{"id":"https://openalex.org/W2896421189","doi":"https://doi.org/10.1177/0194599818803584","title":"Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals","display_name":"Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals","publication_year":2018,"publication_date":"2018-10-16","ids":{"openalex":"https://openalex.org/W2896421189","doi":"https://doi.org/10.1177/0194599818803584","mag":"2896421189","pmid":"https://pubmed.ncbi.nlm.nih.gov/30322354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6389372"},"language":"en","primary_location":{"id":"doi:10.1177/0194599818803584","doi":"https://doi.org/10.1177/0194599818803584","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0194599818803584","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0194599818803584","source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/0194599818803584","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022275862","display_name":"Robert Jay Morrison","orcid":"https://orcid.org/0000-0002-2313-8542","observed_orcids":["https://orcid.org/0000-0002-2313-8542"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Morrison","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery University of Michigan Ann Arbor Michigan USA","Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery University of Michigan Ann Arbor Michigan USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097780783","display_name":"Nicolas\u2010George Katsantonis","orcid":"https://orcid.org/0000-0002-7979-6130","observed_orcids":["https://orcid.org/0000-0002-7979-6130"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas\u2010George Katsantonis","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042606734","display_name":"Kevin Motz","orcid":"https://orcid.org/0000-0002-9255-7265","observed_orcids":["https://orcid.org/0000-0002-9255-7265"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Motz","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Baltimore Maryland USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Baltimore Maryland USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022299075","display_name":"Alexander T. Hillel","orcid":"https://orcid.org/0000-0001-8471-5449","observed_orcids":["https://orcid.org/0000-0001-8471-5449"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander T. Hillel","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Baltimore Maryland USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Baltimore Maryland USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017373475","display_name":"C. Gaelyn Garrett","orcid":"https://orcid.org/0000-0002-3434-8844","observed_orcids":["https://orcid.org/0000-0002-3434-8844"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Gaelyn Garrett","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026727547","display_name":"James L. Netterville","orcid":"https://orcid.org/0000-0002-7282-8769","observed_orcids":["https://orcid.org/0000-0002-7282-8769"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Netterville","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051812693","display_name":"Christopher Todd Wootten","orcid":"https://orcid.org/0000-0002-9189-6353","observed_orcids":["https://orcid.org/0000-0002-9189-6353","https://orcid.org/0000-0003-2739-8218"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher T. Wootten","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090398738","display_name":"Susan M. Majka","orcid":"https://orcid.org/0000-0002-1005-1552","observed_orcids":["https://orcid.org/0000-0002-1005-1552"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M. Majka","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063872240","display_name":"Timothy S. Blackwell","orcid":"https://orcid.org/0000-0002-0337-7052","observed_orcids":["https://orcid.org/0000-0002-0337-7052"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy S. Blackwell","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA","Veterans Affairs Tennessee Valley Healthcare Services, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Veterans Affairs Tennessee Valley Healthcare Services, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I4210101790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035624344","display_name":"Wonder P. Drake","orcid":"https://orcid.org/0000-0001-9406-3130","observed_orcids":["https://orcid.org/0000-0001-9406-3130"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wonder P. Drake","raw_affiliation_strings":["Division of Infectious Disease, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Disease, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068181002","display_name":"Alexander H. Gelbard","orcid":"https://orcid.org/0000-0003-0078-1305","observed_orcids":["https://orcid.org/0000-0003-0078-1305"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander Gelbard","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Nashville Tennessee USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068181002"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":2.637,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.90636217,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"160","issue":"1","first_page":"107","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11260","display_name":"Tracheal and airway disorders","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11260","display_name":"Tracheal and airway disorders","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-subglottic-stenosis","display_name":"idiopathic subglottic stenosis","score":1.0},{"id":"https://openalex.org/keywords/airway-fibrosis","display_name":"airway fibrosis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/scar-fibroblasts","display_name":"scar fibroblasts","score":0.9589999914169312},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9129999876022339},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/extracellular-matrix-production","display_name":"extracellular matrix synthesis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.5899999737739563},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chemokine-ligand-2","display_name":"chemokine ligand 2","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9559999704360962},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8619999885559082},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/myeloid-cell-recruitment","display_name":"myeloid cell recruitment","score":0.902999997138977},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.7638665437698364},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5359640121459961},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5128143429756165},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48216384649276733},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4748002588748932},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.47416749596595764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4501974582672119},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39780476689338684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.355837881565094},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.32108092308044434},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.22789782285690308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06958875060081482}],"mesh":[{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007829","descriptor_name":"Laryngostenosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007829","descriptor_name":"Laryngostenosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1177/0194599818803584","doi":"https://doi.org/10.1177/0194599818803584","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0194599818803584","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0194599818803584","source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},{"id":"pmid:30322354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30322354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:5386941","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6389372","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6389372","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6389372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Otolaryngol Head Neck Surg","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/191976","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/191976","pdf_url":"https://hdl.handle.net/2027.42/191976","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.7302/21977","doi":"https://doi.org/10.7302/21977","is_oa":true,"landing_page_url":"https://doi.org/10.7302/21977","pdf_url":null,"source":{"id":"https://openalex.org/S7407053136","display_name":"University of Michigan Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1177/0194599818803584","doi":"https://doi.org/10.1177/0194599818803584","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0194599818803584","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0194599818803584","source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3533921386","display_name":"Role of Lung MSC in Emphysema","funder_award_id":"R01HL116597","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4888224157","display_name":"Lung MSC regulate angiogenesis and repair during fibrosis","funder_award_id":"R01HL136449","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6560196548","display_name":null,"funder_award_id":"1409\u201022214","funder_id":"https://openalex.org/F4320308927","funder_display_name":"Patient-Centered Outcomes Research Institute"},{"id":"https://openalex.org/G682852095","display_name":"Mechanisms of Familial Pulmonary Fibrosis","funder_award_id":"P01HL092870","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8309508816","display_name":"Molecular Interrogation of the Host-Pathogen Interface in Idiopathic Subglottic Stensosis","funder_award_id":"R01HL146401","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8821912288","display_name":"Microbial induction of sarcoidosis CD4+ T cell dysfunction","funder_award_id":"R01HL117074","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000909512","display_name":"Mentoring in Translational Research in Interstitial Lung Diseases","funder_award_id":"K24HL127301","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320308927","display_name":"Patient-Centered Outcomes Research Institute","ror":"https://ror.org/014q65q44"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2896421189.pdf","grobid_xml":"https://content.openalex.org/works/W2896421189.