{"id":"https://openalex.org/W2895326014","doi":"https://doi.org/10.1172/jci.insight.59125","title":"Clinical implications of monitoring nivolumab immunokinetics in non\u2013small cell lung cancer patients","display_name":"Clinical implications of monitoring nivolumab immunokinetics in non\u2013small cell lung cancer patients","publication_year":2018,"publication_date":"2018-10-03","ids":{"openalex":"https://openalex.org/W2895326014","doi":"https://doi.org/10.1172/jci.insight.59125","mag":"2895326014","pmid":"https://pubmed.ncbi.nlm.nih.gov/30282824","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6237460"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.59125","doi":"https://doi.org/10.1172/jci.insight.59125","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.59125","pdf_url":"http://insight.jci.org/articles/view/59125/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/59125/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030649173","display_name":"Akio Osa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Osa","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047621468","display_name":"Takeshi Uenami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106555","display_name":"Toneyama National Hospital","ror":"https://ror.org/01ppsp263","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Uenami","raw_affiliation_strings":["Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030855728","display_name":"Shohei Koyama","orcid":"https://orcid.org/0000-0002-6897-9417","observed_orcids":["https://orcid.org/0000-0002-6897-9417"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shohei Koyama","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071346389","display_name":"Kosuke Fujimoto","orcid":"https://orcid.org/0000-0002-2948-549X","observed_orcids":["https://orcid.org/0000-0002-2948-549X"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Fujimoto","raw_affiliation_strings":["Department of Immunology and Genomics, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan","Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Genomics, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002727514","display_name":"Daisuke Okuzaki","orcid":"https://orcid.org/0000-0002-4552-783X","observed_orcids":["https://orcid.org/0000-0002-4552-783X"]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Okuzaki","raw_affiliation_strings":["DNA-Chip Developmental Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4552-783X","affiliations":[{"raw_affiliation_string":"DNA-Chip Developmental Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059661775","display_name":"Takayuki Takimoto","orcid":"https://orcid.org/0000-0003-0740-4836","observed_orcids":["https://orcid.org/0000-0003-0740-4836"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Takimoto","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086649224","display_name":"Haruhiko Hirata","orcid":"https://orcid.org/0000-0002-1134-7283","observed_orcids":["https://orcid.org/0000-0002-1134-7283"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruhiko Hirata","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034638155","display_name":"Yukihiro Yano","orcid":"https://orcid.org/0000-0002-6829-1778","observed_orcids":["https://orcid.org/0000-0002-6829-1778"]},"institutions":[{"id":"https://openalex.org/I4210106555","display_name":"Toneyama National Hospital","ror":"https://ror.org/01ppsp263","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Yano","raw_affiliation_strings":["Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6829-1778","affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112171147","display_name":"Soichiro Yokota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106555","display_name":"Toneyama National Hospital","ror":"https://ror.org/01ppsp263","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Soichiro Yokota","raw_affiliation_strings":["Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090786965","display_name":"Yuhei Kinehara","orcid":"https://orcid.org/0000-0002-9274-225X","observed_orcids":["https://orcid.org/0000-0002-9274-225X"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuhei Kinehara","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027808322","display_name":"Yujiro Naito","orcid":"https://orcid.org/0000-0003-0633-4936","observed_orcids":["https://orcid.org/0000-0003-0633-4936"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yujiro Naito","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050237826","display_name":"Tomoyuki Otsuka","orcid":"https://orcid.org/0000-0003-3394-0720","observed_orcids":["https://orcid.org/0000-0003-3394-0720"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Otsuka","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050860383","display_name":"Masaki Kanazu","orcid":"https://orcid.org/0000-0003-4405-1929","observed_orcids":["https://orcid.org/0000-0003-4405-1929"]},"institutions":[{"id":"https://openalex.org/I4210106555","display_name":"Toneyama National Hospital","ror":"https://ror.org/01ppsp263","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Kanazu","raw_affiliation_strings":["Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4405-1929","affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026488336","display_name":"Muneyoshi Kuroyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Muneyoshi Kuroyama","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112831105","display_name":"Masanari Hamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanari Hamaguchi","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033667677","display_name":"Taro Koba","orcid":"https://orcid.org/0000-0001-7715-9042","observed_orcids":["https://orcid.org/0000-0001-7715-9042"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taro Koba","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074901986","display_name":"Yu Futami","orcid":"https://orcid.org/0000-0002-1665-3474","observed_orcids":["https://orcid.org/0000-0002-1665-3474"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Futami","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108289561","display_name":"Mikako Ishijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106555","display_name":"Toneyama National Hospital","ror":"https://ror.org/01ppsp263","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikako Ishijima","raw_affiliation_strings":["Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033484471","display_name":"Yasuhiko Suga","orcid":"https://orcid.org/0000-0002-4906-8810","observed_orcids":["https://orcid.org/0000-0002-4906-8810"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Suga","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069426726","display_name":"Yuki Akazawa","orcid":"https://orcid.org/0000-0002-2427-3690","observed_orcids":["https://orcid.org/0000-0002-2427-3690","https://orcid.org/0009-0006-0380-2713"]},"institutions":[{"id":"https://openalex.org/I4210106555","display_name":"Toneyama National Hospital","ror":"https://ror.org/01ppsp263","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Akazawa","raw_affiliation_strings":["Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008976390","display_name":"Hirotomo Machiyama","orcid":"https://orcid.org/0009-0002-9155-3956","observed_orcids":["https://orcid.org/0009-0002-9155-3956"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotomo Machiyama","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040981480","display_name":"Kota Iwahori","orcid":"https://orcid.org/0000-0002-9891-6003","observed_orcids":["https://orcid.org/0000-0002-9891-6003"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Iwahori","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083709357","display_name":"Hyota Takamatsu","orcid":"https://orcid.org/0000-0002-0382-5142","observed_orcids":["https://orcid.org/0000-0002-0382-5142"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hyota Takamatsu","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041796082","display_name":"Izumi Nagatomo","orcid":"https://orcid.org/0000-0001-5382-4327","observed_orcids":["https://orcid.org/0000-0001-5382-4327"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Izumi Nagatomo","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064765702","display_name":"Yoshito Takeda","orcid":"https://orcid.org/0000-0003-2905-6537","observed_orcids":["https://orcid.org/0000-0003-2905-6537"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshito Takeda","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064912253","display_name":"Hiroshi Kida","orcid":"https://orcid.org/0000-0002-9351-7855","observed_orcids":["https://orcid.org/0000-0002-9351-7855"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kida","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012107830","display_name":"Esra A. Akbay","orcid":"https://orcid.org/0000-0002-4149-2529","observed_orcids":["https://orcid.org/0000-0002-4149-2529"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esra A. Akbay","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004171995","display_name":"Peter S. Hammerman","orcid":"https://orcid.org/0009-0006-9143-899X","observed_orcids":["https://orcid.org/0009-0006-9143-899X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter S. Hammerman","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019034689","display_name":"Kwok\u2010Kin Wong","orcid":"https://orcid.org/0000-0001-6323-235X","observed_orcids":["https://orcid.org/0000-0001-6323-235X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwok-kin Wong","raw_affiliation_strings":["Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028608171","display_name":"Glenn Dranoff","orcid":"https://orcid.org/0000-0002-2341-7517","observed_orcids":["https://orcid.org/0000-0002-2341-7517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Dranoff","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109424750","display_name":"Masahide Mori","orcid":"https://orcid.org/0009-0007-9223-3854","observed_orcids":["https://orcid.org/0009-0007-9223-3854"]},"institutions":[{"id":"https://openalex.org/I4210106555","display_name":"Toneyama National Hospital","ror":"https://ror.org/01ppsp263","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahide Mori","raw_affiliation_strings":["Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Hospital Organization, Toneyama National Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210106555","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023719583","display_name":"Takashi Kijima","orcid":"https://orcid.org/0000-0003-4249-4021","observed_orcids":["https://orcid.org/0000-0003-4249-4021"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Kijima","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026633755","display_name":"Atsushi Kumanogoh","orcid":"https://orcid.org/0000-0003-4749-7117","observed_orcids":["https://orcid.org/0000-0003-4749-7117"]},"institutions":[{"id":"https://openalex.org/I4405286165","display_name":"Institute for Open and Transdisciplinary Research Initiatives","ror":"https://ror.org/01atnm274","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286165","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Kumanogoh","raw_affiliation_strings":["Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan","Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405286165"]},{"raw_affiliation_string":"Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5023719583","https://openalex.org/A5026633755","https://openalex.org/A5030855728"],"corresponding_institution_ids":["https://openalex.org/I4405286165","https://openalex.org/I4405287342","https://openalex.org/I98285908"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":8.872,"has_fulltext":true,"cited_by_count":227,"citation_normalized_percentile":{"value":0.98862063,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"3","issue":"19","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/t-cell-monitoring","display_name":"T cell monitoring","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5799999833106995},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.3840000033378601},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.9790703058242798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7615180611610413},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6487376093864441},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6278241872787476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.554690957069397},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5544223785400391},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5413936972618103},{"id":"https://openalex.org/C45121317","wikidata":"https://www.wikidata.org/wiki/Q4927287","display_name":"Blocking antibody","level":3,"score":0.5222314596176147},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.4417426288127899},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3885355591773987},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.332813560962677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2859033942222595},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci.insight.59125","doi":"https://doi.org/10.1172/jci.insight.59125","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.59125","pdf_url":"http://insight.jci.org/articles/view/59125/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5206717","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6237460","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6237460","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6237460","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:30282824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30282824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.59125","doi":"https://doi.org/10.1172/jci.insight.59125","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.59125","pdf_url":"http://insight.jci.org/articles/view/59125/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1172700517","display_name":"MUC1-C Oncoprotein Evades Immune Destruction in Non-small Cell Lung Cancer","funder_award_id":"R01CA166480","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G369962788","display_name":"Therapeutic strategies for specific subsets of KRAS mutant lung cancers","funder_award_id":"R01CA140594","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4276115010","display_name":"Investigation on pathological implications of guidance molecules in neuro-immune-metabolism.","funder_award_id":"18H05282","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5783697281","display_name":null,"funder_award_id":"JP18cm0106335","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6790461652","display_name":null,"funder_award_id":"JP18cm059042","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7141784875","display_name":"Regulating the sensitivity of lung cancer to immunotherapy through inhibiting neutrophil activation and promoting T cell infiltration in tumors","funder_award_id":"17K16045","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G775311310","display_name":"Novel disease-specific autoantibodies of difuse interstitial lung diseases","funder_award_id":"16K09537","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895326014.pdf","grobid_xml":"https://content.openalex.org/works/W2895326014.