{"id":"https://openalex.org/W2894586965","doi":"https://doi.org/10.1016/j.joca.2018.08.024","title":"A systematic review of the small molecule studies of osteoarthritis using nuclear magnetic resonance and mass spectroscopy","display_name":"A systematic review of the small molecule studies of osteoarthritis using nuclear magnetic resonance and mass spectroscopy","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2894586965","doi":"https://doi.org/10.1016/j.joca.2018.08.024","mag":"2894586965","pmid":"https://pubmed.ncbi.nlm.nih.gov/30287397"},"language":"en","primary_location":{"id":"doi:10.1016/j.joca.2018.08.024","doi":"https://doi.org/10.1016/j.joca.2018.08.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2018.08.024","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.joca.2018.08.024","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002004948","display_name":"Matthew K. J. Jaggard","orcid":"https://orcid.org/0000-0001-6661-7837","observed_orcids":["https://orcid.org/0000-0001-6661-7837"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M.K.J. Jaggard","raw_affiliation_strings":["Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom. Electronic address: m.k.j.jaggard@doctors.org.uk","Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6661-7837","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom. Electronic address: m.k.j.jaggard@doctors.org.uk","institution_ids":["https://openalex.org/I153355300"]},{"raw_affiliation_string":"Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102742658","display_name":"Claire L. Boulang\u00e9","orcid":"https://orcid.org/0000-0002-9022-0159","observed_orcids":["https://orcid.org/0000-0002-9022-0159"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C.L. Boulang\u00e9","raw_affiliation_strings":["Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011787009","display_name":"Pouya Akhbari","orcid":"https://orcid.org/0000-0002-3812-5605","observed_orcids":["https://orcid.org/0000-0002-3812-5605"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Akhbari","raw_affiliation_strings":["Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3812-5605","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090281093","display_name":"Uddhav Vaghela","orcid":"https://orcid.org/0000-0003-3525-4388","observed_orcids":["https://orcid.org/0000-0003-3525-4388"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"U. Vaghela","raw_affiliation_strings":["School of Medicine, Imperial College London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067050743","display_name":"Rajarshi Bhattacharya","orcid":"https://orcid.org/0000-0002-0725-2388","observed_orcids":["https://orcid.org/0000-0002-0725-2388"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Bhattacharya","raw_affiliation_strings":["Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070792216","display_name":"Horace R. T. Williams","orcid":"https://orcid.org/0000-0001-5889-7584","observed_orcids":["https://orcid.org/0000-0001-5889-7584"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H.R.T. Williams","raw_affiliation_strings":["Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028056295","display_name":"John C. Lindon","orcid":"https://orcid.org/0000-0002-0916-6360","observed_orcids":["https://orcid.org/0000-0002-0916-6360"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.C. Lindon","raw_affiliation_strings":["Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071615443","display_name":"Chinmay Madhukar Gupte","orcid":"https://orcid.org/0000-0003-1317-4512","observed_orcids":["https://orcid.org/0000-0003-1317-4512"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C.M. Gupte","raw_affiliation_strings":["Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002004948"],"corresponding_institution_ids":["https://openalex.org/I153355300"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":0.3157,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.2590879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"4","first_page":"560","last_page":"570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/small-molecule-metabolism","display_name":"small molecule metabolism","score":0.8610000014305115},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.972000002861023},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.6819999814033508},{"id":"https://openalex.org/keywords/anaerobic-metabolism","display_name":"anaerobic metabolism","score":0.9750000238418579},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lipid-composition","display_name":"lipid composition","score":0.6899999976158142},{"id":"https://openalex.org/keywords/proteoglycan-degradation","display_name":"proteoglycan degradation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6809999942779541},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6445321440696716},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5834311842918396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.558040976524353},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4802677631378174},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4327843189239502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4270781874656677},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.4149349629878998},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37635338306427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3397020697593689},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3201029598712921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2619997262954712},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.joca.2018.08.024","doi":"https://doi.org/10.1016/j.joca.2018.08.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2018.08.024","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},{"id":"pmid:30287397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30287397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and cartilage","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.joca.2018.08.024","doi":"https://doi.org/10.1016/j.joca.2018.08.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2018.08.024","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315071","display_name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320284","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W41470836","https://openalex.org/W159112688","https://openalex.org/W1495854428","https://openalex.org/W1536694576","https://openalex.org/W1560638706","https://openalex.org/W1573431383","https://openalex.org/W1791199433","https://openalex.org/W1907429131","https://openalex.org/W1924772894","https://openalex.org/W1964087281","https://openalex.org/W1965227906","https://openalex.org/W1973296785","https://openalex.org/W1978165909","https://openalex.org/W1978772759","https://openalex.org/W1978864283","https://openalex.org/W1979115759","https://openalex.org/W1983674644","https://openalex.org/W1987627808","https://openalex.org/W1996575538","https://openalex.org/W1996875545","https://openalex.org/W2007113290","https://openalex.org/W2013422659","https://openalex.org/W2021673142","https://openalex.org/W2024759250","https://openalex.org/W2044286906","https://openalex.org/W2044633090","https://openalex.org/W2062222093","https://openalex.org/W2064445380","https://openalex.org/W2067535874","https://openalex.org/W2068798370","https://openalex.org/W2074736416","https://openalex.org/W2079983620","https://openalex.org/W2091557482","https://openalex.org/W2095392254","https://openalex.org/W2097760482","https://openalex.org/W2106711119","https://openalex.org/W2108633234","https://openalex.org/W2119919478","https://openalex.org/W2121804105","https://openalex.org/W2131002362","https://openalex.org/W2158726793","https://openalex.org/W2159482845","https://openalex.org/W2188794141","https://openalex.org/W2214034113","https://openalex.org/W2227610719","https://openalex.org/W2409193268","https://openalex.org/W2411966055","https://openalex.org/W2420613970","https://openalex.org/W2421228811","https://openalex.org/W2507018117","https://openalex.org/W2586462015","https://openalex.org/W2754011655","https://openalex.org/W2768158470","https://openalex.org/W2774530388","https://openalex.org/W4229554023","https://openalex.org/W4294216483","https://openalex.org/W6653335171"],"related_works":["https://openalex.org/W2068798370","https://openalex.org/W3112876016","https://openalex.org/W2943246799","https://openalex.org/W2891329739","https://openalex.org/W2755773028","https://openalex.org/W4387140297","https://openalex.org/W4316039566","https://openalex.org/W4396748117","https://openalex.org/W1560638706","https://openalex.org/W3214782466"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-10-12T00:00:00"}