{"id":"https://openalex.org/W2895387828","doi":"https://doi.org/10.3389/fcimb.2018.00348","title":"Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae","display_name":"Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae","publication_year":2018,"publication_date":"2018-10-03","ids":{"openalex":"https://openalex.org/W2895387828","doi":"https://doi.org/10.3389/fcimb.2018.00348","mag":"2895387828","pmid":"https://pubmed.ncbi.nlm.nih.gov/30338245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6178895"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2018.00348","doi":"https://doi.org/10.3389/fcimb.2018.00348","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2018.00348","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcimb.2018.00348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022362699","display_name":"Rafael Ayerbe-Algaba","orcid":"https://orcid.org/0000-0002-2894-3866","observed_orcids":["https://orcid.org/0000-0002-2894-3866"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Ayerbe-Algaba","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050650222","display_name":"Mar\u00eda Luisa Gil-Marqu\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Luisa Gil-Marqu\u00e9s","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063305537","display_name":"Jim\u00e9nez-Mej\u00edas Me","orcid":"https://orcid.org/0000-0001-5331-6648","observed_orcids":["https://orcid.org/0000-0001-5331-6648"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Enrique Jim\u00e9nez-Mej\u00edas","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014540591","display_name":"Viviana S\u00e1nchez-Encinales","orcid":"https://orcid.org/0000-0002-6999-4555","observed_orcids":["https://orcid.org/0000-0002-6999-4555"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Viviana S\u00e1nchez-Encinales","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045210983","display_name":"Raquel Parra-Mill\u00e1n","orcid":"https://orcid.org/0000-0003-1670-4259","observed_orcids":["https://orcid.org/0000-0003-1670-4259"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Parra-Mill\u00e1n","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078433301","display_name":"Mar\u00eda Eugenia Pach\u00f3n-Ib\u00e1\u00f1ez","orcid":"https://orcid.org/0000-0001-7969-8162","observed_orcids":["https://orcid.org/0000-0001-7969-8162"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Eugenia Pach\u00f3n-Ib\u00e1\u00f1ez","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076347067","display_name":"Jer\u00f3nimo Pach\u00f3n","orcid":"https://orcid.org/0000-0002-8166-5308","observed_orcids":["https://orcid.org/0000-0002-8166-5308"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jer\u00f3nimo Pach\u00f3n","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","Department of Medicine, University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]},{"raw_affiliation_string":"Department of Medicine, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016077959","display_name":"Younes Smani","orcid":"https://orcid.org/0000-0001-9302-8384","observed_orcids":["https://orcid.org/0000-0001-9302-8384"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Younes Smani","raw_affiliation_strings":["Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016077959","https://openalex.org/A5076347067"],"corresponding_institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":3.5021,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.93532269,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"348","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niclosamide","display_name":"niclosamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colistin","display_name":"colistin","score":1.0},{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":0.9200000166893005},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/colistin-resistance","display_name":"colistin resistance","score":0.9890000224113464},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4880000054836273},{"id":"https://openalex.org/keywords/synergistic-antibacterial-activity","display_name":"synergistic antibacterial activity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/multidrug-resistant-gram-negative-bacteria","display_name":"multidrug-resistant Gram-negative bacteria","score":0.7009999752044678},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.8050000071525574},{"id":"https://openalex.org/keywords/bacterial-surface-charge","display_name":"bacterial surface charge","score":0.6909999847412109},{"id":"https://openalex.org/keywords/time-kill-kinetics","display_name":"time-kill kinetics","score":0.8379999995231628},{"id":"https://openalex.org/keywords/anthelmintic-repurposing","display_name":"anthelmintic repurposing","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.9746584892272949},{"id":"https://openalex.org/C2776315533","wikidata":"https://www.wikidata.org/wiki/Q3241189","display_name":"Acinetobacter baumannii","level":4,"score":0.9407489895820618},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.8493434190750122},{"id":"https://openalex.org/C2776306103","wikidata":"https://www.wikidata.org/wiki/Q418523","display_name":"Niclosamide","level":2,"score":0.8385305404663086},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7182075381278992},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.46194204688072205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37188926339149475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32221996784210205},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16709551215171814},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.06422996520996094},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.04764777421951294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04648357629776001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003091","descriptor_name":"Colistin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009534","descriptor_name":"Niclosamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D040981","descriptor_name":"Acinetobacter