{"id":"https://openalex.org/W2895440587","doi":"https://doi.org/10.1186/s12879-018-3420-2","title":"Development of a sandwich ELISA to detect Leishmania 40S ribosomal protein S12 antigen from blood samples of visceral leishmaniasis patients","display_name":"Development of a sandwich ELISA to detect Leishmania 40S ribosomal protein S12 antigen from blood samples of visceral leishmaniasis patients","publication_year":2018,"publication_date":"2018-10-03","ids":{"openalex":"https://openalex.org/W2895440587","doi":"https://doi.org/10.1186/s12879-018-3420-2","mag":"2895440587","pmid":"https://pubmed.ncbi.nlm.nih.gov/30285653","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6171325"},"language":"en","primary_location":{"id":"doi:10.1186/s12879-018-3420-2","doi":"https://doi.org/10.1186/s12879-018-3420-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12879-018-3420-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12879-018-3420-2.pdf","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12879-018-3420-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082082356","display_name":"Wen\u2010Wei Zhang","orcid":"https://orcid.org/0000-0003-1996-876X","observed_orcids":["https://orcid.org/0000-0003-1996-876X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wen-Wei Zhang","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107063607","display_name":"Ayan Kumar Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134315084","display_name":"Rajendra Memorial National Institute of Health Research","ror":"https://ror.org/020cmsc29","country_code":"IN","type":"facility","lineage":["https://openalex.org/I134315084","https://openalex.org/I37048141"]},{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ayan Kumar Ghosh","raw_affiliation_strings":["Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna, Bihar, India","institution_ids":["https://openalex.org/I134315084","https://openalex.org/I37048141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081638166","display_name":"Raodoh Mohamath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330732676","display_name":"Infectious Disease Research Institute","ror":"https://ror.org/03y4myd35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1330732676"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raodoh Mohamath","raw_affiliation_strings":["Infectious Disease Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I1330732676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075443021","display_name":"Jacqueline Whittle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330732676","display_name":"Infectious Disease Research Institute","ror":"https://ror.org/03y4myd35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1330732676"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Whittle","raw_affiliation_strings":["Infectious Disease Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I1330732676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000819032","display_name":"Alessandro Picone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330732676","display_name":"Infectious Disease Research Institute","ror":"https://ror.org/03y4myd35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1330732676"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro Picone","raw_affiliation_strings":["Infectious Disease Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I1330732676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083487513","display_name":"Patrick Lypaczewski","orcid":"https://orcid.org/0000-0002-5550-712X","observed_orcids":["https://orcid.org/0000-0002-5550-712X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick Lypaczewski","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040959574","display_name":"Momar Ndao","orcid":"https://orcid.org/0000-0002-9012-4212","observed_orcids":["https://orcid.org/0000-0002-9012-4212"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Momar Ndao","raw_affiliation_strings":["National Reference Center for Parasitology, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Reference Center for Parasitology, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007414771","display_name":"Randall F. Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330732676","display_name":"Infectious Disease Research Institute","ror":"https://ror.org/03y4myd35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1330732676"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall F Howard","raw_affiliation_strings":["Infectious Disease Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I1330732676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083176889","display_name":"Pradeep Kumar Das","orcid":"https://orcid.org/0000-0002-7796-6546","observed_orcids":["https://orcid.org/0000-0002-7796-6546"]},"institutions":[{"id":"https://openalex.org/I134315084","display_name":"Rajendra Memorial National Institute of Health Research","ror":"https://ror.org/020cmsc29","country_code":"IN","type":"facility","lineage":["https://openalex.org/I134315084","https://openalex.org/I37048141"]},{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pradeep Das","raw_affiliation_strings":["Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna, Bihar, India","institution_ids":["https://openalex.org/I134315084","https://openalex.org/I37048141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069585538","display_name":"Steven