{"id":"https://openalex.org/W2896053285","doi":"https://doi.org/10.3390/ijms19103264","title":"Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer","display_name":"Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer","publication_year":2018,"publication_date":"2018-10-20","ids":{"openalex":"https://openalex.org/W2896053285","doi":"https://doi.org/10.3390/ijms19103264","mag":"2896053285","pmid":"https://pubmed.ncbi.nlm.nih.gov/30347840","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6214025"},"language":"en","primary_location":{"id":"doi:10.3390/ijms19103264","doi":"https://doi.org/10.3390/ijms19103264","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms19103264","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.3390/ijms19103264","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051210077","display_name":"Sangiliyandi Gurunathan","orcid":"https://orcid.org/0000-0001-9924-8433","observed_orcids":["https://orcid.org/0000-0001-9924-8433"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sangiliyandi Gurunathan","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025835928","display_name":"Min-Hee Kang","orcid":"https://orcid.org/0000-0003-4402-7064","observed_orcids":["https://orcid.org/0000-0003-4402-7064"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Hee Kang","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0003-4402-7064","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011405782","display_name":"Muhammad Qasim","orcid":"https://orcid.org/0000-0003-0279-5305","observed_orcids":["https://orcid.org/0000-0003-0279-5305"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Muhammad Qasim","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0003-0279-5305","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001188270","display_name":"Jin\u2010Hoi Kim","orcid":"https://orcid.org/0000-0003-1232-5307","observed_orcids":["https://orcid.org/0000-0003-1232-5307"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin-Hoi Kim","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1232-5307","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001188270","https://openalex.org/A5051210077"],"corresponding_institution_ids":["https://openalex.org/I24062138"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":2.0716,"has_fulltext":true,"cited_by_count":383,"citation_normalized_percentile":{"value":0.89662447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"19","issue":"10","first_page":"3264","last_page":"3264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-nanomedicine","display_name":"cancer nanomedicine","score":0.8190000057220459},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.5920000076293945},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.843999981880188},{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dendrimers","display_name":"dendrimers","score":0.9760000109672546},{"id":"https://openalex.org/keywords/carbon-nanotubes","display_name":"carbon nanotubes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/graphene-oxide","display_name":"graphene oxide","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nanodiamonds","display_name":"nanodiamonds","score":0.8479999899864197},{"id":"https://openalex.org/keywords/c60","display_name":"C60","score":0.9729999899864197},{"id":"https://openalex.org/keywords/metal-nanoparticles","display_name":"metal nanoparticles","score":0.9409999847412109},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/theranostic-nanocarriers","display_name":"theranostic nanocarriers","score":0.8489999771118164},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7193980813026428},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.627788782119751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5865057110786438},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5757438540458679},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5329108238220215},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5117916464805603},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4620157480239868},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.46042418479919434},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4554559290409088},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4395716190338135},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4375704824924469},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3319404125213623},