baumannii","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.3389/fcimb.2018.00348","doi":"https://doi.org/10.3389/fcimb.2018.00348","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2018.00348","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5136460","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6178895","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30338245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30338245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:dnet:idus________::e00b3228985369333fb4b525e54ab8cd","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle//11441/101684","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6178895","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6178895/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmh:oai:www.repositoriosalud.es:10668/13106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178895/pdf","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2018.00348/pdf","source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:digital.csic.es:10261/180415","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/180415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:3d5d2261943d439d93b4628f65286cba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3d5d2261943d439d93b4628f65286cba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)","raw_type":"article"},{"id":"pmh:oai:idus.us.es:11441/101684","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle//11441/101684","pdf_url":null,"source":{"id":"https://openalex.org/S4306400333","display_name":"idUS (Universidad de Sevilla)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2018.00348","doi":"https://doi.org/10.3389/fcimb.2018.00348","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2018.00348","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1075404386","display_name":null,"funder_award_id":"PI16/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G1758722712","display_name":"Eficacia terap\u00e9utica de la oxiclozanida como terapia combinada con colistina in vitro y en modelos experimentales murinos de infecciones graves","funder_award_id":"PI16/01378","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2708544407","display_name":null,"funder_award_id":"PI16/","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895387828.pdf","grobid_xml":"https://content.openalex.org/works/W2895387828.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1791789643","https://openalex.org/W1855595511","https://openalex.org/W1964226118","https://openalex.org/W1977482442","https://openalex.org/W1979184180","https://openalex.org/W1985819704","https://openalex.org/W1986647861","https://openalex.org/W1991471402","https://openalex.org/W1992705797","https://openalex.org/W2013883719","https://openalex.org/W2017310905","https://openalex.org/W2025413826","https://openalex.org/W2031354676","https://openalex.org/W2034012142","https://openalex.org/W2044668858","https://openalex.org/W2076639843","https://openalex.org/W2081183202","https://openalex.org/W2088021352","https://openalex.org/W2101737047","https://openalex.org/W2116245384","https://openalex.org/W2117940625","https://openalex.org/W2123334163","https://openalex.org/W2127511446","https://openalex.org/W2133268685","https://openalex.org/W2134340025","https://openalex.org/W2135732696","https://openalex.org/W2141144075","https://openalex.org/W2142758007","https://openalex.org/W2149161141","https://openalex.org/W2150616218","https://openalex.org/W2154773472","https://openalex.org/W2166348498","https://openalex.org/W2168543282","https://openalex.org/W2335790828","https://openalex.org/W2411665716","https://openalex.org/W2464417828","https://openalex.org/W2520472295","https://openalex.org/W2611935044","https://openalex.org/W2738499922","https://openalex.org/W2774100192","https://openalex.org/W2797757758","https://openalex.org/W2801716135","https://openalex.org/W4236829767"],"related_works":["https://openalex.org/W2912318433","https://openalex.org/W4285085337","https://openalex.org/W2781339284","https://openalex.org/W2509557099","https://openalex.org/W2805766059","https://openalex.org/W4389179785","https://openalex.org/W2905760322","https://openalex.org/W4402982924","https://openalex.org/W4378555115","https://openalex.org/W4410721778"],"abstract_inverted_index":{"Colistin":[0],"is":[1],"among":[2],"the":[3,18,41,56,86,159],"few":[4,20],"antibiotics":[5],"effective":[6],"against":[7,67,118,136],"multidrug-resistant":[8],"Acinetobacter":[9],"baumannii":[10,24,74,100,123,141,166,192],"and":[11,25,36,70,75,85,96,101,120,124,134,138,142,167,183,193,204],"Klebsiella":[12],"pneumoniae":[13,27,103,169,195],"clinical":[14],"isolates.":[15],"However,":[16],"in":[17,63,104,111,170,196],"last":[19],"years,":[21],"colistin-resistant":[22,71],"A.":[23,73,99,122,140,165,191],"K.":[26,76,102,125,143,168,194],"strains":[28],"have":[29],"emerged.":[30],"Therefore,":[31],"combination":[32,64,112],"therapies,":[33],"between":[34,132],"colistin":[35,44,66,114,135,149],"other":[37],"old":[38],"drugs,":[39],"restoring":[40],"activity":[42,57,117,131],"of":[43,50,58,94,98,106,158,172,198,225],"are":[45],"required.":[46],"The":[47,78,91],"main":[48],"objective":[49],"this":[51],"study":[52],"was":[53,108,150],"to":[54],"analyse":[55],"niclosamide,":[59],"an":[60],"anthelmintic":[61],"drug,":[62],"with":[65,113,217],"colistin-susceptible":[68],"(Col-S)":[69],"(Col-R)":[72],"pneumoniae.":[77,126],"MIC":[79],"were":[80,89],"determined":[81],"by":[82],"microdilution":[83],"assay":[84],"time-kill":[87],"curves":[88,128],"performed.":[90],"zeta":[92],"potential":[93,221],"Col-S":[95,119,137],"Col-R":[97,121,139,164,190,226],"presence":[105,171],"niclosamide":[107,133,147,173,199,213],"assessed.":[109],"Niclosamide":[110],"showed":[115,129],"improved":[116],"Time-killing":[127],"synergic":[130],"pneumoniae,":[144],"especially":[145],"when":[146],"or":[148],"added":[151],"for":[152,223],"second":[153],"time":[154],"at":[155],"4":[156],"h":[157,161],"24":[160],"killing":[162],"curve.":[163],"exhibited":[174],"a":[175,220],"greater":[176],"negative":[177],"charge":[178],"(-34.95":[179],"\u00b1":[180,185,201,206],"0.35":[181],"mV":[182,203],"-38.85":[184],"0.92":[186],"mV;":[187],"P<0.05)":[188],"than":[189],"absence":[197],"(-26.85":[200],"3.65":[202],"-35.27":[205],"0.72":[207],"mV).":[208],"These":[209],"data":[210],"suggest":[211],"that":[212],"might":[214],"be":[215],"combined":[216],"colistin,":[218],"being":[219],"alternative":[222],"treatment":[224],"Gram-negative":[227],"bacilli":[228],"infections.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-10-12T00:00:00"}
