{"id":"https://openalex.org/W2895820020","doi":null,"title":"GENETIC EVOLUTION AND PROGNOSTIC DETERMINANTS OF PANCREATIC CANCER ON LONGITUDINAL LIQUID BIOPSIES","display_name":"GENETIC EVOLUTION AND PROGNOSTIC DETERMINANTS OF PANCREATIC CANCER ON LONGITUDINAL LIQUID BIOPSIES","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2895820020","mag":"2895820020"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1946","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/899","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1946&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1946&context=utgsbs_dissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082179566","display_name":"Vincent Bernard","orcid":"https://orcid.org/0000-0003-1555-608X","observed_orcids":["https://orcid.org/0000-0003-1555-608X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vincent Bernard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082179566"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.27390000224113464,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9810000061988831},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.7950000166893005},{"id":"https://openalex.org/keywords/dna-barcoding","display_name":"DNA barcoding","score":0.8840000033378601},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/disease-progression-prediction","display_name":"disease progression prediction","score":0.6240000128746033},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.949999988079071},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.796999990940094},{"id":"https://openalex.org/keywords/longitudinal-tumor-monitoring","display_name":"longitudinal tumor monitoring","score":0.5230000019073486},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6990716457366943},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.5575962066650391},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4730861783027649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4345041811466217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37954413890838623},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3531810939311981}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1946","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/899","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1946&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:2895820020","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/899/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1946","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/899","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1946&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895820020.pdf","grobid_xml":"https://content.openalex.org/works/W2895820020.grobid-xml"},"referenced_works_count":168,"referenced_works":["https://openalex.org/W117895612","https://openalex.org/W301388723","https://openalex.org/W604736615","https://openalex.org/W838548246","https://openalex.org/W1500925570","https://openalex.org/W1527347967","https://openalex.org/W1533942137","https://openalex.org/W1534453667","https://openalex.org/W1535707905","https://openalex.org/W1541217688","https://openalex.org/W1563800735","https://openalex.org/W1565005755","https://openalex.org/W1593424453","https://openalex.org/W1601681275","https://openalex.org/W1762620449","https://openalex.org/W1785779992","https://openalex.org/W1847306764","https://openalex.org/W1864344361","https://openalex.org/W1940268157","https://openalex.org/W1963774361","https://openalex.org/W1964064067","https://openalex.org/W1966790902","https://openalex.org/W1967489571","https://openalex.org/W1968657935","https://openalex.org/W1968812902","https://openalex.org/W1969002010","https://openalex.org/W1969607893","https://openalex.org/W1970845320","https://openalex.org/W1973268287","https://openalex.org/W1973740519","https://openalex.org/W1975616447","https://openalex.org/W1980125751","https://openalex.org/W1980520251","https://openalex.org/W1981820123","https://openalex.org/W1983466841","https://openalex.org/W1983970047","https://openalex.org/W1991881518","https://openalex.org/W1998036846","https://openalex.org/W1998516681","https://openalex.org/W2011458181","https://openalex.org/W2012366039","https