{"id":"https://openalex.org/W2895334183","doi":"https://doi.org/10.1371/journal.pntd.0006864","title":"Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration","display_name":"Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2895334183","doi":"https://doi.org/10.1371/journal.pntd.0006864","mag":"2895334183","pmid":"https://pubmed.ncbi.nlm.nih.gov/30273343","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6181437"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0006864","doi":"https://doi.org/10.1371/journal.pntd.0006864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0006864","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006864&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006864&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043011666","display_name":"Marleen Werkman","orcid":"https://orcid.org/0000-0002-2252-9357","observed_orcids":["https://orcid.org/0000-0002-2252-9357"]},"institutions":[{"id":"https://openalex.org/I1336856363","display_name":"Natural History Museum","ror":"https://ror.org/039zvsn29","country_code":"GB","type":"archive","lineage":["https://openalex.org/I1336856363"]},{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Marleen Werkman","raw_affiliation_strings":["London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2252-9357","affiliations":[{"raw_affiliation_string":"London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]},{"raw_affiliation_string":"The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom","institution_ids":["https://openalex.org/I1336856363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033136483","display_name":"Jaspreet Toor","orcid":"https://orcid.org/0000-0003-1510-397X","observed_orcids":["https://orcid.org/0000-0003-1510-397X"]},"institutions":[{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jaspreet Toor","raw_affiliation_strings":["London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007342092","display_name":"Carolin Vegvari","orcid":"https://orcid.org/0000-0003-2018-011X","observed_orcids":["https://orcid.org/0000-0003-2018-011X"]},"institutions":[{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carolin Vegvari","raw_affiliation_strings":["London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2018-011X","affiliations":[{"raw_affiliation_string":"London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James E. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336856363","display_name":"Natural History Museum","ror":"https://ror.org/039zvsn29","country_code":"GB","type":"archive","lineage":["https://openalex.org/I1336856363"]},{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James E. Wright","raw_affiliation_strings":["London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]},{"raw_affiliation_string":"The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom","institution_ids":["https://openalex.org/I1336856363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043581494","display_name":"James E. Truscott","orcid":"https://orcid.org/0000-0002-2555-7636","observed_orcids":["https://orcid.org/0000-0002-2555-7636"]},"institutions":[{"id":"https://openalex.org/I1336856363","display_name":"Natural History Museum","ror":"https://ror.org/039zvsn29","country_code":"GB","type":"archive","lineage":["https://openalex.org/I1336856363"]},{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James E. Truscott","raw_affiliation_strings":["London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]},{"raw_affiliation_string":"The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom","institution_ids":["https://openalex.org/I1336856363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003303767","display_name":"Kristjana \u00c1sbj\u00f6rnsd\u00f3ttir","orcid":"https://orcid.org/0000-0002-3263-3457","observed_orcids":["https://orcid.org/0000-0002-3263-3457"]},"institutions":[{"id":"https://openalex.org/I1336856363","display_name":"Natural History Museum","ror":"https://ror.org/039zvsn29","country_code":"GB","type":"archive","lineage":["https://openalex.org/I1336856363"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Kristjana H. \u00c1sbj\u00f6rnsd\u00f3ttir","raw_affiliation_strings":["Departments of Global Health, Medicine (Infectious Disease), Pediatrics and Epidemiology, University of Washington, Seattle, Washington, United States of America","The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Global Health, Medicine (Infectious Disease), Pediatrics and Epidemiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom","institution_ids":["https://openalex.org/I1336856363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089919219","display_name":"Arianna