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.31326937675476074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1906985640525818},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.15560567378997803},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14976558089256287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.101666659116745},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms19103264","doi":"https://doi.org/10.3390/ijms19103264","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms19103264","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6214025","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6214025/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6214025/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:5180139","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6214025","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30347840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30347840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms19103264","doi":"https://doi.org/10.3390/ijms19103264","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms19103264","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321372","display_name":"Konkuk University","ror":"https://ror.org/025h1m602"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2896053285.pdf","grobid_xml":"https://content.openalex.org/works/W2896053285.grobid-xml"},"referenced_works_count":219,"referenced_works":["https://openalex.org/W9013959","https://openalex.org/W31945190","https://openalex.org/W768201224","https://openalex.org/W1516107827","https://openalex.org/W1519008817","https://openalex.org/W1525515409","https://openalex.org/W1557101680","https://openalex.org/W1564553363","https://openalex.org/W1573363574","https://openalex.org/W1589920570","https://openalex.org/W1603230122","https://openalex.org/W1789224823","https://openalex.org/W1810905367","https://openalex.org/W1858500974","https://openalex.org/W1865572427","https://openalex.org/W1921986114","https://openalex.org/W1945600986","https://openalex.org/W1965800158","https://openalex.org/W1967408187","https://openalex.org/W1968163125","https://openalex.org/W1968681772","https://openalex.org/W1969402650","https://openalex.org/W1969950242","https://openalex.org/W1971641168","https://openalex.org/W1972455690","https://openalex.org/W1972651273","https://openalex.org/W1972739162","https://openalex.org/W1972822048","https://openalex.org/W1973169780","https://openalex.org/W1975775640","https://openalex.org/W1976334506","https://openalex.org/W1980136215","https://openalex.org/W1982207352","https://openalex.org/W1984677649","https://openalex.org/W1985574515","https://openalex.org/W1988497535","https://openalex.org/W1989109875","https://openalex.org/W1990964768","https://openalex.org/W1991605413","https://openalex.org/W1992630683","https://openalex.org/W1992865052","https://openalex.org/W1994964874","https://openalex.org/W1997308573","https://openalex.org/W1997703672","https://openalex.org/W1997972415","https://openalex.org/W1999729424","https://openalex.org/W1999966467","https://openalex.org/W2000205238","https://openalex.org/W2000274448","https://openalex.org/W2003539641","https://openalex.org/W2005162944","https://openalex.org/W2006055464","https://openalex.org/W2006371280","https://openalex.org/W2007542364","https://openalex.org/W2007560160","https://openalex.org/W2009451653","https://openalex.org/W2010678063","https://openalex.org/W2010769290","https://openalex.org/W2011529228","https://openalex.org/W2011764610","https://openalex.org/W2012192443","https://openalex.org/W2012986646","https://openalex.org/W2014682490","https://openalex.org/W2015006203","https://openalex.org/W2015988445","https://openalex.org/W2017638822","https://openalex.org/W2018700733","https://openalex.org/W2021496901","https://openalex.org/W2021664831","https://openalex.org/W2021691065","https://openalex.org/W2025449370","https://openalex.org/W2027013223","https://openalex.org/W2031113169","https://openalex.org/W2031946486","https://openalex.org/W2033492289","https://openalex.org/W2034585139","https://openalex.org/W2034735099","https://openalex.org/W2035071760","https://openalex.org/W2035323604","https://openalex.org/W2037041572","https://openalex.org/W2037064988","https://openalex.org/W2040299357","https://openalex.org/W2043869451","https://openalex.org/W2043991456","https://openalex.org/W2044232327","