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W183636652","https://openalex.org/W1505833426","https://openalex.org/W1548753867","https://openalex.org/W1875866852","https://openalex.org/W1895601060","https://openalex.org/W1925654693","https://openalex.org/W1964184380","https://openalex.org/W1966608706","https://openalex.org/W1977437151","https://openalex.org/W1978695171","https://openalex.org/W1983260461","https://openalex.org/W1996997066","https://openalex.org/W1997131908","https://openalex.org/W1998905025","https://openalex.org/W2015141049","https://openalex.org/W2015912102","https://openalex.org/W2031694374","https://openalex.org/W2032788173","https://openalex.org/W2033884349","https://openalex.org/W2055348159","https://openalex.org/W2055712900","https://openalex.org/W2061047385","https://openalex.org/W2065184077","https://openalex.org/W2065949135","https://openalex.org/W2067754406","https://openalex.org/W2083467607","https://openalex.org/W2085099489","https://openalex.org/W2087180040","https://openalex.org/W2095715691","https://openalex.org/W2106341988","https://openalex.org/W2107277218","https://openalex.org/W2117559606","https://openalex.org/W2124841074","https://openalex.org/W2136808380","https://openalex.org/W2141411192","https://openalex.org/W2142249617","https://openalex.org/W2145007867","https://openalex.org/W2154733572","https://openalex.org/W2263390674","https://openalex.org/W2428301625","https://openalex.org/W2436699703","https://openalex.org/W2597638978","https://openalex.org/W2610273044","https://openalex.org/W2623528309","https://openalex.org/W2757048625","https://openalex.org/W2761253664","https://openalex.org/W2784123747"],"related_works":["https://openalex.org/W2428301625","https://openalex.org/W2997849143","https://openalex.org/W4400594751","https://openalex.org/W4394762638","https://openalex.org/W4377092204","https://openalex.org/W4407137213","https://openalex.org/W4416229537","https://openalex.org/W4384523714","https://openalex.org/W2163938125","https://openalex.org/W1972281728"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"characterize":[2],"the":[3,68,127,200],"phenotype":[4,69],"and":[5,18,48,58,70,102,107,118,121,129,172],"function":[6],"of":[7,73,131,145,194,199],"fibroblasts":[8,75,111],"derived":[9],"from":[10,41],"airway":[11],"scar":[12,21,83,110,142,158],"in":[13,64,203],"idiopathic":[14,44],"subglottic":[15],"stenosis":[16],"(iSGS)":[17],"to":[19,24,66,76,96,112,126,167,179],"explore":[20],"fibroblast":[22,38,84,143,159],"response":[23,72],"interleukin":[25],"17A":[26],"(IL-17A).":[27],"STUDY":[28],"DESIGN:":[29],"Basic":[30],"science.":[31],"SETTING:":[32],"Laboratory.":[33],"SUBJECTS":[34],"AND":[35],"METHODS:":[36],"Primary":[37],"cell":[39],"lines":[40],"iSGS":[42,82,141,157,204],"subjects,":[43,47],"pulmonary":[45],"fibrosis":[46],"normal":[49],"control":[50],"airways":[51],"were":[52,62],"utilized":[53],"for":[54,190,197],"analysis.":[55],"Protein,":[56],"molecular,":[57],"flow":[59],"cytometric":[60],"techniques":[61],"applied":[63],"vitro":[65],"assess":[67],"functional":[71],"disease":[74],"IL-17A.":[77],"RESULTS:":[78],"Mechanistically,":[79],"IL-17A":[80,154,201],"drives":[81,156],"proliferation":[85],"(":[86,134,149],"P":[87,104,135,150],"<":[88,136],".01),":[89],"synergizes":[90,161],"with":[91,162],"transforming":[92,163],"growth":[93,164],"factor":[94,148,165],"\u00df1":[95,166],"promote":[97,168],"extracellular":[98,169],"matrix":[99,170],"production":[100,144],"(collagen":[101],"fibronectin;":[103],"=":[105,151],".04),":[106],"directly":[108,155],"stimulates":[109],"produce":[113],"chemokines":[114],"(chemokine":[115],"ligand":[116],"2)":[117],"cytokines":[119],"(IL-6":[120],"granulocyte-macrophage":[122,146],"colony-stimulating":[123,147],"factor)":[124],"critical":[125],"recruitment":[128],"differentiation":[130],"myeloid":[132],"cells":[133],".01).":[137],"Glucocorticoids":[138,177],"abrogated":[139],"IL-17A-dependent":[140],".02).":[152],"CONCLUSION:":[153],"proliferation,":[160],"production,":[171],"amplifies":[173],"local":[174],"inflammatory":[175,183],"signaling.":[176,184],"appear":[178],"partially":[180],"abrogate":[181],"fibroblast-dependent":[182],"These":[185],"results":[186],"offer":[187],"mechanistic":[188],"support":[189],"future":[191],"translational":[192],"study":[193],"clinical":[195],"reagents":[196],"manipulation":[198],"pathway":[202],"patients.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-26T00:00:00"}
