{"id":"https://openalex.org/W2895839418","doi":"https://doi.org/10.1093/annonc/mdy289.001","title":"Intratumoral (IT) Injection of the TLR9 agonist tilsotolimod (IMO-2125) in combination with ipilimumab (ipi) triggers durable responses in PD-1 inhibitor refractory metastatic melanoma (rMM): Results from a multicenter, phase I/II study","display_name":"Intratumoral (IT) Injection of the TLR9 agonist tilsotolimod (IMO-2125) in combination with ipilimumab (ipi) triggers durable responses in PD-1 inhibitor refractory metastatic melanoma (rMM): Results from a multicenter, phase I/II study","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2895839418","doi":"https://doi.org/10.1093/annonc/mdy289.001","mag":"2895839418"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdy289.001","doi":"https://doi.org/10.1093/annonc/mdy289.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy289.001","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/annonc/mdy289.001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030834372","display_name":"Adi K. Diab","orcid":"https://orcid.org/0009-0000-8944-1547","observed_orcids":["https://orcid.org/0009-0000-8944-1547","https://orcid.org/0000-0002-0153-0244"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Diab","raw_affiliation_strings":["Melanoma, MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050132330","display_name":"Cara Haymaker","orcid":"https://orcid.org/0000-0002-1317-9287","observed_orcids":["https://orcid.org/0000-0002-1317-9287"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Haymaker","raw_affiliation_strings":["Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051328429","display_name":"Chantale Bernatchez","orcid":"https://orcid.org/0000-0001-5926-3460","observed_orcids":["https://orcid.org/0000-0001-5926-3460"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Bernatchez","raw_affiliation_strings":["Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032181259","display_name":"Robert H.I. Andtbacka","orcid":"https://orcid.org/0000-0002-4182-1126","observed_orcids":["https://orcid.org/0000-0002-4182-1126"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.H.I. Andtbacka","raw_affiliation_strings":["Surgical Oncology, Huntsman Cancer Institute, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology, Huntsman Cancer Institute, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084480627","display_name":"Montaser F. Shaheen","orcid":"https://orcid.org/0009-0006-1542-2267","observed_orcids":["https://orcid.org/0009-0006-1542-2267"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Shaheen","raw_affiliation_strings":["Medicine, University of Arizona Cancer Center North, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Arizona Cancer Center North, Tucson, AZ, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025067315","display_name":"Douglas Buckner Johnson","orcid":"https://orcid.org/0000-0002-6390-773X","observed_orcids":["https://orcid.org/0000-0002-6390-773X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Johnson","raw_affiliation_strings":["Medical Oncology, Vanderbilt University, Nashville, TN, USA","Melanoma, MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Melanoma, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044766130","display_name":"Joseph Markowitz","orcid":"https://orcid.org/0000-0003-2490-5464","observed_orcids":["https://orcid.org/0000-0003-2490-5464"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Markowitz","raw_affiliation_strings":["Medical Oncology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049243227","display_name":"Igor J. Puzanov","orcid":"https://orcid.org/0000-0002-9803-3497","observed_orcids":["https://orcid.org/0000-0002-9803-3497"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Puzanov","raw_affiliation_strings":["Melanoma, Roswell Park Cancer Center, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma, Roswell Park Cancer Center, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034845901","display_name":"Ravi Murthy","orcid":"https://orcid.org/0000-0003-1395-3890","observed_orcids":["https://orcid.org/0000-0003-1395-3890"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Murthy","raw_affiliation_strings":["Interventional Radiology, MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Radiology, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101799590","display_name":"Daniel Hartman Johnson","orcid":"https://orcid.org/0000-0002-4778-686X","observed_orcids":["https://orcid.org/0000-0002-4778-686X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.H. Johnson","raw_affiliation_strings":["Medical Oncology, Vanderbilt University, Nashville, TN, USA","Melanoma, MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Melanoma, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112326932","display_name":"Marihella L. James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. James","raw_affiliation_strings":["Melanoma, MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088479580","display_name":"S. Chunduru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142714","display_name":"Idera Pharmaceuticals (United States)","ror":"https://ror.org/03zts9g74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Chunduru","raw_affiliation_strings":["Translational Biology, Idera Pharmaceuticals, Exton, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Biology, Idera Pharmaceuticals, Exton, PA, USA","institution_ids":["https://openalex.org/I4210142714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080068791","display_name":"James