{"id":"https://openalex.org/W2894684124","doi":null,"title":"THE PHTHALATE DBP-INDUCED CYTOTOXICITY AND APOP-TOSIS VIA GENE EXPRESSION OF p53, Bcl2 AND Bax IN TUMOR CELL LINES","display_name":"THE PHTHALATE DBP-INDUCED CYTOTOXICITY AND APOP-TOSIS VIA GENE EXPRESSION OF p53, Bcl2 AND Bax IN TUMOR CELL LINES","publication_year":2018,"publication_date":"2018-09-06","ids":{"openalex":"https://openalex.org/W2894684124","mag":"2894684124"},"language":"en","primary_location":{"id":"mag:2894684124","doi":null,"is_oa":true,"landing_page_url":"http://journal.esg.net.eg/index.php/EJGC/article/view/275","pdf_url":null,"source":{"id":"https://openalex.org/S2764740768","display_name":"Egyptian Journal of Genetics and Cytology","issn_l":"0046-161X","issn":["0046-161X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318978","host_organization_name":"The Egyptian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310318978"],"host_organization_lineage_names":["The Egyptian Society of Genetics"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Egyptian Journal of Genetics and Cytology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://journal.esg.net.eg/index.php/EJGC/article/view/275","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110598608","display_name":"Neima K. Al-Senosy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Neima Al-Senosy","raw_affiliation_strings":["Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108188539","display_name":"A. A. Awad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A. A. Awad","raw_affiliation_strings":["Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110525575","display_name":"Rania A. A. Younis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rania A. A. Younis","raw_affiliation_strings":["Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112463182","display_name":"F. M. Abdel-Tawab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"F. M. Abdel-Tawab","raw_affiliation_strings":["Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of genetics, Faculty of Agriculture, Ain Shams University, Cairo","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107720978"],"apc_list":{"value":750,"currency":"EGP","value_usd":null},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dibutyl-phthalate","display_name":"dibutyl phthalate","score":0.9509999752044678},{"id":"https://openalex.org/keywords/phthalate-plasticizers","display_name":"phthalate plasticizers","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8240000009536743},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.800000011920929},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2781005124","wikidata":"https://www.wikidata.org/wiki/Q84483575","display_name":"Phthalate","level":2,"score":0.8679331541061401},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7642028331756592},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7266959547996521},{"id":"https://openalex.org/C2779643248","wikidata":"https://www.wikidata.org/wiki/Q415612","display_name":"Dibutyl phthalate","level":2,"score":0.6397843956947327},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5854030251502991},{"id":"https://openalex.org/C58968531","wikidata":"https://www.wikidata.org/wiki/Q910212","display_name":"Plasticizer","level":2,"score":0.5238271355628967},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.517924964427948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5078919529914856},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.504715085029602},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4408559501171112},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.435242235660553},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4214513897895813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3240179419517517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31207185983657837},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2786804437637329},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05610272288322449},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2894684124","doi":null,"is_oa":true,"landing_page_url":"http://journal.esg.net.eg/index.php/EJGC/article/view/275","pdf_url":null,"source":{"id":"https://openalex.org/S2764740768","display_name":"Egyptian Journal of Genetics and Cytology","issn_l":"0046-161X","issn":["0046-161X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318978","host_organization_name":"The Egyptian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310318978"],"host_organization_lineage_names":["The