G. Reed","orcid":"https://orcid.org/0000-0003-2193-100X","observed_orcids":["https://orcid.org/0000-0003-2193-100X"]},"institutions":[{"id":"https://openalex.org/I1330732676","display_name":"Infectious Disease Research Institute","ror":"https://ror.org/03y4myd35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1330732676"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven G Reed","raw_affiliation_strings":["Infectious Disease Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I1330732676"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089387183","display_name":"Greg Matlashewski","orcid":"https://orcid.org/0000-0002-8971-5525","observed_orcids":["https://orcid.org/0000-0002-8971-5525"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Greg Matlashewski","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada. greg.matlashewski@mcgill.ca","Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada. greg.matlashewski@mcgill.ca","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec, H3A2B4, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089387183"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":3.0345,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.9135553,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"500","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/visceral-leishmaniasis","display_name":"visceral leishmaniasis","score":1.0},{"id":"https://openalex.org/keywords/leishmania-donovani","display_name":"Leishmania donovani","score":0.9200000166893005},{"id":"https://openalex.org/keywords/sandwich-elisa","display_name":"sandwich ELISA","score":0.9750000238418579},{"id":"https://openalex.org/keywords/blood-based-diagnostics","display_name":"blood-based diagnosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/post-kala-azar-dermal-leishmaniasis","display_name":"post-kala-azar dermal leishmaniasis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/rabbit-polyclonal-antibody","display_name":"rabbit polyclonal antibody","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.7895421981811523},{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.6554107666015625},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6354506611824036},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.5701209902763367},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5302507281303406},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.525160014629364},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49475592374801636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48752328753471375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46153438091278076},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.4586946368217468},{"id":"https://openalex.org/C2781257258","wikidata":"https://www.wikidata.org/wiki/Q1950789","display_name":"Leishmania infantum","level":4,"score":0.45372653007507324},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.4487687945365906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42139557003974915},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.2941828966140747},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.2692306637763977},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.24030247330665588},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007898","descriptor_name":"Leishmaniasis, Visceral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007898","descriptor_name":"Leishmaniasis, Visceral","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007898","descriptor_name":"Leishmaniasis, Visceral","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018512","descriptor_name":"Parasitemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018512","descriptor_name":"Parasitemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D058069","descriptor_name":"Neglected Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058345","descriptor_name":"Asymptomatic Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059208","descriptor_name":"Parasite Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12879-018-3420-2","doi":"https://doi.org/10.1186/s12879-018-3420-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12879-018-3420-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12879-018-3420-2.pdf","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5127659","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6171325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6171325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6171325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infect Dis","raw_type":"Text"},{"id":"pmid:30285653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30285653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b29f35f943ef41a6be214c68c7c50f49","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b29f35f943ef41a6be214c68c7c50f49","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12879-018-3420-2","doi":"https://doi.org/10.1186/s12879-018-3420-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12879-018-3420-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12879-018-3420-2.pdf","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3288094539","display_name":null,"funder_award_id":"236334","funder_id":"https://openalex.org/F4320338067","funder_display_name":"Institute