{"id":"https://openalex.org/W2895813269","doi":"https://doi.org/10.1016/j.jalz.2018.06.1860","title":"P3\u2010496: SEVERE HYPOGLYCEMIA AND COGNITIVE FUNCTIONING IN OLDER ADULTS WITH TYPE 1 DIABETES: THE STUDY OF LONGEVITY IN DIABETES (SOLID)","display_name":"P3\u2010496: SEVERE HYPOGLYCEMIA AND COGNITIVE FUNCTIONING IN OLDER ADULTS WITH TYPE 1 DIABETES: THE STUDY OF LONGEVITY IN DIABETES (SOLID)","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2895813269","doi":"https://doi.org/10.1016/j.jalz.2018.06.1860","mag":"2895813269"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2018.06.1860","doi":"https://doi.org/10.1016/j.jalz.2018.06.1860","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.1860","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079965027","display_name":"MARY ELIZABETH LACY","orcid":"https://orcid.org/0000-0002-8814-8725","observed_orcids":["https://orcid.org/0000-0002-8814-8725"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary E. Lacy","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087266700","display_name":"Paola Gilsanz","orcid":"https://orcid.org/0000-0002-7635-381X","observed_orcids":["https://orcid.org/0000-0002-7635-381X"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Gilsanz","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA","University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012569127","display_name":"Michal Schnaider Beeri","orcid":"https://orcid.org/0000-0002-4254-9742","observed_orcids":["https://orcid.org/0000-0002-4254-9742"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Michal Schnaider Beeri","raw_affiliation_strings":["Icahn School of Medicine, Mount Sinai, New York, NY, USA","The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine, Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040058035","display_name":"Andrew John Karter","orcid":"https://orcid.org/0000-0001-5527-316X","observed_orcids":["https://orcid.org/0000-0001-5527-316X"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Karter","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052785465","display_name":"Charles P. Quesenberry","orcid":"https://orcid.org/0000-0001-8272-9126","observed_orcids":["https://orcid.org/0000-0001-8272-9126"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles P. Quesenberry","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091019550","display_name":"Rachel A. Whitmer","orcid":"https://orcid.org/0009-0006-9511-6138","observed_orcids":["https://orcid.org/0009-0006-9511-6138"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Whitmer","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA","University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079965027"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17734346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"7S_Part_24","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C197268465","wikidata":"https://www.wikidata.org/wiki/Q355122","display_name":"Memory span","level":4,"score":0.817882776260376},{"id":"https://openalex.org/C97530452","wikidata":"https://www.wikidata.org/wiki/Q7920939","display_name":"Verbal fluency test","level":4,"score":0.6984867453575134},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.625735878944397},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6054961085319519},{"id":"https://openalex.org/C162967406","wikidata":"https://www.wikidata.org/wiki/Q384176","display_name":"Stroop effect","level":3,"score":0.6036626100540161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4823271930217743},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.467960923910141},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.462148517370224},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.45748841762542725},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.4505298435688019},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4473513662815094},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4241892993450165},{"id":"https://openalex.org/C2778355293","wikidata":"https://www.wikidata.org/wiki/Q3997285","display_name":"Trail Making