{"id":"https://openalex.org/W2896007352","doi":"https://doi.org/10.1038/s41398-018-0269-5","title":"Extracting stability increases the SNP heritability of emotional problems in young people","display_name":"Extracting stability increases the SNP heritability of emotional problems in young people","publication_year":2018,"publication_date":"2018-10-17","ids":{"openalex":"https://openalex.org/W2896007352","doi":"https://doi.org/10.1038/s41398-018-0269-5","mag":"2896007352","pmid":"https://pubmed.ncbi.nlm.nih.gov/30333497","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6193004"},"language":"en","primary_location":{"id":"doi:10.1038/s41398-018-0269-5","doi":"https://doi.org/10.1038/s41398-018-0269-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0269-5","pdf_url":"https://www.nature.com/articles/s41398-018-0269-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41398-018-0269-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058690514","display_name":"Rosa Cheesman","orcid":"https://orcid.org/0000-0002-6543-0402","observed_orcids":["https://orcid.org/0000-0002-6543-0402"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rosa Cheesman","raw_affiliation_strings":["Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. rosa.cheesman@kcl.ac.uk","Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-6543-0402","affiliations":[{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. rosa.cheesman@kcl.ac.uk","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040717769","display_name":"Kirstin Lee Purves","orcid":"https://orcid.org/0000-0002-8110-5554","observed_orcids":["https://orcid.org/0000-0002-8110-5554"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kirstin L. Purves","raw_affiliation_strings":["Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-8110-5554","affiliations":[{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013110004","display_name":"Jean\u2010Baptiste Pingault","orcid":"https://orcid.org/0000-0003-2557-4716","observed_orcids":["https://orcid.org/0000-0003-2557-4716","https://orcid.org/0000-0001-8852-1836"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jean-Baptiste Pingault","raw_affiliation_strings":["Division of Psychology and Language Sciences, University College London, London, UK","Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychology and Language Sciences, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007752410","display_name":"Gerome D. Breen","orcid":"https://orcid.org/0000-0003-2053-1792","observed_orcids":["https://orcid.org/0000-0003-2053-1792"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gerome Breen","raw_affiliation_strings":["NIHR Biomedical Research Centre for Mental Health; South London and Maudsley NHS Trust, London, SE5 8AF, UK","Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Biomedical Research Centre for Mental Health; South London and Maudsley NHS Trust, London, SE5 8AF, UK","institution_ids":["https://openalex.org/I200323923"]},{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073502352","display_name":"Fr\u00fchling Vesta Rijsdijk","orcid":"https://orcid.org/0000-0003-4762-2803","observed_orcids":["https://orcid.org/0000-0003-4762-2803"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fruhling Rijsdij k","raw_affiliation_strings":["Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007723142","display_name":"Robert J. Plomin","orcid":"https://orcid.org/0000-0002-0756-3629","observed_orcids":["https://orcid.org/0000-0002-0756-3629"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Plomin","raw_affiliation_strings":["Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005532183","display_name":"Thalia Catherine Eley","orcid":"https://orcid.org/0000-0001-6458-0700","observed_orcids":["https://orcid.org/0000-0001-6458-0700"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]},{"id":"https://openalex.org/I33618826","display_name":"Centre for Mental Health","ror":"https://ror.org/04yy7zb66","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I33618826"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thalia C. Eley","raw_affiliation_strings":["NIHR Biomedical Research Centre for Mental Health; South London and Maudsley NHS Trust, London, SE5 8AF, UK","Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","NIHR Biomedical Research Centre for Mental Health","South London and Maudsley NHS Trust, London, SE5 8AF, UK"],"raw_orcid":"https://orcid.org/0000-0001-6458-0700","affiliations":[{"raw_affiliation_string":"NIHR Biomedical Research Centre for Mental Health; South London and Maudsley NHS Trust, London, SE5 8AF, UK","institution_ids":["https://openalex.org/I200323923"]},{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Cent re, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"NIHR Biomedical Research Centre for Mental Health","institution_ids":["https://openalex.org/I33618826"]},{"raw_affiliation_string":"South London and Maudsley NHS Trust, London, SE5 8AF, UK","institution_ids":["https://openalex.org/I200323923"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058690514"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":3432,"currency":"EUR","value_usd":3701},"fwci":2.4154,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.89441375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"223","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10182","display_name":"Child and Adolescent Psychosocial and Emotional Development","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emotional-problems","display_name":"emotional problems","score":0.9580000042915344},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.8029999732971191},{"id":"https://openalex.org/keywords/snp-heritability","display_name":"SNP