{"id":"https://openalex.org/W2895842688","doi":"https://doi.org/10.1016/j.jaci.2018.10.001","title":"CSF3R/CD114 mediates infection-dependent transition to severe asthma","display_name":"CSF3R/CD114 mediates infection-dependent transition to severe asthma","publication_year":2018,"publication_date":"2018-10-09","ids":{"openalex":"https://openalex.org/W2895842688","doi":"https://doi.org/10.1016/j.jaci.2018.10.001","mag":"2895842688","pmid":"https://pubmed.ncbi.nlm.nih.gov/30312710"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2018.10.001","doi":"https://doi.org/10.1016/j.jaci.2018.10.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.10.001","pdf_url":"http://www.jacionline.org/article/S0091674918314301/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jacionline.org/article/S0091674918314301/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100700757","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0002-0901-5183","observed_orcids":["https://orcid.org/0000-0002-0901-5183"]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hao Wang","raw_affiliation_strings":["School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108443147","display_name":"Meaghan FitzPatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210153402","display_name":"CSL (Australia)","ror":"https://ror.org/044tc0x05","country_code":"AU","type":"company","lineage":["https://openalex.org/I4210153402"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Meaghan FitzPatrick","raw_affiliation_strings":["Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia; CSL Limited, Parkville, Victoria, Australia","CSL Limited, Parkville, Victoria, Australia","Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia; CSL Limited, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"CSL Limited, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I4210153402"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008951630","display_name":"Nicholas J. Wilson","orcid":"https://orcid.org/0000-0002-5574-9516","observed_orcids":["https://orcid.org/0000-0002-5574-9516"]},"institutions":[{"id":"https://openalex.org/I4210153402","display_name":"CSL (Australia)","ror":"https://ror.org/044tc0x05","country_code":"AU","type":"company","lineage":["https://openalex.org/I4210153402"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas J. Wilson","raw_affiliation_strings":["CSL Limited, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSL Limited, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I4210153402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103836241","display_name":"Desiree Anthony","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Desiree Anthony","raw_affiliation_strings":["School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069450540","display_name":"Patrick C. Reading","orcid":"https://orcid.org/0000-0002-8860-5308","observed_orcids":["https://orcid.org/0000-0002-8860-5308"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Patrick C. Reading","raw_affiliation_strings":["WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia","Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia","WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210088630","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I4210088630","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080099666","display_name":"Catherine Satzke","orcid":"https://orcid.org/0000-0003-3164-8849","observed_orcids":["https://orcid.org/0000-0003-3164-8849"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Catherine Satzke","raw_affiliation_strings":["Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia; Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia","Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia; Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]},{"raw_affiliation_string":"Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089345912","display_name":"Eileen  Margaret Dunne","orcid":"https://orcid.org/0000-0001-5542-0780","observed_orcids":["https://orcid.org/0000-0001-5542-0780"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Eileen M. Dunne","raw_affiliation_strings":["Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210150290"]},{"raw_affiliation_string":"Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016217164","display_name":"Paul Vincent Licciardi","orcid":"https://orcid.org/0000-0001-6086-6285","observed_orcids":["https://orcid.org/0000-0001-6086-6285"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul V. Licciardi","raw_affiliation_strings":["Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210150290"]},{"raw_affiliation_string":"Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076011525","display_name":"Huei Jiunn Seow","orcid":"https://orcid.org/0000-0002-4790-4811","observed_orcids":["https://orcid.org/0000-0002-4790-4811"]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Huei Jiunn Seow","raw_affiliation_strings":["School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038771478","display_name":"Kristy Nichol","orcid":"https://orcid.org/0000-0002-7912-9709","observed_orcids":["https://orcid.org/0000-0002-7912-9709"]},"institutions":[{"id":"https://openalex.org/I2800479947","display_name":"John Hunter Hospital","ror":"https://ror.org/0187t0j49","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800479947","https://openalex.org/I4210154888"]},{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kristy