{"id":"https://openalex.org/W2895896895","doi":"https://doi.org/10.1152/physiol.00027.2018","title":"Energy Constraint as a Novel Mechanism Linking Exercise and Health","display_name":"Energy Constraint as a Novel Mechanism Linking Exercise and Health","publication_year":2018,"publication_date":"2018-10-10","ids":{"openalex":"https://openalex.org/W2895896895","doi":"https://doi.org/10.1152/physiol.00027.2018","mag":"2895896895","pmid":"https://pubmed.ncbi.nlm.nih.gov/30303776"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.00027.2018","doi":"https://doi.org/10.1152/physiol.00027.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1152/physiol.00027.2018","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/physiol.00027.2018","source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.physiology.org/doi/pdf/10.1152/physiol.00027.2018","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088651339","display_name":"Herman Pontzer","orcid":"https://orcid.org/0000-0003-2397-6543","observed_orcids":["https://orcid.org/0000-0003-2397-6543"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herman Pontzer","raw_affiliation_strings":["Evolutionary Anthropology, Duke University, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolutionary Anthropology, Duke University, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088651339"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":0.8087,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.66545455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"33","issue":"6","first_page":"384","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.21619999408721924,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.04650000110268593,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/energy-constraints","display_name":"energy constraints","score":0.9039999842643738},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.8759999871253967},{"id":"https://openalex.org/keywords/immunity","display_name":"immunity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/reproduction","display_name":"reproduction","score":0.9589999914169312},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":1.0},{"id":"https://openalex.org/keywords/health","display_name":"health","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6277504563331604},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.6158089637756348},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5939791798591614},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.549706220626831},{"id":"https://openalex.org/C59659247","wikidata":"https://www.wikidata.org/wiki/Q11990","display_name":"Reproduction","level":2,"score":0.47245052456855774},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.4695335626602173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39456906914711},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.34861135482788086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27609848976135254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1838836669921875},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.15411126613616943},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09175053238868713},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08896377682685852},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0728854238986969},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07215449213981628},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006262","descriptor_name":"Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/physiol.00027.2018","doi":"https://doi.org/10.1152/physiol.00027.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1152/physiol.00027.2018","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/physiol.00027.2018","source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},{"id":"pmid:30303776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30303776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology (Bethesda, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1152/physiol.00027.2018","doi":"https://doi.org/10.1152/physiol.00027.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1152/physiol.00027.2018","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/physiol.00027.2018","source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895896895.pdf","grobid_xml":"https://content.openalex.org/works/W2895896895.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W12946444","https://openalex.org/W581981666","https://openalex.org/W1532377123","https://openalex.org/W1542915511","https://openalex.org/W1549409082","https://openalex.org/W1562154062","https://openalex.org/W1600826881","https://openalex.org/W1770799467","https://openalex.org/W1944060889","https://openalex.org/W1964146644","https://openalex.org/W1974950104","https://openalex.org/W1975274499","https://openalex.org/W1976031759","https://openalex.org/W1991312798","https://openalex.org/W1991668800","https://openalex.org/W1995670244","https://openalex.org/W2015605463","https://openalex.org/W2022549947","https://openalex.org/W2022592547","https://openalex.org/W2024328614","https://openalex.org/W2026906748","https://openalex.org/W2028370541","https://openalex.org/W2031811366","https://openalex.org/W2035831689","https://openalex.org/W2043631914","https://openalex.org/W2055079769","https://openalex.org/W2064100845","https://openalex.org/W2071721757","https://openalex.org/W2086552655","https://openalex.org/W2096528587","https://openalex.org/W2101391314","https://openalex.org/W2103921787","https://openalex.org/W2113080377","https://openalex.org/W2115612634","https://openalex.org/W2116508930","https://openalex.org/W2118016322","https://openalex.org/W2119207706","https://openalex.org/W2121467598","https://openalex.org/W2122219818","https://openalex.org/W2127454674","https://openalex.org/W2130717807","https://openalex.org/W2131193972","https://openalex.org/W2134788841","https://openalex.org/W2135672891","https://openalex.org/W2135696647","https://openalex.org/W2137606959","https://openalex.org/W2137673947","https://openalex.org/W2139716393","https://openalex.org/W2142551473","https://openalex.org/W2149215959","https://openalex.org/W2158302351","https://openalex.org/W2158629827","https://openalex.org/W2159702711","https://openalex.org/W2160653327","https://openalex.org/W2164180695","https://openalex.org/W2164932960","https://openalex.org/W2167498879","https://openalex.org/W2170933413","https://openalex.org/W2172123562","https://openalex.org/W2252322719","https://openalex.org/W2254163651","https://openalex.org/W2271463522","https://openalex.org/W2286490707","https://openalex.org/W2292128505","https://openalex.org/W2321400963","https://openalex.org/W2410865911","https://openalex.org/W2418612746","https://openalex.org/W2480853566","https://openalex.org/W2530379949","https://openalex.org/W2571719897","https://openalex.org/W2587112322","https://openalex.org/W2590439164","https://openalex.org/W2600001048","https://openalex.org/W2624144577","https://openalex.org/W2741861568","https://openalex.org/W2744937573","https://openalex.org/W2746103056","https://openalex.org/W2752562791","https://openalex.org/W2762055201","https://openalex.org/W2763387947","https://openalex.org/W2782804476","https://openalex.org/W2792782460","https://openalex.org/W2794127566","https://openalex.org/W2795324360","https://openalex.org/W2797237250","https://openalex.org/W2798244659","https://openalex.org/W2807714346","https://openalex.org/W2807736017","https://openalex.org/W2883512297","https://openalex.org/W4299541734"],"related_works":["https://openalex.org/W2321400963","https://openalex.org/W619931176","https://openalex.org/W7171943745","https://openalex.org/W2371312606","https://openalex.org/W180707840","https://openalex.org/W2970335309","https://openalex.org/W2026356554","https://openalex.org/W2058328249","https://openalex.org/W2003818003","https://openalex.org/W2187027319"],"abstract_inverted_index":{"Humans":[0],"and":[1,30],"other":[2,24],"species":[3],"adapt":[4],"dynamically":[5],"to":[6],"changes":[7],"in":[8],"daily":[9],"physical":[10,42],"activity,":[11,26],"maintaining":[12],"total":[13],"energy":[14],"expenditure":[15],"within":[16],"a":[17],"narrow":[18],"range.":[19],"Chronic":[20],"exercise":[21],"thus":[22],"suppresses":[23],"physiological":[25],"including":[27],"immunity,":[28],"reproduction,":[29],"stress":[31],"response.":[32],"This":[33],"exercise-induced":[34],"downregulation":[35],"improves":[36],"health":[37],"at":[38,48],"moderate":[39],"levels":[40],"of":[41],"activity":[43],"but":[44],"can":[45],"be":[46],"detrimental":[47],"extreme":[49],"workloads.":[50]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-26T00:00:00"}