{"id":"https://openalex.org/W2896575748","doi":"https://doi.org/10.1523/eneuro.0260-18.2018","title":"Enlarged Optic Nerve Axons and Reduced Visual Function in Mice with Defective Microfibrils","display_name":"Enlarged Optic Nerve Axons and Reduced Visual Function in Mice with Defective Microfibrils","publication_year":2018,"publication_date":"2018-09-01","ids":{"openalex":"https://openalex.org/W2896575748","doi":"https://doi.org/10.1523/eneuro.0260-18.2018","mag":"2896575748","pmid":"https://pubmed.ncbi.nlm.nih.gov/30406200","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6220594"},"language":"en","primary_location":{"id":"doi:10.1523/eneuro.0260-18.2018","doi":"https://doi.org/10.1523/eneuro.0260-18.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1523/eneuro.0260-18.2018","pdf_url":"https://www.eneuro.org/content/eneuro/5/5/ENEURO.0260-18.2018.full.pdf","source":{"id":"https://openalex.org/S4210172947","display_name":"eNeuro","issn_l":"2373-2822","issn":["2373-2822"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eneuro","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.eneuro.org/content/eneuro/5/5/ENEURO.0260-18.2018.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030701924","display_name":"Hang\u2010Jing Wu","orcid":"https://orcid.org/0000-0002-3736-6634","observed_orcids":["https://orcid.org/0000-0002-3736-6634"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hang-Jing Wu","raw_affiliation_strings":["Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033766833","display_name":"Ralph J. Hazlewood","orcid":"https://orcid.org/0000-0002-2233-0970","observed_orcids":["https://orcid.org/0000-0002-2233-0970"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph J. Hazlewood","raw_affiliation_strings":["Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004283621","display_name":"John Kuchtey","orcid":"https://orcid.org/0000-0001-5226-8648","observed_orcids":["https://orcid.org/0000-0001-5226-8648"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kuchtey","raw_affiliation_strings":["Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063990859","display_name":"Rachel W. Kuchtey","orcid":"https://orcid.org/0000-0003-0353-3315","observed_orcids":["https://orcid.org/0000-0003-0353-3315"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachel W. Kuchtey","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232-0022","Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","Vanderbilt University","Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232-0022","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232-8808","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063990859"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":2925,"currency":"USD","value_usd":2925},"apc_paid":{"value":2925,"currency":"USD","value_usd":2925},"fwci":0.7538,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.71681686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"5","first_page":"ENEURO.0260","last_page":"18.2018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.8849999904632568},{"id":"https://openalex.org/keywords/microfibrils","display_name":"microfibrils","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fibrillin-1","display_name":"fibrillin-1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/visual-function","display_name":"visual function","score":0.5230000019073486},{"id":"https://openalex.org/keywords/electroretinography","display_name":"electroretinogram","score":0.843999981880188},{"id":"https://openalex.org/keywords/pia-mater","display_name":"pia mater","score":0.7450000047683716},{"id":"https://openalex.org/keywords/elastic-fibers","display_name":"elastic fibers","score":0.859000027179718},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.6460000276565552},{"id":"https://openalex.org/keywords/age-related-neurodegeneration","display_name":"age-related neurodegeneration","score":0.625}],"concepts":[{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.8195920586585999},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7695833444595337},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.7269867658615112},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.7028171420097351},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.541063129901886},{"id":"https://openalex.org/C2776455902","wikidata":"https://www.wikidata.org/wiki/Q417913","display_name":"Microfibril","level":3,"score":0.5374333262443542},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.526420533657074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46176546812057495},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.43689629435539246},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.4207388162612915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3137344717979431},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25034964084625244},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020894","descriptor_name":"Microfibrils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/eneuro.0260-18.2018","doi":"https://doi.org/10.1523/eneuro.0260-18.