{"id":"https://openalex.org/W2896472679","doi":"https://doi.org/10.1016/j.jaci.2018.09.032","title":"Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization","display_name":"Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization","publication_year":2018,"publication_date":"2018-10-16","ids":{"openalex":"https://openalex.org/W2896472679","doi":"https://doi.org/10.1016/j.jaci.2018.09.032","mag":"2896472679","pmid":"https://pubmed.ncbi.nlm.nih.gov/30339851"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2018.09.032","doi":"https://doi.org/10.1016/j.jaci.2018.09.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.09.032","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075082324","display_name":"Norimasa Tamehiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norimasa Tamehiro","raw_affiliation_strings":["Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112243063","display_name":"Kyoko Nishida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko Nishida","raw_affiliation_strings":["Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan; Department of Immunology, Tokyo Medical and Dental University, Tokyo, Japan","Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","Department of Immunology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan; Department of Immunology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781","https://openalex.org/I4210094012"]},{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]},{"raw_affiliation_string":"Department of Immunology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073179665","display_name":"Yu Sugita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Sugita","raw_affiliation_strings":["Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kunihiro Hayakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiro Hayakawa","raw_affiliation_strings":["Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111939798","display_name":"Hiroyo Oda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyo Oda","raw_affiliation_strings":["Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022780870","display_name":"Takeshi Nitta","orcid":"https://orcid.org/0000-0003-2384-3062","observed_orcids":["https://orcid.org/0000-0003-2384-3062"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Nitta","raw_affiliation_strings":["Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Miwa Nakano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miwa Nakano","raw_affiliation_strings":["Communal laboratory, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Communal laboratory, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026930555","display_name":"Akiko Nishioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Nishioka","raw_affiliation_strings":["Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048146458","display_name":"Reiko Yanobu\u2010Takanashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Yanobu-Takanashi","raw_affiliation_strings":["Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113578371","display_name":"Motohito Goto","orcid":"https://orcid.org/0000-0001-6288-4583","observed_orcids":["https://orcid.org/0000-0001-6288-4583"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motohito Goto","raw_affiliation_strings":["Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081091607","display_name":"Tadashi Okamura","orcid":"https://orcid.org/0000-0001-8457-1561","observed_orcids":["https://orcid.org/0000-0001-8457-1561"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Okamura","raw_affiliation_strings":["Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan; Department of Infectious Diseases, Research Institute, National Center for Global health and Medicine, Chiba, Japan","Department of Infectious Diseases, Research Institute, National Center for Global health and Medicine, Chiba, Japan","Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan; Department of Infectious Diseases, Research Institute, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]},{"raw_affiliation_string":"Department of Infectious Diseases, Research Institute, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]},{"raw_affiliation_string":"Department of Laboratory Animal Medicine, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083648067","display_name":"Reiko Adachi","orcid":"https://orcid.org/0000-0002-6628-884X","observed_orcids":["https://orcid.org/0000-0002-6628-884X"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Adachi","raw_affiliation_strings":["Department of Biochemistry, National Institute of Health Sciences, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Institute of Health Sciences, Kawasaki, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015182819","display_name":"Kazunari Kondo","orcid":"https://orcid.org/0000-0002-2662-4626","observed_orcids":["https://orcid.org/0000-0002-2662-4626"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunari Kondo","raw_affiliation_strings":["Department of Biochemistry, National Institute of Health Sciences, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Institute of Health Sciences, Kawasaki, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082909666","display_name":"Akimichi Morita","orcid":"https://orcid.org/0000-0001-8372-3754","observed_orcids":["https://orcid.org/0000-0001-8372-3754"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akimichi Morita","raw_affiliation_strings":["Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039369148","display_name":"Harumi Suzuki","orcid":"https://orcid.org/0000-0003-3616-9361","observed_orcids":["https://orcid.org/0000-0003-3616-9361"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Harumi Suzuki","raw_affiliation_strings":["Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan. Electronic address: hsuzuki@ri.ncgm.go.jp","Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan. Electronic address: hsuzuki@ri.ncgm.go.jp","institution_ids":["https://openalex.org/I4210094012"]},{"raw_affiliation_string":"Department of Immunology and Pathology, National