{"id":"https://openalex.org/W2895875365","doi":"https://doi.org/10.1111/ene.13851","title":"Comparison of two high doses of oral methylprednisolone for multiple sclerosis relapses: a pilot, multicentre, randomized, double\u2010blind, non\u2010inferiority trial","display_name":"Comparison of two high doses of oral methylprednisolone for multiple sclerosis relapses: a pilot, multicentre, randomized, double\u2010blind, non\u2010inferiority trial","publication_year":2018,"publication_date":"2018-10-23","ids":{"openalex":"https://openalex.org/W2895875365","doi":"https://doi.org/10.1111/ene.13851","mag":"2895875365","pmid":"https://pubmed.ncbi.nlm.nih.gov/30351511"},"language":"en","primary_location":{"id":"doi:10.1111/ene.13851","doi":"https://doi.org/10.1111/ene.13851","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ene.13851","pdf_url":null,"source":{"id":"https://openalex.org/S162635963","display_name":"European Journal of Neurology","issn_l":"1351-5101","issn":["1351-5101","1468-1331"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020962127","display_name":"Jos\u00e9 Vicente Herv\u00e1s","orcid":"https://orcid.org/0000-0002-1132-0291","observed_orcids":["https://orcid.org/0000-0002-1132-0291"]},"institutions":[{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. V. Herv\u00e1s\u2010Garc\u00eda","raw_affiliation_strings":["Neuroscience Department, Hospital Germans Trias-i-Pujol, Badalona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1132-0291","affiliations":[{"raw_affiliation_string":"Neuroscience Department, Hospital Germans Trias-i-Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210153460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051646532","display_name":"L. Rami\u00f3\u2010Torrent\u00e0","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154933","display_name":"Hospital Universitari de Girona Doctor Josep Trueta","ror":"https://ror.org/04g27v387","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210154933"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L. Rami\u00f3\u2010Torrent\u00e0","raw_affiliation_strings":["Neurology Department, Hospital Doctor Josep Trueta, Girona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital Doctor Josep Trueta, Girona, Spain","institution_ids":["https://openalex.org/I4210154933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075497872","display_name":"Lu\u00eds Brieva","orcid":"https://orcid.org/0000-0002-5871-6189","observed_orcids":["https://orcid.org/0000-0002-5871-6189"]},"institutions":[{"id":"https://openalex.org/I2802050926","display_name":"Hospital Universitari Arnau de Vilanova","ror":"https://ror.org/01p3tpn79","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050926","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L. Brieva\u2010Ruiz","raw_affiliation_strings":["Neurology Department, Hospital Arnau Vilanova, Lleida, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital Arnau Vilanova, Lleida, Spain","institution_ids":["https://openalex.org/I2802050926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026141567","display_name":"J. Batll\u00e9\u2010Nadal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116432","display_name":"Hospital Sant Pau i Santa Tecla","ror":"https://ror.org/021rvrs67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116432"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Batll\u00e9\u2010Nadal","raw_affiliation_strings":["Neurology Department, Xarxa Sanitaria i Social Santa Tecla, Tarragona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Xarxa Sanitaria i Social Santa Tecla, Tarragona, Spain","institution_ids":["https://openalex.org/I4210116432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108210492","display_name":"Esther Moral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131965","display_name":"Hospital de Sant Joan Desp\u00ed Mois\u00e8s Broggi","ror":"https://ror.org/03n6b6g81","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210131965"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Moral","raw_affiliation_strings":["Neurology Department Hospital de Sant Joan Desp\u00ed Mois\u00e8s Broggi Barcelona Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department Hospital de Sant Joan Desp\u00ed Mois\u00e8s Broggi Barcelona Spain","institution_ids":["https://openalex.org/I4210131965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101494320","display_name":"Yolanda Blanco","orcid":"https://orcid.org/0000-0002-1834-0498","observed_orcids":["https://orcid.org/0000-0002-1834-0498"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Y. Blanco","raw_affiliation_strings":["Institut