{"id":"https://openalex.org/W2896409403","doi":"https://doi.org/10.3892/or.2018.6785","title":"Downregulation of cyclooxygenase\u20111 stimulates mitochondrial apoptosis through the NF\u2011\u03baB signaling pathway in colorectal cancer cells","display_name":"Downregulation of cyclooxygenase\u20111 stimulates mitochondrial apoptosis through the NF\u2011\u03baB signaling pathway in colorectal cancer cells","publication_year":2018,"publication_date":"2018-10-12","ids":{"openalex":"https://openalex.org/W2896409403","doi":"https://doi.org/10.3892/or.2018.6785","mag":"2896409403","pmid":"https://pubmed.ncbi.nlm.nih.gov/30320345"},"language":"en","primary_location":{"id":"doi:10.3892/or.2018.6785","doi":"https://doi.org/10.3892/or.2018.6785","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2018.6785","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2018.6785/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/or.2018.6785/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101951814","display_name":"Lei Ding","orcid":"https://orcid.org/0000-0002-0572-9832","observed_orcids":["https://orcid.org/0000-0002-0572-9832","https://orcid.org/0009-0001-2157-0841"]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Ding","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028651137","display_name":"Huan Gu","orcid":"https://orcid.org/0000-0001-7300-6997","observed_orcids":["https://orcid.org/0000-0001-7300-6997"]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Gu","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060916129","display_name":"Zhenwei Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenwei Lan","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059801425","display_name":"Qingchun Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingchun Lei","raw_affiliation_strings":["Department of Neurosurgery, Pu'er City People's Hospital, Pu'er, Yunnan 66500, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Pu'er City People's Hospital, Pu'er, Yunnan 66500, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695520","display_name":"Wenxue Wang","orcid":"https://orcid.org/0000-0002-9137-8302","observed_orcids":["https://orcid.org/0000-0002-9137-8302"]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxue Wang","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075219509","display_name":"Jiangfei Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangfei Ruan","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Yu","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087984965","display_name":"Jie Lin","orcid":"https://orcid.org/0000-0002-5198-2070","observed_orcids":["https://orcid.org/0000-0002-5198-2070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Lin","raw_affiliation_strings":["Key Laboratory of Molecular Cancer Biology, Yunnan Education Department, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Cancer Biology, Yunnan Education Department, Kunming, Yunnan 650091, P.R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101588457","display_name":"Qinghua Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghua Cui","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China","institution_ids":["https://openalex.org/I189210763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7202,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81769401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"41","issue":"1","first_page":"559","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7350000143051147},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9819999933242798},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.871999979019165},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.984000027179718},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6463922262191772},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6198715567588806},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6072627305984497},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5351577401161194},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5181192755699158},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5177223086357117},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4811495542526245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47674477100372314},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4730469584465027},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4678282141685486},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4435516893863678},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.43521618843078613},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42541152238845825},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.41904932260513306},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.41635510325431824},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3302374482154846},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2661969065666199},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09956276416778564},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.08331060409545898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2018.6785","doi":"https://doi.org/10.3892/or.2018.6785","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2018.6785","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2018.6785/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:30320345