://openalex.org/W2013970540","https://openalex.org/W2014882257","https://openalex.org/W2018535250","https://openalex.org/W2020480128","https://openalex.org/W2021341670","https://openalex.org/W2021472146","https://openalex.org/W2022805251","https://openalex.org/W2027735722","https://openalex.org/W2029475032","https://openalex.org/W2029916187","https://openalex.org/W2030701238","https://openalex.org/W2032003837","https://openalex.org/W2033406275","https://openalex.org/W2034702779","https://openalex.org/W2034886137","https://openalex.org/W2036217528","https://openalex.org/W2037038224","https://openalex.org/W2044211072","https://openalex.org/W2044548139","https://openalex.org/W2045519549","https://openalex.org/W2046577405","https://openalex.org/W2048888260","https://openalex.org/W2050164769","https://openalex.org/W2054932475","https://openalex.org/W2059924533","https://openalex.org/W2061772840","https://openalex.org/W2062109911","https://openalex.org/W2062696188","https://openalex.org/W2066254965","https://openalex.org/W2067826589","https://openalex.org/W2067904749","https://openalex.org/W2069612054","https://openalex.org/W2076470991","https://openalex.org/W2076984763","https://openalex.org/W2080526961","https://openalex.org/W2081943572","https://openalex.org/W2084770914","https://openalex.org/W2085697325","https://openalex.org/W2086072858","https://openalex.org/W2086080480","https://openalex.org/W2088288388","https://openalex.org/W2096837288","https://openalex.org/W2097709883","https://openalex.org/W2099505694","https://openalex.org/W2100801124","https://openalex.org/W2103441770","https://openalex.org/W2104549677","https://openalex.org/W2104641188","https://openalex.org/W2108234281","https://openalex.org/W2109130949","https://openalex.org/W2109564400","https://openalex.org/W2110054105","https://openalex.org/W2111898090","https://openalex.org/W2111976640","https://openalex.org/W2112569907","https://openalex.org/W2113754052","https://openalex.org/W2115093090","https://openalex.org/W2118143563","https://openalex.org/W2118151336","https://openalex.org/W2119180969","https://openalex.org/W2121743948","https://openalex.org/W2123144110","https://openalex.org/W2124887618","https://openalex.org/W2124977765","https://openalex.org/W2128891846","https://openalex.org/W2132014528","https://openalex.org/W2133654949","https://openalex.org/W2134921841","https://openalex.org/W2136601868","https://openalex.org/W2137900362","https://openalex.org/W2138155367","https://openalex.org/W2138532131","https://openalex.org/W2138713106","https://openalex.org/W2139224474","https://openalex.org/W2141663748","https://openalex.org/W2141819495","https://openalex.org/W2146542392","https://openalex.org/W2146973661","https://openalex.org/W2147243980","https://openalex.org/W2148748525","https://openalex.org/W2150400324","https://openalex.org/W2150550712","https://openalex.org/W2152061559","https://openalex.org/W2153011144","https://openalex.org/W2153768374","https://openalex.org/W2154866190","https://openalex.org/W2157826180","https://openalex.org/W2158217645","https://openalex.org/W2159407099","https://openalex.org/W2160982674","https://openalex.org/W2164495087","https://openalex.org/W2165064122","https://openalex.org/W2166178545","https://openalex.org/W2169895148","https://openalex.org/W2171237493","https://openalex.org/W2171892226","https://openalex.org/W2207038926","https://openalex.org/W2263317399","https://openalex.org/W2272204389","https://openalex.org/W2285093314","https://openalex.org/W2324165948","https://openalex.org/W2346990949","https://openalex.org/W2363537531","https://openalex.org/W2397675599","https://openalex.org/W2402712181","https://openalex.org/W2412485289","https://openalex.org/W2460179076","https://openalex.org/W2515067935","https://openalex.org/W2521338131","https://openalex.org/W2523829367","https://openalex.org/W2564452722","https://openalex.org/W2566478217","https://openalex.org/W2566484518","https://openalex.org/W2587366712","https://openalex.org/W2605365281","https://openalex.org/W2607521817","https://openalex.org/W2608738563","https://openalex.org/W2615498501","https://openalex.org/W2619475721","https://openalex.org/W2632058739","https://openalex.org/W2735284619","https://openalex.org/