Nichol","raw_affiliation_strings":["Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","institution_ids":["https://openalex.org/I2800479947","https://openalex.org/I4210087646","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","institution_ids":["https://openalex.org/I2800479947"]},{"raw_affiliation_string":"Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063587197","display_name":"Ian Michael Adcock","orcid":"https://orcid.org/0000-0003-2101-8843","observed_orcids":["https://orcid.org/0000-0003-2101-8843"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian M. Adcock","raw_affiliation_strings":["Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036414874","display_name":"Kian Fan Chung","orcid":"https://orcid.org/0000-0001-7101-1426","observed_orcids":["https://orcid.org/0000-0001-7101-1426"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kian Fan Chung","raw_affiliation_strings":["Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008084743","display_name":"Gary P. Anderson","orcid":"https://orcid.org/0000-0001-6580-3398","observed_orcids":["https://orcid.org/0000-0001-6580-3398"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gary P. Anderson","raw_affiliation_strings":["Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060211723","display_name":"Ross Vlahos","orcid":"https://orcid.org/0000-0001-8443-7071","observed_orcids":["https://orcid.org/0000-0001-8443-7071"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ross Vlahos","raw_affiliation_strings":["School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia; Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia; Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I82951845"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023800164","display_name":"Peter A. B. Wark","orcid":"https://orcid.org/0000-0001-5676-6126","observed_orcids":["https://orcid.org/0000-0001-5676-6126"]},"institutions":[{"id":"https://openalex.org/I2800479947","display_name":"John Hunter Hospital","ror":"https://ror.org/0187t0j49","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800479947","https://openalex.org/I4210154888"]},{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Wark","raw_affiliation_strings":["Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","institution_ids":["https://openalex.org/I2800479947","https://openalex.org/I4210087646","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia","institution_ids":["https://openalex.org/I2800479947"]},{"raw_affiliation_string":"Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079475266","display_name":"Steven Bozinovski","orcid":"https://orcid.org/0000-0001-6533-8641","observed_orcids":["https://orcid.org/0000-0001-6533-8641"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Steven Bozinovski","raw_affiliation_strings":["School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia; Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: steven.bozinovski@rmit.edu.au","Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia; Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: steven.bozinovski@rmit.edu.au","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I82951845"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5079475266"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I82951845"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":{"value":4900,"currency":"USD","value_usd":4900},"fwci":1.956,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.85553059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"143","issue":"2","first_page":"785","last_page":"788.e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.621999979019165},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/persistent-asthma","display_name":"persistent asthma","score":0.6859999895095825},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.7639999985694885},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.699999988079071},{"id":"https://openalex.org/keywords/neutrophil-trafficking","display_name":"neutrophil trafficking","score":0.7820000052452087},{"id":"https://openalex.org/keywords/asthma-susceptibility","display_name":"asthma susceptibility","score":0.6259999871253967},{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.675000011920929},{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.45399999618530273},{"id":"https://openalex.org/keywords/nasopharyngeal-carriage","display_name":"nasopharyngeal carriage","score":0.7580000162124634},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5895751118659973},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5631299614906311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5102458000183105},{"id":"https://openalex.org/C2778070265","wikidata":"https://www.wikidata.org/wiki/Q18048067","display_name":"Thymic stromal lymphopoietin","level":3,"score":0.503865659236908},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.49921202659606934},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.43998515605926514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4399797320365906},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.4210575222969055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40817171335220337},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.30979233980178833},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.26070713996887207}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016184","descriptor_name":"Receptors, Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039741","descriptor_name":"Antigens, Dermatophagoides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.jaci.2018.10.001","doi":"https://doi.org/10.1016/j.jaci.2018.10.