https://openalex.org/W2095280927","https://openalex.org/W2110233724","https://openalex.org/W2120369399","https://openalex.org/W2121508096","https://openalex.org/W2126335768","https://openalex.org/W2128891183","https://openalex.org/W2130988208","https://openalex.org/W2132637814","https://openalex.org/W2134861134","https://openalex.org/W2135190897","https://openalex.org/W2138508631","https://openalex.org/W2149542788","https://openalex.org/W2150822416","https://openalex.org/W2152438166","https://openalex.org/W2152970852","https://openalex.org/W2154612705","https://openalex.org/W2155899899","https://openalex.org/W2156561767","https://openalex.org/W2158766243","https://openalex.org/W2168153190","https://openalex.org/W2169550012","https://openalex.org/W2170170033","https://openalex.org/W2345554661","https://openalex.org/W2401478493","https://openalex.org/W2460062293","https://openalex.org/W2475437687","https://openalex.org/W2544114634","https://openalex.org/W2558207675","https://openalex.org/W2566188612","https://openalex.org/W2608960550","https://openalex.org/W2609239411","https://openalex.org/W2609422947","https://openalex.org/W2610554832","https://openalex.org/W2612519453","https://openalex.org/W2620884102","https://openalex.org/W2621892125","https://openalex.org/W2652717092","https://openalex.org/W2724956132","https://openalex.org/W2731637345","https://openalex.org/W2737936840","https://openalex.org/W2740051188","https://openalex.org/W2741629554","https://openalex.org/W2765528534","https://openalex.org/W2766010571","https://openalex.org/W2768710521","https://openalex.org/W2786541519","https://openalex.org/W4233208848"],"related_works":["https://openalex.org/W2987355628","https://openalex.org/W2780562416","https://openalex.org/W4387610806","https://openalex.org/W4233208848","https://openalex.org/W2256449325","https://openalex.org/W4388603693","https://openalex.org/W7207425462","https://openalex.org/W4400408212","https://openalex.org/W3042812233","https://openalex.org/W3086473011"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,4,38,46,99,140,167],"neurites":[3,12],"individual":[5,36],"neurons":[6,15,37],"to":[7,17,54,75,93,150,180],"distinguish":[8],"between":[9,69,134],"themselves":[10],"and":[11,16,32,91,129,156,158,183,188],"from":[13],"other":[14,53],"avoid":[18,51],"self":[19],"(self-avoidance)":[20],"plays":[21,160],"a":[22,113,161],"key":[23,92],"role":[24,163],"in":[25,29,84,110,164,186,191,202,206],"neural":[26,169],"circuit":[27],"assembly":[28],"both":[30],"invertebrates":[31],"vertebrates.":[33],"Similarly,":[34],"when":[35],"the":[39,47,87,97,138,145,165,192],"same":[40],"type":[41],"project":[42],"into":[43],"receptive":[44],"fields":[45],"brain,":[48],"they":[49],"must":[50],"each":[52],"maximize":[55],"target":[56],"coverage":[57],"(tiling).":[58],"Counterintuitively,":[59],"these":[60,82],"processes":[61],"are":[62,86,196],"driven":[63],"by":[64,120,131],"highly":[65],"specific":[66],"homophilic":[67,132,177],"interactions":[68,133,178],"cell":[70,101,115],"surface":[71,102,116,139],"proteins":[72,83],"that":[73,175],"lead":[74,179],"neurite":[76],"repulsion":[77],"rather":[78],"than":[79],"adhesion.":[80],"Among":[81],"vertebrates":[85],"clustered":[88],"protocadherins":[89],"(Pcdhs),":[90],"their":[94],"function":[95],"is":[96,118,127,148],"generation":[98],"enormous":[100],"structural":[103],"diversity.":[104],"Here":[105],"we":[106],"review":[107],"recent":[108],"advances":[109],"understanding":[111],"how":[112,124,144],"Pcdh":[114,135,146,173,193],"code":[117,126,147],"generated":[119],"stochastic":[121],"promoter":[122],"choice;":[123],"this":[125],"amplified":[128],"read":[130],"complexes":[136],"at":[137],"neurons;":[141],"and,":[142],"finally,":[143],"translated":[149],"cellular":[151],"function,":[152],"which":[153],"mediates":[154],"self-avoidance":[155],"tiling":[157],"thus":[159],"central":[162],"development":[166],"complex":[168],"circuits.":[170],"Not":[171],"surprisingly,":[172],"mutations":[174],"diminish":[176],"wiring":[181],"defects":[182],"abnormal":[184],"behavior":[185],"mice,":[187],"sequence":[189],"variants":[190],"gene":[194],"cluster":[195],"associated":[197],"with":[198],"autism":[199],"spectrum":[200],"disorders":[201],"family-based":[203],"genetic":[204],"studies":[205],"humans.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":17}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-26T00:00:00"}