Test","level":4,"score":0.4229486882686615},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.41930124163627625},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4156598150730133},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4061020314693451},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.40423479676246643},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2517194151878357},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20969843864440918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20865961909294128},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.18283778429031372},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11422955989837646},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.081676185131073},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2018.06.1860","doi":"https://doi.org/10.1016/j.jalz.2018.06.1860","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.1860","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2998592777","https://openalex.org/W2017241399","https://openalex.org/W7097460111","https://openalex.org/W4281490205","https://openalex.org/W3005771861","https://openalex.org/W2507561469","https://openalex.org/W2980573109","https://openalex.org/W2507733566","https://openalex.org/W2922520373","https://openalex.org/W2165563030"],"abstract_inverted_index":{"Findings":[0],"from":[1,64,300],"previous":[2],"studies":[3],"regarding":[4],"the":[5,23,31,43,65,87,183,196,209,303,319,355],"association":[6,44,184,227],"between":[7,45,185,228],"severe":[8,49,286,341],"hypoglycemia":[9,50,287],"and":[10,52,81,146,158,167,187,193,216,231,245],"cognitive":[11,53,132,188,263,289,346],"function":[12,54,139,189,264,290,347],"among":[13,293],"individuals":[14,27],"with":[15,28,62,121,236,254,273,288,296,307,330,334],"type":[16,297],"1":[17,124,298],"diabetes":[18,299],"(T1D)":[19],"are":[20],"inconsistent.":[21],"Given":[22],"increasing":[24],"lifespan":[25],"of":[26,33,67,83,103,224,285,305,325,352,357],"T1D,":[29],"understanding":[30],"role":[32,351],"glycemic":[34],"control":[35],"on":[36,58,78,268,354],"brain":[37,356],"health":[38],"is":[39],"crucial.":[40],"We":[41],"examined":[42],"past-year":[46],"exposure":[47,85,93,98,115,215,230,257,275],"to":[48,181,234,276,328],"(SH)":[51],"using":[55],"data":[56],"collected":[57],"783":[59,197],"older":[60,294,313],"adults":[61,198,295,306],"T1D":[63,308,358],"Study":[66],"Longevity":[68],"in":[69,86,106,126,208,252,318],"Diabetes":[70],"(SOLID).":[71],"At":[72],"baseline,":[73],"participants":[74],"were":[75,134,172,179,248,280],"categorized":[76],"based":[77],"self-reported":[79],"frequency":[80],"severity":[82],"SH":[84,95,100,117,186,207,229,256,277,317,336,353],"past":[88,210,320],"12":[89],"months":[90],"into:":[91],"no":[92,206,237,331],"(0":[94],"events);":[96],"minimal":[97,214,274],"(1-3":[99],"events":[101,118],"none":[102],"which":[104],"resulted":[105],"an":[107],"ER":[108],"visit/hospitalization":[109],"or":[110,113,119,128],"diabetic":[111],"coma);":[112],"high":[114,219,255,335],"(>3":[116],"1-3":[120],"at":[122,136,291],"least":[123],"resulting":[125],"ER/hospitalization":[127],"coma).":[129],"The":[130],"following":[131],"domains":[133,270],"evaluated":[135],"baseline:":[137],"executive":[138,239],"(List":[140],"Sorting,":[141],"Trail":[142],"Making,":[143],"Category":[144],"Fluency":[145,164],"Stroop":[147],"Interference":[148],"Test),":[149,166],"working":[150,241],"memory":[151],"(Digit":[152],"Span":[153,156],"Backwards,":[154],"Visual":[155],"Backwards":[157],"List":[159],"Sorting),":[160],"verbal":[161,243],"fluency":[162,244],"(Verbal":[163],"Phenomic":[165],"global":[168,246],"cognition.":[169,232],"All":[170],"scores":[171],"standardized":[173],"(mean=0;":[174],"SD=1).":[175],"Generalized":[176],"linear":[177],"models":[178],"used":[180],"evaluate":[182],"adjusting":[190],"for":[191,271],"age":[192,200],"sex.":[194],"Of":[195],"(mean":[199],"67.27;":[201],"51%":[202],"female),":[203],"69%":[204],"reported":[205,213,218,316],"year,":[211],"16%":[212],"15%":[217],"exposure.":[220],"Results":[221],"showed":[222],"evidence":[223],"a":[225,349],"gradient":[226],"Compared":[233],"those":[235,253,272,329,333],"exposure,":[238],"function,":[240],"memory,":[242],"cognition":[247],"all":[249,260,269,323],"significantly":[250],"lower":[251,267],"(Figure":[258],"1;":[259],"p-values":[261],"<0.01);":[262],"was":[265],"slightly":[266],"though":[278],"findings":[279],"not":[281],"statistically":[282],"significant.":[283],"Association":[284],"baseline":[292],"SOLID":[301],"In":[302],"cohort":[304],"who":[309],"have":[310],"lived":[311],"into":[312],"adulthood,":[314],"31%":[315],"year.":[321],"Across":[322],"measures":[324],"cognition,":[326],"compared":[327],"SH,":[332],"(more":[337],"frequent":[338],"and/or":[339],"more":[340],"hypoglycemic":[342],"events)":[343],"had":[344],"worse":[345],"suggesting":[348],"deleterious":[350],"patients.":[359]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-10-26T00:00:00"}