{"id":"https://openalex.org/W2896114129","doi":"https://doi.org/10.1158/0008-5472.can-18-1662","title":"The E2F1\u2013miR-520/372/373\u2013SPOP Axis Modulates Progression of Renal Carcinoma","display_name":"The E2F1\u2013miR-520/372/373\u2013SPOP Axis Modulates Progression of Renal Carcinoma","publication_year":2018,"publication_date":"2018-10-22","ids":{"openalex":"https://openalex.org/W2896114129","doi":"https://doi.org/10.1158/0008-5472.can-18-1662","mag":"2896114129","pmid":"https://pubmed.ncbi.nlm.nih.gov/30348808"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-18-1662","doi":"https://doi.org/10.1158/0008-5472.can-18-1662","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-1662","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102000748","display_name":"Meng Ding","orcid":"https://orcid.org/0009-0009-8452-1279","observed_orcids":["https://orcid.org/0009-0009-8452-1279"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Ding","raw_affiliation_strings":["1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"raw_affiliation_string":"2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaolan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolan Lu","raw_affiliation_strings":["1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"raw_affiliation_string":"2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416987","display_name":"Cheng Wang","orcid":"https://orcid.org/0000-0002-1834-2119","observed_orcids":["https://orcid.org/0000-0002-1834-2119","https://orcid.org/0009-0002-2044-666X"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Wang","raw_affiliation_strings":["1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"raw_affiliation_string":"2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079972852","display_name":"Quan Zhao","orcid":"https://orcid.org/0000-0002-8533-1938","observed_orcids":["https://orcid.org/0000-0002-8533-1938"]},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Zhao","raw_affiliation_strings":["2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101422874","display_name":"Jingping Ge","orcid":"https://orcid.org/0000-0002-4464-3230","observed_orcids":["https://orcid.org/0000-0002-4464-3230"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingping Ge","raw_affiliation_strings":["3Department of Urology, Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Urology, Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108241592","display_name":"Qiuyuan Xia","orcid":"https://orcid.org/0000-0002-0952-7437","observed_orcids":["https://orcid.org/0000-0002-0952-7437"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuyuan Xia","raw_affiliation_strings":["4Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100607468","display_name":"Junjun Wang","orcid":"https://orcid.org/0000-0003-0507-1724","observed_orcids":["https://orcid.org/0000-0003-0507-1724"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjun Wang","raw_affiliation_strings":["1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I4391768173","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082076770","display_name":"Ke Zen","orcid":"https://orcid.org/0000-0002-5166-2974","observed_orcids":["https://orcid.org/0000-0002-5166-2974"]},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Zen","raw_affiliation_strings":["2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112212826","display_name":"Chen\u2010Yu Zhang","orcid":"https://orcid.org/0000-0002-7329-7162","observed_orcids":["https://orcid.org/0000-0002-7329-7162"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Yu Zhang","raw_affiliation_strings":["1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"raw_affiliation_string":"2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":null,"display_name":"Chunni Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunni Zhang","raw_affiliation_strings":["1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"raw_affiliation_string":"2State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4483,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.79551082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"78","issue":"24","first_page":"6771","last_page":"6784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/speckle-type-poz-protein","display_name":"SPOP","score":0.9319999814033508},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6240000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.47099998593330383},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7720000147819519},{"id":"https://openalex.org/keywords/3-utr-targeting","display_name":"3' UTR targeting","score":0.5879999995231628},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7014816999435425},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6075927019119263},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5346606969833374},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.5316691398620605},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.525231122970581},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5021026134490967},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4998950958251953},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48052462935447693},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.479927122592926},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4590024948120117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4452195167541504},{"id":"https://openalex.org/C183022183","wikidata":"https://www.wikidata.org/wiki/Q15333016","display_name":"E2F1","level":4,"score":0.4306294322013855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3604243993759155},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30456340312957764},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2581106424331665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22787263989448547},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.15953809022903442},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.11024677753448486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09162035584449768},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08077111840248108},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06572985649108887}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050687","descriptor_name":"E2F1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-18-1662","doi":"https://doi.org/10.1158/0008-5472.can-18-1662","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-1662","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:30348808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30348808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3255455796","display_name":null,"funder_award_id":"81772282","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5027723589","display_name":null,"funder_award_id":"81472021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5739206836","display_name":null,"funder_award_id":"5431ZZXM1601","funder_id":"https://openalex.org/F4320335685","funder_display_name":"State