{"id":"https://openalex.org/W2896175809","doi":"https://doi.org/10.1093/nar/gky894","title":"Mapping interfacial hydration in ETS-family transcription factor complexes with DNA: a chimeric approach","display_name":"Mapping interfacial hydration in ETS-family transcription factor complexes with DNA: a chimeric approach","publication_year":2018,"publication_date":"2018-09-22","ids":{"openalex":"https://openalex.org/W2896175809","doi":"https://doi.org/10.1093/nar/gky894","mag":"2896175809","pmid":"https://pubmed.ncbi.nlm.nih.gov/30295801","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6237740"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gky894","doi":"https://doi.org/10.1093/nar/gky894","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky894","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gky894","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091591683","display_name":"Amanda V. Albrecht","orcid":"https://orcid.org/0000-0002-7699-0480","observed_orcids":["https://orcid.org/0000-0002-7699-0480"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda V Albrecht","raw_affiliation_strings":["Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044617978","display_name":"Hye Mi Kim","orcid":"https://orcid.org/0009-0007-1172-1793","observed_orcids":["https://orcid.org/0009-0007-1172-1793"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye Mi Kim","raw_affiliation_strings":["Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067232575","display_name":"Gregory M.K. Poon","orcid":"https://orcid.org/0000-0001-5107-9458","observed_orcids":["https://orcid.org/0000-0001-5107-9458"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory M K Poon","raw_affiliation_strings":["Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA","Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA"],"raw_orcid":"https://orcid.org/0000-0001-5107-9458","affiliations":[{"raw_affiliation_string":"Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]},{"raw_affiliation_string":"Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067232575"],"corresponding_institution_ids":["https://openalex.org/I181565077"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":0.5332,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61978574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"46","issue":"20","first_page":"10577","last_page":"10588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interfacial-hydration","display_name":"interfacial hydration","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.968999981880188},{"id":"https://openalex.org/keywords/ets1","display_name":"ETS1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-dna-recognition","display_name":"protein-DNA recognition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.8619999885559082},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sequence-specificity","display_name":"sequence specificity","score":0.621999979019165},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7798367142677307},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6858372688293457},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6814003586769104},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6485658884048462},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5681027173995972},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.48091718554496765},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.47503000497817993},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4254888892173767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4123663008213043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33555856347084045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3328455686569214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2839147746562958},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000099232","descriptor_name":"Proto-Oncogene Protein Spi-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009995","descriptor_name":"Osmosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050784","descriptor_name":"Proto-Oncogene Protein c-ets-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gky894","doi":"https://doi.org/10.1093/nar/gky894","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky894","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5206756","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6237740","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6237740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6237740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:30295801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30295801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gky894","doi":"https://doi.org/10.1093/nar/gky894","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky894","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1292584736","display_name":"Direct activation of hematopoietic transcription factors","funder_award_id":"R21HL129063","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4081887556","display_name":null,"funder_award_id":"MCB 15451600","funder_id":"https://openalex.org/F4320307381","funder_display_name":"National