{"id":"https://openalex.org/W2896874669","doi":"https://doi.org/10.1161/str.49.suppl_1.wp111","title":"Abstract WP111: Post-stroke Remote Limb Conditioning Shifts Monocyte to a Pro-inflammatory Subset and Improves Functional Recovery in Chronic Stroke","display_name":"Abstract WP111: Post-stroke Remote Limb Conditioning Shifts Monocyte to a Pro-inflammatory Subset and Improves Functional Recovery in Chronic Stroke","publication_year":2018,"publication_date":"2018-01-22","ids":{"openalex":"https://openalex.org/W2896874669","doi":"https://doi.org/10.1161/str.49.suppl_1.wp111","mag":"2896874669"},"language":"en","primary_location":{"id":"doi:10.1161/str.49.suppl_1.wp111","doi":"https://doi.org/10.1161/str.49.suppl_1.wp111","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.49.suppl_1.wp111","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102024515","display_name":"Jiwon Yang","orcid":"https://orcid.org/0000-0003-4226-7224","observed_orcids":["https://orcid.org/0000-0003-4226-7224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiwon Yang","raw_affiliation_strings":["Burke-Cornell Med Rsch Institute, White Plains, NY","Jiwon Yang Burke-Cornell Med Rsch Institute, White Plains, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burke-Cornell Med Rsch Institute, White Plains, NY","institution_ids":[]},{"raw_affiliation_string":"Jiwon Yang Burke-Cornell Med Rsch Institute, White Plains, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004992795","display_name":"Cesar Beltran","orcid":"https://orcid.org/0009-0009-3260-8970","observed_orcids":["https://orcid.org/0009-0009-3260-8970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cesar Beltran","raw_affiliation_strings":["Burke-Cornell Med Rsch Institute, White Plains, NY","Cesar Beltran Burke-Cornell Med Rsch Institute, White Plains, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burke-Cornell Med Rsch Institute, White Plains, NY","institution_ids":[]},{"raw_affiliation_string":"Cesar Beltran Burke-Cornell Med Rsch Institute, White Plains, NY","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076292863","display_name":"Sunghee Cho","orcid":"https://orcid.org/0000-0002-9988-8227","observed_orcids":["https://orcid.org/0000-0002-9988-8227"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunghee Cho","raw_affiliation_strings":["Burke-Cornell Med Rsch Institute, White Plains, NY","Sunghee Cho Burke-Cornell Med Rsch Institute, White Plains, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burke-Cornell Med Rsch Institute, White Plains, NY","institution_ids":[]},{"raw_affiliation_string":"Sunghee Cho Burke-Cornell Med Rsch Institute, White Plains, NY","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.21279999613761902,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7839999794960022},{"id":"https://openalex.org/keywords/inflammatory-monocytes","display_name":"inflammatory monocytes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ly6c","display_name":"Ly6C","score":0.8100000023841858},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.7059999704360962},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7759926319122314},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6545131206512451},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6111139059066772},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6008243560791016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3809836208820343},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33607929944992065},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.49.suppl_1.wp111","doi":"https://doi.org/10.1161/str.49.suppl_1.wp111","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.49.suppl_1.wp111","