{"id":"https://openalex.org/W2895101315","doi":"https://doi.org/10.1055/a-0654-1324","title":"Kopfschmerzen \u2013 Update 2018","display_name":"Kopfschmerzen \u2013 Update 2018","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2895101315","doi":"https://doi.org/10.1055/a-0654-1324","mag":"2895101315"},"language":"en","primary_location":{"id":"doi:10.1055/a-0654-1324","doi":"https://doi.org/10.1055/a-0654-1324","is_oa":true,"landing_page_url":"https://doi.org/10.1055/a-0654-1324","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0654-1324.pdf","source":{"id":"https://openalex.org/S4210183627","display_name":"Neurologie up2date","issn_l":"2511-3453","issn":["2511-3453","2511-3658"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologie up2date","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0654-1324.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033104412","display_name":"Hans\u2010Christoph Diener","orcid":"https://orcid.org/0000-0002-6556-8612","observed_orcids":["https://orcid.org/0000-0002-6556-8612"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hans-Christoph Diener","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069865671","display_name":"Charly Gaul","orcid":"https://orcid.org/0000-0002-9362-3711","observed_orcids":["https://orcid.org/0000-0002-9362-3711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charly Gaul","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063750372","display_name":"Dagny Holle","orcid":"https://orcid.org/0000-0003-4872-0384","observed_orcids":["https://orcid.org/0000-0003-4872-0384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dagny Holle-Lee","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066411482","display_name":"Tim Patrick J\u00fcrgens","orcid":"https://orcid.org/0000-0002-1481-6997","observed_orcids":["https://orcid.org/0000-0002-1481-6997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim J\u00fcrgens","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073479440","display_name":"Torsten Kraya","orcid":"https://orcid.org/0000-0002-6060-3810","observed_orcids":["https://orcid.org/0000-0002-6060-3810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Torsten Kraya","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044562854","display_name":"Tobias Kurth","orcid":"https://orcid.org/0000-0001-7169-2620","observed_orcids":["https://orcid.org/0000-0001-7169-2620","https://orcid.org/0000-0002-8994-7860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Kurth","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086706994","display_name":"Steffen N\u00e4gel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steffen N\u00e4gel","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041465970","display_name":"Lars Neeb","orcid":"https://orcid.org/0000-0002-1940-6399","observed_orcids":["https://orcid.org/0000-0002-1940-6399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars Neeb","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102958740","display_name":"Andreas Straube","orcid":"https://orcid.org/0000-0003-0765-3760","observed_orcids":["https://orcid.org/0000-0003-0765-3760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Straube","raw_affiliation_strings":["Sie haben Ihre Zeitschrift noch nicht","freigeschaltet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sie haben Ihre Zeitschrift noch nicht","institution_ids":[]},{"raw_affiliation_string":"freigeschaltet","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033104412"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1965,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5826495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"01","first_page":"107","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/headache","display_name":"headache","score":0.859000027179718},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tension-type-headache","display_name":"tension-type headache","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cluster-headache","display_name":"cluster headache","score":0.7990000247955322},{"id":"https://openalex.org/keywords/medication-overuse-headache","display_name":"medication overuse