Rubin Means","orcid":"https://orcid.org/0000-0002-4087-7080","observed_orcids":["https://orcid.org/0000-0002-4087-7080"]},"institutions":[{"id":"https://openalex.org/I1336856363","display_name":"Natural History Museum","ror":"https://ror.org/039zvsn29","country_code":"GB","type":"archive","lineage":["https://openalex.org/I1336856363"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Arianna Rubin Means","raw_affiliation_strings":["Departments of Global Health, Medicine (Infectious Disease), Pediatrics and Epidemiology, University of Washington, Seattle, Washington, United States of America","The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Global Health, Medicine (Infectious Disease), Pediatrics and Epidemiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom","institution_ids":["https://openalex.org/I1336856363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043790717","display_name":"Judd L. Walson","orcid":"https://orcid.org/0000-0003-4836-720X","observed_orcids":["https://orcid.org/0000-0003-4836-720X"]},"institutions":[{"id":"https://openalex.org/I1336856363","display_name":"Natural History Museum","ror":"https://ror.org/039zvsn29","country_code":"GB","type":"archive","lineage":["https://openalex.org/I1336856363"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Judd L. Walson","raw_affiliation_strings":["Departments of Global Health, Medicine (Infectious Disease), Pediatrics and Epidemiology, University of Washington, Seattle, Washington, United States of America","The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Global Health, Medicine (Infectious Disease), Pediatrics and Epidemiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom","institution_ids":["https://openalex.org/I1336856363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049396774","display_name":"Roy Malcolm Anderson","orcid":"https://orcid.org/0000-0002-9528-3175","observed_orcids":["https://orcid.org/0000-0002-9528-3175"]},"institutions":[{"id":"https://openalex.org/I1336856363","display_name":"Natural History Museum","ror":"https://ror.org/039zvsn29","country_code":"GB","type":"archive","lineage":["https://openalex.org/I1336856363"]},{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roy M. Anderson","raw_affiliation_strings":["London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London Centre for Neglected Tropical Disease Research (LCNTDR), Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]},{"raw_affiliation_string":"The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom","institution_ids":["https://openalex.org/I1336856363"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043011666"],"corresponding_institution_ids":["https://openalex.org/I1336856363","https://openalex.org/I4210163563","https://openalex.org/I47508984"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2057,"currency":"EUR","value_usd":2218},"fwci":1.814,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.8186155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"10","first_page":"e0006864","last_page":"e0006864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soil-transmitted-helminths","display_name":"soil-transmitted helminths","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transmission-interruption","display_name":"transmission interruption","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mass-drug-administration","display_name":"mass drug administration","score":0.9679999947547913},{"id":"https://openalex.org/keywords/stopping-criterion","display_name":"stopping rules","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rebound","display_name":"rebound","score":0.781000018119812},{"id":"https://openalex.org/keywords/ascaris-lumbricoides","display_name":"Ascaris lumbricoides","score":0.9679999947547913},{"id":"https://openalex.org/keywords/necator-americanus","display_name":"Necator americanus","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mda-coverage","display_name":"MDA coverage","score":0.640999972820282},{"id":"https://openalex.org/keywords/prevalence-threshold","display_name":"prevalence threshold","score":0.5099999904632568},{"id":"https://openalex.org/keywords/agent-based-modeling","display_name":"agent-based modeling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/community-based-treatment","display_name":"community-based treatment","score":0.5640000104904175},{"id":"https://openalex.org/keywords/reinfection","display_name":"reinfection","score":0.4959999918937683},{"id":"https://openalex.org/keywords/school-based-deworming","display_name":"school-based deworming","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.8001899719238281},{"id":"https://openalex.org/C2780133432","wikidata":"https://www.wikidata.org/wiki/Q6784028","display_name":"Mass