{"id":"https://openalex.org/W2894659869","doi":"https://doi.org/10.1016/j.mam.2018.09.003","title":"Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection","display_name":"Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection","publication_year":2018,"publication_date":"2018-09-30","ids":{"openalex":"https://openalex.org/W2894659869","doi":"https://doi.org/10.1016/j.mam.2018.09.003","mag":"2894659869","pmid":"https://pubmed.ncbi.nlm.nih.gov/30244005","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6204315"},"language":"en","primary_location":{"id":"doi:10.1016/j.mam.2018.09.003","doi":"https://doi.org/10.1016/j.mam.2018.09.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mam.2018.09.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0098299718301006/pdf","source":{"id":"https://openalex.org/S61794117","display_name":"Molecular Aspects of Medicine","issn_l":"0098-2997","issn":["0098-2997","1872-9452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Aspects of Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0098299718301006/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068398524","display_name":"Nicolas Guillermo Bazan","orcid":"https://orcid.org/0000-0002-9243-5444","observed_orcids":["https://orcid.org/0000-0002-9243-5444"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicolas G. Bazan","raw_affiliation_strings":["Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA. Electronic address: nbazan@lsuhsc.edu","Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA. Electronic address: nbazan@lsuhsc.edu","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068398524"],"corresponding_institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"],"apc_list":{"value":5220,"currency":"USD","value_usd":5220},"apc_paid":{"value":5220,"currency":"USD","value_usd":5220},"fwci":2.5494,"has_fulltext":true,"cited_by_count":160,"citation_normalized_percentile":{"value":0.93044713,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"64","issue":null,"first_page":"18","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docosanoids","display_name":"docosanoids","score":0.9779999852180481},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9480000138282776},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8370000123977661},{"id":"https://openalex.org/keywords/photoreceptors","display_name":"photoreceptors","score":0.5989999771118164},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adipor1","display_name":"AdipoR1","score":0.902999997138977},{"id":"https://openalex.org/keywords/elovl4","display_name":"ELOVL4","score":0.9509999752044678},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7540000081062317},{"id":"https://openalex.org/keywords/dopaminergic-neuroprotection","display_name":"dopaminergic neuroprotection","score":0.7289999723434448},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.796999990940094},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6639999747276306},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.824999988079071},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7379999756813049},{"id":"https://openalex.org/keywords/neurotrauma","display_name":"neurotrauma","score":0.7099999785423279},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8477415442466736},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5995389223098755},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.5894262790679932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5888593196868896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42049640417099},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3700057566165924},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.360084593296051},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.2019389271736145}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054419","descriptor_name":"Receptors, Adiponectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054419","descriptor_name":"Receptors, Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.mam.2018.09.003","doi":"https://doi.org/10.1016/j.mam.2018.09.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mam.2018.09.