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W2010121426","https://openalex.org/W2019799131","https://openalex.org/W2032166347","https://openalex.org/W2064273388","https://openalex.org/W2079936875","https://openalex.org/W2104347254","https://openalex.org/W2104966044","https://openalex.org/W2138936980","https://openalex.org/W2139192665","https://openalex.org/W2149639441","https://openalex.org/W2156353875","https://openalex.org/W2156906256","https://openalex.org/W2198093519","https://openalex.org/W2210453860","https://openalex.org/W2252550602","https://openalex.org/W2273119405","https://openalex.org/W2281666530","https://openalex.org/W2289841322","https://openalex.org/W2336076245","https://openalex.org/W2345250542","https://openalex.org/W2425731878","https://openalex.org/W2464620827","https://openalex.org/W2527905628","https://openalex.org/W2554618897","https://openalex.org/W2560367415","https://openalex.org/W2560704457","https://openalex.org/W2572174216","https://openalex.org/W2587048937","https://openalex.org/W2592145452","https://openalex.org/W2592423822","https://openalex.org/W2594042408","https://openalex.org/W2605630275","https://openalex.org/W2609289346","https://openalex.org/W2625612917","https://openalex.org/W2626312449","https://openalex.org/W2763732021","https://openalex.org/W2767551096","https://openalex.org/W2791043965","https://openalex.org/W2794137041","https://openalex.org/W2796582438","https://openalex.org/W2797675588","https://openalex.org/W2805354595","https://openalex.org/W2806388842","https://openalex.org/W2831487285"],"related_works":["https://openalex.org/W2770254724","https://openalex.org/W2765585644","https://openalex.org/W2969442970","https://openalex.org/W2989900426","https://openalex.org/W4223433636","https://openalex.org/W2591247335","https://openalex.org/W2970618013","https://openalex.org/W2598819900","https://openalex.org/W3006932250","https://openalex.org/W2143488876"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"PD-1-blocking":[2],"antibody":[3,25],"nivolumab":[4,55,129,147,197,231],"persists":[5,26],"in":[6,115,156,162,173,177,235],"patients":[7,83,118,178,201],"several":[8],"weeks":[9,136],"after":[10,56,137],"the":[11,20,24,31,47,90,138,143,159,185,210,271],"last":[12,139],"infusion.":[13],"However,":[14],"no":[15],"study":[16],"has":[17],"systematically":[18],"evaluated":[19],"maximum":[21],"duration":[22,35,48],"that":[23],"on":[27],"T":[28,64,72,107,112,174,191,205,236],"cells":[29,73,175,237],"or":[30,40,151,248],"association":[32],"between":[33,102],"this":[34],"and":[36,51,67,104,213,233,278,285,289,291,297],"residual":[37,52,241],"therapeutic":[38],"efficacy":[39,53,242],"potential":[41],"adverse":[42],"events.":[43],"METHODS:":[44],"To":[45,88],"define":[46],"of":[49,54,92,142,146,153,158,189,228,246,273],"binding":[50,130,232],"discontinuation,":[57],"we":[58,98],"developed":[59,120],"a":[60,170,221],"simplified":[61],"strategy":[62,227],"for":[63,95,270,282,294],"cell":[65,80,113,206],"monitoring":[66,114,165,229],"used":[68],"it":[69],"to":[70,196],"analyze":[71],"from":[74,77],"peripheral":[75],"blood":[76],"11":[78,160],"non-small":[79],"lung":[81,122],"cancer":[82],"previously":[84],"treated":[85],"with":[86,179,215],"nivolumab.":[87],"determine":[89,240],"suitability":[91],"our":[93,226],"method":[94],"other":[96],"applications,":[97],"compared":[99],"transcriptome":[100],"profiles":[101],"nivolumab-bound":[103,190],"nivolumab-unbound":[105],"CD8":[106],"cells.":[108],"We":[109],"also":[110],"applied":[111],"2":[116,200],"nivolumab-treated":[117],"who":[119,202],"progressive":[121,180],"tumors":[123],"during":[124],"long-term":[125,164],"follow-up.":[126],"RESULTS:":[127],"Prolonged":[128],"was":[131,166,265],"detected":[132],"more":[133],"than":[134],"20":[135],"infusion,":[140],"regardless":[141],"total":[144],"number":[145],"infusions":[148],"(2-15":[149],"doses)":[150],"type":[152],"subsequent":[154,249],"treatment,":[155],"9":[157],"cases":[161],"which":[163,193],"possible.":[167],"Ki-67":[168,234],"positivity,":[169],"proliferation":[171,207],"marker,":[172],"decreased":[176],"disease.":[181],"Transcriptome":[182],"profiling":[183],"identified":[184],"signals":[186],"regulating":[187],"activation":[188],"cells,":[192],"may":[194],"contribute":[195],"resistance.":[198],"In":[199],"restarted":[203],"nivolumab,":[204],"markers":[208],"exhibited":[209],"opposite":[211],"trend":[212],"correlated":[214],"clinical":[216],"response.":[217],"CONCLUSIONS:":[218],"Although":[219],"only":[220],"few":[222],"samples":[223],"were":[224],"analyzed,":[225],"both":[230],"might":[238],"help":[239],"under":[243],"various":[244],"types":[245],"concurrent":[247],"treatment.":[250],"TRIAL":[251],"REGISTRATION:":[252],"University":[253],"Hospital":[254],"Medical":[255,283],"Information":[256],"Network":[257],"Clinical":[258],"Trials":[259],"Registry,":[260],"UMIN000024623.":[261],"FUNDING:":[262],"This":[263],"work":[264],"supported":[266],"by":[267],"Japan":[268,280],"Society":[269],"Promotion":[272],"Science":[274,296],"KAKENHI":[275],"(JP17K16045,":[276],"JP18H05282,":[277],"JP15K09220),":[279],"Agency":[281],"Research":[284,293],"Development":[286],"(JP17cm0106310,":[287],"JP18cm0106335":[288],"JP18cm059042),":[290],"Core":[292],"Evolutional":[295],"Technology":[298],"(JPMJCR16G2).":[299]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":40},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-12T00:00:00"}