heritability","score":0.8740000128746033},{"id":"https://openalex.org/keywords/childhood-anxiety","display_name":"childhood anxiety","score":0.6000000238418579},{"id":"https://openalex.org/keywords/adolescent-depression","display_name":"adolescent depression","score":0.8479999899864197},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.7279999852180481},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.765999972820282},{"id":"https://openalex.org/keywords/gene-discovery","display_name":"gene discovery","score":0.6179999709129333},{"id":"https://openalex.org/keywords/gene-prediction","display_name":"gene prediction","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.7946599125862122},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6370089650154114},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5688972473144531},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5152709484100342},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.4332469701766968},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4248066842556},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4057499170303345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3345278799533844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31871476769447327},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.21696561574935913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19411703944206238},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1876257061958313},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1470692753791809},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.11945635080337524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014427","descriptor_name":"Twins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41398-018-0269-5","doi":"https://doi.org/10.1038/s41398-018-0269-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0269-5","pdf_url":"https://www.nature.com/articles/s41398-018-0269-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5140113","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6193004","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6193004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6193004","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmid:30333497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30333497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:02b5d6124401409bbe7cf13d480d018d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/02b5d6124401409bbe7cf13d480d018d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry, Vol 8, Iss 1, Pp 1-9 (2018)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10061226","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10061226/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry , 8 , Article 223. (2018)","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/1dd92afb-007f-427b-a911-5d8ea6d2ef57","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/files/103309102/Extracting_stability_increases_the_Publishedonline17October2018_GOLD_VoR_CC_BY_.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cheesman, R, Purves, K, Pingault, J-B, Breen, G, Rijsdijk, F V, Plomin, R & Eley, T 2018, 'Extracting stability increases the SNP heritability of emotional problems in young people', Translational Psychiatry, vol. 8, 223 . https://doi.org/10.1038/s41398-018-0269-5","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire/a7ac6709-4003-48cb-9dd1-859dc2ec5112","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/a7ac6709-4003-48cb-9dd1-859dc2ec5112","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cheesman, R, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Purves, K L, Pingault, J B, Breen, G, Rijsdij k, F, Plomin, R & Eley, T C 2018, 'Extracting stability increases the SNP heritability of emotional problems in young people', Translational Psychiatry, vol. 8, no. 1, 223. https://doi.org/10.1038/s41398-018-0269-5","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41398-018-0269-5","doi":"https://doi.org/10.1038/s41398-018-0269-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0269-5","pdf_url":"https://www.nature.com/articles/s41398-018-0269-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8288999795913696,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1093531541","display_name":null,"funder_award_id":"FP7/20072013","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2496263360","display_name":null,"funder_award_id":"G0901245","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2761558319","display_name":null,"funder_award_id":"G0901245","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2973790809","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4449860107","display_name":"3/7 Psychiatric Genomics Consortium: Finding actionable variation","funder_award_id":"U01MH109536","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4507396198","display_name":"Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strateg","funder_award_id":"602768","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G463724992","display_name":null,"funder_award_id":"MR/M021475","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4795622352","display_name":"Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics.","funder_award_id":"MR/M021475/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6042139217","display_name":"Colorado Adoption Project/Twin Study of Lifespan behavioral development & cognitive aging [CATSLife2]","funder_award_id":"R01AG046938","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6413291808","display_name":null,"funder_award_id":"MQ16IP16","funder_id":"https://openalex.org/F4320312944","funder_display_name":"MQ: Transforming Mental Health"},{"id":"https://openalex.org/G7624716486","display_name":null,"funder_award_id":"MR/M021475/1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7811339367","display_name":null,"funder_award_id":"1771728","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G8496061556","display_name":"Master of Science in Social Genetic and Developmental Psychiatry","funder_award_id":"1668713","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8658852833","display_name":null,"funder_award_id":"AG046938","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320312944","display_name":"MQ: Transforming Mental Health","ror":null},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2896007352.pdf","grobid_xml":"https://content.openalex.org/works/W2896007352.