{"id":"https://openalex.org/W2897346404","doi":"https://doi.org/10.1016/j.coche.2018.09.008","title":"Sensors for biomanufacturing process development: facilitating the shift from batch to continuous manufacturing","display_name":"Sensors for biomanufacturing process development: facilitating the shift from batch to continuous manufacturing","publication_year":2018,"publication_date":"2018-10-23","ids":{"openalex":"https://openalex.org/W2897346404","doi":"https://doi.org/10.1016/j.coche.2018.09.008","mag":"2897346404"},"language":"en","primary_location":{"id":"doi:10.1016/j.coche.2018.09.008","doi":"https://doi.org/10.1016/j.coche.2018.09.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coche.2018.09.008","pdf_url":null,"source":{"id":"https://openalex.org/S2764724535","display_name":"Current Opinion in Chemical Engineering","issn_l":"2211-3398","issn":["2211-3398"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Engineering","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035035270","display_name":"Timothy R Holzberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy R Holzberg","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088991723","display_name":"Valencia E. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valencia Watson","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020518834","display_name":"Sheniqua Brown","orcid":"https://orcid.org/0000-0002-6575-7544","observed_orcids":["https://orcid.org/0000-0002-6575-7544"]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheniqua Brown","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":"https://orcid.org/0000-0002-6575-7544","affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031866950","display_name":"Abhay U. Andar","orcid":"https://orcid.org/0000-0001-6647-7870","observed_orcids":["https://orcid.org/0000-0001-6647-7870"]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhay Andar","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":"https://orcid.org/0000-0001-6647-7870","affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018497661","display_name":"Xudong Ge","orcid":"https://orcid.org/0000-0003-1733-398X","observed_orcids":["https://orcid.org/0000-0003-1733-398X"]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xudong Ge","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046823574","display_name":"Yordan V. Kostov","orcid":"https://orcid.org/0000-0002-7903-9682","observed_orcids":["https://orcid.org/0000-0002-7903-9682"]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yordan Kostov","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043940183","display_name":"Leah M. Tolosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Tolosa","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050140316","display_name":"Govind Rao","orcid":"https://orcid.org/0000-0001-6140-7582","observed_orcids":["https://orcid.org/0000-0001-6140-7582"]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Govind Rao","raw_affiliation_strings":["Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Sensor Technology, Department of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","institution_ids":["https://openalex.org/I79272384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.3189,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.29124215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"22","issue":null,"first_page":"115","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.2304999977350235,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomanufacturing","display_name":"bioproduction","score":0.7720000147819519},{"id":"https://openalex.org/keywords/continuous-bioprocessing","display_name":"continuous bioprocessing","score":0.824999988079071},{"id":"https://openalex.org/keywords/batch-to-continuous-transition","display_name":"batch-to-continuous transition","score":0.7379999756813049},{"id":"https://openalex.org/keywords/process-analytical-technology","display_name":"process analytical technology","score":0.9070000052452087},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.7310000061988831},{"id":"https://openalex.org/keywords/biopharmaceutical-manufacturing","display_name":"biopharmaceutical manufacturing","score":0.890999972820282},{"id":"https://openalex.org/keywords/process-monitoring-and-control","display_name":"process monitoring and control","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2775893736","wikidata":"https://www.wikidata.org/wiki/Q25324110","display_name":"Biomanufacturing","level":2,"score":0.9534134268760681},{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.8434731364250183},{"id":"https://openalex.org/C2780548022","wikidata":"https://www.wikidata.org/wiki/Q614396","display_name":"Continuous production","level":2,"score":0.6206038594245911},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.6057263612747192},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5633690357208252},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5298713445663452},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.5216948390007019},{"id":"https://openalex.org/C178144697","wikidata":"https://www.wikidata.org/wiki/Q2111609","display_name":"Process analytical technology","level":3,"score":0.5007278919219971},{"id":"https://openalex.org/C155386361","wikidata":"https://www.wikidata.org/wiki/Q1649571","display_name":"Process control","level":3,"score":0.49826478958129883},{"id":"https://openalex.org/C2988729646","wikidata":"https://www.wikidata.org/wiki/Q838129","display_name":"Process development","level":2,"score":0.4819631278514862},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.42975443601608276},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.42391282320022583},{"id":"https://openalex.org/C172658912","wikidata":"https://www.wikidata.org/wiki/Q661613","display_name":"Batch processing","level":2,"score":0.41935741901397705},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3994032144546509},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.38917580246925354},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.16293933987617493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87717796","wikidata":"https://www.wikidata.org/wiki/Q146326","display_name":"Environmental engineering","level":1,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.coche.2018.09.008","doi":"https://doi.org/10.1016/j.coche.2018.09.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coche.2018.09.008","pdf_url":null,"source":{"id":"https://openalex.org/S2764724535","display_name":"Current Opinion in Chemical Engineering","issn_l":"2211-3398","issn":["2211-3398"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W940673965","https://openalex.org/W1441236973","https://openalex.org/W1535363819","https://openalex.org/W1910179562","https://openalex.org/W1915353445","https://openalex.org/W1968001050","https://openalex.org/W1976208842","https://openalex.org/W1983562528","https://openalex.org/W1983837936","https://openalex.org/W1987130080","https://openalex.org/W1987191121","https://openalex.org/W1999481657","https://openalex.org/W2002127906","https://openalex.org/W2002926047","https://openalex.org/W2006341340","https://openalex.org/W2026756682","https://openalex.org/W2027465966","https://openalex.org/W2048744915","https://openalex.org/W2052204213","https://openalex.org/W2053498910","https://openalex.org/W2058212201","https://openalex.org/W2059605539","https://openalex.org/W2061471252","https://openalex.org/W2069473534","https://openalex.org/W2085884133","https://openalex.org/W2115320104","https://openalex.org/W2118633409","https://openalex.org/W2120483313","https://openalex.org/W2136254684","https://openalex.org/W2145697300","https://openalex.org/W2146402498","https://openalex.org/W2149717386","https://openalex.org/W2150637735","https://openalex.org/W2160132765","https://openalex.org/W2167242797","https://openalex.org/W2168193475","https://openalex.org/W2223147105","https://openalex.org/W2280388944","https://openalex.org/W2281158957","https://openalex.org/W2311892490","https://openalex.org/W2475526351","https://openalex.org/W2482996159","https://openalex.org/W2497039129","https://openalex.org/W2501842328","https://openalex.org/W2516905987","https://openalex.org/W2517268326","https://openalex.org/W2567981205","https://openalex.org/W2591875863","https://openalex.org/W2592174776","https://openalex.org/W2622858400","https://openalex.org/W2734449167","https://openalex.org/W2742103546","https://openalex.org/W2749542039"],"related_works":["https://openalex.org/W2085488202","https://openalex.org/W2949802089","https://openalex.org/W4391663428","https://openalex.org/W3173595117","https://openalex.org/W1724871304","https://openalex.org/W1482898112","https://openalex.org/W2021433808","https://openalex.org/W4234039875","https://openalex.org/W4388086126","https://openalex.org/W4384818822"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-10-26T00:00:00"}