{"id":"https://openalex.org/W2895854040","doi":"https://doi.org/10.1186/s12931-018-0907-8","title":"Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis","display_name":"Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis","publication_year":2018,"publication_date":"2018-10-19","ids":{"openalex":"https://openalex.org/W2895854040","doi":"https://doi.org/10.1186/s12931-018-0907-8","mag":"2895854040","pmid":"https://pubmed.ncbi.nlm.nih.gov/30340638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6194688"},"language":"en","primary_location":{"id":"doi:10.1186/s12931-018-0907-8","doi":"https://doi.org/10.1186/s12931-018-0907-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0907-8","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0907-8","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2895854040"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0907-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039072605","display_name":"Hee\u2010Young Yoon","orcid":"https://orcid.org/0000-0001-9852-0036","observed_orcids":["https://orcid.org/0000-0001-9852-0036"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee-Young Yoon","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619967","display_name":"Sojung Park","orcid":"https://orcid.org/0000-0002-2731-8188","observed_orcids":["https://orcid.org/0000-0002-2731-8188","https://orcid.org/0009-0004-7783-8503","https://orcid.org/0000-0001-9374-2377"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sojung Park","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109193687","display_name":"Dong Soon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Soon Kim","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055570107","display_name":"Jin Woo Song","orcid":"https://orcid.org/0000-0001-5121-3522","observed_orcids":["https://orcid.org/0000-0001-5121-3522"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin Woo Song","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea. jwsong@amc.seoul.kr","Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5121-3522","affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea. jwsong@amc.seoul.kr","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055570107"],"corresponding_institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":8.0138,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.98378282,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"203","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nintedanib","display_name":"nintedanib","score":1.0},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fvc-decline","display_name":"forced vital capacity decline","score":0.8999999761581421},{"id":"https://openalex.org/keywords/total-lung-capacity","display_name":"total lung capacity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9089999794960022},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5289999842643738},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2780171596","wikidata":"https://www.wikidata.org/wiki/Q15149723","display_name":"Nintedanib","level":4,"score":0.9864694476127625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8312073945999146},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.79506516456604},{"id":"https://openalex.org/C55520419","wikidata":"https://www.wikidata.org/wiki/Q660995","display_name":"Vital capacity","level":5,"score":0.7820332050323486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7382920384407043},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6127804517745972},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48641180992126465},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4197290241718292},{"id":"https://openalex.org/C165637977","wikidata":"https://www.wikidata.org/wiki/Q11067835","display_name":"Diffusing capacity","level":4,"score":0.29890871047973633},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.27628207206726074},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.116310715675354}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12931-018-0907-8","doi":"https://doi.org/10.1186/s12931-018-0907-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0907-8","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0907-8","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5146921","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6194688","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30340638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30340638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6194688","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6194688/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respir Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3377d8aac41d4906b4578e717e6cb865","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3377d8aac41d4906b4578e717e6cb865","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, Vol 19, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12931-018-0907-8","doi":"https://doi.org/10.1186/s12931-018-0907-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0907-8","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0907-8","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4533744855","display_name":null,"funder_award_id":"NRF-2016R1A2B4016318","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895854040.pdf","grobid_xml":"https://content.openalex.org/works/W2895854040.