{"id":"https://openalex.org/W2895694137","doi":"https://doi.org/10.1039/c8nr06851h","title":"Precise synchronization of hyperthermia\u2013chemotherapy: photothermally induced on-demand release from injectable hydrogels of gold nanocages","display_name":"Precise synchronization of hyperthermia\u2013chemotherapy: photothermally induced on-demand release from injectable hydrogels of gold nanocages","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2895694137","doi":"https://doi.org/10.1039/c8nr06851h","mag":"2895694137","pmid":"https://pubmed.ncbi.nlm.nih.gov/30351339"},"language":"en","primary_location":{"id":"doi:10.1039/c8nr06851h","doi":"https://doi.org/10.1039/c8nr06851h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8nr06851h","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089270650","display_name":"Jiangshan Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangshan Wan","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Consun Pharmaceutical Group, Guangzhou 510530, P. R. China","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Consun Pharmaceutical Group, Guangzhou 510530, P. R. China","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108071984","display_name":"Shinan Geng","orcid":"https://orcid.org/0009-0002-5203-3798","observed_orcids":["https://orcid.org/0009-0002-5203-3798"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shinan Geng","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007009932","display_name":"Hao Zhao","orcid":"https://orcid.org/0000-0002-5848-9457","observed_orcids":["https://orcid.org/0000-0002-5848-9457"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Zhao","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-5848-9457","affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035078111","display_name":"Xiaole Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaole Peng","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075740805","display_name":"Jiabao Xu","orcid":"https://orcid.org/0000-0002-3802-8311","observed_orcids":["https://orcid.org/0000-0002-3802-8311"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiabao Xu","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055854899","display_name":"Meihe Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meihe Wei","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067724860","display_name":"Junxiong Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junxiong Mao","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029083062","display_name":"Yang Zhou","orcid":"https://orcid.org/0000-0001-6867-6443","observed_orcids":["https://orcid.org/0000-0001-6867-6443"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhou","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078032840","display_name":"Quan Gang Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Quan Zhu","raw_affiliation_strings":["Consun Pharmaceutical Group","Guangzhou 510530","Institute of Consun Co. for Chinese Medicine in Kidney Diseases","P. R. China","Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Consun Pharmaceutical Group, Guangzhou 510530, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consun Pharmaceutical Group","institution_ids":[]},{"raw_affiliation_string":"Guangzhou 510530","institution_ids":[]},{"raw_affiliation_string":"Institute of Consun Co. for Chinese Medicine in Kidney Diseases","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Consun Pharmaceutical Group, Guangzhou 510530, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101551550","display_name":"Yanbing Zhao","orcid":"https://orcid.org/0000-0002-0675-6680","observed_orcids":["https://orcid.org/0000-0002-0675-6680"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanbing Zhao","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074"],"raw_orcid":"https://orcid.org/0000-0002-0675-6680","affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029849389","display_name":"Xiangliang Yang","orcid":"https://orcid.org/0000-0003-0683-8763","observed_orcids":["https://orcid.org/0000-0003-0683-8763"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangliang Yang","raw_affiliation_strings":["College of Life Science and Technology","Huazhong University of Science and Technology","National Engineering Research Center for Nanomedicine","P. R. China","Wuhan 430074","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Wuhan 430074","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029849389","https://openalex.org/A5101551550"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":null,"apc_paid":null,"fwci":2.7965,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.90947906,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"42","first_page":"20020","last_page":"20032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gold-nanocages","display_name":"gold nanocages","score":0.9100000262260437},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.675000011920929},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.777999997138977},{"id":"https://openalex.org/keywords/injectable-hydrogel","display_name":"injectable hydrogel","score":0.8659999966621399},{"id":"https://openalex.org/keywords/thermoresponsive-polymers","display_name":"thermoresponsive polymers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/n-isopropylacrylamide-copolymers","display_name":"N-isopropylacrylamide copolymers","score":0.8230000138282776},{"id":"https://openalex.org/keywords/on-demand-drug-release","display_name":"on-demand drug release","score":0.875},{"id":"https://openalex.org/keywords/near-infrared-irradiation","display_name":"near-infrared irradiation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.45399999618530273},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C128355301","wikidata":"https://www.wikidata.org/wiki/Q6964001","display_name":"Nanocages","level":3,"score":0.9103444814682007},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8957695960998535},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.5703820586204529},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4795779585838318},{"id":"https://openalex.org/C2983523559","wikidata":"https://www.wikidata.org/wiki/Q410657","display_name":"On