{"id":"https://openalex.org/W2895818291","doi":"https://doi.org/10.1371/journal.pone.0203903","title":"Urinary steroid profiling in women hints at a diagnostic signature of the polycystic ovary syndrome: A pilot study considering neglected steroid metabolites","display_name":"Urinary steroid profiling in women hints at a diagnostic signature of the polycystic ovary syndrome: A pilot study considering neglected steroid metabolites","publication_year":2018,"publication_date":"2018-10-11","ids":{"openalex":"https://openalex.org/W2895818291","doi":"https://doi.org/10.1371/journal.pone.0203903","mag":"2895818291","pmid":"https://pubmed.ncbi.nlm.nih.gov/30308019","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6181287"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0203903","doi":"https://doi.org/10.1371/journal.pone.0203903","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0203903","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0203903&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0203903&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022018506","display_name":"Nasser A. Dhayat","orcid":"https://orcid.org/0000-0001-8310-5921","observed_orcids":["https://orcid.org/0000-0001-8310-5921"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nasser A. Dhayat","raw_affiliation_strings":["Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040710721","display_name":"Nesa Marti","orcid":"https://orcid.org/0000-0002-0482-4280","observed_orcids":["https://orcid.org/0000-0002-0482-4280"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nesa Marti","raw_affiliation_strings":["Pediatric Endocrinology and Diabetology, Department of Pediatrics and Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology and Diabetology, Department of Pediatrics and Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068461476","display_name":"Z. Kollmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Zahraa Kollmann","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064311658","display_name":"Amineh Troendle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137807","display_name":"Lindenhofspital","ror":"https://ror.org/03z4rrt03","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210137807"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Amineh Troendle","raw_affiliation_strings":["Lindenhofspital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lindenhofspital, Bern, Switzerland","institution_ids":["https://openalex.org/I4210137807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017090852","display_name":"Lia Bally","orcid":"https://orcid.org/0000-0003-1993-7672","observed_orcids":["https://orcid.org/0000-0003-1993-7672"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lia Bally","raw_affiliation_strings":["Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054142384","display_name":"Genevi\u00e8ve Escher","orcid":"https://orcid.org/0000-0001-7836-7927","observed_orcids":["https://orcid.org/0000-0001-7836-7927","https://orcid.org/0000-0002-5125-2262"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Genevi\u00e8ve Escher","raw_affiliation_strings":["Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070110597","display_name":"Michael Groessl","orcid":"https://orcid.org/0000-0002-6740-5980","observed_orcids":["https://orcid.org/0000-0002-6740-5980"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael Gr\u00f6ssl","raw_affiliation_strings":["Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079383821","display_name":"Daniel Ackermann","orcid":"https://orcid.org/0000-0003-0550-354X","observed_orcids":["https://orcid.org/0000-0003-0550-354X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Ackermann","raw_affiliation_strings":["Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014249691","display_name":"Bel\u00e9n Ponte","orcid":"https://orcid.org/0000-0003-4730-6050","observed_orcids":["https://orcid.org/0000-0003-4730-6050"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Belen Ponte","raw_affiliation_strings":["Nephrology Service, Department of Specialties of Internal Medicine, University Hospital of Geneva, Gen\u00e8ve, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Department of Specialties of Internal Medicine, University Hospital of Geneva, Gen\u00e8ve, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047558641","display_name":"Menno T Pruijm","orcid":"https://orcid.org/0000-0003-1027-1851","observed_orcids":["https://orcid.org/0000-0003-1027-1851"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Menno Pruijm","raw_affiliation_strings":["Nephrology Service, University Hospital of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, University Hospital of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040998367","display_name":"Michael D. M\u00fcller","orcid":"https://orcid.org/0000-0002-6915-4820","observed_orcids":["https://orcid.org/0000-0002-6915-4820"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael M\u00fcller","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052685330","display_name":"Bruno Vogt","orcid":"https://orcid.org/0000-0002-1548-6387","observed_orcids":["https://orcid.org/0000-0002-1548-6387"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bruno Vogt","raw_affiliation_strings":["Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension and Department of BioMedical Research, Inselspital, University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111975487","display_name":"Martin Birkh\u00e4user","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin H. Birkh\u00e4user","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072307317","display_name":"Murielle Bochud","orcid":"https://orcid.org/0000-0002-5727-0218","observed_orcids":["https://orcid.org/0000-0002-5727-0218"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210135124","display_name":"Institute of Social and Preventive Medicine","ror":"https://ror.org/038esz880","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210135124","https://openalex.org/I4210149340","https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Murielle