of Infection and Immunity"},{"id":"https://openalex.org/G3958702757","display_name":"Access to Advanced Health Institute - to develop a research tool to identify individuals infected with Leishmania donovani parasites in the absence of visceral leishmaniasis disease to ...","funder_award_id":"OPP1084251","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G4179533221","display_name":null,"funder_award_id":"OPP49932 and OPP1084251","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G5171654929","display_name":"Access to Advanced Health Institute - to develop a highly specific diagnostic test and an accurate test of cure for visceral leishmaniasis","funder_award_id":"OPP49932","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320338067","display_name":"Institute of Infection and Immunity","ror":"https://ror.org/05wdecy17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895440587.pdf","grobid_xml":"https://content.openalex.org/works/W2895440587.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1602010694","https://openalex.org/W1913812011","https://openalex.org/W1973388584","https://openalex.org/W1984162571","https://openalex.org/W1991173219","https://openalex.org/W1994692841","https://openalex.org/W2001568767","https://openalex.org/W2017585857","https://openalex.org/W2022713265","https://openalex.org/W2039502062","https://openalex.org/W2062016511","https://openalex.org/W2067072833","https://openalex.org/W2090776124","https://openalex.org/W2098851690","https://openalex.org/W2100429492","https://openalex.org/W2107915297","https://openalex.org/W2121363153","https://openalex.org/W2139926426","https://openalex.org/W2152414729","https://openalex.org/W2156382913","https://openalex.org/W2171647918","https://openalex.org/W2308544692","https://openalex.org/W2405696583","https://openalex.org/W2418560528","https://openalex.org/W2495767466","https://openalex.org/W2523819885","https://openalex.org/W2542648267","https://openalex.org/W2599097334","https://openalex.org/W2786849432","https://openalex.org/W2799497882"],"related_works":["https://openalex.org/W3019884051","https://openalex.org/W2083417071","https://openalex.org/W2059975994","https://openalex.org/W2495767466","https://openalex.org/W1913812011","https://openalex.org/W4412151147","https://openalex.org/W2134173634","https://openalex.org/W1959148276","https://openalex.org/W2061380481","https://openalex.org/W2020179059"],"abstract_inverted_index":{"BACKGROUND:":[0],"Visceral":[1],"leishmaniasis":[2,181],"(VL),":[3],"caused":[4],"by":[5],"Leishmania":[6,68,94,124,249],"donovani":[7,152],"complex":[8],"parasites,":[9],"is":[10,16,226],"a":[11,27,112,233,252],"neglected":[12],"parasitic":[13,223],"disease":[14,243],"that":[15,65,96,203,228],"generally":[17],"fatal":[18],"if":[19],"untreated.":[20],"Despite":[21],"decades":[22],"of":[23,34,42,80,143,175,187,197,218],"research":[24],"to":[25,192],"develop":[26],"sensitive":[28,63],"VL":[29,35,176,219,238],"diagnostic":[30],"test,":[31],"definitive":[32],"diagnosis":[33],"still":[36],"mainly":[37],"relies":[38],"on":[39],"the":[40,43,48,123,133,163,204],"visualization":[41],"parasite":[44,254],"in":[45,100,173],"aspirates":[46],"from":[47,70,166,190],"spleen,":[49],"liver":[50],"or":[51,78,146],"bone":[52],"marrow,":[53],"an":[54,185],"invasive":[55],"and":[56,106,136,138,178,221,245],"dangerous":[57],"process":[58],"with":[59,108,132,214,251],"variable":[60],"sensitivity.":[61],"A":[62],"assay":[64,117],"can":[66],"detect":[67,140,162],"antigen":[69,131,165],"blood":[71],"samples":[72,172,217],"will":[73],"help":[74],"confirm":[75],"cause,":[76],"cure":[77],"recurrence":[79,244],"VL.":[81],"METHODS:":[82],"In":[83],"this":[84,229],"study,":[85],"rabbit":[86],"polyclonal":[87],"antibodies":[88,103],"were":[89,104],"raised":[90],"against":[91],"eight":[92],"recombinant":[93],"proteins":[95],"are":[97],"highly":[98],"abundant":[99],"Leishmania.":[101],"The":[102,120,154],"purified":[105,144],"labeled":[107],"biotin":[109],"for":[110,122,236],"developing":[111],"prototype":[113],"sandwich":[114,159,209],"enzyme-linked":[115],"immunosorbent":[116],"(ELISA).":[118],"RESULTS:":[119],"ELISA":[121,160,210,230],"40S":[125,155,205],"ribosomal":[126,156,206],"protein":[127,145,157,207],"S12":[128,158,208],"detected":[129],"target":[130,164],"highest":[134],"sensitivity":[135],"specificity":[137],"could":[139,161,231],"1":[141],"pg":[142],"as":[147,149],"few":[148],"60":[150],"L.":[151],"parasites.":[153],"Peripheral":[167],"Blood":[168],"Mononuclear":[169],"Cell":[170],"(PBMC)":[171],"68%":[174],"patients":[177,220],"post-kala-azar":[179],"dermal":[180],"(PKDL)":[182],"patients,":[183],"providing":[184],"estimation":[186],"parasitemia":[188],"ranging":[189],"15":[191],"80":[193],"amastigotes":[194],"per":[195],"ml":[196],"blood.":[198],"CONCLUSION:":[199],"These":[200],"results":[201],"indicate":[202],"warrants":[211],"further":[212],"tests":[213],"more":[215],"clinical":[216],"other":[222],"diseases.":[224],"It":[225],"hopeful":[227],"become":[232],"useful":[234],"tool":[235],"confirming":[237],"diagnosis,":[239],"monitoring":[240],"treatment":[241],"progress,":[242],"possibly":[246],"detecting":[247],"asymptomatic":[248],"infections":[250],"high":[253],"load.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-12T00:00:00"}