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.10.001","pdf_url":"http://www.jacionline.org/article/S0091674918314301/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:30312710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30312710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Letter"},{"id":"pmh:oai:alma61RMIT.INST:11248173360001341","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.10.001","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27519105","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/CSF3R_CD114_mediates_infection-dependent_transition_to_severe_asthma/27519105","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/65202","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/65202","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"788.e6","raw_type":"Journal Article"},{"id":"pmh:uon:48016","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.13/1468171","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.jaci.2018.10.001","doi":"https://doi.org/10.1016/j.jaci.2018.10.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.10.001","pdf_url":"http://www.jacionline.org/article/S0091674918314301/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1550335965","display_name":null,"funder_award_id":"13-BIO-755-20","funder_id":"https://openalex.org/F4320322997","funder_display_name":"King Abdulaziz City for Science and Technology"},{"id":"https://openalex.org/G2955142657","display_name":null,"funder_award_id":"KACST: 13-BIO-755-20","funder_id":"https://openalex.org/F4320322997","funder_display_name":"King Abdulaziz City for Science and Technology"},{"id":"https://openalex.org/G4258508359","display_name":"Refinement of gene and cell therapies for inherited immunodeficiencies based on human interventions and developing technologies .","funder_award_id":"104807/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4834823448","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0515-10016","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4839860845","display_name":null,"funder_award_id":"098051","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5497690081","display_name":null,"funder_award_id":"MR/L019027","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7342417603","display_name":"Investigating the actions of anti-inflammatory pathways in chronic lung disease","funder_award_id":"FT130100654","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G7791187358","display_name":"Targeting the ALX/FPR2 receptor in COPD","funder_award_id":"1067547","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8666890344","display_name":"Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers","funder_award_id":"098051","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320322160","display_name":"Great Ormond Street Hospital for Children","ror":"https://ror.org/00zn2c847"},{"id":"https://openalex.org/F4320322997","display_name":"King Abdulaziz City for Science and Technology","ror":"https://ror.org/05tdz6m39"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895842688.pdf","grobid_xml":"https://content.openalex.org/works/W2895842688.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1235570584","https://openalex.org/W2055349211","https://openalex.org/W2057192777","https://openalex.org/W2096445205","https://openalex.org/W2100589529","https://openalex.org/W2119706375","https://openalex.org/W2124843402","https://openalex.org/W2125302694","https://openalex.org/W2161528116","https://openalex.org/W2161607615","https://openalex.org/W2309827789","https://openalex.org/W2548228770","https://openalex.org/W2586238008","https://openalex.org/W2614615141","https://openalex.org/W2743599156","https://openalex.org/W2787852705"],"related_works":["https://openalex.org/W2094893870","https://openalex.org/W3030189566","https://openalex.org/W3030153630","https://openalex.org/W3032106133","https://openalex.org/W2990603866","https://openalex.org/W3161991260","https://openalex.org/W1998183937","https://openalex.org/W7046220394","https://openalex.org/W4406980103","https://openalex.org/W4246736895"],"abstract_inverted_index":{"The":[0,123,255,326,1523,1678,1828,1989,2985,3173],"major":[1,1466,1514],"17q12-21":[2],"asthma":[3,27,197,220,235,309,358,389,668,674,678,704,758,873,931,1334,1384,1587,1648,1728,1791,1810,2044,2090,3461],"susceptibility":[4],"and":[5,28,152,161,186,264,306,393,412,451,530,591,635,676,683,712,728,743,745,789,794,972,980,993,1014,1033,1065,1157,1194,1221,1225,1229,1268,1388,1476,1497,1504,1545,1548,1554,1565,1588,1635,1666,1729,1762,1771,1808,1819,1839,1856,1895,1999,2035,2056,2085,2120,2153,2161,2171,2512,2520,2536,2544,2546,2581,2602,2609,2695,2728,2795,2860,2881,2906,2911,2935,2944,2950,2994,3005,3039,3092,3112,3140,3170,3180,3190,3283,3317,3320,3391,3434,3447,3463],"exacerbation":[6],"locus1Bisgaard":[7],"H.":[8,222,2887],"Bonnelykke":[9,231],"K.":[10,232,288,830],"Sleiman":[11],"P.M.":[12],"Brasholt":[13],"M.":[14,72,290,292,416,1255,1414,1714,2072,2206,2469,2560,2562,2627],"Chawes":[15],"B.":[16,74,2897],"Kreiner-Moller":[17],"E.":[18],"et":[19,79,233,295,427,831,1258,1378,1423,1721,2033,2066,2079,2217,2480,2567,2638,2746,2819,2898],"al.Chromosome":[20],"17q21":[21],"gene":[22,114,640,2791],"variants":[23],"are":[24,933,1673,2062,3418],"associated":[25,61,86,750