{"id":"https://openalex.org/W2895755437","doi":"https://doi.org/10.21859/ijb.2153","title":"The Effect of Human Recombinant Tumor Necrosis Factor Receptor-2 on Reducing Inflammatory of Collagen -Induced Arthritis in Balb/c Mice","display_name":"The Effect of Human Recombinant Tumor Necrosis Factor Receptor-2 on Reducing Inflammatory of Collagen -Induced Arthritis in Balb/c Mice","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2895755437","doi":"https://doi.org/10.21859/ijb.2153","mag":"2895755437","pmid":"https://pubmed.ncbi.nlm.nih.gov/31457045","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6697853"},"language":"en","primary_location":{"id":"doi:10.21859/ijb.2153","doi":"https://doi.org/10.21859/ijb.2153","is_oa":true,"landing_page_url":"https://doi.org/10.21859/ijb.2153","pdf_url":"http://www.ijbiotech.com/article_70513_363a62279bb18994c86ee996a325a71c.pdf","source":{"id":"https://openalex.org/S2484379123","display_name":"Iranian Journal of Biotechnology","issn_l":"1728-3043","issn":["1728-3043","2322-2921"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4327876842","host_organization_name":"Armenian Green Publishing Co.","host_organization_lineage":["https://openalex.org/P4327876842"],"host_organization_lineage_names":["Armenian Green Publishing Co."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.ijbiotech.com/article_70513_363a62279bb18994c86ee996a325a71c.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051226294","display_name":"Shahla Korani","orcid":"https://orcid.org/0000-0002-4692-6912","observed_orcids":["https://orcid.org/0000-0002-4692-6912"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shahla Korani","raw_affiliation_strings":["Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026613898","display_name":"Mojgan Bandehpour","orcid":"https://orcid.org/0000-0002-5479-2846","observed_orcids":["https://orcid.org/0000-0002-5479-2846","https://orcid.org/0000-0002-5309-9476"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mojgan Bandehpour","raw_affiliation_strings":["Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089625720","display_name":"Bahram Kazemi","orcid":"https://orcid.org/0000-0002-3072-8831","observed_orcids":["https://orcid.org/0000-0002-3072-8831"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Bahram Kazemi","raw_affiliation_strings":["Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113851593","display_name":"Adel Haghighi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I155419210","display_name":"Islamic Azad University, Science and Research Branch","ror":"https://ror.org/03187yj51","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Adel Haghighi","raw_affiliation_strings":["Department of Pathology, Faculty of Specialized Veterinary Sciences, Sciences & Researches Branch Islamic Azad University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Specialized Veterinary Sciences, Sciences & Researches Branch Islamic Azad University, Tehran, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017947632","display_name":"Amin Reza Nikpoor","orcid":"https://orcid.org/0000-0001-5619-8771","observed_orcids":["https://orcid.org/0000-0001-5619-8771"]},"institutions":[{"id":"https://openalex.org/I4210128695","display_name":"Hormozgan University of Medical Sciences","ror":"https://ror.org/037wqsr57","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210128695"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amin Reza Nikpoor","raw_affiliation_strings":["Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran","institution_ids":["https://openalex.org/I4210128695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5026613898"],"corresponding_institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"],"apc_list":null,"apc_paid":null,"fwci":0.7579,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69969512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"17","issue":"1","first_page":"30","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor-2","display_name":"tumor necrosis factor receptor 2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/arthritis-treatment","display_name":"arthritis treatment","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/paw-edema","display_name":"paw edema","score":0.777999997138977},{"id":"https://openalex.org/keywords/joint-histopathology","display_name":"joint histopathology","score":0.8339999914169312},{"id":"https://openalex.org/keywords/autoimmune-arthritis","display_name":"autoimmune arthritis","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.744381308555603},{"id":"https://openalex.org/C2778844214","wikidata":"https://www.wikidata.org/wiki/Q24963555","display_name":"Collagen-induced arthritis","level":3,"score":0.7050981521606445},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6371126174926758},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6020675301551819},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5053530335426331},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.45553186535835266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4097009301185608},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37025588750839233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36086222529411316},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.352960467338562},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3393216133117676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12940216064453125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.048670947551727295}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21859/ijb.2153","doi":"https://doi.org/10.21859/ijb.2153","is_oa":true,"landing_page_url":"https://doi.org/10.21859/ijb.2153","pdf_url":"http://www.ijbiotech.com/article_70513_363a62279bb18994c86ee996a325a71c.pdf","source":{"id":"https://openalex.org/S2484379123","display_name":"Iranian Journal of Biotechnology","issn_l":"1728-3043","issn":["1728-3043","2322-2921"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4327876842","host_organization_name":"Armenian Green Publishing Co.","host_organization_lineage":["https://openalex.org/P4327876842"],"host_organization_lineage_names":["Armenian Green Publishing Co."