Egyptian Society of Genetics"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Egyptian Journal of Genetics and Cytology","raw_type":null}],"best_oa_location":{"id":"mag:2894684124","doi":null,"is_oa":true,"landing_page_url":"http://journal.esg.net.eg/index.php/EJGC/article/view/275","pdf_url":null,"source":{"id":"https://openalex.org/S2764740768","display_name":"Egyptian Journal of Genetics and Cytology","issn_l":"0046-161X","issn":["0046-161X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318978","host_organization_name":"The Egyptian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310318978"],"host_organization_lineage_names":["The Egyptian Society of Genetics"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Egyptian Journal of Genetics and Cytology","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1612560506","https://openalex.org/W1862030732","https://openalex.org/W1975298668","https://openalex.org/W1981352366","https://openalex.org/W1986246940","https://openalex.org/W1990050054","https://openalex.org/W1995345399","https://openalex.org/W1999543886","https://openalex.org/W2001533493","https://openalex.org/W2010818369","https://openalex.org/W2015395569","https://openalex.org/W2018975695","https://openalex.org/W2019562165","https://openalex.org/W2019643773","https://openalex.org/W2023955385","https://openalex.org/W2026782684","https://openalex.org/W2028787617","https://openalex.org/W2040447482","https://openalex.org/W2041454621","https://openalex.org/W2053620382","https://openalex.org/W2064803825","https://openalex.org/W2066477275","https://openalex.org/W2069180528","https://openalex.org/W2072754176","https://openalex.org/W2087416821","https://openalex.org/W2094373189","https://openalex.org/W2099113454","https://openalex.org/W2128551390","https://openalex.org/W2414072472"],"related_works":["https://openalex.org/W2372710098","https://openalex.org/W2966600854","https://openalex.org/W7214743543","https://openalex.org/W4365143806","https://openalex.org/W2389670066","https://openalex.org/W2363482442","https://openalex.org/W4402300981","https://openalex.org/W2362638980","https://openalex.org/W4224928696","https://openalex.org/W2037653308"],"abstract_inverted_index":{"The":[0,48,67,143,160,172],"components":[1],"of":[2,14,23,56,113,132,154,168,175,184],"phthalate":[3,73],"are":[4],"utilized":[5],"as":[6,33],"softeners":[7],"and":[8,45,59,118,123,157,177],"plasticizers":[9],"in":[10,35,78],"a":[11,20],"wide":[12],"range":[13],"plastic":[15],"materials.":[16],"There":[17],"has":[18],"been":[19],"high":[21],"concern":[22],"potential":[24],"health":[25],"risks":[26],"to":[27,149,190],"humans.":[28],"DBP":[29,58,103,114,136,164],"is":[30,115],"commonly":[31],"used":[32,148],"plasticizer":[34],"food":[36],"containers,":[37],"furniture,":[38],"toys,":[39],"cosmetics,":[40],"cellulose":[41],"plastics,":[42],"latex":[43],"adhesives":[44],"dye":[46],"solvents.":[47],"present":[49],"study":[50],"focused":[51],"on":[52,107,121],"the":[53,57,111,151,182,191],"cytotoxic":[54,105],"activity":[55,106],"its":[60],"pos-sible":[61],"underlying":[62],"mechanisms":[63],"were":[64,179],"also":[65],"investigated.":[66],"results":[68],"showed":[69,162],"that":[70,130,163],"phathalate":[71],"di-n-butyl":[72],"(DBP)":[74],"induced":[75],"profound":[76],"cytotoxicity":[77],"cancer":[79,94],"cells,":[80],"i.":[81],"e.":[82],"Human":[83],"hepatocellular":[84],"carcino-ma":[85],"(HepG2)":[86],"(IC50":[87,98],"=":[88,99],"43.77":[89],"\u03bcg/ml),":[90],"against":[91],"human":[92],"lung":[93],"cell":[95,109,140],"line":[96],"(A549)":[97],"106.3":[100],"\u03bcg/ml).":[101],"Moreover,":[102],"exhibited":[104],"nor-mal":[108],"lines;":[110],"IC50":[112],"254":[116],"\u03bcg/ml":[117,120],"445.3":[119],"THLE2":[122],"Wi38,":[124],"respectively.":[125],"Flow":[126],"cytometric":[127],"analysis":[128],"demonstrated":[129],"treatment":[131],"HepG2":[133],"cells":[134],"with":[135],"increased":[137],"G2/M":[138],"phase":[139],"cycle":[141],"arrest.":[142],"quantitative":[144],"real":[145],"time-PCR":[146],"was":[147,186],"measure":[150],"mRNA":[152,173],"levels":[153,167],"p53,":[155],"Bax,":[156],"Bcl-2":[158],"genes.":[159,171],"data":[161],"changed":[165],"transcriptional":[166],"these":[169],"apoptosis-related":[170],"ex-pression":[174],"p53":[176],"Bax":[178],"up-regulated,":[180],"but,":[181],"transcription":[183],"Bcl2":[185],"significantly":[187],"down-regulated":[188],"com-pared":[189],"control.":[192]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-10-12T00:00:00"}