Key Laboratory of Analytical Chemistry for Life Science"},{"id":"https://openalex.org/G6531451501","display_name":null,"funder_award_id":"2014CB 542300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7760546497","display_name":"\u8840\u6d46\u5206\u6ccc\u578bmiRNA\u4f5c\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5206\u5b50\u6807\u5fd7\u7269\u53ca\u53c2\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u8c03\u8282\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81672102","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G812761450","display_name":null,"funder_award_id":"81401257","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335685","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1490034858","https://openalex.org/W1567201966","https://openalex.org/W1648301895","https://openalex.org/W1848427443","https://openalex.org/W1964605487","https://openalex.org/W1971358860","https://openalex.org/W1973779541","https://openalex.org/W1974740818","https://openalex.org/W1974768373","https://openalex.org/W1975390562","https://openalex.org/W1982772122","https://openalex.org/W1984252723","https://openalex.org/W1994151970","https://openalex.org/W2009190733","https://openalex.org/W2013798280","https://openalex.org/W2015644147","https://openalex.org/W2027899941","https://openalex.org/W2031373802","https://openalex.org/W2039213901","https://openalex.org/W2040191060","https://openalex.org/W2050869737","https://openalex.org/W2061358469","https://openalex.org/W2064292948","https://openalex.org/W2069244750","https://openalex.org/W2085331591","https://openalex.org/W2087061566","https://openalex.org/W2104519300","https://openalex.org/W2111268021","https://openalex.org/W2130979840","https://openalex.org/W2131595192","https://openalex.org/W2141791387","https://openalex.org/W2145021085","https://openalex.org/W2149554227","https://openalex.org/W2151221689","https://openalex.org/W2159715390","https://openalex.org/W2161600258","https://openalex.org/W2162674813","https://openalex.org/W2163199119","https://openalex.org/W2163652992","https://openalex.org/W2166010840","https://openalex.org/W2169194081","https://openalex.org/W2285425357","https://openalex.org/W2341868983","https://openalex.org/W2473490811","https://openalex.org/W2519137542","https://openalex.org/W2539122019","https://openalex.org/W2570618306","https://openalex.org/W2590724511","https://openalex.org/W2608952641","https://openalex.org/W2622047107","https://openalex.org/W2917837889","https://openalex.org/W6671555608"],"related_works":["https://openalex.org/W3037678785","https://openalex.org/W4379806302","https://openalex.org/W4391980161","https://openalex.org/W2203066110","https://openalex.org/W2886245314","https://openalex.org/W4407190313","https://openalex.org/W2473490811","https://openalex.org/W3194619445","https://openalex.org/W2972477728","https://openalex.org/W3198156217"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"renal":[2],"cell":[3],"carcinoma":[4],"(RCC)":[5],"is":[6],"the":[7,49,68,137,164],"most":[8],"malignant":[9],"urologic":[10],"cancer,":[11],"its":[12],"pathogenesis":[13,178],"remains":[14],"unclear,":[15],"and":[16,54,71,81,89,96,110,149,151,179],"effective":[17,185],"treatments":[18],"for":[19,156,183],"advanced":[20],"RCC":[21,34,46,62,92,147,169,177],"are":[22],"still":[23],"lacking.":[24],"Here,":[25],"we":[26],"report":[27],"that":[28,136,163],"a":[29,142,153],"novel":[30],"E2F1\u2013miR-520/372/373\u2013SPOP":[31],"axis":[32,139,167],"controls":[33],"carcinogenesis.":[35],"Speckle-type":[36],"POZ":[37],"protein":[38,59,74],"(SPOP)":[39],"was":[40,52,125],"upregulated":[41],"in":[42,61,94,97,114,146],"over":[43],"90%":[44],"of":[45,79,91,101,122,176],"tissues,":[47],"whereas":[48],"miR-520/372/373":[50,65,103,123],"family":[51,66,104,124],"downregulated":[53],"correlated":[55],"inversely":[56],"with":[57],"SPOP":[58,69,73],"levels":[60,83],"tissues.":[63],"The":[64],"targeted":[67,157,186],"3\u2032-UTR":[70],"suppressed":[72],"expression,":[75],"leading":[76],"to":[77,173],"elevation":[78],"PTEN":[80],"DUSP7":[82],"and,":[84],"consequently,":[85],"decreased":[86,106],"proliferation,":[87],"invasion/migration,":[88],"metastasis":[90,112,150],"cells":[93],"vitro":[95],"vivo.":[98],"Tail-vein":[99],"delivery":[100],"therapeutic":[102],"significantly":[105],"both":[107],"tumor":[108],"size":[109],"lung":[111],"ratio":[113],"mice":[115],"bearing":[116],"orthotopic":[117],"xenograft":[118],"tumors.":[119],"Decreased":[120],"expression":[121],"mediated":[126],"by":[127],"transcription":[128],"factor":[129],"E2F1.":[130],"In":[131],"conclusion,":[132],"our":[133,174],"results":[134],"demonstrate":[135],"E2F1-miR-520/372/373\u2013SPOP":[138],"functions":[140],"as":[141],"key":[143],"signaling":[144],"pathway":[145],"progression":[148],"represents":[152],"promising":[154],"opportunity":[155],"therapies.":[158,187],"Significance:":[159],"These":[160],"findings":[161],"show":[162],"E2F1-miR-520/372/373":[165],"family\u2013SPOP":[166],"promotes":[168],"progression,":[170],"thereby":[171],"contributing":[172],"understanding":[175],"unveiling":[180],"new":[181],"avenues":[182],"more":[184]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-26T00:00:00"}