https://openalex.org/W2045651730","https://openalex.org/W2045943346","https://openalex.org/W2047305537","https://openalex.org/W2048536214","https://openalex.org/W2049819597","https://openalex.org/W2052312685","https://openalex.org/W2053702257","https://openalex.org/W2054603000","https://openalex.org/W2055533824","https://openalex.org/W2055892918","https://openalex.org/W2055951605","https://openalex.org/W2058837304","https://openalex.org/W2059227878","https://openalex.org/W2064196398","https://openalex.org/W2064674946","https://openalex.org/W2068624900","https://openalex.org/W2068887595","https://openalex.org/W2070329733","https://openalex.org/W2071238491","https://openalex.org/W2072166383","https://openalex.org/W2075522584","https://openalex.org/W2075890776","https://openalex.org/W2078817346","https://openalex.org/W2079641266","https://openalex.org/W2080071499","https://openalex.org/W2081501602","https://openalex.org/W2082511916","https://openalex.org/W2084953152","https://openalex.org/W2085359041","https://openalex.org/W2086439684","https://openalex.org/W2086646496","https://openalex.org/W2087985414","https://openalex.org/W2088434615","https://openalex.org/W2089248591","https://openalex.org/W2089340480","https://openalex.org/W2089984379","https://openalex.org/W2092329959","https://openalex.org/W2093410682","https://openalex.org/W2095571709","https://openalex.org/W2096552337","https://openalex.org/W2096616783","https://openalex.org/W2097603366","https://openalex.org/W2098818411","https://openalex.org/W2106489628","https://openalex.org/W2106787323","https://openalex.org/W2110311974","https://openalex.org/W2112559551","https://openalex.org/W2116972515","https://openalex.org/W2118618046","https://openalex.org/W2123029732","https://openalex.org/W2123103156","https://openalex.org/W2126088749","https://openalex.org/W2126810504","https://openalex.org/W2127410754","https://openalex.org/W2128565080","https://openalex.org/W2133470905","https://openalex.org/W2136558504","https://openalex.org/W2137335948","https://openalex.org/W2138473858","https://openalex.org/W2138966657","https://openalex.org/W2139848084","https://openalex.org/W2147867809","https://openalex.org/W2148994001","https://openalex.org/W2149076882","https://openalex.org/W2149267995","https://openalex.org/W2149456801","https://openalex.org/W2151980465","https://openalex.org/W2153827701","https://openalex.org/W2155118487","https://openalex.org/W2158631186","https://openalex.org/W2159098445","https://openalex.org/W2168103311","https://openalex.org/W2170740525","https://openalex.org/W2171414383","https://openalex.org/W2173249787","https://openalex.org/W2185481272","https://openalex.org/W2206344695","https://openalex.org/W2217025161","https://openalex.org/W2228049941","https://openalex.org/W2234155771","https://openalex.org/W2235523093","https://openalex.org/W2292987449","https://openalex.org/W2300671107","https://openalex.org/W2302003756","https://openalex.org/W2315984401","https://openalex.org/W2317470873","https://openalex.org/W2318420170","https://openalex.org/W2323559471","https://openalex.org/W2325705480","https://openalex.org/W2331195265","https://openalex.org/W2332974012","https://openalex.org/W2402215681","https://openalex.org/W2409703865","https://openalex.org/W2417680062","https://openalex.org/W2472818278","https://openalex.org/W2480866527","https://openalex.org/W2487355051","https://openalex.org/W2511825493","https://openalex.org/W2516494441","https://openalex.org/W2519678626","https://openalex.org/W2521880295","https://openalex.org/W2524184260","https://openalex.org/W2550569856","https://openalex.org/W2556178469","https://openalex.org/W2560098972","https://openalex.org/W2582199058","https://openalex.org/W2589269825","https://openalex.org/W2594430330","https://openalex.org/W2596154436","https://openalex.org/W2612140572","https://openalex.org/W2618502094","https://openalex.org/W2698746343","https://openalex.org/W2732625227","https://openalex.org/W2735460356","https://openalex.org/W2739463248","https://openalex.org/W2744713071","https://openalex.org/W2748098644","https://openalex.org/W2749208559","https://openalex.org/W2749239767","https://openalex.org/W2750462799","https://openalex.org/W2751226697","https://openalex.org/W2751600998","https://openalex.org/W2753932015","https://openalex.org/W2754286728","https://openalex.org/W2756731688","https://openalex.org/W2760903876","https://openalex.org