Bochud","raw_affiliation_strings":["Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210135124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108489142","display_name":"Christa E. Fl\u00fcck","orcid":"https://orcid.org/0000-0002-4568-5504","observed_orcids":["https://orcid.org/0000-0002-4568-5504"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Christa E. Fl\u00fcck","raw_affiliation_strings":["Pediatric Endocrinology and Diabetology, Department of Pediatrics and Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-4568-5504","affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology and Diabetology, Department of Pediatrics and Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"last","author":{"id":null,"display_name":"members of the SKIPOGH Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"members of the SKIPOGH Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5108489142"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.8566,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.95848522,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"10","first_page":"e0203903","last_page":"e0203903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urinary-steroid-profiling","display_name":"urinary steroid profiling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/24-hour-urine-collection","display_name":"24-hour urine collection","score":0.7749999761581421},{"id":"https://openalex.org/keywords/androstanediol","display_name":"androstanediol","score":0.796999990940094},{"id":"https://openalex.org/keywords/estriol","display_name":"estriol","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9869999885559082},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8080000281333923},{"id":"https://openalex.org/keywords/steroid-metabolites","display_name":"steroid metabolites","score":0.515999972820282},{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.7979999780654907},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5019999742507935},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.6399999856948853},{"id":"https://openalex.org/keywords/enzyme-activity-ratio","display_name":"enzyme activity ratio","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.8114269971847534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5559977293014526},{"id":"https://openalex.org/C2777335581","wikidata":"https://www.wikidata.org/wiki/Q409721","display_name":"Estriol","level":3,"score":0.5374963879585266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.525054931640625},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.500316858291626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4969470798969269},{"id":"https://openalex.org/C2776250704","wikidata":"https://www.wikidata.org/wiki/Q906054","display_name":"Pregnanediol","level":3,"score":0.49580177664756775},{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.4611527919769287},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4444953203201294},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.43662649393081665},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.42169833183288574},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.41777801513671875},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.37459540367126465},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3668194115161896},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.34106749296188354},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.15426847338676453},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.10580524802207947}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":13,"locations":[{"id":"doi:10.1371/journal.pone.0203903","doi":"https://doi.org/10.1371/journal.pone.0203903","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0203903","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0203903&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5144732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6181287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30308019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30308019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6181287","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6181287/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:serval.unil.ch:BIB_7E1032F0E418","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_7E1032F0E418","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one, vol. 13, no. 10, pp. e0203903","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:115361","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:115361","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 1932-6203","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unil.ch:iris/219371","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/219371","pdf_url":"https://iris.unil.ch/bitstreams/76cece55-e5e9-42ce-9df6-94210041623d/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:doi:10.7892/boris.119741","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/164146","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:119741","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/119741/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:a3129054edc645e88753762425a14de3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a3129054edc645e88753762425a14de3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 13, Iss 10, p e0203903 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7196564","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Urinary_steroid_profiling_in_women_hints_at_a_diagnostic_signature_of_the_polycystic_ovary_syndrome_A_pilot_study_considering_neglected_steroid_metabolites/7196564","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:unige.ch:unige:115361","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:115361","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1932-6203","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.7892/boris.119741","doi":"https://doi.org/10.7892/boris.119741","is_oa":true,"landing_page_url":"https://doi.org/10.7892/boris.119741","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0203903","doi":"https://doi.org/10.1371/journal.pone.0203903","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0203903","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0203903&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1725499163","display_name":"Towards