W2751788109","https://openalex.org/W2754606968","https://openalex.org/W2783674487","https://openalex.org/W2794302389","https://openalex.org/W2916922933","https://openalex.org/W3170143802"],"related_works":["https://openalex.org/W3154132826","https://openalex.org/W2908327692","https://openalex.org/W4312473872","https://openalex.org/W4311622258","https://openalex.org/W2948385772","https://openalex.org/W7204078428","https://openalex.org/W4389938226","https://openalex.org/W2886731683","https://openalex.org/W3005960416","https://openalex.org/W4409260289"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1],"adenocarcinoma":[2],"(PDAC)":[3],"has":[4,284],"one":[5],"of":[6,18,49,56,103,117,134,161,177,186,195,217,224,245,269,271,288],"the":[7,63,97,115,132,162,178,246,280],"lowest":[8],"5-year":[9],"survival":[10,302],"rates":[11],"amongst":[12],"solid":[13],"tumors.":[14],"As":[15],"early":[16],"detection":[17,270],"PDAC":[19,50],"is":[20,68,144],"unusual":[21],"and":[22,31,59,107,138,154,170,208,221],"typically":[23],"incidental,":[24],"most":[25],"patients":[26,72,113,289],"present":[27],"with":[28,74,257],"locally":[29],"advanced":[30,111],"metastatic":[32,79],"disease":[33,112,219],"where":[34],"effective":[35],"therapeutic":[36,108,291],"strategies":[37],"remain":[38],"a":[39,83,88,141,174,183,242,294],"significant":[40],"unmet":[41],"need.":[42],"Specifically,":[43],"surrogate":[44,176],"biomarkers":[45],"for":[46,93,99,286],"tumor":[47,66,152,180,197,237],"monitoring":[48],"may":[51,298],"lead":[52,299],"to":[53,125,146,226,234,265,300],"improved":[54],"elucidation":[55],"clinical":[57],"actionability":[58],"prognostic":[60,209],"potential.":[61],"On":[62],"other":[64],"hand,":[65],"tissue":[67],"rarely":[69],"sampled":[70],"in":[71,110,131,201,211,239,274,304],"presenting":[73],"de":[75],"novo":[76],"or":[77,87],"recurrent":[78],"PDAC,":[80],"apart":[81],"from":[82,165,279],"fine":[84],"needle":[85,90],"aspiration":[86],"core":[89],"biopsy":[91],"performed":[92],"diagnosis.":[94],"This":[95],"precludes":[96],"opportunity":[98],"elucidating":[100],"molecular":[101,259],"underpinnings":[102],"cancer":[104,213,248],"recurrence,":[105],"chemoresistance,":[106],"decision-making":[109],"over":[114],"course":[116],"their":[118],"therapy.":[119,228],"For":[120],"this":[121,283],"reason,":[122],"we":[123,262],"aim":[124],"use":[126],"so":[127],"called":[128],"\u201cliquid":[129],"biopsies\u201d":[130],"form":[133],"circulating":[135,155],"nucleic":[136,198],"acids":[137],"exosomes":[139,156],"as":[140,173],"strategy":[142],"that":[143,191,276,297],"amenable":[145],"longitudinal,":[147],"relatively":[148],"non-invasive":[149],"sampling.":[150],"Circulating":[151],"DNA":[153],"contain":[157],"genetic":[158],"cargo":[159],"representative":[160],"neoplastic":[163],"cells":[164],"which":[166],"they":[167],"are":[168,263,277],"released":[169],"can":[171,203],"serve":[172],"reliable":[175],"patient\u2019s":[179],"DNA,":[181],"enabling":[182],"new":[184],"way":[185],"interrogating":[187],"cancers.":[188],"We":[189,229],"demonstrate":[190],"serial":[192],"quantitative":[193],"measurements":[194],"these":[196],"acid":[199],"sources":[200],"circulation":[202,240,275],"provide":[204],"clinically":[205],"relevant":[206],"predictive":[207],"information":[210],"pancreatic":[212,247],"patients,":[214],"including":[215],"anticipation":[216],"impending":[218],"progression":[220],"putative":[222],"mechanisms":[223],"resistance":[225],"ongoing":[227],"also":[230],"describe":[231],"our":[232,267],"ability":[233],"specifically":[235],"capture":[236],"material":[238],"following":[241],"comprehensive":[243],"characterization":[244],"exosomal":[249],"\u201csurfaceome\u201d.":[250],"By":[251],"leveraging":[252],"an":[253],"immune-capture":[254],"approach":[255,296],"paired":[256],"ultrasensitive":[258],"barcoding":[260],"techniques,":[261],"able":[264],"increase":[266],"sensitivity":[268],"rare":[272],"molecules":[273],"derived":[278],"tumor.":[281],"Ultimately,":[282],"implications":[285],"stratification":[287],"into":[290],"\u201cbuckets\u201d":[292],"through":[293],"personalized":[295],"greater":[301],"benefits":[303],"PDAC.":[305]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-10-26T00:00:00"}
