{"id":"https://openalex.org/W2895855995","doi":"https://doi.org/10.1016/j.jalz.2018.06.2888","title":"F4\u201007\u201001: LC AND FRONTOPARIETAL NETWORK FUNCTION IN NORMAL AGING","display_name":"F4\u201007\u201001: LC AND FRONTOPARIETAL NETWORK FUNCTION IN NORMAL AGING","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2895855995","doi":"https://doi.org/10.1016/j.jalz.2018.06.2888","mag":"2895855995"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2018.06.2888","doi":"https://doi.org/10.1016/j.jalz.2018.06.2888","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.2888","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048937263","display_name":"Mara Mather","orcid":"https://orcid.org/0000-0003-4331-6112","observed_orcids":["https://orcid.org/0000-0003-4331-6112"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mara Mather","raw_affiliation_strings":["University of South California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032666143","display_name":"David Clewett","orcid":"https://orcid.org/0000-0003-0026-8034","observed_orcids":["https://orcid.org/0000-0003-0026-8034"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Clewett","raw_affiliation_strings":["New York University, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University, New York City, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078752012","display_name":"Briana L. Kennedy","orcid":"https://orcid.org/0000-0002-3155-7800","observed_orcids":["https://orcid.org/0000-0002-3155-7800"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Briana Kennedy","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004642364","display_name":"Shawn Nielson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn Nielson","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083664557","display_name":"Ringo Huang","orcid":"https://orcid.org/0000-0003-3158-0864","observed_orcids":["https://orcid.org/0000-0003-3158-0864"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ringo Huang","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081210176","display_name":"Ricardo Velasco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Velasco","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005730771","display_name":"Kristie Tu","orcid":"https://orcid.org/0000-0003-2058-1159","observed_orcids":["https://orcid.org/0000-0003-2058-1159"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristie Tu","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jiyoon Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyoon Han","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048937263"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.132,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48242011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"7S_Part_26","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.163100004196167,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":1.0},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.6178547143936157},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6115278601646423},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.5756800174713135},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.45088234543800354},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4487975835800171},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.43512478470802307},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.4261758327484131},{"id":"https://openalex.org/C2778233910","wikidata":"https://www.wikidata.org/wiki/Q2490706","display_name":"Intraparietal sulcus","level":3,"score":0.4156211316585541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29985788464546204},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.2706356644630432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2593056559562683},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.1931818723678589},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17159563302993774}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2018.06.2888","doi":"https://doi.org/10.1016/j.jalz.2018.06.2888","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.2888","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6965031977","https://openalex.org/W7116961418","https://openalex.org/W2804091850","https://openalex.org/W4400076366","https://openalex.org/W7124391793","https://openalex.org/W1759447231","https://openalex.org/W7116854803","https://openalex.org/W4386324840","https://openalex.org/W4380883268","https://openalex.org/W4375951937"],"abstract_inverted_index":{"The":[0,23],"locus":[1],"coeruleus":[2],"(LC)":[3],"plays":[4],"a":[5,19,109,157,199,304],"critical":[6],"role":[7],"in":[8,18,50,136,146,181,206,261,291,335,348],"regulating":[9],"executive":[10],"function":[11,77,266],"via":[12,96,186,216],"the":[13,28,66,80,86,93,122,137,184,192,223,243,273,312],"release":[14],"of":[15,27,35,41,68,159,183,272,332],"norepinephrine":[16],"(NE)":[17],"frontoparietal":[20,201,219,279,315],"brain":[21,30],"network.":[22],"LC":[24,43,59,76,114,118,155,247,262,275,301,313,321,336],"is":[25,72,277,317],"one":[26],"first":[29,39],"areas":[31],"to":[32,62,113,121,151],"show":[33],"signs":[34,40],"tau":[36],"pathology,":[37],"with":[38,253,303,319],"this":[42],"pathology":[44],"typically":[45],"evident":[46],"by":[47,298],"early":[48],"adulthood":[49],"most":[51],"people.":[52],"In":[53,85,139,225,307],"addition,":[54,140,308],"prior":[55,120],"work":[56],"has":[57],"linked":[58,112],"structural":[60],"integrity":[61],"cognitive":[63],"abilities":[64],"at":[65],"end":[67],"life.":[69,164],"Yet":[70],"little":[71],"known":[73],"about":[74],"how":[75,343],"changes":[78,260],"throughout":[79],"typical":[81],"human":[82],"aging":[83],"process.":[84],"current":[87],"study,":[88],"we":[89,141],"tested":[90],"whether":[91,143],"stimulating":[92],"LC-NE":[94,178,213],"system":[95,179,214],"isometric":[97,129,188],"exercise":[98,131,344],"(a":[99],"handgrip":[100,130,189,217,227],"squeezing":[101],"task)":[102],"could":[103],"improve":[104],"older":[105,168,209,235],"adults\u2019":[106],"attention":[107,123],"during":[108,173],"task":[110,190],"previously":[111],"function.":[115],"To":[116],"manipulate":[117],"activity":[119,135,180,215,281,302],"task,":[124],"some":[125],"participants":[126,185],"performed":[127],"an":[128,187,268],"that":[132,294],"increased":[133,177,218,228],"BOLD":[134],"LC.":[138],"examined":[142],"individual":[144],"differences":[145],"LC-frontoparietal":[147,229,255],"functional":[148,174,231,256],"connectivity":[149,232,310],"relate":[150],"MRI":[152,249,323],"contrast":[153,250],"reflecting":[154],"neuromelanin,":[156],"by-product":[158],"monoamine":[160],"metabolism":[161],"across":[162,222,242],"one's":[163],"Eighty-seven":[165],"(younger":[166],"and":[167,282,314],"women)":[169],"detected":[170],"auditory":[171],"oddballs":[172],"MRI.":[175],"We":[176,287],"half":[182],"before":[191],"oddball":[193,196],"task.":[194,224],"Hearing":[195],"sounds":[197],"activated":[198],"right":[200],"network,":[202],"but":[203,338],"significantly":[204],"more":[205,233],"younger":[207,239],"than":[208,237],"women.":[210,240],"Inducing":[211],"higher":[212,246],"network":[220,230,280,316],"engagement":[221],"particular,":[226],"for":[234,238],"women":[236],"Furthermore,":[241],"whole":[244],"group,":[245],"neuromelanin":[248,322],"was":[251],"associated":[252,318],"greater":[254],"connectivity.":[257],"Whether":[258],"age-related":[259,289,333],"structure":[263],"impact":[264],"its":[265],"remains":[267],"open":[269],"question.":[270],"One":[271],"key":[274],"functions":[276],"modulating":[278],"thereby":[283],"influencing":[284],"selective":[285],"attention.":[286],"find":[288],"impairments":[290],"these":[292],"processes":[293],"can":[295,345],"be":[296],"alleviated":[297],"increasing":[299],"tonic":[300],"simple":[305],"exercise.":[306],"diminished":[309],"between":[311],"decreased":[320],"contrast.":[324],"Thus,":[325],"our":[326],"findings":[327],"not":[328],"only":[329],"provide":[330,340],"evidence":[331],"decline":[334],"function,":[337],"also":[339],"insights":[341],"into":[342],"enhance":[346],"cognition":[347],"aging.":[349]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-10-26T00:00:00"}