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1757222072","https://openalex.org/W1964124382","https://openalex.org/W2042146535","https://openalex.org/W2045756883","https://openalex.org/W2066138662","https://openalex.org/W2069724928","https://openalex.org/W2079988825","https://openalex.org/W2080831548","https://openalex.org/W2089756110","https://openalex.org/W2106320546","https://openalex.org/W2106408170","https://openalex.org/W2117488044","https://openalex.org/W2120791222","https://openalex.org/W2122415095","https://openalex.org/W2125078269","https://openalex.org/W2138871107","https://openalex.org/W2141922649","https://openalex.org/W2145106519","https://openalex.org/W2148754568","https://openalex.org/W2152974152","https://openalex.org/W2157869208","https://openalex.org/W2167383172","https://openalex.org/W2462000645","https://openalex.org/W2469138893","https://openalex.org/W2507379588","https://openalex.org/W2510319197","https://openalex.org/W2524005801","https://openalex.org/W2561981946","https://openalex.org/W2597638604","https://openalex.org/W2748660768","https://openalex.org/W2766726468","https://openalex.org/W2767378828","https://openalex.org/W2768006414","https://openalex.org/W2788452276","https://openalex.org/W2790223305","https://openalex.org/W4245666729"],"related_works":["https://openalex.org/W2726643436","https://openalex.org/W3000956463","https://openalex.org/W2790223305","https://openalex.org/W2764063328","https://openalex.org/W4411085290","https://openalex.org/W2507379588","https://openalex.org/W2462000645","https://openalex.org/W3082109398","https://openalex.org/W2947966909","https://openalex.org/W2505469254"],"abstract_inverted_index":{"BACKGROUND:":[0],"Phase":[1],"3":[2],"trials":[3],"have":[4],"shown":[5],"that":[6],"nintedanib":[7,43,227],"reduces":[8],"the":[9,38,93,138,152,169,191,197,229,237,252],"decline":[10,94,130],"in":[11,16,44,96,122,128,137,151,166,185,228,236],"forced":[12],"vital":[13],"capacity":[14,78,112],"(FVC)":[15],"patients":[17,45,57],"with":[18,24,46],"mild-to-moderate":[19],"idiopathic":[20],"pulmonary":[21],"fibrosis":[22],"(IPF)":[23],"acceptable":[25],"safety":[26,41,224],"profiles;":[27],"however,":[28],"its":[29],"effects":[30],"on":[31],"advanced":[32,47,70,139,198,230,253],"IPF":[33,56,71],"are":[34],"unclear.":[35],"We":[36],"investigated":[37],"efficacy":[39,222],"and":[40,109,174,223],"of":[42,63,168,193,204,214,226,245],"IPF.":[48],"METHODS:":[49],"Prospective":[50],"data":[51],"were":[52,232],"obtained":[53],"from":[54],"108":[55],"administered":[58],"at":[59],"least":[60],"one":[61],"dose":[62],"nintedanib.":[64],"Of":[65],"these":[66],"patients,":[67],"47.2%":[68],"had":[69],"(FVC":[72],"<":[73,79,120],"50%":[74],"predicted,":[75],"or":[76],"diffusing":[77],"30%":[80],"predicted).":[81],"RESULTS:":[82],"The":[83,221],"median":[84],"treatment":[85,133,180,205],"duration":[86],"was":[87,134,188],"42.2":[88],"weeks.":[89],"Nintedanib":[90],"significantly":[91],"reduced":[92],"rate":[95,131],"both":[97],"FVC":[98,129],"(-":[99,114,141,155],"0.55%":[100],"[before]":[101],"vs.":[102,116,143,157,208,218],"-0.32%":[103],"[after]":[104],"predicted/month,":[105,118,145,159],"p":[106,119,146,160],"=":[107,147,161],"0.020)":[108],"total":[110],"lung":[111],"(TLC)":[113],"0.35%":[115],"-0.06%":[117],"0.001)":[121],"all":[123],"patients.":[124],"A":[125],"significant":[126],"improvement":[127],"after":[132],"also":[135],"observed":[136,189],"group":[140,154,199,231,239],"0.77%":[142],"-0.22%":[144],"0.003),":[148],"but":[149],"not":[150],"non-advanced":[153,238],"0.41%":[156],"-0.33%":[158],"0.564).":[162],"Adverse":[163],"events":[164],"occurred":[165],"97.2%":[167],"cohort,":[170],"including":[171],"diarrhoea":[172],"(50.0%)":[173],"anorexia":[175],"(45.4%).":[176],"Following":[177],"adjustment":[178],"for":[179,190,241],"duration,":[181],"no":[182],"inter-group":[183],"difference":[184],"odds":[186],"ratio":[187],"occurrence":[192],"adverse":[194],"events.":[195],"However,":[196],"showed":[200],"a":[201,212,242],"higher":[202,243],"frequency":[203,244],"interruption":[206],"(68.0%":[207],"40.0%),":[209],"mainly":[210],"as":[211],"result":[213],"disease":[215],"progression":[216],"(47.1%":[217],"36.4%).":[219],"CONCLUSIONS:":[220],"profiles":[225],"comparable":[233],"to":[234,251],"those":[235],"except":[240],"discontinuation,":[246],"which":[247],"may":[248],"be":[249],"due":[250],"status":[254],"itself.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-10-26T00:00:00"}