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W159606373","https://openalex.org/W1848381484","https://openalex.org/W1916191403","https://openalex.org/W1936043210","https://openalex.org/W1963980581","https://openalex.org/W1970309247","https://openalex.org/W1973388014","https://openalex.org/W1976844911","https://openalex.org/W1985285768","https://openalex.org/W2017972509","https://openalex.org/W2025802167","https://openalex.org/W2032442232","https://openalex.org/W2033151532","https://openalex.org/W2045933122","https://openalex.org/W2050206510","https://openalex.org/W2051972782","https://openalex.org/W2059359883","https://openalex.org/W2063114183","https://openalex.org/W2094866171","https://openalex.org/W2096269744","https://openalex.org/W2098405376","https://openalex.org/W2102290926","https://openalex.org/W2105186619","https://openalex.org/W2110048796","https://openalex.org/W2114544492","https://openalex.org/W2118826874","https://openalex.org/W2119838065","https://openalex.org/W2123370096","https://openalex.org/W2142500707","https://openalex.org/W2144359585","https://openalex.org/W2145871419","https://openalex.org/W2148874864","https://openalex.org/W2158667250","https://openalex.org/W2161633633","https://openalex.org/W2195783463","https://openalex.org/W2265828636","https://openalex.org/W2340656051","https://openalex.org/W2345621280","https://openalex.org/W2402373502","https://openalex.org/W2528247382","https://openalex.org/W2538222437","https://openalex.org/W2545020374","https://openalex.org/W2593282707","https://openalex.org/W2738082385","https://openalex.org/W2754739128","https://openalex.org/W2766869107","https://openalex.org/W2783186471","https://openalex.org/W2799352280"],"related_works":["https://openalex.org/W2144359585","https://openalex.org/W2754739128","https://openalex.org/W2104760484","https://openalex.org/W7095592941","https://openalex.org/W4385669569","https://openalex.org/W2036389857","https://openalex.org/W2402373502","https://openalex.org/W2010083978","https://openalex.org/W2129573980","https://openalex.org/W2142500707"],"abstract_inverted_index":{"Twin":[0,133,158],"studies":[1],"have":[2],"shown":[3],"that":[4,36,61,88],"emotional":[5,33,96,110,140,216,233,256],"problems":[6,34,97,111,141,217,234,257],"(anxiety":[7],"and":[8,12,27,49,70,117,123,134,146,209,243,260],"depression)":[9],"in":[10,66,126,214,228,258],"childhood":[11],"adolescence":[13],"are":[14,24],"moderately":[15],"heritable":[16],"(~20-50%).":[17],"In":[18],"contrast,":[19],"DNA-based":[20],"'SNP":[21],"heritability'":[22],"estimates":[23,137],"generally":[25],"<15%":[26],"non-significant.":[28],"One":[29],"notable":[30],"feature":[31],"of":[32,95,253],"is":[35,52,65],"they":[37],"can":[38],"be":[39,75],"somewhat":[40],"transient,":[41],"but":[42],"the":[43,92,127,251],"moderate":[44],"stability":[45,94],"seen":[46],"across":[47,50,68,71,113],"time":[48,69],"raters":[51],"predominantly":[53],"influenced":[54],"by":[55,62,120,173],"stable":[56,139,176,200,215,255],"genetic":[57,83,238],"influences.":[58],"This":[59],"suggests":[60],"capturing":[63,91],"what":[64],"common":[67],"raters,":[72],"we":[73],"might":[74],"more":[76,226],"likely":[77],"to":[78,153,168,187],"tap":[79],"into":[80],"any":[81],"underlying":[82],"vulnerability.":[84],"We":[85,102],"therefore":[86],"hypothesised":[87],"a":[89],"phenotype":[90],"pervasive":[93],"would":[98],"show":[99],"higher":[100,198],"heritability.":[101],"fitted":[103],"single-factor":[104],"latent":[105],"trait":[106,177],"models":[107],"using":[108],"12":[109,116],"measures":[112,167],"ages":[114],"7,":[115],"16,":[118],"rated":[119],"parents,":[121],"teachers":[122],"children":[124],"themselves":[125],"Twins":[128],"Early":[129],"Development":[130],"Study":[131],"sample.":[132],"SNP":[135,179],"heritability":[136,159,180],"for":[138,155,165,199,205],"(N":[142],"=":[143,171,190,193,220,246],"6110":[144,147],"pairs":[145],"unrelated":[148],"individuals,":[149],"respectively)":[150],"were":[151],"compared":[152],"those":[154],"individual":[156,166,230],"measures.":[157,231],"increased":[160],"from":[161,182],"45%":[162],"on":[163,175,184],"average":[164,185],"76%":[169],"(se":[170,189],"0.023)":[172],"focusing":[174],"variance.":[178],"rose":[181],"5%":[183],"(n.s.)":[186],"14%":[188],"0.049;":[191],"p":[192,219],"0.002).":[194],"Heritability":[195],"was":[196,225],"also":[197,235],"within-rater":[201],"composites.":[202],"Polygenic":[203],"scores":[204],"both":[206],"adult":[207,241],"anxiety":[208,244],"depression":[210,242],"significantly":[211],"explained":[212,224],"variance":[213,223],"(0.4%;":[218],"0.0001).":[221],"The":[222],"than":[227],"most":[229],"Stable":[232],"showed":[236],"significant":[237],"correlation":[239],"with":[240],"(average":[245],"52%).":[247],"These":[248],"results":[249],"demonstrate":[250],"value":[252],"examining":[254],"gene-finding":[259],"prediction":[261],"studies.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-26T00:00:00"}