headache","score":0.8169999718666077},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.718999981880188},{"id":"https://openalex.org/keywords/anti-cgrp-monoclonal-antibodies","display_name":"CGRP monoclonal antibodies","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cgrp-receptor-antibody","display_name":"CGRP receptor antibody","score":0.6380000114440918},{"id":"https://openalex.org/keywords/triptans","display_name":"triptans","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neurostimulation","display_name":"neurostimulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/transcutaneous-vagus-nerve-stimulation","display_name":"transcutaneous vagus nerve stimulation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/sleep-related-headache","display_name":"sleep-related headache","score":0.6399999856948853},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9670000076293945},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7018150687217712},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5699644088745117}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/a-0654-1324","doi":"https://doi.org/10.1055/a-0654-1324","is_oa":true,"landing_page_url":"https://doi.org/10.1055/a-0654-1324","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0654-1324.pdf","source":{"id":"https://openalex.org/S4210183627","display_name":"Neurologie up2date","issn_l":"2511-3453","issn":["2511-3453","2511-3658"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologie up2date","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1055/a-0654-1324","doi":"https://doi.org/10.1055/a-0654-1324","is_oa":true,"landing_page_url":"https://doi.org/10.1055/a-0654-1324","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0654-1324.pdf","source":{"id":"https://openalex.org/S4210183627","display_name":"Neurologie up2date","issn_l":"2511-3453","issn":["2511-3453","2511-3658"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologie up2date","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2895101315.pdf","grobid_xml":"https://content.openalex.org/works/W2895101315.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1855519556","https://openalex.org/W2056567279","https://openalex.org/W2073823099","https://openalex.org/W2098592809","https://openalex.org/W2116458765","https://openalex.org/W2157733244","https://openalex.org/W2161485885","https://openalex.org/W2180068571","https://openalex.org/W2268603990","https://openalex.org/W2304169055","https://openalex.org/W2330918085","https://openalex.org/W2345359830","https://openalex.org/W2358893902","https://openalex.org/W2396552979","https://openalex.org/W2407529127","https://openalex.org/W2410394972","https://openalex.org/W2416895451","https://openalex.org/W2500896050","https://openalex.org/W2511401330","https://openalex.org/W2529718195","https://openalex.org/W2547168075","https://openalex.org/W2549116677","https://openalex.org/W2554035658","https://openalex.org/W2556639481","https://openalex.org/W2562082350","https://openalex.org/W2572462304","https://openalex.org/W2584665639","https://openalex.org/W2586565416","https://openalex.org/W2589013099","https://openalex.org/W2589023116","https://openalex.org/W2591887583","https://openalex.org/W2592354866","https://openalex.org/W2601741875","https://openalex.org/W2605813551","https://openalex.org/W2606222148","https://openalex.org/W2606425885","https://openalex.org/W2606667267","https://openalex.org/W2607690235","https://openalex.org/W2608751463","https://openalex.org/W2610668356","https://openalex.org/W2612355478","https://openalex.org/W2624753971","https://openalex.org/W2676947678","https://openalex.org/W2737267746","https://openalex.org/W2738985862","https://openalex.org/W2739665591","https://openalex.org/W2740022105","https://openalex.org/W2746744701","https://openalex.org/W2748627085","https://openalex.org/W2755406481","https://openalex.org/W2755738595","https://openalex.org/W2756414511","https://openalex.org/W2760684802","https://openalex.org/W2763230077","https://openalex.org/W2765862961","https://openalex.org/W2768357559","https://openalex.org/W2770386726","https://openalex.org/W2770965214","https://openalex.org/W2774831914","https://openalex.org/W2785597664","https://openalex.org/W2792403667","https://openalex.org/W2794583203","https://openalex.org