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30320345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2018.6785","doi":"https://doi.org/10.3892/or.2018.6785","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2018.6785","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2018.6785/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2202724351","display_name":"\u5185\u5916\u8054\u52a8\u534f\u540c\u4fc3\u8fdbsTRAIL\u6297\u80bf\u7624\u4f5c\u7528\u7684\u80bf\u7624\u5fae\u73af\u5883\u89e6\u53d1\u5f0f\u878d\u5408\u86cb\u767d\u7684\u6784\u5efa\u53ca\u6548\u5e94\u673a\u5236\u7814\u7a76","funder_award_id":"81660583","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2869776631","display_name":null,"funder_award_id":"81760507","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4345389712","display_name":"miR-375\u4f5c\u4e3a\u7ed3\u76f4\u80a0\u764c\u65e9\u671f\u8bca\u65ad\u6807\u8bb0\u53ca\u8c03\u63a7\u673a\u7406\u7814\u7a76","funder_award_id":"81360310","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8022600949","display_name":"FE65\u5bf9\u6d77\u9a6c\u7a81\u89e6\u53ef\u5851\u6027\u548c\u5b66\u4e60\u8bb0\u5fc6\u8c03\u63a7\u4f5c\u7528\u7684\u7ec6\u80de\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"81360175","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G856417146","display_name":null,"funder_award_id":"81760507, 81360310, 81360175","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2896409403.pdf","grobid_xml":"https://content.openalex.org/works/W2896409403.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W329007366","https://openalex.org/W1964483580","https://openalex.org/W1980100638","https://openalex.org/W1982718980","https://openalex.org/W2029547213","https://openalex.org/W2039191003","https://openalex.org/W2049821512","https://openalex.org/W2076974145","https://openalex.org/W2079624094","https://openalex.org/W2081119227","https://openalex.org/W2106787323","https://openalex.org/W2129935236","https://openalex.org/W2141017342","https://openalex.org/W2156608191","https://openalex.org/W2162102504","https://openalex.org/W2170717609","https://openalex.org/W2256814822","https://openalex.org/W2399683938","https://openalex.org/W2559687683","https://openalex.org/W2589302412","https://openalex.org/W4231107149"],"related_works":["https://openalex.org/W1911406724","https://openalex.org/W2123107307","https://openalex.org/W1999168962","https://openalex.org/W2023108227","https://openalex.org/W4393021550","https://openalex.org/W2163642722","https://openalex.org/W3013755306","https://openalex.org/W2409811039","https://openalex.org/W2083636189","https://openalex.org/W2378081224"],"abstract_inverted_index":{"The":[0,21,126],"prognosis":[1],"of":[2,18,23,28,35,45,86,103,112,131,145,157,177,186,208],"patients":[3,87],"with":[4,88,206],"colorectal":[5,84],"cancer":[6,106],"(CRC)":[7],"remains":[8,70],"poor":[9],"owing":[10],"to":[11,32,79],"diagnosis":[12],"typically":[13],"occurring":[14],"at":[15],"advanced":[16],"stages":[17],"the":[19,24,33,38,62,73,92,101,123,134,143,173,184,187,200,209],"disease.":[20],"understanding":[22],"molecular":[25,63],"regulatory":[26],"signatures":[27],"CRC":[29,69,93,120],"may":[30],"lead":[31],"identification":[34],"biomarkers":[36],"for":[37],"early":[39],"detection,":[40],"prevention":[41],"and":[42,90,97,118,150,164],"clinical":[43],"intervention":[44],"CRC.":[46,223],"Epidemiological":[47],"studies":[48],"have":[49],"indicated":[50,190],"that":[51,129,191,203],"cyclooxygenase\u20111":[52],"(COX\u20111)":[53],"serves":[54],"an":[55],"active":[56],"function":[57,102,202],"in":[58,68,83,91,105,116,122,222],"colon":[59],"carcinogenesis.":[60],"However,":[61],"mechanism":[64],"underlying":[65],"COX\u20111":[66,76,104,113,132,158,192,216],"regulation":[67],"unknown.":[71],"In":[72],"present":[74,124,188],"study,":[75],"was":[77,114],"identified":[78],"be":[80],"markedly":[81],"upregulated":[82],"tissues":[85],"CRC,":[89],"cell":[94,196],"lines":[95],"HCT116":[96,117],"HT29.":[98],"To":[99],"determine":[100],"development,":[107],"short":[108],"hairpin":[109],"RNA":[110],"knockdown":[111],"employed":[115],"HT29":[119],"cells":[121],"study.":[125],"results":[127,185,214],"demonstrated":[128],"silencing":[130],"depolarized":[133],"mitochondrial":[135,153,201],"membrane":[136],"potential,":[137],"inhibited":[138],"adenosine":[139],"triphosphate":[140],"production,":[141],"induced":[142],"generation":[144],"intracellular":[146],"reactive":[147],"oxygen":[148],"species":[149],"triggered":[151,195],"caspase\u2011dependent":[152],"apoptosis.":[154],"Furthermore,":[155],"depletion":[156],"suppressed":[159],"anti\u2011apoptotic":[160],"B\u2011cell":[161],"lymphoma":[162],"2":[163],"enhanced":[165],"pro\u2011apoptotic":[166],"Bcl\u20112\u2011associated":[167],"X":[168],"protein":[169],"expression":[170],"by":[171,198],"inhibiting":[172],"p65":[174],"subunit":[175],"phosphorylation":[176],"nuclear":[178],"factor":[179],"\u03baB":[180],"(NF\u2011\u03baB).":[181],"Taken":[182],"together,":[183],"study":[189],"inhibition":[193],"significantly":[194],"death":[197],"destroying":[199],"is":[204],"associated":[205],"deactivation":[207],"NF\u2011\u03baB":[210],"signaling":[211],"pathway.":[212],"These":[213],"suggest":[215],"as":[217],"a":[218],"potential":[219],"anticancer":[220],"target":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-26T00:00:00"}