Biomedical Research August-Pi-Sunyer, Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Biomedical Research August-Pi-Sunyer, Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078566505","display_name":"Antonio Tom\u00e1s Cano-Orgaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Cano\u2010Orgaz","raw_affiliation_strings":["Neurology Department, Hospital Mataro, Mataro, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital Mataro, Mataro, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026966625","display_name":"Silvia Presas\u2010Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S. Presas\u2010Rodr\u00edguez","raw_affiliation_strings":["Neuroscience Department, Hospital Germans Trias-i-Pujol, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Department, Hospital Germans Trias-i-Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210153460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014511134","display_name":"Ferr\u00e0n Torres","orcid":"https://orcid.org/0000-0002-7355-7913","observed_orcids":["https://orcid.org/0000-0002-7355-7913"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F. Torres","raw_affiliation_strings":["Institut Biomedical Research August-Pi-Sunyer, Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Biomedical Research August-Pi-Sunyer, Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020674239","display_name":"Jaume Capellades","orcid":"https://orcid.org/0000-0002-1417-4496","observed_orcids":["https://orcid.org/0000-0002-1417-4496"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Capellades","raw_affiliation_strings":["Neuroradiology department, Hospital Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroradiology department, Hospital Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070502674","display_name":"Cristina M. Ramo-Tello","orcid":"https://orcid.org/0000-0001-8643-5053","observed_orcids":["https://orcid.org/0000-0001-8643-5053"]},"institutions":[{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. Ramo\u2010Tello","raw_affiliation_strings":["Neuroscience Department, Hospital Germans Trias-i-Pujol, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Department, Hospital Germans Trias-i-Pujol, Badalona, Spain","institution_ids":["https://openalex.org/I4210153460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5020962127"],"corresponding_institution_ids":["https://openalex.org/I4210153460"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.4924,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61994419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"3","first_page":"525","last_page":"532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.734000027179718},{"id":"https://openalex.org/keywords/relapse-treatment","display_name":"relapse treatment","score":0.6819999814033508},{"id":"https://openalex.org/keywords/high-dose-corticosteroids","display_name":"high-dose corticosteroids","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.875},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8700000047683716},{"id":"https://openalex.org/keywords/expanded-disability-status-scale","display_name":"Expanded Disability Status Scale","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gadolinium-enhancing-lesions","display_name":"gadolinium-enhancing lesions","score":0.9229999780654907},{"id":"https://openalex.org/keywords/t2-lesions","display_name":"T2 lesions","score":0.7570000290870667},{"id":"https://openalex.org/keywords/disability-progression","display_name":"disability progression","score":0.7099999785423279},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9070000052452087},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9697767496109009},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.7133387923240662},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6942105293273926},{"id":"https://openalex.org/C2994577977","wikidata":"https://www.wikidata.org/wiki/Q1203526","display_name":"Pilot trial","level":3,"score":0.6312882304191589},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.6194143891334534},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5568088889122009},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.39949795603752136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.308374285697937},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.20231157541275024},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.10788694024085999},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.05822122097015381},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05562654137611389}],"mesh":[{"descriptor_ui":"D000074099","descriptor_name":"Equivalence Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/ene.13851","doi":"https://doi.org/10.1111/ene.13851","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ene.13851","pdf_url":null,"source":{"id":"https://openalex.org/S162635963","display_name":"European