{"id":"https://openalex.org/W28964847","doi":"https://doi.org/10.1177/039139889301600707","title":"A Preliminary Study of the Fixation Mechanism of Collagen Reaction with a Polyepoxy Fixative","display_name":"A Preliminary Study of the Fixation Mechanism of Collagen Reaction with a Polyepoxy Fixative","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W28964847","doi":"https://doi.org/10.1177/039139889301600707","mag":"28964847","pmid":"https://pubmed.ncbi.nlm.nih.gov/8370609"},"language":"en","primary_location":{"id":"doi:10.1177/039139889301600707","doi":"https://doi.org/10.1177/039139889301600707","is_oa":false,"landing_page_url":"https://doi.org/10.1177/039139889301600707","pdf_url":null,"source":{"id":"https://openalex.org/S10751480","display_name":"The International Journal of Artificial Organs","issn_l":"0391-3988","issn":["0391-3988","1724-6040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Artificial Organs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R. Tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Tu","raw_affiliation_strings":["Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049696802","display_name":"Rodolfo C. Quijano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.C. Quijano","raw_affiliation_strings":["Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C.L. Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.L. Lu","raw_affiliation_strings":["Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060256613","display_name":"S.H. Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Shen","raw_affiliation_strings":["Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068668414","display_name":"E. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Wang","raw_affiliation_strings":["Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058203897","display_name":"Cary Hata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Hata","raw_affiliation_strings":["Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089060265","display_name":"Dingsheng Lin","orcid":"https://orcid.org/0000-0003-2021-0155","observed_orcids":["https://orcid.org/0000-0003-2021-0155"]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Lin","raw_affiliation_strings":["Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baxter Healthcare Corporation, Edwards CVS Division, Irvine, California - USA","institution_ids":["https://openalex.org/I99484792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I99484792"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.5019,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.78666058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"16","issue":"7","first_page":"537","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutaraldehyde","display_name":"glutaraldehyde","score":0.6660000085830688},{"id":"https://openalex.org/keywords/crosslinking-mechanism","display_name":"crosslinking mechanism","score":0.6380000114440918},{"id":"https://openalex.org/keywords/denaturation-temperature","display_name":"denaturation temperature","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tanning","display_name":"tanning","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bioprosthesis","display_name":"bioprosthesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/fixation-temperature","display_name":"fixation temperature","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2780848204","wikidata":"https://www.wikidata.org/wiki/Q3127040","display_name":"Fixative","level":3,"score":0.9712988138198853},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.6562080979347229},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5407893657684326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3669986128807068},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3237946629524231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10748538374900818},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.09066402912139893},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.05608662962913513},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001807","descriptor_name":"Blood Vessel Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011126","descriptor_name":"Polypropylenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013895","descriptor_name":"Thoracic Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/039139889301600707","doi":"https://doi.org/10.1177/039139889301600707","is_oa":false,"landing_page_url":"https://doi.org/10.1177/039139889301600707","pdf_url":null,"source":{"id":"https://openalex.org/S10751480","display_name":"The International Journal of Artificial Organs","issn_l":"0391-3988","issn":["0391-3988","1724-6040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Artificial Organs","raw_type":"journal-article"},{"id":"pmid:8370609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8370609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of artificial organs","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W135037860","https://openalex.org/W1447600850","https://openalex.org/W1575149124","https://openalex.org/W1986874008","https://openalex.org/W1988950689","https://openalex.org/W2000155858","https://openalex.org/W2009377812","https://openalex.org/W2054760402","https://openalex.org/W2057709834","https://openalex.org/W2059692836","https://openalex.org/W2071048073","https://openalex.org/W2071668899","https://openalex.org/W2087451742","https://openalex.org/W2091580010","https://openalex.org/W2092717233","https://openalex.org/W2114220683","https://openalex.org/W2154852947","https://openalex.org/W2201894882","https://openalex.org/W4211097305","https://openalex.org/W4249798057","https://openalex.org/W4323237860"],"related_works":["https://openalex.org/W1997180043","https://openalex.org/W2057709834","https://openalex.org/W4300348365","https://openalex.org/W2020093241","https://openalex.org/W2129403825","https://openalex.org/W1984887257","https://openalex.org/W2037723394","https://openalex.org/W1977705730","https://openalex.org/W2075056504","https://openalex.org/W1993013582"],"abstract_inverted_index":{"A":[0],"new":[1],"biomaterial":[2,22],"has":[3,23,36],"been":[4],"developed":[5],"by":[6],"fixing":[7],"native":[8],"collagens":[9],"with":[10,31,69,133,184],"a":[11,37,79,98,124,185],"polyepoxy":[12],"compound":[13],"(PC)":[14],"fixative.":[15,177],"Prior":[16],"studies":[17],"have":[18],"shown":[19],"that":[20,166],"this":[21,49],"comparable":[24],"properties":[25],"as":[26,42,78],"compared":[27],"to":[28,52,103,180],"collagen":[29],"fixed":[30,68,93],"glutaraldehyde":[32],"(GA)":[33],"and":[34,75,91],"thus":[35],"great":[38],"promise":[39],"for":[40,143],"use":[41],"an":[43],"implantable":[44],"bioprosthesis.":[45],"The":[46,109,161],"purpose":[47],"of":[48,56,81,107,127,129,141,152,155],"study":[50],"was":[51,113],"understand":[53],"the":[54,57,62,89,92,105,120,134,136,139,144,153,156,175],"mechanism":[55],"amino":[58,85,100,131,159,169],"acids-PC":[59],"reactions":[60],"in":[61,88,138,147],"fixation":[63,82,162,186],"process.":[64],"Bovine":[65],"arteries":[66,94],"were":[67,95,171],"PC":[70,176],"under":[71],"various":[72],"pH,":[73],"concentration":[74],"temperature":[76,111,122],"conditions":[77],"function":[80],"time.":[83],"Individual":[84],"acid":[86,101],"components":[87],"fresh":[90],"assayed":[96],"using":[97],"Beckman":[99],"analyzer":[102],"determine":[104],"degree":[106,140],"tanning.":[108],"denaturation":[110,121],"(Td)":[112],"also":[114],"measured":[115],"on":[116],"each":[117],"sample.":[118],"Since":[119],"is":[123],"direct":[125],"indication":[126],"cross-linking":[128],"individual":[130],"acids":[132,170],"fixative,":[135],"difference":[137],"tanning":[142],"same":[145],"increase":[146],"Td":[148],"may":[149],"be":[150,181],"indicative":[151],"quantity":[154],"masked,":[157],"non-cross-linked":[158],"acids.":[160],"reaction":[163],"data":[164],"indicated":[165],"not":[167],"all":[168],"cross-linked":[172],"upon":[173],"contacting":[174],"Masking":[178],"appeared":[179],"more":[182],"substantial":[183],"at":[187],"higher":[188],"pH":[189],"values.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}