{"id":"https://openalex.org/W2895890381","doi":"https://doi.org/10.1016/j.jalz.2018.06.1447","title":"P3\u2010091: MODELING TAUOPATHY USING AAV\u2010MEDIATED SOMATIC BRAIN TRANSGENESIS","display_name":"P3\u2010091: MODELING TAUOPATHY USING AAV\u2010MEDIATED SOMATIC BRAIN TRANSGENESIS","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2895890381","doi":"https://doi.org/10.1016/j.jalz.2018.06.1447","mag":"2895890381"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2018.06.1447","doi":"https://doi.org/10.1016/j.jalz.2018.06.1447","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.1447","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048465733","display_name":"Emily J. Koller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily J. Koller","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050903223","display_name":"Elsa Gonzalez De La Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elsa Gonzalez De La Cruz","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004977571","display_name":"Katherine D. Gaines","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine D. Gaines","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057702915","display_name":"Timothy A. Machula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Machula","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011965074","display_name":"Kevin H. Strang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin H. Strang","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101730835","display_name":"Xuefei Liu","orcid":"https://orcid.org/0000-0002-1843-6107","observed_orcids":["https://orcid.org/0000-0002-1843-6107"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuefei Liu","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079182304","display_name":"Cara J. Riffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cara J. Riffe","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103858730","display_name":"Daniel H. Ryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Ryu","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068446551","display_name":"Christopher Janus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Janus","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058688886","display_name":"Todd Eliot Golde","orcid":"https://orcid.org/0000-0003-1867-7071","observed_orcids":["https://orcid.org/0000-0003-1867-7071"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd E. Golde","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005020048","display_name":"Benoit I. Giasson","orcid":"https://orcid.org/0000-0003-2992-4234","observed_orcids":["https://orcid.org/0000-0003-2992-4234"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benoit I. Giasson","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082320489","display_name":"Paramita Chakrabarty","orcid":"https://orcid.org/0000-0002-6226-3776","observed_orcids":["https://orcid.org/0000-0002-6226-3776"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paramita Chakrabarty","raw_affiliation_strings":["University of Florida Gainesville FL USA","University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Gainesville FL USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048465733"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14964356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"7S_Part_20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.9898742437362671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6513955593109131},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.633100152015686},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5736376047134399},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5466294288635254},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.5228714942932129},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.521840512752533},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5001716613769531},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.48762574791908264},{"id":"https://openalex.org/C73247094","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Transgenesis","level":5,"score":0.4832085371017456},{"id":"https://openalex.org/C2779390119","wikidata":"https://www.wikidata.org/wiki/Q917227","display_name":"Sandhoff disease","level":3,"score":0.4321480989456177},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3484002351760864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34718450903892517},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31379419565200806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22184830904006958},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21096742153167725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1744789481163025},{"id":"https://openalex.org/C519853106","wikidata":"https://www.wikidata.org/wiki/Q3640158","display_name":"Reproductive