/W2803715733","https://openalex.org/W2805181790","https://openalex.org/W2805937849","https://openalex.org/W2895101315","https://openalex.org/W4248919376"],"related_works":["https://openalex.org/W2695839277","https://openalex.org/W2650541094","https://openalex.org/W2980429199","https://openalex.org/W4389497901","https://openalex.org/W2413740895","https://openalex.org/W49848034","https://openalex.org/W2917095704","https://openalex.org/W2480331959","https://openalex.org/W4400763861","https://openalex.org/W1966901543"],"abstract_inverted_index":{"All":[0],"articles":[1],"of":[2],"this":[3],"category":[4],"Die":[5,26,42],"Kopfschmerzforschung":[6],"macht":[7],"Fortschritte.":[8],"Dies":[9],"zeigt":[10],"sich":[11,166],"an":[12,60],"der":[13,44,52,54,81,111,126,135,155,157,160,230,248],"gro\u00dfen":[14],"Zahl":[15],"von":[16,24,83,184,213],"Publikationen":[17],"zur":[18,173],"Epidemiologie,":[19],"Pathophysiologie,":[20],"Akuttherapie":[21,134],"und":[22,49,69,113,145,198,256],"Prophylaxe":[23,156],"Kopfschmerzen.":[25],"vorliegende":[27],"\u00dcbersicht":[28],"referiert":[29],"die":[30,98,101,120,133,192,199,215,241],"wichtigsten":[31],"Studien":[32,46,58,73],"zu":[33,91,196],"Kopfschmerzen":[34],"aus":[35],"dem":[36],"Zeitraum":[37],"2017":[38],"bis":[39],"Juni":[40],"2018.":[41],"Auswahl":[43,121],"referierten":[45],"ist":[47],"subjektiv":[48],"erfolgte":[50],"nach":[51,217],"Einsch\u00e4tzung":[53],"Autoren.":[55],"Kernaussagen":[56],"Epidemiologische":[57],"belegen":[59],"immer":[61],"gr\u00f6\u00dferen":[62],"Populationen":[63],"einen":[64],"eindeutigen":[65],"Zusammenhang":[66],"zwischen":[67],"Migr\u00e4ne":[68,162],"vaskul\u00e4ren":[70],"Krankheiten.":[71],"Pathophysiologische":[72],"zeigen":[74],"eine":[75,88,168,226,251],"bedeutende":[76],"Rolle":[77,90],"des":[78,233],"Hypothalamus":[79],"bei":[80,211],"Generierung":[82],"Migr\u00e4neattacken.":[84],"Dabei":[85],"scheint":[86],"Glutamat":[87],"wichtige":[89],"spielen.":[92],"Neue":[93],"MRT-Studien":[94],"mit":[95,202,222,229,254],"Kontrastmittel":[96],"unterst\u00fctzen":[97],"Annahme,":[99],"dass":[100],"Blut-Hirn-Schranke":[102],"w\u00e4hrend":[103],"Migr\u00e4neattacken":[104],"intakt":[105],"bleibt.":[106],"Trotz":[107],"statistischer":[108],"Unterschiede":[109],"in":[110,117,132,154],"Wirksamkeit":[112,193],"Vertr\u00e4glichkeit":[114,170],"verschiedener":[115],"Triptane":[116],"Metaanalysen":[118],"bleibt":[119],"eines":[122],"Triptans":[123],"individuell.":[124],"Verfahren":[125],"Neurostimulation":[127],"finden":[128],"jetzt":[129],"auch":[130],"Eingang":[131],"Migr\u00e4ne.":[136],"Monoklonale":[137],"humanisierte":[138],"Antik\u00f6rper":[139,148],"gegen":[140,149],"CGRP":[141],"(Calcitonin":[142],"Gene-related":[143],"Peptide)":[144],"ein":[146],"vollhumaner":[147],"den":[150],"CGRP-Rezeptor":[151],"sind":[152],"sowohl":[153],"episodischen":[158],"wie":[159],"chronischen":[161],"wirksam.":[163],"Sie":[164],"zeichnen":[165],"durch":[167],"gute":[169],"aus.":[171],"Langzeitdaten":[172],"Sicherheit":[174],"liegen":[175],"noch":[176],"nicht":[177],"vor.":[178],"Eine":[179],"aktuelle":[180],"Metaanalyse":[181],"zum":[182],"Einsatz":[183],"trizyklischen":[185],"Antidepressiva":[186],"beim":[187,209],"Kopfschmerz":[188,210,239],"vom":[189],"Spannungstyp":[190],"belegt":[191],"im":[194],"Vergleich":[195],"Placebo":[197],"\u00dcberlegenheit":[200],"verglichen":[201],"SSRI":[203],"(selektive":[204],"Serotonin-Reuptake-Inhibitoren).":[205],"Elektronische":[206],"Tageb\u00fccher":[207],"k\u00f6nnen":[208],"\u00dcbergebrauch":[212],"Medikamenten":[214],"R\u00fcckfallwahrscheinlichkeit":[216],"Medikamentenpause":[218],"reduzieren.":[219],"Bei":[220,247],"Patienten":[221],"chronischem":[223],"Clusterkopfschmerz":[224],"kann":[225],"erfolgreiche":[227],"Attackentherapie":[228],"transkutanen":[231],"Stimulation":[232],"N.":[234],"vagus":[235],"erfolgen.":[236],"Beim":[237],"schlafgebundenen":[238],"spielt":[240],"Melatoninaussch\u00fcttung":[242],"wohl":[243],"keine":[244],"wesentliche":[245],"Rolle.":[246],"Trigeminusneuralgie":[249],"besteht":[250],"erhebliche":[252],"Komorbidit\u00e4t":[253],"Depressionen":[255],"Angsterkrankungen.":[257]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-10-12T00:00:00"}