/W2768818187","https://openalex.org/W2793323124","https://openalex.org/W2954115414","https://openalex.org/W2986139234","https://openalex.org/W4226329146","https://openalex.org/W4242566504","https://openalex.org/W4245672533","https://openalex.org/W7073802703"],"related_works":["https://openalex.org/W2974642733","https://openalex.org/W2317470873","https://openalex.org/W4406471330","https://openalex.org/W2520665252","https://openalex.org/W4386438160","https://openalex.org/W2397958007","https://openalex.org/W1994658380","https://openalex.org/W3092956477","https://openalex.org/W7165912660","https://openalex.org/W2981221964"],"abstract_inverted_index":{"Cancer":[0],"represents":[1],"a":[2,21,97,210],"group":[3],"of":[4,12,26,41,53,60,116,131,142,145,160,184,213,217,221,226,280],"heterogeneous":[5],"diseases":[6],"characterized":[7],"by":[8],"uncontrolledgrowth":[9],"and":[10,32,49,57,69,82,125,147,180,205,216,252],"spread":[11],"abnormal":[13],"cells,":[14],"ultimately":[15],"leading":[16],"to":[17,92,100,104,109,113,163,175,192,199],"death.":[18],"Nanomedicine":[19],"plays":[20],"significantrole":[22],"in":[23,38,224,230],"the":[24,35,39,58,114,128,143,156,165,182,195,214,218,265,278],"development":[25],"nanodrugs,":[27],"nanodevices,":[28],"drug":[29,185],"delivery":[30],"systems":[31],"nanocarriers.":[33],"Someof":[34],"major":[36,98],"issues":[37],"treatment":[40,70,102,159],"cancer":[42,101],"are":[43,233],"multidrug":[44],"resistance":[45,108],"(MDR),":[46],"narrow":[47],"therapeuticwindow":[48],"undesired":[50],"side":[51],"effects":[52],"available":[54],"anticancer":[55,132,148,170,206,260],"drugs":[56,133,171],"limitations":[59],"anticancerdrugs.":[61],"Several":[62],"nanosystems":[63],"being":[64],"utilized":[65],"for":[66,267,271],"detection,":[67],"diagnosis":[68],"such":[71],"as":[72,155],"theranosticcarriers,":[73],"liposomes,":[74,234],"carbon":[75,240],"nanotubes,":[76],"quantum":[77],"dots,":[78],"polymeric":[79,236],"micelles,":[80],"dendrimers":[81],"metallicnanoparticles.":[83],"However,":[84,270],"nonbiodegradable":[85],"nanoparticles":[86,135],"causes":[87],"high":[88],"tissue":[89],"accumulation":[90],"andleads":[91],"toxicity.":[93],"MDR":[94,111],"is":[95,139,190],"considered":[96],"impediment":[99],"due":[103],"metastatictumors":[105],"that":[106,141],"develop":[107],"chemotherapy.":[110],"contributes":[112],"failure":[115],"chemotherapiesin":[117],"various":[118,259],"cancers,":[119],"including":[120],"breast,":[121],"ovarian,":[122],"lung,":[123],"gastrointestinal":[124],"hematological":[126],"malignancies.Moreover,":[127],"therapeutic":[129],"efficiency":[130],"or":[134],"(NPs)":[136],"used":[137,223,255],"alone":[138],"lessthan":[140],"combination":[144,201,268],"NPs":[146,204,254],"drugs.":[149],"Combination":[150],"therapy":[151,168,202,257],"has":[152,172,263],"long":[153],"beenadopted":[154],"standard":[157],"first-line":[158],"several":[161],"malignancies":[162],"improve":[164],"clinical":[166,272],"outcome.Combination":[167],"with":[169,258],"been":[173],"shown":[174],"generally":[176],"induce":[177],"synergistic":[178],"drugactions":[179],"deter":[181],"onset":[183],"resistance.":[186],"Therefore,":[187],"this":[188,231],"review":[189,232],"designed":[191],"report":[193],"andanalyze":[194],"recent":[196],"progress":[197],"made":[198],"address":[200],"using":[203],"drugs.We":[207],"first":[208],"provide":[209],"comprehensive":[211],"overview":[212],"angiogenesis":[215],"different":[219],"types":[220],"NPscurrently":[222],"treatments":[225],"cancer;":[227],"those":[228],"emphasized":[229],"polymericNPs,":[235],"micelles":[237],"(PMs),":[238],"dendrimers,":[239],"NPs,":[241],"nanodiamond":[242],"(ND),":[243],"fullerenes,":[244],"carbonnanotubes":[245],"(CNTs),":[246],"graphene":[247],"oxide":[248],"(GO),":[249],"GO":[250],"nanocomposites":[251],"metallic":[253],"forcombination":[256],"agents.":[261],"Nanotechnology":[262],"provided":[264],"convenienttools":[266],"therapy.":[269],"translation,":[273],"we":[274],"need":[275],"continued":[276],"improvementsin":[277],"field":[279],"nanotechnology.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":59},{"year":2024,"cited_by_count":55},{"year":2023,"cited_by_count":51},{"year":2022,"cited_by_count":59},{"year":2021,"cited_by_count":54},{"year":2020,"cited_by_count":48},{"year":2019,"cited_by_count":25}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-10-26T00:00:00"}