,800,2754,2827],"with":[26,62,87,262,279,504,541,561,575,667,738,751,843,871,875,930,987,1031,1041,1106,1111,1121,1134,1141,1182,1285,1383,1550,1593,1617,1644,1707,1861,2124,2132,2196,2241,2258,2291,2333,2508,2620,2755,2828,2978,3016,3152,3209,3257,3265,3289,3358,3459],"exacerbations":[29],"but":[30,773,1294],"not":[31,107,199,469,536,595,623,766,896,1070,1290,3340],"atopy":[32,263],"in":[33,91,190,242,359,439,481,492,499,524,571,586,612,642,661,688,691,735,771,782,801,841,869,886,947,955,983,1019,1027,1061,1102,1137,1203,1230,1271,1325,1332,1381,1456,1602,1647,1671,1675,1705,1726,1832,1859,1970,2064,2094,2229,2269,2300,2338,2492,2531,2578,2650,2670,2690,2908,2997,3123,3175,3225,3384,3437,3450],"early":[34],"childhood.Am":[35],"J":[36,245,1866,2585,2759,2832],"Respir":[37,1731,1867,2046,2096,2586,2760,2833],"Crit":[38,1868,2587],"Care":[39,1869,2588],"Med.":[40,246,1435,1870,2589],"2009;":[41,96],"179:":[42],"179-185Crossref":[43],"PubMed":[44,99,250,321,446,857,1279,1396,1439,1736,1874,2051,2236,2499,2593,2657,2767,2840,2921],"Scopus":[45,100,251,322,447,858,1280,1397,1440,1737,1875,2052,2103,2237,2500,2594,2658,2768,2841,2922],"(174)":[46],"Google":[47,102,253,324,449,860,1282,1399,1442,1739,1877,2054,2105,2239,2502,2596,2660,2770,2843,2924],"Scholar":[48,103,254,325,450,861,1283,1400,1443,1740,1878,2055,2106,2240,2503,2597,2661,2771,2844],"has":[49,198],"been":[50,200,277],"identified":[51],"as":[52,130,273,282,615,686,913,1447,1464,1696,1778,1795,1814,2019,2203,2432,2466,2553,2624,2700,2724,2732,2805,2884,2929,2940,3252,3314,3420],"the":[53,92,171,174,191,205,240,336,353,379,385,466,493,518,550,554,587,630,643,650,756,817,915,1020,1062,1090,1125,1152,1165,1171,1204,1240,1262,1302,1345,1350,1357,1402,1513,1536,1541,1551,1563,1581,1651,1683,1744,1749,1755,1768,1833,1885,1983,2039,2189,2242,2288,2368,2414,2427,2443,2579,2796,2802,3083,3093,3185,3226,3242,3247,3253,3309,3315,3329,3349,3385,3438,3468],"only":[54,568,609,2174,2425],"genetic":[55],"locus":[56,117],"that":[57,118,260,329,381,515,923,1151,1318,1361,1469,2422],"is":[58,106,111,146,214,369,925,1330,1347,1406,1724,2753,2826],"also":[59,215,582,809,1024,1057,1081,1214,1316,1407,3230],"reproducibly":[60],"total":[63,1787,1805,1825,2545],"white":[64],"blood":[65,2617],"cell":[66,1692,1788,1806,1826,2081,2549,3025],"count.2Soranzo":[67],"N.":[68,294],"Spector":[69],"T.D.":[70],"Mangino":[71],"Kuhnel":[73],"Rendon":[75],"A.":[76,78,2076,2745,2818],"Teumer":[77],"al.A":[80],"genome-wide":[81],"meta-analysis":[82],"identifies":[83],"22":[84],"loci":[85],"eight":[88],"hematological":[89],"parameters":[90],"HaemGen":[93],"consortium.Nat":[94],"Genet.":[95],"41:":[97],"1182-1190Crossref":[98],"(429)":[101],"However,":[104,362],"it":[105,1336],"known":[108,129],"whether":[109,1083],"there":[110,924],"a":[112,154,216,341,363,391,542,811,926,1183,1231,1448,1465,1489,1594,1639,1702,1971,1980,2158,2270,2301,2382,2521,2674,2696,2711,2789,2909,2953,2968,3008,3032,3059,3076,3197],"common":[113],"within":[115,133,3467],"this":[116,134,375,398,482,562,592,692,887,956,1034,1147,1494],"links":[119],"these":[120,367],"phenotypic":[121,2012],"traits.":[122],"colony-stimulating":[124,1191],"factor-3":[125,2389],"(CSF3)":[126],"gene,":[127],"alternatively":[128],"G-CSF,":[131],"resides":[132],"locus.":[135],"CSF3":[136,140,626,639,658,727,746,768,784,793,894,910,1180,1213,1319,1463,1480,3446],"binds":[137],"exclusively":[138],"to":[139,153,194,275,371,1163,1199,1207,1339,1364,1386,1429,1451,1473,1492,1609,1783,1800,2157,2178,2183,2324,2404,2533,2666,2707,2788,3069,3216,3241,3302],"receptor":[141,838,1264,2390],"(CSF3R,":[142],"or":[143,349,475,1596,1606,1629,1751,1781,1798,2277,2308,2342,2393,2931,3260,3286,3328,3333,3344,3364],"CD114/G-CSFR),":[144],"which":[145,1068,1174,1355],"highly":[147],"expressed":[148,908,3419],"on":[149,157,707,1227,1580,1682,2615,2868,2967,3058,3206],"mature":[150],"neutrophils":[151,1785,1818,3111],"lesser":[155],"extent":[156],"mononuclear":[158],"cells,":[159],"platelets,":[160],"lung":[162,437,512,644,715,1021,1066,2227,2490,2572,2648,2671,2688,2719,2873,2904,2989,3053,3119,3148,3345,3393],"interstitial":[163],"stromal":[164],"cells.":[165],"Although":[166,893],"CSF3R/CD114":[167],"signaling":[168,383,940,1487],"can":[169],"dictate":[170],"intensity":[172],"of":[173,204,239,302,308,332,355,387,407,465,511,632,653,681,702,776,836,905,918,928,1049,1154,1167,1185,1261,1304,1323,1344,1352,1359,1485,1525,1540,1543,1560,1567,1583,1586,1642,1668,1685,1754,1786,1804,1824,1830,1925,1928,1931,1948,1951,1954,1982,2038,2058,2089,2181,2272,2303,2387,2417,2606,2988,3010,3023,3052,3061,3086,3188,3192,3222,3352,3444,3457],"host":[175],"defense":[176],"inflammatory":[177,671,1273,1686,2036],"response":[178,593,1035,2532],"during":[179,1211,1512,1638,2413,2426],"bacterial":[180,237,778,1054,1309,1669,2682,2912],"infection":[181,305,345,435,1161,2225,2488,2646,2905],"by":[182,207,340,432,471,539,598,941,999,1008,1039,1073,1114,1218,1349,1409,1522,1535,1837,2169,2222,2287,2485,2574,2643,2686,2749,2801,2822,3116,3321,3325,3369,3454],"regulating":[183],"neutrophil":[184,753,967,977,996,1201,1209,1216,1266,1299],"granulopoiesis":[185,1202],"trafficking,":[187],"its":[188],"role":[189],"infection-dependent":[192,388,1321,1471],"transition":[193,1472],"persistent,":[195],"severe":[196,844,872,1340,1457,1477,1994,2043,3460],"investigated.":[201],"Neonatal":[202,2192],"colonization":[203,238,411,464],"nasopharynx":[206,467],"potentially