demand","level":2,"score":0.460889995098114},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4448954164981842},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.41368788480758667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2578875422477722},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21598830819129944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1944979429244995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06487944722175598},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.06444525718688965},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.061694949865341187},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C49774154","wikidata":"https://www.wikidata.org/wiki/Q131765","display_name":"Multimedia","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044367","descriptor_name":"Phase Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c8nr06851h","doi":"https://doi.org/10.1039/c8nr06851h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8nr06851h","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:30351339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30351339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3454951132","display_name":null,"funder_award_id":"81627901","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7537699172","display_name":null,"funder_award_id":"81673016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334079","display_name":"Gruppo Nazionale per il Calcolo Scientifico","ror":"https://ror.org/02rnys730"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W876766385","https://openalex.org/W1678884887","https://openalex.org/W1967284562","https://openalex.org/W1968927007","https://openalex.org/W1971479823","https://openalex.org/W1978094200","https://openalex.org/W1982161876","https://openalex.org/W1988783116","https://openalex.org/W1988902294","https://openalex.org/W1989230986","https://openalex.org/W2013342651","https://openalex.org/W2021401252","https://openalex.org/W2022013198","https://openalex.org/W2026319736","https://openalex.org/W2033156964","https://openalex.org/W2034538920","https://openalex.org/W2034677002","https://openalex.org/W2035097645","https://openalex.org/W2039710696","https://openalex.org/W2042659519","https://openalex.org/W2042669918","https://openalex.org/W2043710789","https://openalex.org/W2045729510","https://openalex.org/W2060916907","https://openalex.org/W2062486688","https://openalex.org/W2063470712","https://openalex.org/W2068916215","https://openalex.org/W2077566437","https://openalex.org/W2085669091","https://openalex.org/W2088926532","https://openalex.org/W2102444643","https://openalex.org/W2104174252","https://openalex.org/W2112227276","https://openalex.org/W2128255400","https://openalex.org/W2129084113","https://openalex.org/W2130166533","https://openalex.org/W2131935157","https://openalex.org/W2138534590","https://openalex.org/W2141438559","https://openalex.org/W2152939220","https://openalex.org/W2156124327","https://openalex.org/W2163429511","https://openalex.org/W2165232616","https://openalex.org/W2165921162","https://openalex.org/W2170558349","https://openalex.org/W2210056821","https://openalex.org/W2298349456","https://openalex.org/W2317286806","https://openalex.org/W2320589001","https://openalex.org/W2322194440","https://openalex.org/W2410208054","https://openalex.org/W2417973730","https://openalex.org/W2524270896","https://openalex.org/W2564004426","https://openalex.org/W2605278786","https://openalex.org/W2614546493","https://openalex.org/W2804596530","https://openalex.org/W4245403358"],"related_works":["https://openalex.org/W2795785672","https://openalex.org/W2760920146","https://openalex.org/W2188416658","https://openalex.org/W2952721389","https://openalex.org/W7155366993","https://openalex.org/W3082623341","https://openalex.org/W2079306198","https://openalex.org/W2774542529","https://openalex.org/W2763046181","https://openalex.org/W3184482728"],"abstract_inverted_index":{"Though":[0],"a":[1,5,52],"therapeutic":[2],"sequence":[3,82],"plays":[4],"key":[6],"role":[7],"in":[8,105],"tumor":[9,113],"therapy,":[10],"little":[11],"attention":[12],"has":[13],"been":[14],"paid":[15],"to":[16],"its":[17],"influence":[18],"on":[19],"multimodal":[20],"combined":[21],"therapy.":[22],"Herein,":[23],"we":[24],"developed":[25],"gold":[26],"nanocages":[27],"(GNC@PNA-hls)":[28],"decorated":[29],"with":[30,80,126],"two":[31],"kinds":[32],"of":[33,46,83,124],"temperature":[34],"sensitive":[35],"p(N-isopropyl-acrylamide-acrylic":[36],"acid)":[37],"copolymers":[38],"(PNA-hs":[39],"and":[40,143,145],"PNA-ls)":[41],"for":[42,129],"precise":[43,139],"antitumor":[44,77,107,149],"coordination":[45],"thermo-chemotherapy.":[47],"Doxorubicin-loaded":[48],"GNC@PNA-hls":[49],"(Dox-GNC@PNA-hls)":[50],"showed":[51,74],"steady":[53],"photothermally":[54],"induced":[55],"on-demand":[56],"release":[57],"under":[58],"multiple":[59],"near-infrared":[60],"(NIR)":[61],"irradiations.":[62],"In":[63],"vitro":[64],"evaluations":[65],"indicated":[66,110,134],"that":[67,111,135],"concurrent":[68],"thermo-chemotherapy":[69],"treatments":[70],"(Dox":[71,91],"-":[72],"L)":[73,93],"the":[75,81,112,122],"best":[76],"effect,":[78],"compared":[79],"either":[84],"doxorubicin":[85,99],"treatment":[86,100,123],"followed":[87,97],"by":[88,98,121],"NIR":[89,95,127],"radiation":[90,96,128],"+":[92,102],"or":[94],"(L":[101],"Dox).":[103],"The":[104],"vivo":[106],"efficacy":[108],"also":[109],"volume":[114],"was":[115],"totally":[116],"suppressed":[117],"(ca.":[118],"0.14":[119],"cm3)":[120],"Dox-GNC@PNA-hls":[125,136],"14":[130],"days.":[131],"These":[132],"results":[133],"could":[137],"achieve":[138],"synchronization":[140],"between":[141],"hyperthermia":[142],"chemotherapy,":[144],"effectively":[146],"enhance":[147],"their":[148],"efficacy.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-12T00:00:00"}