biology","level":4,"score":0.0},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2018.06.1447","doi":"https://doi.org/10.1016/j.jalz.2018.06.1447","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.1447","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141490098","https://openalex.org/W2117071840","https://openalex.org/W2983621322","https://openalex.org/W2071580328","https://openalex.org/W3000446097","https://openalex.org/W3111502935","https://openalex.org/W2404733949","https://openalex.org/W2022083204","https://openalex.org/W2004465879","https://openalex.org/W4376108338"],"abstract_inverted_index":{"Intracellular":[0],"accumulation":[1],"of":[2,11,41,59,63,69,98,110,125,144,158,182,205,235,250,277,308],"aggregated":[3],"hyperphosphorylated":[4],"tau":[5,24,101,146,164,187,221,227,260,292,309,331],"protein":[6],"is":[7,86,104],"a":[8,99,149,239,253],"neuropathological":[9,197],"hallmark":[10],"neurodegenerative":[12,75,268],"proteinopathies,":[13],"such":[14],"as":[15,119,121,213],"Alzheimer's":[16],"disease":[17,28,241],"and":[18,38,44,141,191,196,208,215,252,261,272,305],"primary":[19],"tauopathies.":[20],"Understanding":[21],"how":[22],"different":[23,163,186,290,319],"variants":[25,147,188],"lead":[26,129],"to":[27,33,130,137,245,266,287,317],"pathogenesis":[29],"will":[30],"allow":[31,135,285,298],"us":[32,136,286,299],"mechanistically":[34],"elucidate":[35],"molecular":[36,96,140,326],"properties":[37,97,143],"differential":[39,132],"etiologies":[40],"wild":[42,167,206],"type":[43,168,207],"tauopathy-associated":[45,145,291],"variants.":[46,293,310],"Currently":[47],"there":[48],"are":[49],"several":[50,209],"transgenic":[51],"mouse":[52,254],"models":[53,90,181,283,297,312],"that":[54,88,107,201,284],"can":[55,128,313],"recapitulate":[56],"substantial":[57],"aspects":[58],"tauopathy.":[60,183],"Though":[61],"most":[62],"these":[64,89,131],"faithfully":[65],"recreate":[66],"age-progressive":[67,220],"hyperphosphorylation":[68],"tau,":[70],"many":[71],"do":[72],"not":[73],"show":[74],"changes,":[76],"behavioral":[77,195,270,334],"abnormalities":[78,271,335],"or":[79],"frank":[80],"neurofibrillary":[81],"tangles":[82],"(NFT).":[83],"While":[84],"it":[85,103],"possible":[87,106],"may":[91],"be":[92,315],"tracking":[93],"only":[94,224],"the":[95,108,111,116,122,126,139,225,262,324],"particular":[100,325],"variant,":[102],"entirely":[105],"strain":[109],"mouse,":[112],"its":[113],"immune":[114],"phenotype,":[115],"promoter":[117],"used":[118,316],"well":[120],"tissue":[123],"distribution":[124],"transgene":[127],"phenotypes.":[133],"To":[134],"study":[138],"physiological":[142],"on":[148,323],"standardized":[150],"genetic":[151],"background,":[152],"we":[153,174],"performed":[154],"neonatal":[155],"intraceberoventricular":[156],"injections":[157],"recombinant":[159],"adeno-associated":[160],"viruses":[161],"overexpressing":[162],"mutants":[165,211],"in":[166,218],"mice.":[169],"This":[170],"results":[171],"in,":[172],"what":[173],"have":[175],"previously":[176],"described":[177],"as,":[178],"\u2018somatic":[179],"transgenesis\u2019":[180],"Mice":[184],"expressing":[185,228],"were":[189],"aged":[190],"extensively":[192],"characterized":[193],"using":[194],"parameters.":[198],"We":[199,279],"find":[200],"CNS":[202],"targeted":[203],"expression":[204],"FTD-associated":[210],"(such":[212],"P301L":[214,226,259],"P301S)":[216],"result":[217],"extensive":[219,267],"hyperphosphorylation.":[222],"However,":[223],"mice":[229],"develop":[230],"NFT":[231,246,273],"by":[232,247,274],"9":[233],"months":[234,249,276],"age.":[236,278],"In":[237],"contrast,":[238],"Pick's":[240],"associated":[242],"variant":[243,264],"leads":[244,265],"3":[248,275],"age":[251],"model":[255],"which":[256],"expresses":[257],"both":[258],"PiD":[263],"features,":[269],"report":[280],"various":[281],"tauopathy":[282],"molecularly":[288],"phenotype":[289,327],"These":[294,311],"somatic":[295],"transgenesis":[296],"an":[300],"alternative":[301],"platform":[302],"for":[303],"cost-effective":[304],"rapid":[306],"phenotyping":[307],"also":[314],"test":[318],"therapeutic":[320],"interventions":[321],"based":[322],"being":[328],"targeted,":[329],"i.e.,":[330],"phosphorylation,":[332],"neurodegeneration,":[333],"and/or":[336],"NFT.":[337]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}