":[208],"pathogenic":[209],"bacteria":[210,334,1831],"including":[211,976,1187,1657],"Streptococcus":[212,3415],"pneumoniae":[213,281,462,1169,2198,2260,2669,3382],"risk":[217,307,354],"factor":[218,1192],"for":[219,521,974,1508,1562,1569,1898,2122,2165,2188,2352,3021],"development.3Bisgaard":[221],"Hermansen":[223],"M.N.":[224],"Buchvald":[225],"F.":[226,2074],"Loland":[227],"L.":[228,2564],"Halkjaer":[229],"L.B.":[230],"al.Childhood":[234],"after":[236,2367,2442,3377],"airway":[241,1128,1431,1607,1753,1854,2456,2527],"neonates.N":[243],"Engl":[244],"2007;":[247],"357:":[248],"1487-1495Crossref":[249],"(757)":[252],"Childhood":[256],"Asthma":[257,708,1662,1965,1975],"Study":[258,2007],"found":[259],"children":[261],"chronic":[265,1862],"wheeze":[266],"at":[267,390,486,696,891,960,2137,2144,3007],"age":[268,2138,2247,2281,2322],"5":[269,1620,2182,2353],"years":[270],"were":[271,496,535,567,732,866,1005,1520,1533,1578,1615,1625,1636,1680,1765,1881,1896,2117,2130,2142,2186,2194,2253,2285,2330,2363,2376,2430,2438,2449,2506,2551,2613,2786,2846,2927,2948,2975,3003,3014,3029,3114,3270,3294,3312,3356],"twice":[272],"likely":[274],"have":[276],"colonized":[278],"S":[280,461,1168,2197,2259,2668,3381],"neonates.4Teo":[283],"S.M.":[284],"Mok":[285],"D.":[286,1249,2556,2889],"Pham":[287],"Kusel":[289],"Serralha":[291],"Troy":[293],"al.The":[296],"infant":[297,2251],"nasopharyngeal":[298,333,409,2610],"microbiome":[299],"impacts":[300],"severity":[301,386],"lower":[303,337,494,714,1172],"respiratory":[304,344,544],"development.Cell":[310],"Host":[311],"Microbe.":[312],"2015;":[313,1436,2048],"17:":[314],"704-715Abstract":[315],"Full":[316,318,852,854],"Text":[317,319,853,855],"PDF":[320,856],"(552)":[323],"authors":[327],"suggest":[328],"transient":[330],"incursions":[331],"into":[335,459,670,1170,1239,1301,1748],"airways":[338,495,526,556,1092,1346],"triggered":[339],"fever-causing":[342],"viral":[343,414,1160,2910],"(respiratory":[346],"syncytial":[347,1852],"virus":[348,474,2202,2294],"influenza":[350,472,2200,2223,2292,2486,2644],"virus)":[351],"increases":[352,1425],"developing":[356],"persistent":[357,1475],"atopic":[360],"children.":[361],"plausible":[364],"mechanism":[365],"linking":[366],"cofactors":[368],"yet":[370],"be":[372,3303],"identified.":[373],"In":[374,488,603,791,1146,1459,2381,2454,2525,3348],"study,":[376,1148],"we":[377,400,656,1056,1149,1315,1444,1461],"tested":[378],"hypothesis":[380],"CSF3-CSF3R":[382],"dictates":[384],"cellular":[392],"molecular":[394,2087],"level.":[395],"To":[396,648,1741,2163],"test":[397,3323,3332],"hypothesis,":[399],"adapted":[401],"our":[402,654,948],"previously":[403,2204,2467,2554,2625,2733,2806,2885],"published":[404],"mouse":[405,949,3065],"model":[406,950,3249],"neonatal":[408,633],"pneumococcal":[410,429,490,1059,2219,2482,2640,2903,3342],"acute":[413,1159],"infection,5FitzPatrick":[415],"Royce":[417,2207,2470,2628],"S.G.":[418,2208,2471,2629],"Langenbach":[419,2209,2472,2630],"S.":[420,822,1412,2070,2210,2473,2631,2735,2808,2891],"McQualter":[421,1503,2211,2474,2632],"J.":[422,1732,2032,2047,2097,2212,2475,2633],"Reading":[423,2213,2476,2634],"P.C.":[424,2214,2477,2635],"Wijburg":[425,2215,2478,2636,2892],"O.":[426,2216,2479,2637,2893],"al.Neonatal":[428,2218,2481,2639],"colonisation":[430,2220,2483,2641],"caused":[431,2168,2221,2484,2642,2748,2821],"Influenza":[433,3403],"A":[434,473,742,2201,2224,2293,2487,2570,2645,3404],"alters":[436,2226,2489,2647],"function":[438,716,2228,2491,2649],"adult":[440,1576,1985,2042,2230,2493,2651],"mice.Sci":[441,2231,2494,2652],"Rep.":[442,2232,2495,2653],"2016;":[443,1276,2233,2496,2654],"6:":[444,2234,2497,2655],"22751Crossref":[445,2235,2498,2656],"(3)":[448],"superimposed":[452],"subsequent":[453],"house-dust":[454],"mite":[455],"(HDM)":[456],"aeroallergen":[457,2335],"exposure":[458,2429],"adulthood.":[460],"(EF3030)":[463],"was":[468,594,608,748,798,895,1023,1036,1069,1108,1131,1746,1760,1776,1835,2314,2402,2458,2518,2523,2529,2542,2600,2664,2684,2705,2715,2730,2774,2866,2990,3042,3056,3080,3150,3194,3204,3229,3250,3300,3395],"altered":[470,597,1072],"HDM":[476,505,516,576,580,620,636,988,1107,1142,1155,2310,2334,2370,2418,2428,3353],"(see":[477,951,1076],"Fig":[478,884,952,1077],"E1,":[479,507,528,558,578,601,618,646],"A,":[480,954,3347],"article's":[483,693,888,957],"Online":[484,694,889,958],"Repository":[485,695,890,959],"www.jacionline.org).":[487,697,892,961],"contrast,":[489,604],"loads":[491],"significantly":[497,548,569,596,610,624,637,713,733,867,897,964,1006,1037,1071,1109],"increased":[498,517,538,549,570,611,638,868,898,1026,1176],"coinfected":[500,572,614,984,1028,1103,1138],"neonates":[501,616],"chronically":[502],"challenged":[503,574,986,1030,1105,1140],"(Fig":[506,527,557,577,600,617,645,740,760,786,805,969,990,1011,1044,1093,1117,1143],"B).":[508],"Histological":[509],"assessment":[510,3022],"pathology":[513],"demonstrated":[514,1589],"area":[519,552],"positive":[520,777,3095],"mucus":[522,551,1087,1099,1123,1324,1363,1432],"staining":[523],"small":[525,555,1091],"C":[529],"D).":[531,559],"HDM-induced":[532,605],"mucin":[533,1426],"levels":[534,566,731,770,865,911,1088,2577],"further":[537,2938],"inoculation":[540],"single":[543],"pathogen,":[545],"whereas":[546,629],"coinfection":[547,599,634,2913],"surrounding":[553,1089],"Consistent":[560,1120,1284],"finding,":[563],"Muc5AC":[564,795],"transcript":[565,627,659,730,769,796,3442],"mice":[573,613,985,1029,1104,1139,1306,2176,2193,2252,2284,2329,2375,2406,2421,2448,2505,3355],"E).":[579,790,1015],"challenge":[581,621,1611],"elicited":[583],"eosinophilic":[584,684,1790],"inflammation":[585,607,1051,1270,1496,2907],"bronchoalveolar":[588],"(BAL)":[589],"compartment,":[590],"F).":[602,807,1046],"neutrophilic":[606,673,1050,1178,1727],"G).":[619],"did":[622,765,1289,3339],"alter":[625],"levels,":[628],"combination":[631,1153,1630],"expression":[641,660,747,785,797,864,3436,3443],"H).":[647,1119],"assess":[649],"translational":[651],"relevance":[652],"findings,":[655],"examined":[657],"bronchial":[662,803],"biopsies":[663,804,1880],"obtained":[664,1883,2315],"from":[665,816,1767,1884,2316,2677,2710,2717,2848,2872,3048,3099,3110,3184,3246,3308],"adults":[666],"grouped":[669,1681],"phenotypes:":[672],"(NA)":[675],"nonneutrophilic":[677],"(non-NA;":[679],"consisting":[680],"paucigranulocytic":[682,1809],"asthma,":[685,772],"summarized":[687],"Table":[689,1676],"E1":[690],"NA":[698,719,736,1772],"had":[699,2009],"poor":[700],"control":[701,920,2002,2164,2395,2433,3366],"their":[703,1509,2133],"symptoms":[705],"based":[706],"Control":[709,1663,1966,1976],"Questionnaire":[710,1664],"scores":[711],"(median":[717],"FEV1%,":[718,1661],"72%":[720],"vs":[721],"non-NA":[722,739],"85%;":[723],"P":[724,880,901,3296],"<":[725,881],".04).":[726],"CSF3R":[729,863,939,1236,1288,1313,1446,1486,3338,3435,3449],"higher":[734,783],"compared":[737,874],"1,":[741,761,787,806],"B),":[744],"positively":[749,799],"BAL":[752,779,966,1672,1690,1802,1834,2541,2548,2607,3207,3227,3389],"numbers":[754,968,997],"across":[755],"entire":[757],"cohort":[759,1991,3311],"C).":[762,994],"Atopy":[763],"status":[764],"affect":[767,3341],"rather":[774,1295],"presence":[775,1667,1829],"cultures":[780,1670],"resulted":[781,3183],"D":[788,1013],"addition,":[792],"asthmatic":[802,1995],"We":[808,935,1080,1499,1978],"analyzed":[810,1979,2966,2977,3057,3098,3272,3453],"transcriptomic":[812],"sputum":[813,2059,2092,3451],"data":[814,3269,3307],"set":[815],"U-BIOPRED":[818,1984,1990,2041,3439,3469],"cohort,6Rossios":[819],"C.":[820,828,2895],"Pavlidis":[821,2069],"Hoda":[823],"U.":[824],"Kuo":[825,2065],"C.H.":[826],"Wiegman":[827],"Russell":[829],"al.Sputum":[832],"transcriptomics":[833,1987,2060,2093],"reveal":[834],"upregulation":[835],"IL-1":[837],"family":[839],"members":[840],"patients":[842,1382,1679,1860],"asthma.J":[845],"Allergy":[846],"Clin":[847,1391],"Immunol.":[848,1275],"2018;":[849,1393],"141:":[850],"560-570Abstract":[851],"(120)":[859],"where":[862,1757],"those":[870,929,3458],"healthy":[876,919,2001,3464],"volunteers":[877],"(1.9-fold":[878],"increase,":[879,900],".005;":[882],"see":[883],"E3":[885],"(1.2-fold":[899],"=":[902,1774,1793,1812,1905,1908,1911,1914,1997,2005,3398],".09),":[903],"33":[904],"84":[906],"(39%)":[907],"high":[909,2932],"(defined":[912],"above":[914],"95th":[916],"percentile":[917],"distribution),":[921],"confirming":[922],"subset":[927,1981],"who":[932],"CSF3high.":[934],"next":[936],"therapeutically":[937],"targeted":[938,1483],"administering":[942],"an":[943,1158,3210],"anti-CSF3R":[944,3361],"mAb":[945],"(\u03b1-CSF3R)":[946,2391,3363],"E2,":[953,1078],"\u03b1-CSF3R":[962,1009,1042,1074,1084,1112,1135],"administration":[963],"reduced":[965,1007,1038,1086,1110,1297],"2,":[970,991,1012,1045,1094,1118,1144],"A)":[971],"markers":[973,2878],"NETosis":[975],"elastase":[978,3202],"activity":[979,1018,1455,3203],"double-stranded":[981,3223,3235],"DNA":[982,2683,3224,3236],"allergen":[989,1156],"B":[992],"Lung":[995],"determined":[998,1836,2552,2800,3396],"flow":[1000,2972],"cytometry":[1001],"(Ly6G+,":[1002],"Siglec":[1003,2858,2882,2942],"F\u2212)":[1004],"treatment":[1010,1043,1075,1085,1113,2371,2446],"Total":[1016],"peroxidase":[1017,1454],"tissue":[1022,2599,2611,2672,2689,2720,3054,3120,3394],"markedly":[1025,1175],"HDM,":[1032],"50%":[1040,1116],"Because":[1047,1401],"inhibition":[1048,1484],"may":[1052],"compromise":[1053],"clearance,":[1055],"evaluated":[1058],"load":[1060,3383],"nasopharynx,":[1063,3387],"BAL,":[1064,1770],"tissue,":[1067],"B-D).":[1079],"assessed":[1082,1637,2364,2439,2530],"G,":[1095],"representative":[1096],"images).":[1097],"Elevated":[1098],"production":[1100,1322,1481],"observed":[1101],"approximately":[1115,2377,2450],"excessive":[1122,1298],"obstructing":[1124],"airways,":[1126,1173],"methacholine-induced":[1127],"hyperreactivity":[1129],"(Rn)":[1130],"completely":[1132,1291],"reversed":[1133],"therapy":[1136,1634],"I).":[1145],"demonstrate":[1150],"cooperate":[1162],"induce":[1164],"dispersion":[1166],"CSF3-dependent":[1177],"inflammation.":[1179],"cooperates":[1181],"number":[1184],"factors":[1186],"IL-6,":[1188],"IL-3,":[1189],"granulocyte-macrophage":[1190],"(GM-CSF),":[1193],"reactive":[1195],"oxygen":[1196],"species":[1197],"(ROS)":[1198],"stimulate":[1200],"bone":[1205],"marrow":[1206],"restore":[1208],"homeostasis":[1210],"infection.":[1212],"promotes":[1215,1320,2571],"trafficking":[1217,1238,1267,1300],"modulating":[1219],"chemokine":[1220],"adhesion":[1222],"receptors":[1223],"(CXCR2":[1224],"CD62L)":[1226],"neutrophils,":[1228,1293],"murine":[1232],"arthritis":[1233],"model,":[1234],"blocking":[1235,1287,1312],"prevented":[1237],"arthritic":[1241],"joint":[1242,1269],"without":[1243,1307,2256],"inducing":[1244],"peripheral":[1245],"neutropenia.7Campbell":[1246],"I.K.":[1247],"Leong":[1248],"Edwards":[1250],"K.M.":[1251],"Rayzman":[1252],"V.":[1253],"Ng