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6697853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6697853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Biotechnol","raw_type":"Text"},{"id":"pmid:31457045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31457045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of biotechnology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21859/ijb.2153","doi":"https://doi.org/10.21859/ijb.2153","is_oa":true,"landing_page_url":"https://doi.org/10.21859/ijb.2153","pdf_url":"http://www.ijbiotech.com/article_70513_363a62279bb18994c86ee996a325a71c.pdf","source":{"id":"https://openalex.org/S2484379123","display_name":"Iranian Journal of Biotechnology","issn_l":"1728-3043","issn":["1728-3043","2322-2921"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4327876842","host_organization_name":"Armenian Green Publishing Co.","host_organization_lineage":["https://openalex.org/P4327876842"],"host_organization_lineage_names":["Armenian Green Publishing Co."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323457","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895755437.pdf","grobid_xml":"https://content.openalex.org/works/W2895755437.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W172167078","https://openalex.org/W1986217661","https://openalex.org/W2027280431","https://openalex.org/W2038729399","https://openalex.org/W2052680550","https://openalex.org/W2055287053","https://openalex.org/W2090385274","https://openalex.org/W2092953668","https://openalex.org/W2093754713","https://openalex.org/W2101840353","https://openalex.org/W2106623534","https://openalex.org/W2110826367","https://openalex.org/W2129587266","https://openalex.org/W2170521635","https://openalex.org/W2729669760","https://openalex.org/W2739029889","https://openalex.org/W2739357299","https://openalex.org/W2747197979","https://openalex.org/W2791302651","https://openalex.org/W2805138503","https://openalex.org/W2811253121","https://openalex.org/W4231289568"],"related_works":["https://openalex.org/W2898872314","https://openalex.org/W2794085649","https://openalex.org/W1528765374","https://openalex.org/W2035180752","https://openalex.org/W2014533380","https://openalex.org/W1608343961","https://openalex.org/W2054425175","https://openalex.org/W2030909284","https://openalex.org/W87806022","https://openalex.org/W1847099633"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,53,122,157,176],"tumor":[2],"necrosis":[3],"factor":[4],"alpha":[5],"(TNF\u03b1)":[6],"is":[7,20,41,58,232],"a":[8,233],"cytokine":[9],"that":[10,179,197,214,230],"produced":[11],"principally":[12],"by":[13,83],"monocyte/macrophages":[14],"and":[15,111,116,135,161,188],"T":[16],"lymphocytes,":[17],"respectively.":[18],"TNF\u03b1":[19],"recognized":[21],"as":[22,128],"the":[23,43,61,65,92,103,149,215,222,237,240],"primary":[24],"mediator":[25],"of":[26,34,45,55,64,124,151,199,218,224,239],"immunity":[27],"in":[28,72,80,106,114,137,164,168,186],"inflammation":[29],"reaction.":[30],"One":[31],"important":[32],"application":[33],"Tumor":[35],"Necrosis":[36],"Factor":[37],"Receptor":[38],"2":[39],"(TNFR2)":[40],"for":[42,236],"treatment":[44,180,238],"autoimmune":[46],"diseases":[47],"like":[48],"rheumatoid":[49,225],"arthritis":[50,70],"(RA).":[51],"OBJECTIVES:":[52],"aim":[54],"this":[56],"study":[57,212],"to":[59],"examine":[60],"therapeutic":[62],"trace":[63],"recombinant":[66,104,200],"humanTNFR2":[67],"on":[68,96],"collagen-induced":[69],"(CIA)":[71],"mice.":[73],"MATERIALS":[74],"AND":[75],"METHODS:":[76],"CIA":[77],"was":[78,154],"created":[79],"20":[81],"mice":[82,93],"immunization":[84],"with":[85,102,171,181],"bovine":[86],"type":[87],"II":[88],"collagen":[89],"(CII).":[90],"After":[91],"were":[94,100,139],"boosted":[95],"day":[97],"21,":[98],"they":[99],"injected":[101],"protein":[105],"test":[107],"group":[108],"(1":[109],"mg.kg-1)":[110],"assessed":[112],"edema":[113,185],"paws":[115,187],"knee":[117],"joints":[118,152,189,207],"after":[119],"two":[120],"weeks.":[121],"quantities":[123],"inflammatory":[125],"cytokines":[126,158],"such":[127],"TNF-\u03b1,":[129,159],"interleukin-1":[130],"beta":[131],"(IL-\u03b21),":[132],"interleukin-6":[133],"(IL-6),":[134],"interleukin-10(IL-10)":[136],"serum":[138,165],"evaluated":[140],"through":[141],"enzyme-linked":[142],"immunosorbent":[143],"assay":[144],"(ELISA)":[145],"kit.":[146],"In":[147],"addition,":[148],"histopathology":[150],"sections":[153],"analyzed.":[155],"RESULTS:":[156],"IL-1\u03b2,":[160],"IL-6":[162],"values":[163],"markedly":[166],"decreased":[167],"groups":[169],"treated":[170],"TNFR2":[172,182,219,231],"(P":[173,190],"<":[174,191],"0.01-0.001).":[175,192],"results":[177],"showed":[178],"significantly":[183],"reduced":[184],"CONCLUSIONS:":[193],"Pathological":[194],"investigations":[195],"proved":[196],"administration":[198],"TNF":[201],"receptor":[202],"has":[203],"blocked":[204],"or":[205],"protected":[206],"from":[208],"progressive":[209],"damage.":[210],"This":[211],"suggests":[213],"anti-arthritic":[216],"effectiveness":[217],"will":[220],"repress":[221],"symptoms":[223],"arthritis.":[226],"Moreover,":[227],"it":[228],"seems":[229],"strong":[234],"candidate":[235],"RA":[241],"disease.":[242]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-10-12T00:00:00"}