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2969750320","https://openalex.org/W4388773086","https://openalex.org/W3133299433","https://openalex.org/W2257938787","https://openalex.org/W4407049612","https://openalex.org/W2340192487","https://openalex.org/W2292788197","https://openalex.org/W2952294166","https://openalex.org/W2791385803","https://openalex.org/W2597739224"],"abstract_inverted_index":{"Objective:":[0],"Post-stroke":[1],"remote":[2],"limb":[3],"conditioning":[4],"(PSLC)":[5],"has":[6],"been":[7],"shown":[8],"protective":[9,18],"effect":[10],"in":[11,39,177,184,199,239,254,275],"preclinical":[12],"and":[13,53,94,113,117,130,140,155,194,224,234,248],"clinical":[14],"studies.":[15],"However,":[16],"underlying":[17],"mechanisms":[19],"are":[20],"multiple":[21],"but":[22,218],"not":[23,213],"clearly":[24],"defined.":[25],"Although":[26],"inflammation":[27,33],"exacerbates":[28],"stroke":[29,292],"injury,":[30],"studies":[31],"showed":[32],"also":[34],"plays":[35],"a":[36,99,208,265,281,287],"key":[37],"role":[38,267],"conditioning-mediated":[40],"protection.":[41],"This":[42,278],"study":[43,263,279],"investigated":[44],"if":[45],"PSLC":[46,78,153,162,190,229,253,285],"induces":[47],"changes":[48,55,183],"of":[49,88,252,268,284],"monocyte/macrophage":[50],"(MM)":[51],"subsets":[52],"the":[54,110,185,200],"contribute":[56],"to":[57,68,136,207,271],"PSLC-induced":[58,272],"functional":[59,273],"benefits.":[60],"Method:":[61],"C57BL/6":[62],"male":[63],"mice":[64],"(12-week-old)":[65],"were":[66,107,133,146,159,181],"subjected":[67],"transient":[69],"middle":[70],"cerebral":[71],"artery":[72],"occlusion":[73],"(MCAO)":[74],"for":[75,290],"30":[76],"min.":[77],"was":[79,125,219,244],"induced":[80],"2h":[81],"after":[82],"MCAO":[83],"by":[84,119],"applying":[85],"5":[86,89,95],"cycles":[87],"min":[90,96],"inflation":[91],"(200":[92],"mmHg)":[93],"deflation":[97],"with":[98,221,256],"cuff":[100],"on":[101],"left":[102],"hind":[103],"limb.":[104],"Mononuclear":[105],"cells":[106,145],"isolated":[108],"from":[109,150],"spleen,":[111],"blood":[112],"brain":[114,202,215],"at":[115,127],"3D":[116],"analyzed":[118],"flow":[120],"cytometer.":[121],"Acute":[122],"injury":[123,216,258],"size":[124,217],"measured":[126],"3D.":[128],"Motor":[129],"gait":[131,225],"functions":[132],"assessed":[134],"up":[135],"4-month":[137],"using":[138],"Rotarod":[139],"Catwalk.":[141],"Additionally,":[142],"na\u00efve":[143],"spleen":[144,186],"treated":[147],"sera":[148],"obtained":[149],"sham-conditioned":[151],"or":[152],"animals,":[154],"MM":[156,210,246],"subset":[157,176,198,211,238],"shifts":[158],"determined.":[160],"Results:":[161],"significantly":[163],"decreased":[164,191],"anti-inflammatory":[165],"(Ly-6C":[166,173],"low":[167,193,233],")":[168,175],"monocytes":[169,270],"without":[170],"changing":[171],"pro-inflammatory":[172,209,269],"high":[174,197,237],"blood,":[178],"while":[179],"there":[180],"no":[182],"(Fig":[187,203,227,241,259],"A).":[188],"Similarly,":[189],"Ly-6C":[192,196,236],"increased":[195,235],"stroked":[201],"B).":[204],"The":[205,262],"shift":[206,247],"did":[212],"attenuate":[214],"associated":[220],"improved":[222],"motor":[223],"function":[226],"D).":[228],"serum":[230],"reduced":[231],"Ly6-C":[232],"splenocytes":[240],"C).":[242],"There":[243],"bigger":[245,257],"greater":[249],"behavioral":[250],"benefits":[251,274],"animals":[255],"E&F).":[260],"Conclusion:":[261],"demonstrates":[264],"contributing":[266],"chronic":[276],"stroke.":[277],"provides":[280],"potential":[282],"application":[283],"as":[286],"neuroimmune-based":[288],"strategy":[289],"ischemic":[291],"patients.":[293]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2018-10-26T00:00:00"}