Sleep Foundation"},{"id":"https://openalex.org/G8868132504","display_name":null,"funder_award_id":"15451600","funder_id":"https://openalex.org/F4320337397","funder_display_name":"Division of Molecular and Cellular Biosciences"}],"funders":[{"id":"https://openalex.org/F4320307381","display_name":"National Sleep Foundation","ror":"https://ror.org/00zc1hf95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1528728345","https://openalex.org/W1964408441","https://openalex.org/W1965127482","https://openalex.org/W1968572994","https://openalex.org/W1970157213","https://openalex.org/W1971578941","https://openalex.org/W1972241850","https://openalex.org/W1974909022","https://openalex.org/W1982258330","https://openalex.org/W1984734912","https://openalex.org/W1985177466","https://openalex.org/W1985459186","https://openalex.org/W1987474460","https://openalex.org/W1992994326","https://openalex.org/W1994470704","https://openalex.org/W2001456726","https://openalex.org/W2003183846","https://openalex.org/W2003967338","https://openalex.org/W2005739967","https://openalex.org/W2009180555","https://openalex.org/W2021387846","https://openalex.org/W2022484296","https://openalex.org/W2026690931","https://openalex.org/W2032088412","https://openalex.org/W2033902642","https://openalex.org/W2038135364","https://openalex.org/W2043218293","https://openalex.org/W2074703985","https://openalex.org/W2083219374","https://openalex.org/W2083693209","https://openalex.org/W2087431455","https://openalex.org/W2093961756","https://openalex.org/W2094007125","https://openalex.org/W2102403688","https://openalex.org/W2108765440","https://openalex.org/W2110356179","https://openalex.org/W2129713711","https://openalex.org/W2136274073","https://openalex.org/W2144109577","https://openalex.org/W2145010689","https://openalex.org/W2146886804","https://openalex.org/W2152665189","https://openalex.org/W2155557355","https://openalex.org/W2160304959","https://openalex.org/W2164569166","https://openalex.org/W2204959575","https://openalex.org/W2326712231","https://openalex.org/W2338749310","https://openalex.org/W2416365174","https://openalex.org/W2515193564","https://openalex.org/W2595131753","https://openalex.org/W2602360663","https://openalex.org/W2743728766","https://openalex.org/W2766367793","https://openalex.org/W2807380229"],"related_works":["https://openalex.org/W2913316993","https://openalex.org/W2602360663","https://openalex.org/W6917488113","https://openalex.org/W2093961756","https://openalex.org/W2015211094","https://openalex.org/W2007072155","https://openalex.org/W2083693209","https://openalex.org/W2059276151","https://openalex.org/W2595131753","https://openalex.org/W2790810163"],"abstract_inverted_index":{"Hydration":[0],"of":[1,7,55,89,93,102,120,133,165],"interfaces":[2],"is":[3,15,40],"a":[4,16,66,90],"major":[5],"determinant":[6,184],"target":[8],"specificity":[9,183],"in":[10,20,42,96,124,159],"protein/DNA":[11],"interactions.":[12],"Interfacial":[13],"hydration":[14,39,95,122,179],"highly":[17],"variable":[18],"feature":[19],"DNA":[21,52],"recognition":[22,104],"by":[23],"ETS":[24,59],"transcription":[25],"factors":[26],"and":[27,156,174],"functionally":[28],"relates":[29],"to":[30,33,85],"cellular":[31],"responses":[32],"osmotic":[34,86],"stress.":[35],"To":[36],"understand":[37],"how":[38],"mediated":[41],"the":[43,51,56,100,103,107,118,131,140,150,162,166],"conserved":[44],"ETS/DNA":[45],"binding":[46,154],"interface,":[47],"secondary":[48],"structures":[49],"comprising":[50],"contact":[53],"surface":[54],"strongly":[57],"hydrated":[58,74],"member":[60],"PU.1":[61,125,157,187],"were":[62],"substituted,":[63],"one":[64],"at":[65,130,136],"time,":[67],"with":[68,161,188],"corresponding":[69],"elements":[70],"from":[71],"its":[72,194],"sparsely":[73],"relative":[75,196],"Ets-1.":[76,197],"The":[77,170],"resultant":[78],"PU.1/Ets-1":[79],"chimeras":[80,108],"exhibited":[81],"variably":[82],"reduced":[83],"sensitivity":[84],"pressure,":[87],"indicative":[88],"distributed":[91],"pattern":[92],"interfacial":[94],"wildt-ype":[97],"PU.1.":[98],"With":[99],"exception":[101],"helix":[105],"H3,":[106],"retained":[109],"substantially":[110],"high":[111],"affinities.":[112],"Ets-1":[113],"residues":[114,168],"could":[115],"therefore":[116,177],"offset":[117],"loss":[119],"favorable":[121],"contributions":[123],"via":[126],"low-water":[127],"interactions,":[128],"but":[129],"cost":[132],"decreased":[134],"selectivity":[135],"base":[137],"positions":[138],"flanking":[139],"5'-GGA-3'":[141],"core":[142,151],"consensus.":[143],"Substitutions":[144],"within":[145],"H3":[146],"alone,":[147],"which":[148],"contacts":[149],"consensus,":[152],"impaired":[153],"affinity":[155],"transactivation":[158],"accordance":[160],"evolutionary":[163],"separation":[164],"chimeric":[167],"involved.":[169],"combined":[171],"biophysical,":[172],"bioinformatics":[173],"functional":[175],"data":[176],"supports":[178],"as":[180],"an":[181],"evolved":[182],"that":[185],"endows":[186],"more":[189],"stringent":[190],"sequence":[191],"selection":[192],"over":[193],"ancestral":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-26T00:00:00"}
