{"id":"https://openalex.org/W2895836456","doi":"https://doi.org/10.1371/journal.pone.0205449","title":"Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial\u2013mesenchymal transition in human colon cancer cells","display_name":"Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial\u2013mesenchymal transition in human colon cancer cells","publication_year":2018,"publication_date":"2018-10-11","ids":{"openalex":"https://openalex.org/W2895836456","doi":"https://doi.org/10.1371/journal.pone.0205449","mag":"2895836456","pmid":"https://pubmed.ncbi.nlm.nih.gov/30308035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6181375"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0205449","doi":"https://doi.org/10.1371/journal.pone.0205449","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0205449","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0205449&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0205449&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048041099","display_name":"Sanghee Kang","orcid":"https://orcid.org/0000-0002-6097-8831","observed_orcids":["https://orcid.org/0000-0002-6097-8831"]},"institutions":[{"id":"https://openalex.org/I4405258752","display_name":"Korea University Guro Hospital","ror":"https://ror.org/0154bb690","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405258752"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sanghee Kang","raw_affiliation_strings":["Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-6097-8831","affiliations":[{"raw_affiliation_string":"Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405258752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110511934","display_name":"Bo Ram Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258752","display_name":"Korea University Guro Hospital","ror":"https://ror.org/0154bb690","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405258752"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bo Ram Kim","raw_affiliation_strings":["Department of Oncology, Korea University Guro Hospital, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Korea University Guro Hospital, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405258752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003029657","display_name":"Myoung Hee Kang","orcid":"https://orcid.org/0000-0002-0182-9721","observed_orcids":["https://orcid.org/0000-0002-0182-9721"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myoung-Hee Kang","raw_affiliation_strings":["ASAN Medical Center, Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ASAN Medical Center, Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615207","display_name":"Dae Young Kim","orcid":"https://orcid.org/0000-0002-6337-7505","observed_orcids":["https://orcid.org/0000-0002-6337-7505"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Young Kim","raw_affiliation_strings":["Graduate School of Medicine, Korea University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine, Korea University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436304","display_name":"Dae-Hee Lee","orcid":"https://orcid.org/0000-0002-8960-1632","observed_orcids":["https://orcid.org/0000-0002-8960-1632"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4405258752","display_name":"Korea University Guro Hospital","ror":"https://ror.org/0154bb690","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405258752"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Hee Lee","raw_affiliation_strings":["Department of Oncology, Korea University Guro Hospital, Seoul, Republic of Korea","Graduate School of Medicine, Korea University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Korea University Guro Hospital, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405258752"]},{"raw_affiliation_string":"Graduate School of Medicine, Korea University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074290142","display_name":"Sang Cheul Oh","orcid":"https://orcid.org/0000-0002-0527-6001","observed_orcids":["https://orcid.org/0000-0002-0527-6001"]},"institutions":[{"id":"https://openalex.org/I4405258752","display_name":"Korea University Guro Hospital","ror":"https://ror.org/0154bb690","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405258752"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Cheul Oh","raw_affiliation_strings":["Department of Oncology, Korea University Guro Hospital, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Korea University Guro Hospital, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405258752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065059021","display_name":"Byung Wook Min","orcid":"https://orcid.org/0000-0002-3621-5113","observed_orcids":["https://orcid.org/0000-0002-3621-5113"]},"institutions":[{"id":"https://openalex.org/I4405258752","display_name":"Korea University Guro Hospital","ror":"https://ror.org/0154bb690","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405258752"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung Wook Min","raw_affiliation_strings":["Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405258752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008353375","display_name":"Jun Won Um","orcid":"https://orcid.org/0000-0002-0506-0235","observed_orcids":["https://orcid.org/0000-0002-0506-0235"]},"institutions":[{"id":"https://openalex.org/I4405261856","display_name":"Korea University Ansan Hospital","ror":"https://ror.org/05yp5js06","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405261856"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jun Won Um","raw_affiliation_strings":["Department of Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4405261856"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008353375"],"corresponding_institution_ids":["https://openalex.org/I4405261856"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.1706,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.7642481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"10","first_page":"e0205449","last_page":"e0205449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8809999823570251},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9049999713897705},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.6359999775886536},{"id":"https://openalex.org/keywords/patient-survival-prediction","display_name":"patient survival