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0098299718301006/pdf","source":{"id":"https://openalex.org/S61794117","display_name":"Molecular Aspects of Medicine","issn_l":"0098-2997","issn":["0098-2997","1872-9452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Aspects of Medicine","raw_type":"journal-article"},{"id":"pmid:30244005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30244005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular aspects of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5838867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6204315","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6204315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6204315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Aspects Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.mam.2018.09.003","doi":"https://doi.org/10.1016/j.mam.2018.09.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mam.2018.09.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0098299718301006/pdf","source":{"id":"https://openalex.org/S61794117","display_name":"Molecular Aspects of Medicine","issn_l":"0098-2997","issn":["0098-2997","1872-9452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Aspects of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G22196907","display_name":"Phospholipid and Arachidonic Acid Signaling in Epilepsy","funder_award_id":"R01NS023002","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3613090993","display_name":"Neuroprotection Lipid Signaling in Ischemia Reperfusion","funder_award_id":"R01NS046741","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8912018433","display_name":"Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience","funder_award_id":"P30GM103340","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8957520093","display_name":null,"funder_award_id":"NS2302","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000859373","display_name":"RPE Messengers, Transcription and Photoreceptor Renewal","funder_award_id":"R01EY005121","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2894659869.pdf","grobid_xml":"https://content.openalex.org/works/W2894659869.grobid-xml"},"referenced_works_count":215,"referenced_works":["https://openalex.org/W1443476078","https://openalex.org/W1480035757","https://openalex.org/W1485407919","https://openalex.org/W1513719789","https://openalex.org/W1519218320","https://openalex.org/W1532542691","https://openalex.org/W1567065116","https://openalex.org/W1577144537","https://openalex.org/W1578226137","https://openalex.org/W1579290445","https://openalex.org/W1601310757","https://openalex.org/W1739691545","https://openalex.org/W1767023496","https://openalex.org/W1891888434","https://openalex.org/W1941650629","https://openalex.org/W1961513473","https://openalex.org/W1963856990","https://openalex.org/W1965953789","https://openalex.org/W1966315067","https://openalex.org/W1967138719","https://openalex.org/W1967326841","https://openalex.org/W1967528858","https://openalex.org/W1968028223","https://openalex.org/W1968028706","https://openalex.org/W1969564013","https://openalex.org/W1969570272","https://openalex.org/W1969871031","https://openalex.org/W1975200070","https://openalex.org/W1975202788","https://openalex.org/W1975730562","https://openalex.org/W1976548321","https://openalex.org/W1977756329","https://openalex.org/W1977813572","https://openalex.org/W1979283544","https://openalex.org/W1981636985","https://openalex.org/W1981896076","https://openalex.org/W1983553517","https://openalex.org/W1984484733","https://openalex.org/W1987270268","https://openalex.org/W1989386811","https://openalex.org/W1990141561","https://openalex.org/W1991084221","https://openalex.org/W1991569123","https://openalex.org/W1992122074","https://openalex.org/W1992431848","https://openalex.org/W1992680479","https://openalex.org/W1993132387","https://openalex.org/W1993464867","https://openalex.org/W1996874802","https://openalex.org/W1997128330","https://openalex.org/W1997255414","https://openalex.org/W1997858872","https://openalex.org/W1997978122","https://openalex.org/W1998693870","https://openalex.org/W2000019568","https://openalex.org/W2000341627","https://openalex.org/W2000344192","https://openalex.org/W2003548320","https://openalex.org/W2004265235","https://openalex.org/W2005317473","https://openalex.org/W2005390270","https://openalex.org/W2005407591","https://openalex.org/W2005800358","https://openalex.org/W2007494385","https://openalex.org/W2009117300","https://openalex.org/W2009578021","https://openalex.org/W2013238661","https://openalex.org/W2016097851","https://openalex.org/W2016548332","https://openalex.org/W2019251983","https://openalex.org/W2022004671","https://openalex.org/W2024073076","https://openalex.org/W2024667826","https://openalex.org/W2026281867","https://openalex.org/W2027429345","https://openalex.org/W2027784977","https://openalex.org/W2031617630","https://openalex.org/W2032919119","https://openalex.org/W2033179944","https://openalex.org/W2035659802","https://openalex.org/W2037156529","https://openalex.org/W2037187198","https://openalex.org/W2039267832","https://openalex.org/W2041510888","https://openalex.org/W2042575144","https://openalex.org/W2043446682","https://openalex.org/W2043446856","https://openalex.org/W2046900303","https://openalex.org/W2048661776","https://openalex.org/W2049017785","https://openalex.org/W2049424212","https://openalex.org/W2049778040","https://openalex.org/W2049796110","https://openalex.org/W2053073979","https://openalex.org/W2054275187","https://openalex.org/W2054858102","https://openalex.org/W2055585878","https://openalex.org/W2056571308","https://openalex.org/W2056824541","https://openalex.org/W2057128909","https://openalex.org/W2057444523","https://openalex.org/W2058488571","https://openalex.org/W2059304461","https://openalex.org/W2061606662","https://openalex.org/W2061638102","https://openalex.org/W2061883196","https://openalex.org/W2062037597","https://openalex.org/W2064170412","https://openalex.org/W2066607845","https://openalex.org/W2069176580","https://openalex.org/W2069722990","https://openalex.org/W2070225076","https://openalex.org/W2070368256","https://openalex.org/W2074424606","https://openalex.org/W2075548690","https://openalex.org/W2076898547","https://openalex.org/W2080855172","https://openalex.org/W2081333064","https://openalex.org/W2082429191","https://openalex.org/W2084393183","https://openalex.org/W2085408531","https://openalex.org/W2086540681","https://openalex.org/W2086771798","https://openalex.org/W2087421641","https://openalex.org/W2087590528","https://openalex.org/W2089005670","https://openalex.org/W2092060809","https://openalex.org/W2092474731","https://openalex.org/W2092884781","https://openalex.org/W2094376682","https://openalex.org/W2097317908","https://openalex.org/W2098557851","https://openalex.org/W2100100832","https://openalex.org/W2100183499","https://openalex.org/W2100409371","https://openalex.org/W2100726346","https://openalex.org/W2102130080","https://openalex.org/W2102138771","https://openalex.org/W2103824935","https://openalex.org/W2104552710","https://openalex.org/W2105285858","https://openalex.org/W2109108939","https://openalex.org/W2109930285","https://openalex.org/W2111757144","https://openalex.org/W2114448829","https://openalex.org/W2114519398","https://openalex.org/W2116840309","https://openalex.org/W2118104226","https://openalex.org/W2118516203","https://openalex.org/W2118868433","https://openalex.org/W2125511265","https://openalex.org/W2125631424","https://openalex.org/W2130852003","https://openalex.org/W2131180711","https://openalex.org/W2133582447","https://openalex.org/W2134077483","https://openalex.org/W2137826993","https://openalex.org/W2137994863","https://openalex.org/W2139528091","https://openalex.org/W2145945334","https://openalex.org/W2146198846","https://openalex.org/W2148073546","https://openalex.org/W2150310369","https://openalex.org/W2151702576","https://openalex.org/W2153716005","https://openalex.org/W2158226583","https://openalex.org/W2158299803","https://openalex.org/W2161367071","https://openalex.org/W2164495642","https://openalex.org/W2166447911","https://openalex.org/W2166543843","https://openalex.org/W2167527031","https://openalex.org/W2168272960","https://openalex.org/W2168480206","https://openalex.org/W2169295104","https://openalex.org/W2170605386","https://openalex.org/W2185649074","https://openalex.org/W2187691436","https://openalex.org/W2203834727","https://openalex.org/W2231058499","https://openalex.org/W2269826147","https://openalex.org/W2328629342","https://openalex.org/W2351934060","https://openalex.org/W2399882212","https://openalex.org/W2411099493","https://openalex.org/W2495437956","https://openalex.org/W2516756255","https://openalex.org/W2521916677","https://openalex.org/W2560668196","https://openalex.org/W2579756956","https://openalex.org/W2585996473","https://openalex.org/W2605925788","https://openalex.org/W2609581908","https://openalex.org/W2614781785","https://openalex.org/W2728974037","https://openalex.org/W2729615630","https://openalex.org/W2745358720","https://openalex.org/W2752112633","https://openalex.org/W2754394790","https://openalex.org/W2760405290","https://openalex.org/W2766185642","https://openalex.org/W2768758846","https://openalex.org/W2783329544","https://openalex.org/W2788640168","https://openalex.org/W2791386016","https://openalex.org/W2807382073","https://openalex.org/W4231147928","https://openalex.org/W4299837043","https://openalex.org/W6634425710","https://openalex.org/W6647278567","https://openalex.org/W6661693924","https://openalex.org/W6675227867","https://openalex.org/W6681796982","https://openalex.org/W6686841950","https://openalex.org/W6731997132"],"related_works":["https://openalex.org/W2049775933","https://openalex.org/W2074160626","https://openalex.org/W2112006373","https://openalex.org/W2026281867","https://openalex.org/W2131581438","https://openalex.org/W1571875869","https://openalex.org/W2479875541","https://openalex.org/W7096195607","https://openalex.org/W3094610493","https://openalex.org/W2097758912"],"abstract_inverted_index":{"The":[0,264],"functional":[1],"significance":[2,70],"of":[3,7,25,45,71,104,116,124,149,152,160,187,203,215,227,233,252,256,266,269,283],"the":[4,8,26,43,46,56,69,72,102,139,185,210,225,245,253,281],"selective":[5],"enrichment":[6],"omega-3":[9],"essential":[10],"fatty":[11,207],"acid":[12,14],"docosahexaenoic":[13],"(DHA;":[15],"22C":[16],"and":[17,41,50,59,64,79,106,126,170,176,212,218,258,277,291,298,304],"6":[18],"double":[19],"bonds)":[20],"in":[21,62,76,94,135,145,163,165,221,260,301],"cellular":[22,287],"membrane":[23,38,90],"phospholipids":[24],"nervous":[27],"system":[28],"is":[29,92],"being":[30],"clarified":[31],"by":[32,42,174,192,274],"defining":[33],"its":[34,216],"specific":[35],"roles":[36],"on":[37],"protein":[39,91],"function":[40,103],"uncovering":[44],"bioactive":[47],"mediators,":[48],"docosanoids":[49,257,278],"elovanoids":[51],"(ELVs).":[52],"Here,":[53],"we":[54,199,230,248],"describe":[55],"preferential":[57],"uptake":[58],"DHA":[60,77,95,175],"metabolism":[61],"photoreceptors":[63],"brain":[65],"as":[66,68,97],"well":[67],"Adiponectin":[73],"receptor":[74],"1":[75],"retention":[78,96],"photoreceptor":[80],"cell":[81,271,284],"(PRC)":[82],"survival.":[83],"We":[84,112],"now":[85],"know":[86],"that":[87,183],"this":[88],"integral":[89],"engaged":[93],"a":[98,179,250],"necessary":[99],"event":[100],"for":[101,224,296],"PRCs":[105],"retinal":[107],"pigment":[108],"epithelial":[109],"(RPE)":[110],"cells.":[111],"present":[113,249],"an":[114,164],"overview":[115],"how":[117],"a)":[118],"NPD1":[119,130,144,158,177],"selectively":[120],"mediates":[121],"preconditioning":[122],"rescue":[123],"RPE":[125,238],"PR":[127],"cells;":[128],"b)":[129],"restores":[131],"aberrant":[132],"neuronal":[133],"networks":[134],"experimental":[136,261],"epileptogenesis;":[137],"c)":[138],"decreased":[140],"ability":[141,235],"to":[142,236,280],"biosynthesize":[143],"memory":[146],"hippocampal":[147],"areas":[148],"early":[150,267],"stages":[151],"Alzheimer's":[153],"disease":[154],"takes":[155],"place;":[156],"d)":[157],"protection":[159],"dopaminergic":[161],"circuits":[162],"vitro":[166],"model":[167],"using":[168],"neurotoxins;":[169],"e)":[171],"bioactivity":[172,255],"elicited":[173],"activate":[178],"neuroprotective":[180],"gene-expression":[181],"program":[182],"includes":[184],"expression":[186],"Bcl-2":[188],"family":[189],"members":[190],"affected":[191],"A\u03b242,":[193],"DHA,":[194],"or":[195],"NPD1.":[196],"In":[197,244],"addition,":[198],"highlight":[200],"ELOVL4":[201],"(ELOngation":[202],"Very":[204],"Long":[205],"chain":[206],"acids-4),":[208],"specifically":[209],"neurological":[211],"ophthalmological":[213],"consequences":[214],"mutations,":[217],"their":[219],"role":[220],"providing":[222],"precursors":[223],"biosynthesis":[226],"ELVs.":[228],"Then":[229],"outline":[231],"evidence":[232],"ELVs":[234,259,276],"protect":[237],"cells,":[239],"which":[240],"sustain":[241],"PRC":[242],"integrity.":[243],"last":[246],"section,":[247],"summary":[251],"protective":[254],"ischemic":[262],"stroke.":[263],"identification":[265],"mechanisms":[268],"neural":[270],"survival":[272],"mediated":[273],"DHA-synthesized":[275],"contributes":[279],"understanding":[282],"function,":[285],"pro-homeostatic":[286],"modulation,":[288],"inflammatory":[289],"responses,":[290],"innate":[292],"immunity,":[293],"opening":[294],"avenues":[295],"prevention":[297],"therapeutic":[299],"applications":[300],"neurotrauma,":[302],"stroke":[303],"neurodegenerative":[305],"diseases.":[306]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-10-12T00:00:00"}
