{"id":"https://openalex.org/W2895897807","doi":"https://doi.org/10.1016/j.biochi.2018.10.012","title":"High altitude mediated skeletal muscle atrophy: Protective role of curcumin","display_name":"High altitude mediated skeletal muscle atrophy: Protective role of curcumin","publication_year":2018,"publication_date":"2018-10-20","ids":{"openalex":"https://openalex.org/W2895897807","doi":"https://doi.org/10.1016/j.biochi.2018.10.012","mag":"2895897807","pmid":"https://pubmed.ncbi.nlm.nih.gov/30347230"},"language":"en","primary_location":{"id":"doi:10.1016/j.biochi.2018.10.012","doi":"https://doi.org/10.1016/j.biochi.2018.10.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biochi.2018.10.012","pdf_url":null,"source":{"id":"https://openalex.org/S75247133","display_name":"Biochimie","issn_l":"0037-9042","issn":["0037-9042","0300-9084","1638-6183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108525614","display_name":"Pooja Chaudhary","orcid":"https://orcid.org/0000-0002-1964-2746","observed_orcids":["https://orcid.org/0000-0002-1964-2746"]},"institutions":[{"id":"https://openalex.org/I51313444","display_name":"Defence Institute of Physiology and Allied Sciences","ror":"https://ror.org/04fzbxp95","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I4210150591","https://openalex.org/I51313444"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pooja Chaudhary","raw_affiliation_strings":["Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India","institution_ids":["https://openalex.org/I51313444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083637077","display_name":"Yogendra Kumar Sharma","orcid":"https://orcid.org/0000-0002-6678-8027","observed_orcids":["https://orcid.org/0000-0002-6678-8027"]},"institutions":[{"id":"https://openalex.org/I51313444","display_name":"Defence Institute of Physiology and Allied Sciences","ror":"https://ror.org/04fzbxp95","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I4210150591","https://openalex.org/I51313444"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogendra Kumar Sharma","raw_affiliation_strings":["Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India","institution_ids":["https://openalex.org/I51313444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103942103","display_name":"Shivani Sharma","orcid":"https://orcid.org/0009-0005-4225-8370","observed_orcids":["https://orcid.org/0009-0005-4225-8370"]},"institutions":[{"id":"https://openalex.org/I51313444","display_name":"Defence Institute of Physiology and Allied Sciences","ror":"https://ror.org/04fzbxp95","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I4210150591","https://openalex.org/I51313444"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivani Sharma","raw_affiliation_strings":["Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India","institution_ids":["https://openalex.org/I51313444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101885923","display_name":"Som Nath Singh","orcid":"https://orcid.org/0000-0002-8661-2467","observed_orcids":["https://orcid.org/0000-0002-8661-2467"]},"institutions":[{"id":"https://openalex.org/I51313444","display_name":"Defence Institute of Physiology and Allied Sciences","ror":"https://ror.org/04fzbxp95","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I4210150591","https://openalex.org/I51313444"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Som Nath Singh","raw_affiliation_strings":["Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India","institution_ids":["https://openalex.org/I51313444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067057858","display_name":"Geetha Suryakumar","orcid":"https://orcid.org/0000-0002-8676-3812","observed_orcids":["https://orcid.org/0000-0002-8676-3812"]},"institutions":[{"id":"https://openalex.org/I51313444","display_name":"Defence Institute of Physiology and Allied Sciences","ror":"https://ror.org/04fzbxp95","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I4210150591","https://openalex.org/I51313444"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Geetha Suryakumar","raw_affiliation_strings":["Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India. Electronic address: geetha.suryakumar@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India. Electronic address: geetha.suryakumar@gmail.com","institution_ids":["https://openalex.org/I51313444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067057858"],"corresponding_institution_ids":["https://openalex.org/I51313444"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.2487,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.78932774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"156","issue":null,"first_page":"138","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.26440000534057617,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hypobaric-hypoxia","display_name":"hypobaric hypoxia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/high-altitude","display_name":"high altitude","score":0.9940000176429749},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":0.7820000052452087},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9670000076293945},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.9639999866485596},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/muscle-fiber-number","display_name":"muscle fiber number","score":0.6439999938011169},{"id":"https://openalex.org/keywords/physical-performance","display_name":"physical performance","score":0.75},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7640690803527832},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.6989508867263794},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6717932224273682},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6631883382797241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5524767637252808},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5427688360214233},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4915243089199066},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.47465234994888306},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.4580780863761902},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.4324130415916443},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.4281397759914398},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3329196572303772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30932456254959106},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3025071918964386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2838478982448578},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17716503143310547},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.07538726925849915},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000531","descriptor_name":"Altitude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000532","descriptor_name":"Altitude Sickness","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000532","descriptor_name":"Altitude Sickness","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000532","descriptor_name":"Altitude Sickness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000532","descriptor_name":"Altitude Sickness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biochi.2018.10.012","doi":"https://doi.org/10.1016/j.biochi.2018.10.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biochi.2018.10.012","pdf_url":null,"source":{"id":"https://openalex.org/S75247133","display_name":"Biochimie","issn_l":"0037-9042","issn":["0037-9042","0300-9084","1638-6183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"journal-article"},{"id":"pmid:30347230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30347230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321024","display_name":"Defence Research and Development Organisation","ror":"https://ror.org/05k37v296"},{"id":"https://openalex.org/F4320323623","display_name":"Ministry of Defence","ror":"https://ror.org/03wejsv15"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W179879772","https://openalex.org/W1503901149","https://openalex.org/W1535680104","https://openalex.org/W1567614586","https://openalex.org/W1590457525","https://openalex.org/W1602328409","https://openalex.org/W1604068141","https://openalex.org/W1694750548","https://openalex.org/W1952579501","https://openalex.org/W1967985758","https://openalex.org/W2008128102","https://openalex.org/W2010716981","https://openalex.org/W2010856745","https://openalex.org/W2014765226","https://openalex.org/W2017429680","https://openalex.org/W2022223340","https://openalex.org/W2026261400","https://openalex.org/W2032136484","https://openalex.org/W2032527946","https://openalex.org/W2039924353","https://openalex.org/W2048227382","https://openalex.org/W2054523680","https://openalex.org/W2061929833","https://openalex.org/W2070973528","https://openalex.org/W2073208345","https://openalex.org/W2074527955","https://openalex.org/W2075919697","https://openalex.org/W2076583181","https://openalex.org/W2082000429","https://openalex.org/W2082710481","https://openalex.org/W2087648632","https://openalex.org/W2098486181","https://openalex.org/W2106945244","https://openalex.org/W2123384926","https://openalex.org/W2123415654","https://openalex.org/W2128055117","https://openalex.org/W2135348702","https://openalex.org/W2143661749","https://openalex.org/W2144203293","https://openalex.org/W2146857090","https://openalex.org/W2150514373","https://openalex.org/W2160748450","https://openalex.org/W2169436026","https://openalex.org/W2175237411","https://openalex.org/W2183086158","https://openalex.org/W2278858962","https://openalex.org/W2365565414","https://openalex.org/W2607199957","https://openalex.org/W2769580895","https://openalex.org/W2933846512","https://openalex.org/W4214778612","https://openalex.org/W4313347802"],"related_works":["https://openalex.org/W2535061995","https://openalex.org/W4226016249","https://openalex.org/W2087648632","https://openalex.org/W7125923499","https://openalex.org/W2322735321","https://openalex.org/W7122613238","https://openalex.org/W7046427248","https://openalex.org/W2890611412","https://openalex.org/W4372336703","https://openalex.org/W4413324120"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-10-26T00:00:00"}