prediction","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9506956338882446},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.8250879049301147},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6673964858055115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5643796324729919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5182301998138428},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5048943161964417},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43166327476501465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.359550803899765},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.29622820019721985},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.11924266815185547}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0205449","doi":"https://doi.org/10.1371/journal.pone.0205449","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0205449","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0205449&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5144806","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6181375","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30308035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30308035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6181375","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6181375/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4b93cc70bb084faaaffff2b060a6442c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4b93cc70bb084faaaffff2b060a6442c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 13, Iss 10, p e0205449 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7198322","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Anti-metastatic_effect_of_metformin_via_repression_of_interleukin_6-induced_epithelial_mesenchymal_transition_in_human_colon_cancer_cells/7198322","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0205449","doi":"https://doi.org/10.1371/journal.pone.0205449","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0205449","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0205449&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G260252922","display_name":null,"funder_award_id":"K0716521","funder_id":"https://openalex.org/F4320321373","funder_display_name":"Korea University"},{"id":"https://openalex.org/G6848113106","display_name":null,"funder_award_id":"NRF-2018R1C1B6007721","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321373","display_name":"Korea University","ror":"https://ror.org/047dqcg40"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895836456.pdf","grobid_xml":"https://content.openalex.org/works/W2895836456.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W38715709","https://openalex.org/W1934094702","https://openalex.org/W1999676174","https://openalex.org/W2000999630","https://openalex.org/W2005903558","https://openalex.org/W2007043238","https://openalex.org/W2007841824","https://openalex.org/W2008528559","https://openalex.org/W2011735982","https://openalex.org/W2020947105","https://openalex.org/W2022200777","https://openalex.org/W2025130292","https://openalex.org/W2026967508","https://openalex.org/W2030797581","https://openalex.org/W2039152216","https://openalex.org/W2043376395","https://openalex.org/W2049897824","https://openalex.org/W2051171548","https://openalex.org/W2053271495","https://openalex.org/W2064656431","https://openalex.org/W2072301671","https://openalex.org/W2078190084","https://openalex.org/W2081540191","https://openalex.org/W2088122814","https://openalex.org/W2093664485","https://openalex.org/W2102194474","https://openalex.org/W2103299694","https://openalex.org/W2104195235","https://openalex.org/W2105269215","https://openalex.org/W2106318432","https://openalex.org/W2130410032","https://openalex.org/W2142127071","https://openalex.org/W2143066955","https://openalex.org/W2166467985","https://openalex.org/W2168630917","https://openalex.org/W2171232394","https://openalex.org/W2299967230","https://openalex.org/W2413609923","https://openalex.org/W4211199921","https://openalex.org/W4233007762"],"related_works":["https://openalex.org/W4283781941","https://openalex.org/W2271575042","https://openalex.org/W2904553013","https://openalex.org/W2560276348","https://openalex.org/W2770576752","https://openalex.org/W3124511465","https://openalex.org/W2557418534","https://openalex.org/W3202828476","https://openalex.org/W3130119312","https://openalex.org/W2039152216"],"abstract_inverted_index":{"Metformin,":[0],"a":[1,19,106],"first-line":[2],"drug":[3],"used":[4],"to":[5,14,34,56,101,111],"treat":[6],"type":[7],"2":[8],"diabetes,":[9],"has":[10],"also":[11],"been":[12],"shown":[13],"have":[15],"anticancer":[16],"effects":[17,43,169],"against":[18],"variety":[20],"of":[21,28,44,52,61,80,179,187],"malignancies,":[22],"including":[23],"colorectal":[24,64],"cancer.":[25],"Although":[26],"inhibition":[27],"the":[29,36,41,58,72,77,97,103,130],"mTOR":[30],"pathway":[31,126,139],"is":[32,183],"known":[33],"be":[35],"most":[37],"important":[38],"mechanism":[39,60,73,186],"for":[40,89],"antitumor":[42,59,185],"metformin,":[45],"other":[46],"mechanisms":[47],"remain":[48],"unclear.":[49],"The":[50],"purpose":[51],"this":[53],"study":[54],"was":[55,87,133],"identify":[57],"metformin":[62],"in":[63,113,152],"cancer":[65,83,145,154],"using":[66,91],"high-throughput":[67],"data,":[68],"and":[69,122,143,164],"then":[70],"test":[71],"experimentally.":[74],"We":[75,148],"identified":[76],"gene":[78,107],"signature":[79,86],"metformin-treated":[81,114],"colon":[82,92,144,153],"cells.":[84,115],"This":[85,116],"processed":[88],"prediction":[90],"adenocarcinoma":[93],"patient":[94,117],"data":[95],"from":[96],"Cancer":[98],"Genome":[99],"Atlas":[100],"classify":[102],"patients":[104],"showing":[105],"expression":[108],"pattern":[109],"similar":[110],"that":[112,129,177],"group":[118,132],"showed":[119],"better":[120],"overall":[121],"disease-free":[123],"survival.":[124],"Furthermore,":[125],"analysis":[127],"revealed":[128],"metformin-predicted":[131],"characterized":[134],"by":[135,172],"decreased":[136],"interleukin":[137],"(IL)-6":[138],"signaling,":[140],"epithelial-mesenchymal":[141,150,181],"transition,":[142],"metastatic":[146],"signaling.":[147],"induced":[149],"transition":[151,182],"cell":[155,162],"lines":[156],"via":[157],"IL-6":[158],"treatment,":[159],"which":[160],"increased":[161],"motility":[163],"promoted":[165],"invasion.":[166],"However,":[167],"these":[168],"were":[170],"blocked":[171],"metformin.":[173,188],"These":[174],"findings":[175],"suggest":[176],"blockade":[178],"IL-6-induced":[180],"an":[184]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-10-26T00:00:00"}