":[1254],"Goldberg":[1256],"G.L.":[1257],"al.Therapeutic":[1259],"targeting":[1260],"G-CSF":[1263],"reduces":[1265,2902],"antibody-mediated":[1272],"arthritis.J":[1274],"197:":[1277],"4392-4402Crossref":[1278],"(58)":[1281],"this,":[1286],"deplete":[1292],"selectively":[1296],"lungs":[1303],"coinfected/HDM-exposed":[1305,2405],"compromising":[1308],"clearance.":[1310],"By":[1311],"signaling,":[1314],"show":[1317],"allergic":[1326],"airways.":[1327],"Mucin":[1328],"overproduction":[1329],"prominent":[1331],"fatal":[1333],"because":[1335],"directly":[1337],"contributes":[1338],"airflow":[1341,1389,1591],"obstruction.":[1342],"Obstruction":[1343],"exacerbated":[1348],"actions":[1351],"eosinophil":[1353],"peroxidase,":[1354],"catalyzes":[1356],"generation":[1358],"oxidants":[1360],"cross-link":[1362],"form":[1365],"hydrogels.8Dunican":[1366],"E.M.":[1367,1420],"Elicker":[1368],"B.M.":[1369,1422],"Gierada":[1370],"D.S.":[1371],"Nagle":[1372],"S.K.":[1373],"Schiebler":[1374],"M.L.":[1375],"Newell":[1376],"J.D.":[1377],"al.Mucus":[1379],"plugs":[1380],"linked":[1385],"eosinophilia":[1387],"obstruction.J":[1390],"Invest.":[1392],"128:":[1394],"997-1009Crossref":[1395],"(242)":[1398],"same":[1403,1886],"pathological":[1404,1453,1495],"process":[1405],"mediated":[1408],"neutrophil-derived":[1410],"myeloperoxidase,9Yuan":[1411],"Hollinger":[1413],"Lachowicz-Scroggins":[1415],"M.E.":[1416],"Kerr":[1417],"S.C.":[1418],"Dunican":[1419],"Daniel":[1421],"al.Oxidation":[1424],"polymer":[1427],"cross-links":[1428],"stiffen":[1430],"gels.Science":[1433],"Transl":[1434],"7:":[1437],"276ra27Crossref":[1438],"(157)":[1441],"identify":[1445,1462],"novel":[1449,1490],"target":[1450],"suppress":[1452],"asthma.":[1458,1478],"summary,":[1460],"effector":[1467],"molecule":[1468],"drives":[1470],"more":[1474],"Antagonising":[1479],"through":[1482],"represents":[1488],"strategy":[1491],"prevent":[1493],"remodeling.":[1498],"thank":[1500],"Dr":[1501],"Jonathan":[1502],"Mr":[1505],"Ivan":[1506],"Bernardo":[1507],"technical":[1510],"assistance":[1511],"experimental":[1515,2190,3248],"protocols.":[1516],"All":[1517,1530,1613,1699,2361,2436,2781,2946,3268],"human":[1518],"procedures":[1519,1532],"approved":[1521,1534],"University":[1524,1542,1547],"Newcastle":[1526],"Human":[1527],"Ethics":[1528,1538],"Committee.":[1529],"animal":[1531],"Animal":[1537],"Committees":[1539],"Melbourne":[1544],"RMIT":[1546],"complied":[1549],"National":[1552],"Health":[1553],"Medical":[1555],"Research":[1556],"Council":[1557],"Australian":[1558],"Code":[1559],"Practice":[1561],"care":[1564],"use":[1566],"animals":[1568],"scientific":[1570],"purposes":[1571],"(8th":[1572],"edition,":[1573],"2013).":[1574],"Twenty-six":[1575],"participants":[1577,2008],"recruited":[1579],"basis":[1582,1684],"doctor":[1584],"diagnosis":[1585],"variable":[1590],"obstruction,":[1592],"15%":[1595],"greater":[1597,1779,1796],"than":[1598,1619,1780,1797,1816,1821,3298],"200":[1599],"mL":[1600,3125],"change":[1601,1646,2799,3174],"FEV1":[1603,1857],"following":[1604,2243],"bronchodilator":[1605,1633],"hyperresponsiveness":[1608],"mannitol":[1610],"test.":[1612],"subjects":[1614,1700,2003],"nonsmokers":[1616],"less":[1618,1815,1820,3297],"packet-year":[1621],"smoking":[1622],"history.":[1623],"Participants":[1624],"prescribed":[1626],"inhaled":[1627,1631],"corticosteroids":[1628],"corticosteroid/long-acting":[1632],"stable":[1640],"phase":[1641],"disease":[1643],"no":[1645],"medications":[1649],"over":[1650,2358],"previous":[1652],"4":[1653,3011,3062],"weeks.":[1654,2140,2360,2380,2453],"Patient":[1655],"characteristics":[1656,2037],"age,":[1658],"sex,":[1659],"atopy,":[1660],"scores,":[1665],"presented":[1674,3251],"E1.":[1677],"phenotypes":[1687,2088],"defined":[1688,1777],"using":[1689,1888,2014,2091,2460,2673,2692,2721,2776,2875,2952,3031,3044,3105,3196,3232,3273],"differential":[1691,2547],"count":[1693],"cutoff":[1694],"values":[1695,2784],"described":[1697,2020],"below.":[1698],"underwent":[1701],"fiberoptic":[1703],"bronchoscopy":[1704],"accordance":[1706],"standard":[1708,2016,2712],"guidelines.E1Sukkar":[1709],"M.B.":[1710],"Wood":[1711],"L.G.":[1712],"Tooze":[1713],"Simpson":[1715],"J.L.":[1716],"McDonald":[1717],"V.M.":[1718],"Gibson":[1719],"P.G.":[1720],"al.Soluble":[1722],"RAGE":[1723],"deficient":[1725],"COPD.Eur":[1730],"2012;":[1733],"39:":[1734],"721-729Crossref":[1735],"(106)":[1738],"minimize":[1742],"variability,":[1743],"bronchoscope":[1745],"inserted":[1747],"third-":[1750],"fourth-generation":[1752],"subject":[1756],"sterile":[1758,2275,2306],"saline":[1759,2276,2278,2307,2346],"instilled":[1761],"collected.":[1763],"Cytospins":[1764],"prepared":[1766,2731],"recovered":[1769],"(n":[1773,1792,1811,1904,1907,1910,1913,1996,2004,3397],"12)":[1775],"equal":[1782,1799],"65%":[1784,1817],"count,":[1789,1807],"8)":[1794],"3.5%":[1801,1822],"eosinophils":[1803,1823,3113],"6)":[1813],"count.":[1827],"qualitative":[1838],"quantitative":[1840],"microbiology.E2Wilkinson":[1841],"T.M.":[1842],"Donaldson":[1843],"G.C.":[1844],"Johnston":[1845],"S.L.":[1846],"Openshaw":[1847],"P.J.":[1848],"Wedzicha":[1849],"J.A.":[1850],"Respiratory":[1851],"virus,":[1853],"inflammation,":[1855],"decline":[1858],"obstructive":[1863],"pulmonary":[1864],"disease.Am":[1865],"2006;":[1871],"173:":[1872],"871-876Crossref":[1873],"(168)":[1876],"Bronchial":[1879],"then":[1882,2976],"areas":[1887,3097],"biopsy":[1889],"forceps":[1890],"applied":[1891],"under":[1892