Center for Global health and Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I4210094012"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039369148"],"corresponding_institution_ids":["https://openalex.org/I4210094012"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":0.644,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.64842461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"143","issue":"5","first_page":"1878","last_page":"1891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhoh","display_name":"RhoH","score":0.9670000076293945},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/chronic-dermatitis","display_name":"chronic dermatitis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.765999972820282},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rorgammat","display_name":"ROR\u03b3t","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ubr5","display_name":"UBR5","score":0.9449999928474426},{"id":"https://openalex.org/keywords/nr2f6","display_name":"NR2F6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.7910000085830688},{"id":"https://openalex.org/keywords/psoriasis-pathogenesis","display_name":"psoriasis pathogenesis","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5312544703483582},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5210244655609131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.519399881362915},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4429289698600769},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3280037045478821}],"mesh":[{"descriptor_ui":"D000097043","descriptor_name":"Interleukin-22","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jaci.2018.09.032","doi":"https://doi.org/10.1016/j.jaci.2018.09.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.09.032","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:30339851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30339851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2060048114","display_name":"Identification of pathogenic cell subsets in rheumatoid arthritis","funder_award_id":"18F18095","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2628981731","display_name":null,"funder_award_id":"19H04802","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4213297136","display_name":null,"funder_award_id":"17H05788","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4734722005","display_name":null,"funder_award_id":"25-103","funder_id":"https://openalex.org/F4320313449","funder_display_name":"National Center for Global Health and Medicine"},{"id":"https://openalex.org/G5458691223","display_name":"Molecular characterization of whole thymic stromal cells","funder_award_id":"19H03485","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6943811122","display_name":null,"funder_award_id":"26-106","funder_id":"https://openalex.org/F4320313449","funder_display_name":"National Center for Global Health and Medicine"},{"id":"https://openalex.org/G7039328866","display_name":"Promotion of osteoimmunology for understanding the new regulatory systems of vertebrate","funder_award_id":"15H05703","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G941285435","display_name":"Characterization of mammary intraepithelial lymphocytes","funder_award_id":"19K22507","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320313449","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324597","display_name":"Manpei Suzuki Diabetes Foundation","ror":"https://ror.org/03pkewe16"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1495161304","https://openalex.org/W1505833426","https://openalex.org/W1507781793","https://openalex.org/W1971708477","https://openalex.org/W1975164490","https://openalex.org/W1975296949","https://openalex.org/W1976355501","https://openalex.org/W1979058179","https://openalex.org/W1979364731","https://openalex.org/W1980354175","https://openalex.org/W1986457181","https://openalex.org/W1991407692","https://openalex.org/W1996293570","https://openalex.org/W1998215486","https://openalex.org/W2001167919","https://openalex.org/W2008063123","https://openalex.org/W2008751364","https://openalex.org/W2011964602","https://openalex.org/W2012097026","https://openalex.org/W2020306516","https://openalex.org/W2031545497","https://openalex.org/W2032576198","https://openalex.org/W2035754589","https://openalex.org/W2046477120","https://openalex.org/W2046957298","https://openalex.org/W2047949586","https://openalex.org/W2058600007","https://openalex.org/W2060458742","https://openalex.org/W2068230018","https://openalex.org/W2070437666","https://openalex.org/W2070873221","https://openalex.org/W2071549331","https://openalex.org/W2074753880","https://openalex.org/W2093670317","https://openalex.org/W2094795565","https://openalex.org/W2096620879","https://openalex.org/W2102889851","https://openalex.org/W2107432039","https://openalex.org/W2117347512","https://openalex.org/W2121126920","https://openalex.org/W2122697606","https://openalex.org/W2122939321","https://openalex.org/W2131493069","https://openalex.org/W2132999475","https://openalex.org/W2141016525","https://openalex.org/W2145114879","https://openalex.org/W2145592512","https://openalex.org/W2159513688","https://openalex.org/W2161712070","https://openalex.org/W2162687226","https://openalex.org/W2166282414","https://openalex.org/W2169051031","https://openalex.org/W2170342761","https://openalex.org/W2313512314","https://openalex.org/W2512241017","https://openalex.org/W2561759163","https://openalex.org/W2611618251","https://openalex.org/W2772946027","https://openalex.org/W6645172339","https://openalex.org/W6668760010"],"related_works":["https://openalex.org/W2795667019","https://openalex.org/W1998215486","https://openalex.org/W2058189541","https://openalex.org/W2619051447","https://openalex.org/W2025035158","https://openalex.org/W2145634436","https://openalex.org/W2336082641","https://openalex.org/W2805452297","https://openalex.org/W3108825402","https://openalex.org/W2801172075"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-26T00:00:00"}
