{"id":"https://openalex.org/W2896904445","doi":"https://doi.org/10.1002/jcb.27846","title":"Flavopiridol's effects on metastasis in KRAS mutant lung adenocarcinoma cells","display_name":"Flavopiridol's effects on metastasis in KRAS mutant lung adenocarcinoma cells","publication_year":2018,"publication_date":"2018-10-14","ids":{"openalex":"https://openalex.org/W2896904445","doi":"https://doi.org/10.1002/jcb.27846","mag":"2896904445","pmid":"https://pubmed.ncbi.nlm.nih.gov/30317654"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.27846","doi":"https://doi.org/10.1002/jcb.27846","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.27846","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004304107","display_name":"\u0130rem Do\u011fan","orcid":"https://orcid.org/0000-0002-3791-3538","observed_orcids":["https://orcid.org/0000-0002-3791-3538"]},"institutions":[{"id":"https://openalex.org/I165891364","display_name":"Ufuk University","ror":"https://ror.org/04dj8ng22","country_code":"TR","type":"education","lineage":["https://openalex.org/I165891364"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Irem Dogan Turacli","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Ufuk University, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3791-3538","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Ufuk University, Ankara, Turkey","institution_ids":["https://openalex.org/I165891364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079854460","display_name":"Funda Dem\u0131rta\u015f Korkmaz","orcid":"https://orcid.org/0000-0003-3978-9427","observed_orcids":["https://orcid.org/0000-0003-3978-9427"]},"institutions":[{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Funda Demirtas Korkmaz","raw_affiliation_strings":["Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028470027","display_name":"Tuba \u00c7andar","orcid":"https://orcid.org/0000-0002-3922-5915","observed_orcids":["https://orcid.org/0000-0002-3922-5915"]},"institutions":[{"id":"https://openalex.org/I165891364","display_name":"Ufuk University","ror":"https://ror.org/04dj8ng22","country_code":"TR","type":"education","lineage":["https://openalex.org/I165891364"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tuba Candar","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, Ufuk University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, Ufuk University, Ankara, Turkey","institution_ids":["https://openalex.org/I165891364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091178220","display_name":"Abdullah Ekmek\u00e7i","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abdullah Ekmekci","raw_affiliation_strings":["Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004304107"],"corresponding_institution_ids":["https://openalex.org/I165891364"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.8891,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73235625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"120","issue":"4","first_page":"5628","last_page":"5635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.3375999927520752,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.3375999927520752,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.30399999022483826,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0723000019788742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavopiridol","display_name":"flavopiridol","score":1.0},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.9200000166893005},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibition","display_name":"cyclin-dependent kinase inhibition","score":0.7429999709129333},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.8410000205039978},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.7239999771118164},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7250000238418579},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/calu-1-cells","display_name":"Calu-1 cells","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8703774213790894},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.640864372253418},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.63214111328125},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6271489858627319},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6186062693595886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35520654916763306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.339995801448822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2924453020095825},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20519322156906128},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12665078043937683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.060387104749679565},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.03596150875091553}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.27846","doi":"https://doi.org/10.1002/jcb.27846","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.27846","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:30317654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30317654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W184174239","https://openalex.org/W1527674890","https://openalex.org/W1977431691","https://openalex.org/W2010992064","https://openalex.org/W2016552601","https://openalex.org/W2022756191","https://openalex.org/W2029446677","https://openalex.org/W2070165132","https://openalex.org/W2103091073","https://openalex.org/W2107020701","https://openalex.org/W2109458089","https://openalex.org/W2115276278","https://openalex.org/W2124532303","https://openalex.org/W2128955496","https://openalex.org/W2131549312","https://openalex.org/W2132374537","https://openalex.org/W2137620209","https://openalex.org/W2159594827","https://openalex.org/W2166923287","https://openalex.org/W2170302386","https://openalex.org/W2280957887","https://openalex.org/W2344620413","https://openalex.org/W2344949419","https://openalex.org/W2545296105","https://openalex.org/W2589001620","https://openalex.org/W2729741613","https://openalex.org/W2731641493","https://openalex.org/W2757698249","https://openalex.org/W2771935866","https://openalex.org/W2779961708","https://openalex.org/W2784192277","https://openalex.org/W2801715001","https://openalex.org/W6607501992"],"related_works":["https://openalex.org/W2101859810","https://openalex.org/W2545296105","https://openalex.org/W2006652368","https://openalex.org/W2131549312","https://openalex.org/W2560703464","https://openalex.org/W2344949419","https://openalex.org/W3037436862","https://openalex.org/W2058314877","https://openalex.org/W2148810752","https://openalex.org/W1999844887"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"is":[2,12,23],"still":[3,188],"no":[4],"clinically":[5],"approved":[6],"agent":[7],"for":[8],"mutant":[9,61,131,207],"KRAS,":[10],"which":[11],"the":[13,39,149,153,178],"most":[14],"common":[15],"alteration":[16],"in":[17,34,128,147,176,205],"non-small-cell":[18],"lung":[19],"cancer":[20],"(NSCLC).":[21],"Flavopiridol":[22,124],"a":[24,169,198],"semisynthetic":[25],"flavonoid":[26],"that":[27,187],"inhibits":[28],"cell":[29,40,66,82],"growth":[30],"through":[31],"cyclin-dependent":[32],"kinases":[33],"G1/S":[35],"or":[36],"G2/M":[37],"of":[38,72,112],"cycle":[41],"and":[42,56,64,91,99,119,144,201],"induces":[43],"apoptosis.":[44],"In":[45],"this":[46],"study,":[47],"we":[48],"evaluated":[49],"its":[50],"effect":[51],"on":[52,59,74,163],"cellular":[53,170],"apoptosis,":[54,97],"survival,":[55,98],"metastasis":[57,199],"mechanisms":[58,186],"KRAS":[60,130,206],"A549,":[62],"Calu-1,":[63],"H2009":[65],"lines.":[67],"METHODS:":[68],"The":[69,85,109],"cytotoxic":[70],"effects":[71,111,162],"flavopiridol":[73,113,193],"NSCLC":[75,132],"cells":[76,86,133,150,179],"were":[77,87,103,114],"determined":[78,104],"by":[79,105,116],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[80],"bromide":[81],"viability":[83],"test.":[84],"treated":[88],"with":[89],"200":[90],"400":[92],"nM":[93],"flavopiridol,":[94],"and,":[95],"then,":[96],"metastasis-related":[100,154],"protein":[101,155],"expressions":[102,156],"Western":[106],"blot":[107],"analysis.":[108],"antimetastatic":[110],"assessed":[115],"wound":[117,142],"healing":[118,143],"Galectin-3":[120,145],"activity":[121,146],"assay.":[122],"RESULTS:":[123],"drastically":[125],"affected":[126],"toxicity":[127],"all":[129,148,177],"at":[134],"nanomolar":[135],"concentrations.":[136],"Also,":[137],"it":[138],"could":[139],"efficiently":[140],"inhibit":[141],"tested.":[151,180],"However,":[152],"did":[157],"not":[158],"reflect":[159],"these":[160],"obvious":[161],"blotting.":[164],"p-Erk":[165],"was":[166],"activated":[167],"as":[168,197],"survival":[171],"mechanism":[172],"to":[173,190],"escape":[174],"apoptosis":[175,203],"CONCLUSION:":[181],"Although":[182],"there":[183],"are":[184],"many":[185],"need":[189],"be":[191,195],"elucidated,":[192],"can":[194],"used":[196],"inhibitor":[200],"an":[202],"inducer":[204],"NSCLC.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-26T00:00:00"}