drug administration","level":3,"score":0.7460923790931702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5668586492538452},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5350028276443481},{"id":"https://openalex.org/C2777461070","wikidata":"https://www.wikidata.org/wiki/Q1345770","display_name":"Deworming","level":3,"score":0.4807714819908142},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46800318360328674},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.39348652958869934},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.32022958993911743},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19752392172813416},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19649294018745422},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19269880652427673},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.15382716059684753},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12297216057777405},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.10706087946891785},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09887012839317322},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074381","descriptor_name":"Mass Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000871","descriptor_name":"Anthelmintics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006373","descriptor_name":"Helminthiasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006373","descriptor_name":"Helminthiasis","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007411","descriptor_name":"Intestinal Diseases, Parasitic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007411","descriptor_name":"Intestinal Diseases, Parasitic","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018562","descriptor_name":"Disease Transmission, Infectious","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pntd.0006864","doi":"https://doi.org/10.1371/journal.pntd.0006864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0006864","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006864&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5144868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6181437","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6181437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6181437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmid:30273343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30273343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:eba87a69032c4c788b2c4df5551c36c8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eba87a69032c4c788b2c4df5551c36c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006864 (2018)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/65242","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/65242","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0006864","doi":"https://doi.org/10.1371/journal.pntd.0006864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0006864","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006864&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4897202970","display_name":null,"funder_award_id":"OPP 1129535","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G6520098237","display_name":null,"funder_award_id":"MR/R015600/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895334183.pdf","grobid_xml":"https://content.openalex.org/works/W2895334183.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W101171454","https://openalex.org/W1524977782","https://openalex.org/W1817956410","https://openalex.org/W1998279724","https://openalex.org/W2000443868","https://openalex.org/W2029856904","https://openalex.org/W2078685387","https://openalex.org/W2090264425","https://openalex.org/W2112355136","https://openalex.org/W2120972232","https://openalex.org/W2141247767","https://openalex.org/W2151211884","https://openalex.org/W2154761658","https://openalex.org/W2229630737","https://openalex.org/W2253183016","https://openalex.org/W2378160108","https://openalex.org/W2472152466","https://openalex.org/W2531386533","https://openalex.org/W2550791203","https://openalex.org/W2563312018","https://openalex.org/W2588313664","https://openalex.org/W2589096383","https://openalex.org/W2592347042","https://openalex.org/W2606681335","https://openalex.org/W2620024595","https://openalex.org/W2620544542","https://openalex.org/W2734076361","https://openalex.org/W2734592288","https://openalex.org/W2782671617","https://openalex.org/W2783816914","https://openalex.org/W2785988168","https://openalex.org/W2795878596","https://openalex.org/W4292696014"],"related_works":["https://openalex.org/W2782671617","https://openalex.org/W4412859769","https://openalex.org/W4405585206","https://openalex.org/W3097437837","https://openalex.org/W2589096383","https://openalex.org/W4403208414","https://openalex.org/W6938939634","https://openalex.org/W2174432114","https://openalex.org/W3189406548","https://openalex.org/W3138954628"],"abstract_inverted_index":{"The":[0,129,319],"current":[1],"World":[2],"Health":[3],"Organization":[4],"strategy":[5,57],"to":[6,33,60,118,133,185,205,225,295],"address":[7],"soil-transmitted":[8],"helminth":[9],"(STH)":[10],"infections":[11],"in":[12,43,49,52,77,120,194],"children":[13,244],"is":[14,85,141,181,210,223],"based":[15],"on":[16],"morbidity":[17],"control":[18,239],"through":[19,344],"routine":[20],"deworming":[21],"of":[22,38,41,67,79,92,96,101,109,137,148,165,173,229,243,273,284,289,300,316,334,346,355,382],"school":[23],"and":[24,48,73,267,286],"pre-school":[25],"aged":[26],"children.":[27],"However,":[28,106],"given":[29,196],"that":[30,309,322],"transmission":[31,97,111,190,208,329,337,375],"continues":[32],"occur":[34],"as":[35,155,183],"a":[36,56,82,175,195,238,352],"result":[37,76],"persistent":[39],"reservoirs":[40],"infection":[42],"untreated":[44],"individuals":[45],"(including":[46],"adults)":[47],"the":[50,90,94,107,135,168,230,281,287,298],"environment,":[51],"many":[53],"settings":[54],"such":[55],"will":[58],"need":[59],"be":[61,160,213,306,326,340],"continued":[62],"for":[63,157,260,263,328,369],"very":[64],"extended":[65],"periods":[66],"time,":[68],"or":[69,189,302,374],"until":[70],"social,":[71],"economic":[72],"environmental":[74],"conditions":[75],"interruption":[78,95,112,191,209,330,338,376],"transmission.":[80],"As":[81],"result,":[83],"there":[84],"currently":[86,142],"much":[87],"discussion":[88],"surrounding":[89],"possibility":[91],"accelerating":[93],"using":[98,113],"alternative":[99],"strategies":[100],"mass":[102],"drug":[103],"administration":[104],"(MDA).":[105],"feasibility":[108,136],"achieving":[110],"MDA":[114,123,285,290,362],"remains":[115],"uncertain":[116],"due":[117],"challenges":[119],"sustaining":[121],"high":[122,149,360],"coverage":[124,291,361],"levels":[125,292],"across":[126,363],"entire":[127],"communities.":[128],"DeWorm3":[130,231],"trial,":[131],"designed":[132],"test":[134],"interrupting":[138],"STH":[139],"transmission,":[140],"ongoing.":[143],"In":[144,198],"DeWorm3,":[145],"three":[146],"years":[147,164,315,333],"treatment":[150,179,242,254,348],"coverage-indicated":[151],"by":[152,162],"mathematical":[153],"models":[154],"necessary":[156],"breaking":[158],"transmission-will":[159],"followed":[161],"two":[163,176,314,332],"surveillance.":[166,318],"Given":[167],"fast":[169],"reinfection":[170],"(bounce-back)":[171],"rates":[172],"STH,":[174],"year":[177],"no":[178],"period":[180],"regarded":[182],"adequate":[184],"assess":[186],"whether":[187,207],"bounce-back":[188,301],"have":[192],"occurred":[193],"location.":[197],"this":[199],"study,":[200],"we":[201],"investigate":[202],"if":[203,297],"criteria":[204],"determine":[206],"unlikely":[211],"can":[212,339],"defined":[214],"at":[215,277,308],"earlier":[216],"timepoints.":[217],"A":[218,271],"stochastic,":[219],"individual-based":[220],"simulation":[221],"model":[222],"employed":[224],"simulate":[226],"core":[227],"aspects":[228],"community-based":[232],"cluster-randomized":[233],"trial.":[234],"This":[235],"trial":[236],"compares":[237],"arm":[240,251],"(annual":[241],"alone":[245],"with":[246,248,255],"MDA)":[247],"an":[249],"intervention":[250],"(community-wide":[252],"biannual":[253],"MDA).":[256],"Simulations":[257],"were":[258,293],"run":[259],"each":[261],"scenario":[262],"both":[264],"Ascaris":[265],"lumbricoides":[266],"hookworm":[268],"(Necator":[269],"americanus).":[270],"range":[272,354],"threshold":[274],"prevalences":[275],"measured":[276],"six":[278],"months":[279,379],"after":[280,313,331],"last":[282],"round":[283],"impact":[288],"evaluated":[294],"see":[296],"likelihood":[299],"elimination":[303],"could":[304],"reliably":[305],"assessed":[307,327],"point,":[310],"rather":[311],"than":[312],"subsequent":[317],"analyses":[320],"suggest":[321,351],"all":[323],"clusters":[324,364],"should":[325],"surveillance,":[335],"unless":[336],"effectively":[341],"ruled":[342],"out":[343],"evidence":[345],"low":[347],"coverage.":[349],"Models":[350],"tight":[353],"homogenous":[356],"prevalence":[357],"estimates":[358],"following":[359,380],"which":[365],"do":[366],"not":[367],"allow":[368],"discrimination":[370],"between":[371],"bounce":[372],"back":[373],"within":[377],"24":[378],"cessation":[381],"MDA.":[383]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-12T00:00:00"}