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1523/eneuro.0260-18.2018","pdf_url":"https://www.eneuro.org/content/eneuro/5/5/ENEURO.0260-18.2018.full.pdf","source":{"id":"https://openalex.org/S4210172947","display_name":"eNeuro","issn_l":"2373-2822","issn":["2373-2822"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eneuro","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5170977","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6220594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6220594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6220594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eNeuro","raw_type":"Text"},{"id":"pmid:30406200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30406200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eNeuro","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/eneuro.0260-18.2018","doi":"https://doi.org/10.1523/eneuro.0260-18.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1523/eneuro.0260-18.2018","pdf_url":"https://www.eneuro.org/content/eneuro/5/5/ENEURO.0260-18.2018.full.pdf","source":{"id":"https://openalex.org/S4210172947","display_name":"eNeuro","issn_l":"2373-2822","issn":["2373-2822"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eneuro","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1149166549","display_name":null,"funder_award_id":"DK59637","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G1690227563","display_name":null,"funder_award_id":"P30EY008126","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G3865556588","display_name":null,"funder_award_id":"DK20593","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G4320917349","display_name":null,"funder_award_id":"DK58404","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G5853943267","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G7220527126","display_name":null,"funder_award_id":"EY08126","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G9000002043","display_name":null,"funder_award_id":"DK-59637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000060478","display_name":null,"funder_award_id":"EY08126","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000081609","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000106052","display_name":null,"funder_award_id":"DK 20593","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000159340","display_name":null,"funder_award_id":"DK-58404","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000883661","display_name":"Targeting Tissue Biomechanics for Treatment of Glaucoma","funder_award_id":"R01EY020894","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000906943","display_name":"Core Grant in Vision Research","funder_award_id":"P30EY008126","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334543","display_name":"Vanderbilt Vision Research Center, Vanderbilt University","ror":null},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2896575748.pdf","grobid_xml":"https://content.openalex.org/works/W2896575748.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W10676789","https://openalex.org/W86000632","https://openalex.org/W119594763","https://openalex.org/W123773561","https://openalex.org/W176348173","https://openalex.org/W228783596","https://openalex.org/W326957580","https://openalex.org/W952754067","https://openalex.org/W982144783","https://openalex.org/W1518549513","https://openalex.org/W1542711346","https://openalex.org/W1600107915","https://openalex.org/W1605339647","https://openalex.org/W1932710260","https://openalex.org/W1969258828","https://openalex.org/W1977689612","https://openalex.org/W1980368328","https://openalex.org/W1981121080","https://openalex.org/W1984401984","https://openalex.org/W1985808169","https://openalex.org/W1986131940","https://openalex.org/W1986496846","https://openalex.org/W1991881484","https://openalex.org/W1993010243","https://openalex.org/W1993051562","https://openalex.org/W1994002167","https://openalex.org/W1997217152","https://openalex.org/W2001989336","https://openalex.org/W2017879166","https://openalex.org/W2018412721","https://openalex.org/W2019116868","https://openalex.org/W2020022921","https://openalex.org/W2024661815","https://openalex.org/W2033445946","https://openalex.org/W2037307037","https://openalex.org/W2039127036","https://openalex.org/W2039677191","https://openalex.org/W2042297916","https://openalex.org/W2045025678","https://openalex.org/W2046549633","https://openalex.org/W2047909825","https://openalex.org/W2048953595","https://openalex.org/W2049381025","https://openalex.org/W2053221182","https://openalex.org/W2055820698","https://openalex.org/W2062015930","https://openalex.org/W2063461910","https://openalex.org/W2071292731","https://openalex.org/W2071782125","https://openalex.org/W2073589440","https://openalex.org/W2075547308","https://openalex.org/W2087647596","https://openalex.org/W2090810024","https://openalex.org/W2091823156","https://openalex.org/W2091932472","https://openalex.org/W2101365155","https://openalex.org/W2104301336","https://openalex.org/W2105753034","https://openalex.org/W2105892139","https://openalex.org/W2114952298","https://openalex.org/W2119765340","https://openalex.org/W2122211002","https://openalex.org/W2123689976","https://openalex.org/W2132679786","https://openalex.org/W2134917726","https://openalex.org/W2145335014","https://openalex.org/W2146279148","https://openalex.org/W2148529294","https://openalex.org/W2150285802","https://openalex.org/W2152350731","https://openalex.org/W2160934458","https://openalex.org/W2161589388","https://openalex.org/W2163509101","https://openalex.org/W2166357227","https://openalex.org/W2168253072","https://openalex.org/W2193723006","https://openalex.org/W2209429827","https://openalex.org/W2252793112","https://openalex.org/W2320447672","https://openalex.org/W2336947397","https://openalex.org/W2341353641","https://openalex.org/W2411898393","https://openalex.org/W2417887489","https://openalex.org/W2476542314","https://openalex.org/W2514114492","https://openalex.org/W2514331260","https://openalex.org/W2526694120","https://openalex.org/W2560520631","https://openalex.org/W2568000928","https://openalex.org/W2585187885","https://openalex.org/W2587304416","https://openalex.org/W2588300742","https://openalex.org/W2604522052","https://openalex.org/W2606735570","https://openalex.org/W2740306829","https://openalex.org/W2765516952","https://openalex.org/W2796169150","https://openalex.org/W2803378090","https://openalex.org/W2886709309","https://openalex.org/W2888554539","https://openalex.org/W4206485229"],"related_works":["https://openalex.org/W3049591346","https://openalex.org/W2918815920","https://openalex.org/W2123598898","https://openalex.org/W2193723006","https://openalex.org/W2069197531","https://openalex.org/W7100779893","https://openalex.org/W2739639393","https://openalex.org/W4283319984","https://openalex.org/W4403788238","https://openalex.org/W4410396404"],"abstract_inverted_index":{"Abstract":[0],"Glaucoma":[1],"is":[2,26],"a":[3,27,229],"leading":[4],"cause":[5,46],"of":[6,70,75,86,126,152,164,187,192,210,235],"irreversible":[7],"vision":[8],"loss":[9],"due":[10,81],"to":[11,58,82,202,233],"retinal":[12],"ganglion":[13],"cell":[14],"(RGC)":[15],"degeneration":[16,72],"that":[17,54,197],"develops":[18],"slowly":[19],"with":[20,36,78,105,144,176],"age.":[21],"Elevated":[22],"intraocular":[23],"pressure":[24],"(IOP)":[25],"significant":[28],"risk":[29],"factor,":[30],"although":[31],"many":[32],"patients":[33],"develop":[34],"glaucoma":[35,47],"IOP":[37,66,92],"in":[38,43,48,73,111,118,129,136,149,154,160,184,205,218],"the":[39,52,87,119,124,130,161,188,211],"normal":[40],"range.":[41],"Mutations":[42],"microfibril-associated":[44],"genes":[45],"animal":[49],"models,":[50],"suggesting":[51,221],"hypothesis":[53],"microfibril":[55,198],"defects":[56],"contribute":[57],"glaucoma.":[59,193],"To":[60],"test":[61],"this":[62],"hypothesis,":[63],"we":[64],"investigated":[65],"and":[67,156,170,228],"functional/structural":[68],"correlates":[69],"RGC":[71,109,116,127],"mice":[74,97,166],"either":[76],"sex":[77],"abnormal":[79],"microfibrils":[80],"heterozygous":[83],"Tsk":[84],"mutation":[85],"fibrilin-1":[88],"gene":[89],"(Fbn1Tsk/+).":[90],"Although":[91],"was":[93,121,133,173,216],"not":[94,122],"affected,":[95,123],"Fbn1Tsk/+":[96,137,155,165,219],"developed":[98],"functional":[99],"deficits":[100],"at":[101],"advanced":[102],"age":[103],"consistent":[104],"glaucoma,":[106],"including":[107],"reduced":[108,135,140],"responses":[110],"electroretinogram":[112],"(ERG)":[113],"experiments.":[114],"While":[115],"density":[117,125,142],"retina":[120],"axons":[128,153],"optic":[131,146,162,177,225],"nerve":[132,178,226],"significantly":[134,168],"mice.":[138],"However,":[139],"axon":[141,171,236],"correlated":[143,175],"expanded":[145],"nerves,":[147],"resulting":[148],"similar":[150],"numbers":[151],"control":[157],"nerves.":[158],"Axons":[159],"nerves":[163],"were":[167],"enlarged":[169],"diameter":[172],"strongly":[174],"area,":[179],"as":[180],"has":[181],"been":[182],"reported":[183],"early":[185],"pathogenesis":[186],"DBA/2J":[189],"mouse":[190],"model":[191],"Our":[194],"results":[195],"suggest":[196],"abnormalities":[199],"can":[200],"lead":[201],"phenotypes":[203],"found":[204,217],"early-stage":[206],"glaucomatous":[207],"neurodegeneration.":[208],"Thinning":[209],"elastic":[212],"fiber-rich":[213],"pia":[214],"mater":[215],"mice,":[220],"mechanisms":[222],"allowing":[223],"for":[224],"expansion":[227],"possible":[230],"biomechanical":[231],"contribution":[232],"determination":[234],"caliber.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-26T00:00:00"}