Geib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142714","display_name":"Idera Pharmaceuticals (United States)","ror":"https://ror.org/03zts9g74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Geib","raw_affiliation_strings":["Oncology Clinical Development, Idera Pharmaceuticals, Exton, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Clinical Development, Idera Pharmaceuticals, Exton, PA, USA","institution_ids":["https://openalex.org/I4210142714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109404831","display_name":"Suzanne Swann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142714","display_name":"Idera Pharmaceuticals (United States)","ror":"https://ror.org/03zts9g74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Swann","raw_affiliation_strings":["Biometrics, Idera Pharmaceuticals, Exton, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biometrics, Idera Pharmaceuticals, Exton, PA, USA","institution_ids":["https://openalex.org/I4210142714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045117751","display_name":"Sana Rahimian","orcid":"https://orcid.org/0009-0003-4663-0446","observed_orcids":["https://orcid.org/0009-0003-4663-0446"]},"institutions":[{"id":"https://openalex.org/I4210142714","display_name":"Idera Pharmaceuticals (United States)","ror":"https://ror.org/03zts9g74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Rahimian","raw_affiliation_strings":["Oncology, Idera Pharmaceuticals, Exton, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Idera Pharmaceuticals, Exton, PA, USA","institution_ids":["https://openalex.org/I4210142714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033798832","display_name":"Patrick Hwu","orcid":"https://orcid.org/0000-0002-8293-1313","observed_orcids":["https://orcid.org/0000-0002-8293-1313","https://orcid.org/0000-0003-0554-2856"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Hwu","raw_affiliation_strings":["Melanoma, MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":{"value":5080,"currency":"USD","value_usd":5080},"fwci":1.0433,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.78395672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":null,"first_page":"viii442","last_page":"viii442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr9-agonist","display_name":"TLR9 agonist","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.906000018119812},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oligonucleotides","display_name":"oligonucleotides","score":0.628000020980835},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.6669999957084656},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9470000267028809},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6349999904632568},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6759999990463257},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.875},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9264945387840271},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.6464686989784241},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49834775924682617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4980795383453369},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4778444468975067},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4396117925643921},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4205940365791321},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.416655957698822},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36085739731788635},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2968091070652008},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2923523783683777},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.24858230352401733},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1873529851436615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16237899661064148},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.12273454666137695}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/annonc/mdy289.001","doi":"https://doi.org/10.1093/annonc/mdy289.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy289.001","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdy289.001","doi":"https://doi.org/10.1093/annonc/mdy289.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy289.001","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3089083840","https://openalex.org/W2891275440","https://openalex.org/W3134949487","https://openalex.org/W2898234770","https://openalex.org/W4399452838","https://openalex.org/W4408179056","https://openalex.org/W7083166301","https://openalex.org/W4236111260","https://openalex.org/W2978739732","https://openalex.org/W2947599368"],"abstract_inverted_index":{"Background:":[0],"Subsequent":[1],"treatment":[2],"with":[3],"ipi":[4],"offers":[5],"10-13%":[6],"ORR":[7],"(Bowyer":[8],"2016,":[9],"Long":[10],"2016)":[11],"in":[12,40,51],"aPD1":[13],"refractory":[14],"MM.":[15],"Tilsotolimod,":[16],"a":[17],"synthetic":[18],"TLR9":[19],"agonist":[20],"oligonucleotide,":[21],"acts":[22],"on":[23],"macrophages":[24],"and":[25,44,49,53],"dendritic":[26],"cells":[27],"to":[28],"alter":[29],"the":[30],"tumor":[31],"microenvironment.":[32],"Local":[33],"drug-induced":[34],"type":[35],"1":[36],"interferon":[37],"response":[38],"results":[39],"increased":[41],"antigen":[42],"presentation":[43],"downstream":[45],"T":[46],"cell":[47],"activation":[48],"proliferation":[50],"injected":[52],"non-injected":[54],"lesions":[55],"(Haymaker,":[56],"SITC":[57],"2017).":[58]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-10-26T00:00:00"}