,2146,2349],"direct":[1893],"vision":[1894],"used":[1897,2187,2431,2665,2706],"RT-quantitative":[1899,2662,2772],"PCR":[1900,2663,2698,2773],"analysis.Table":[1901],"E1Patient":[1902],"characteristicsCharacteristicNA":[1903],"12)Non-NA":[1906],"14)Paucigranuloctyic":[1909],"6)Eosinophilic":[1912],"8)Age":[1915],"(y),":[1916],"median":[1917,3261,3316,3421],"(range)65.5":[1918],"(42-78)55.5":[1919],"(38-57)61":[1920],"(42-76)Sex":[1921],"(M:F)4:84:23:5Atopy,":[1922],"n":[1923,1946],"(%)4":[1924],"12":[1926,1949],"(33)3":[1927],"6":[1929,1952,2379,2452],"(50)7":[1930],"8":[1932,1955,2248],"(88)Median":[1933],"FEV1%":[1934],"(range)72":[1935],"(59-97)84":[1936],"(71-104)86":[1937],"(58-108)Median":[1938],"ACQ":[1939],"(range)2":[1940],"(1-3.3)0.65":[1941],"(0-1.3)2.15":[1942],"(1.1-3.5)+":[1943],"Bacterial":[1944],"culture,":[1945],"(%)8":[1947],"(67)1":[1950],"(17)5":[1953],"(63)%Neutrophil":[1956],"(range)88":[1957],"(67-96)38":[1958],"(1.5-58)26":[1959],"(18-64)%Eosinophils":[1960],"(range)1.1":[1961],"(0.3-2.8)1.4":[1962],"(0.5-3.3)10.5":[1963],"(3.8-47.3)ACQ,":[1964],"Questionnaire.":[1967,1977],"Open":[1968],"table":[1969],"new":[1972],"tab":[1973],"ACQ,":[1974],"baseline":[1986],"data.":[1988],"comprises":[1992],"nonsmoker":[1993],"84)":[1998],"nonasthmatic":[2000],"16).":[2006],"undergone":[2010],"detailed":[2011,2063,3282],"characterization":[2013],"established":[2015],"operating":[2017],"procedures,":[2018],"previously,E3Shaw":[2021],"D.E.":[2022],"Sousa":[2023],"A.R.":[2024],"Fowler":[2025],"S.J.":[2026],"Fleming":[2027],"L.J.":[2028],"Roberts":[2029],"G.":[2030],"Corfield":[2031],"al.Clinical":[2034],"European":[2040],"cohort.Eur":[2045],"46:":[2049],"1308-1321Crossref":[2050],"(355)":[2053],"details":[2057],"methodology":[2061],"al.E4Kuo":[2067],"C.S.":[2068],"Loza":[2071],"Baribaud":[2073],"Rowe":[2075],"Pandis":[2077],"I.":[2078],"al.T-helper":[2080],"type":[2082],"2":[2083,2265],"(Th2)":[2084],"non-Th2":[2086],"U-BIOPRED.Eur":[2095],"2017;":[2098,2918],"49":[2099],"(pii:":[2100],"1602135.":[2101],"https://doi.org/10.1183/13993003.02135-2016)Crossref":[2102],"(232)":[2104],"Advanced":[2107],"pregnant":[2108],"BALB/c":[2109,2250],"dams":[2110,2129],"(Animal":[2111],"Resources":[2112],"Centre,":[2113],"Western":[2114],"Australia,":[2115],"Australia)":[2116,2401],"housed":[2118,2131,2143],"separately":[2119],"monitored":[2121],"birth":[2123],"minimal":[2125],"disruption.":[2126],"Upon":[2127],"birth,":[2128],"litters":[2134],"until":[2135],"weaning":[2136],"3":[2139,2273,2304,2359],"Mice":[2141],"22\u00b0C":[2145],"normal":[2147,2159,3258],"12-hour:":[2148],"12-hour":[2149],"light:":[2150],"dark":[2151],"cycle,":[2152],"given":[2154],"free":[2155],"access":[2156],"diet":[2160],"water.":[2162],"potential":[2166],"variability":[2167],"sex":[2170],"litter":[2172,2179],"size,":[2173],"female":[2175,2328],"born":[2177],"sizes":[2180],"7":[2184],"pups":[2185],"protocol.":[2191],"infected":[2195],"and/or":[2199],"describedE5FitzPatrick":[2205],"(4)":[2238,2501,2659],"minor":[2244],"modifications.":[2245],"At":[2246,2280,2321],"days,":[2249,2283,2326],"inoculated":[2254,2286],"intranasally":[2255,2332],"anesthesia":[2257,2351],"(serotype":[2261],"19F":[2262],"strain":[2263],"EF3030,":[2264],"\u00d7":[2266],"103":[2267],"CFU)":[2268],"volume":[2271,2302],"\u03bcL":[2274,2305,2340,2345,3147,3154],"alone.":[2279],"15":[2282],"intranasal":[2289],"route":[2290],"(strain":[2295],"HKx31,":[2296],"H3N2,":[2297],"500":[2298],"PFU)":[2299],"vehicle.":[2309],"extract":[2311,2752,2825],"(Dermatophagoides":[2312],"pteronyssinus)":[2313],"Greer":[2317],"Laboratories":[2318],"(Charlotte,":[2319],"NC).":[2320],"20":[2323],"21":[2325],"weaned":[2327],"sensitized":[2331],"(10":[2336,2344],"\u03bcg":[2337,2386,3360],"10":[2339,3141,3146],"saline)":[2341],"vehicle":[2343],"alone,":[2347],"VEH)":[2348,2373],"isoflurane":[2350],"consecutive":[2354],"days":[2355],"per":[2356,2701,2725,3064,3090,3400],"week":[2357,2416,3351],"outcomes":[2362,2437],"24":[2365,2440],"hours":[2366,2441,3376],"final":[2369,2444,3378],"(or":[2372],"when":[2374,2447],"aged":[2378,2451],"separate":[2383],"experiment,":[2384],"100":[2385,2539,3359],"anti\u2013colony-stimulating":[2388],"antibody":[2392,2396,3362,3367],"isotype":[2394,3365],"(CSL":[2397],"Limited,":[2398],"Parkville,":[2399],"Victoria,":[2400],"administered":[2403],"via":[2407],"intraperitoneal":[2408,3370],"injection":[2409,3371],"every":[2410,3372],"second":[2411,3373],"day":[2412],"last":[2415,3350],"sensitization.":[2419],"Uninfected":[2420],"received":[2423],"VEH":[2424],"(saline":[2434],"alone).":[2435],"HDM/antibody":[2445,3379],"vivo":[2455,2526],"reactivity":[2457],"measured":[2459,3195,3205,3231],"Flexivent":[2461],"(SCIREQ,":[2462],"Montreal,":[2463],"Quebec,":[2464],"Canada)":[2465],"published.E5FitzPatrick":[2468],"Briefly,":[2504,2681,3075],"anesthetized":[2507],"ketamine":[2509],"(125":[2510],"mg/kg)":[2511,2515],"xylazine":[2513],"(25":[2514],"before":[2516,2964],"tracheotomy":[2517],"performed":[2519,2543,2775,2867,3043],"cannula":[2522],"inserted.":[2524],"responsiveness":[2528],"nebulized":[2534],"PBS":[2535],"methacholine":[2537],"(MCh,":[2538],"mg/mL).":[2540],"counts":[2550],"published.E6Anthony":[2555],"Seow":[2557,2742,2815],"H.J.":[2558,2743,2816],"Uddin":[2559],"Thompson":[2561],"Dousha":[2563],"Vlahos":[2565,2736,2809],"R.":[2566,2737,2810],"al.Serum":[2568]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-10-26T00:00:00"}