a better understanding of human androgen biology in health and disease","funder_award_id":"146127","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2934441430","display_name":"Blood pressure and the kidney: interface between genes and environment","funder_award_id":"124087","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3564397083","display_name":null,"funder_award_id":"33CM30","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G880118091","display_name":null,"funder_award_id":"320030","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895818291.pdf","grobid_xml":"https://content.openalex.org/works/W2895818291.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1530628995","https://openalex.org/W1849978496","https://openalex.org/W1974525651","https://openalex.org/W1978197749","https://openalex.org/W1985005329","https://openalex.org/W1986877274","https://openalex.org/W2009171847","https://openalex.org/W2031854978","https://openalex.org/W2035217519","https://openalex.org/W2062389660","https://openalex.org/W2062615129","https://openalex.org/W2066296351","https://openalex.org/W2069450388","https://openalex.org/W2071127270","https://openalex.org/W2094806637","https://openalex.org/W2120973019","https://openalex.org/W2132144622","https://openalex.org/W2136516201","https://openalex.org/W2144746424","https://openalex.org/W2160234571","https://openalex.org/W2164239451","https://openalex.org/W2167416408","https://openalex.org/W2169585002","https://openalex.org/W2271413404","https://openalex.org/W2339769519","https://openalex.org/W2345441248","https://openalex.org/W2489476135","https://openalex.org/W2493373567","https://openalex.org/W2557976244","https://openalex.org/W2558741448","https://openalex.org/W2607031541"],"related_works":["https://openalex.org/W3011221067","https://openalex.org/W2907586097","https://openalex.org/W4403695077","https://openalex.org/W627585918","https://openalex.org/W4391733691","https://openalex.org/W2120760189","https://openalex.org/W4307396902","https://openalex.org/W4400735934","https://openalex.org/W4313181195","https://openalex.org/W2884660952"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"the":[2,8,100,104,153,168,195,257],"polycystic":[3],"ovary":[4],"syndrome":[5],"(PCOS)":[6],"is":[7,26],"most":[9],"common":[10],"endocrine":[11],"disorder":[12],"in":[13,47,53,86,89,149,156,256],"women":[14,48,94,119],"with":[15,49,96,120,158,205,270],"vast":[16],"metabolic":[17],"consequences,":[18],"its":[19,24],"etiology":[20],"remains":[21,303],"unknown":[22],"and":[23,44,50,107,112,131,163,203,234,259,301],"diagnosis":[25,285],"still":[27],"made":[28],"by":[29,286],"exclusion.":[30],"This":[31],"study":[32],"aimed":[33],"at":[34],"characterizing":[35],"a":[36,245,268,308],"large":[37],"number":[38],"of":[39,66,103,118,145,194,273],"urinary":[40,248],"steroid":[41,64,176,183,249,280],"hormone":[42],"metabolites":[43,146,253],"enzyme":[45,281],"activities":[46],"without":[51],"PCOS":[52,97,108,121,191,243,264,284],"order":[54,150],"to":[55,99,124,134,151,189,211,218,225,232,240,278,298,304],"test":[56],"their":[57],"value":[58],"for":[59,127,132,140,167],"diagnosing":[60],"PCOS.":[61,159],"METHODS:":[62],"Comparative":[63],"profiling":[65],"24h":[67,247],"urine":[68,300],"collections":[69],"using":[70],"an":[71],"established":[72],"in-house":[73],"gas-chromatography":[74],"mass":[75],"spectrometry":[76],"method.":[77],"Data":[78],"were":[79,84,92,122,165],"collected":[80],"mostly":[81],"prospectively.":[82],"Patients":[83],"recruited":[85],"university":[87],"hospitals":[88],"Switzerland.":[90],"Participants":[91],"41":[93],"diagnosed":[95],"according":[98],"current":[101],"criteria":[102],"Androgen":[105],"Excess":[106],"Society":[109],"Task":[110],"Force":[111],"66":[113],"healthy":[114,125],"controls.":[115],"Steroid":[116],"profiles":[117],"compared":[123],"controls":[126],"absolute":[128],"metabolite":[129],"excretion":[130],"substrate":[133],"product":[135],"conversion":[136],"ratios.":[137],"The":[138,179,186],"AUC":[139,206],"over":[141],"1.5":[142],"million":[143],"combinations":[144,170],"was":[147,184],"calculated":[148],"maximize":[152],"diagnostic":[154],"accuracy":[155],"patients":[157],"Sensitivity,":[160],"specificity,":[161],"PPV,":[162],"NPV":[164,235],"indicated":[166],"best":[169,180,187],"containing":[171],"2,":[172],"3":[173],"or":[174],"4":[175],"metabolites.":[177],"RESULTS:":[178],"single":[181,279],"discriminating":[182],"androstanediol.":[185],"combination":[188],"diagnose":[190],"contained":[192],"four":[193],"forty":[196],"measured":[197],"metabolites,":[198],"namely":[199],"androstanediol,":[200],"estriol,":[201],"cortisol":[202],"20\u03b2DHcortisone":[204],"0.961":[207],"(95%":[208,215,222,229,237],"CI":[209,216,223,230,238],"0.926":[210],"0.995),":[212],"sensitivity":[213],"90.2%":[214],"76.9":[217],"97.3),":[219],"specificity":[220],"90.8%":[221],"81.0":[224],"96.5),":[226],"PPV":[227],"86.0%":[228],"72.1":[231],"94.7),":[233],"93.7%":[236],"84.5":[239],"98.2).":[241],"CONCLUSION:":[242],"shows":[244],"specific":[246],"profile,":[250],"if":[251],"neglected":[252],"are":[254],"included":[255],"analysis":[258,262],"non-conventional":[260],"data":[261],"applied.":[263],"does":[265],"not":[266],"share":[267],"profile":[269],"hyperandrogenic":[271],"forms":[272],"congenital":[274],"adrenal":[275],"hyperplasias":[276],"due":[277],"deficiencies.":[282],"Thus":[283],"exclusion":[287],"may":[288],"no":[289],"longer":[290],"be":[291,305],"warranted.":[292],"Whether":[293],"these":[294],"findings":[295],"also":[296],"apply":[297],"spot":[299],"serum,":[302],"tested":[306],"as":[307],"next":[309],"step":[310],"towards":[311],"routine":[312],"clinical":[313],"applicability.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-10-26T00:00:00"}