Journal of Neurology","issn_l":"1351-5101","issn":["1351-5101","1468-1331"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neurology","raw_type":"journal-article"},{"id":"pmid:30351511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30351511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8378115473","display_name":null,"funder_award_id":"EC11/132","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2182772","https://openalex.org/W190441802","https://openalex.org/W1884147825","https://openalex.org/W1908499568","https://openalex.org/W1919743574","https://openalex.org/W1982837470","https://openalex.org/W2022828886","https://openalex.org/W2058674452","https://openalex.org/W2085381003","https://openalex.org/W2091521286","https://openalex.org/W2095821034","https://openalex.org/W2103810134","https://openalex.org/W2122166607","https://openalex.org/W2122545833","https://openalex.org/W2133067884","https://openalex.org/W2141466262","https://openalex.org/W2143953700","https://openalex.org/W2169934167","https://openalex.org/W2318222824","https://openalex.org/W2402638249","https://openalex.org/W2441939542","https://openalex.org/W4242097927"],"related_works":["https://openalex.org/W4389445532","https://openalex.org/W2141466262","https://openalex.org/W2085381003","https://openalex.org/W1908499568","https://openalex.org/W4241834159","https://openalex.org/W2142782773","https://openalex.org/W2769267221","https://openalex.org/W2103810134","https://openalex.org/W1884147825","https://openalex.org/W2471424669"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Oral":[3],"or":[4,193,200,211],"intravenous":[5],"methylprednisolone":[6,39,231],"(\u2265500":[7],"mg/day":[8,41,47],"for":[9,14,52],"5":[10],"days)":[11],"is":[12],"recommended":[13],"multiple":[15],"sclerosis":[16],"(MS)":[17],"relapses.":[18,57],"Nonetheless,":[19],"the":[20,71,92,195,238],"optimal":[21],"dose":[22,95,167,241],"remains":[23],"uncertain.":[24],"We":[25],"compared":[26],"clinical":[27,245],"and":[28,32,121,127,134,136,138,219,246],"radiological":[29,247],"effectiveness,":[30],"safety":[31,137],"quality":[33],"of":[34,37,61,91,197,244],"life":[35],"(QoL)":[36],"oral":[38,230],"[1250":[40],"(standard":[42],"high":[43,49,94,166,240],"dose)]":[44],"versus":[45],"625":[46],"(lesser":[48],"dose),":[50],"both":[51,224],"3":[53],"days]":[54],"in":[55,77,124,184,194,242],"MS":[56,68],"METHODS:":[58],"A":[59,227],"total":[60],"49":[62],"patients":[63],"with":[64],"moderate":[65],"to":[66,156,237],"severe":[67],"relapse":[69],"within":[70],"previous":[72],"15":[73],"days":[74,119,132,160],"were":[75,114,182,221],"randomized":[76],"a":[78,169],"pilot,":[79],"double-blind,":[80],"multicentre,":[81],"non-inferiority":[82,90],"trial":[83],"(ClinicalTrial.gov,":[84],"NCT01986998).":[85],"The":[86,111,142,164],"primary":[87,143],"endpoint":[88],"was":[89,145],"lesser":[93,228],"by":[96],"Expanded":[97],"Disability":[98],"Status":[99],"Scale":[100],"(EDSS)":[101],"score":[102,116,152,172,186],"improvement":[103,173],"on":[104,118,131,174,187,204],"day":[105,175,188,205,212],"30":[106,159,213],"(non-inferiority":[107],"margin,":[108],"1":[109],"point).":[110],"secondary":[112],"endpoints":[113],"EDSS":[115,151,171,185],"change":[117],"7":[120,133,176,206],"90,":[122],"changes":[123],"T1":[125,198],"gadolinium-enhanced":[126,199],"new/enlarged":[128,201],"T2":[129,202],"lesions":[130,203],"30,":[135],"QoL":[139,220],"results.":[140],"RESULTS:":[141],"outcome":[144],"achieved":[146],"[mean":[147],"(95%":[148],"confidence":[149],"interval)":[150],"difference,":[153],"-0.26":[154],"(-0.7":[155],"0.18)":[157],"at":[158,223],"(P":[161,177,190,207,214],"=":[162,178,191,208,215],"0.246)].":[163],"standard":[165,239],"yielded":[168],"superior":[170],"0.028).":[179],"No":[180],"differences":[181],"observed":[183],"90":[189],"0.352)":[192],"number":[196],"0.401,":[209],"0.347)":[210],"0.349,":[216],"0.529).":[217],"Safety":[218],"good":[222],"doses.":[225],"CONCLUSIONS:":[226],"high-dose":[229],"regimen":[232],"may":[233],"not":[234],"be":[235],"inferior":[236],"terms":[243],"response.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-10-26T00:00:00"}