{"id":"https://openalex.org/W2894544169","doi":"https://doi.org/10.1093/nar/gky875","title":"Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein","display_name":"Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein","publication_year":2018,"publication_date":"2018-09-18","ids":{"openalex":"https://openalex.org/W2894544169","doi":"https://doi.org/10.1093/nar/gky875","mag":"2894544169","pmid":"https://pubmed.ncbi.nlm.nih.gov/30256971","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6265486"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gky875","doi":"https://doi.org/10.1093/nar/gky875","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky875","pdf_url":"https://academic.oup.com/nar/article-pdf/46/21/11287/26901630/gky875.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/46/21/11287/26901630/gky875.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013164620","display_name":"Parminder Kaur","orcid":"https://orcid.org/0000-0001-9183-4315","observed_orcids":["https://orcid.org/0000-0001-9183-4315"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Parminder Kaur","raw_affiliation_strings":["Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, NC 27695, USA","Physics Department, North Carolina State University, Raleigh, North Carolina, NC 27695, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Physics Department, North Carolina State University, Raleigh, North Carolina, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058936762","display_name":"Matthew J. Longley","orcid":"https://orcid.org/0000-0002-9352-2814","observed_orcids":["https://orcid.org/0000-0002-9352-2814"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J Longley","raw_affiliation_strings":["Genome Integrity and Structural Biology Laboratory, NIEHS, NIH, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, NIEHS, NIH, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025498462","display_name":"Hai Pan","orcid":"https://orcid.org/0000-0001-6660-9052","observed_orcids":["https://orcid.org/0000-0001-6660-9052"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Pan","raw_affiliation_strings":["Physics Department, North Carolina State University, Raleigh, North Carolina, NC 27695, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physics Department, North Carolina State University, Raleigh, North Carolina, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051576642","display_name":"Hong Wang","orcid":"https://orcid.org/0000-0003-0165-3559","observed_orcids":["https://orcid.org/0000-0003-0165-3559","https://orcid.org/0000-0002-5125-9974"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, NC 27695, USA","Physics Department, North Carolina State University, Raleigh, North Carolina, NC 27695, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Physics Department, North Carolina State University, Raleigh, North Carolina, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075186269","display_name":"William C. Copeland","orcid":"https://orcid.org/0000-0002-0359-0953","observed_orcids":["https://orcid.org/0000-0002-0359-0953"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William C Copeland","raw_affiliation_strings":["Genome Integrity and Structural Biology Laboratory, NIEHS, NIH, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, NIEHS, NIH, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013164620","https://openalex.org/A5075186269"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I137902535","https://openalex.org/I4210095140"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.61,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.84453125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"46","issue":"21","first_page":"11287","last_page":"11302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-single-stranded-dna-binding-protein","display_name":"mitochondrial single-stranded DNA-binding protein","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mitochondrial-dna-replication","display_name":"mitochondrial DNA replication","score":0.8190000057220459},{"id":"https://openalex.org/keywords/dna-wrapping","display_name":"DNA wrapping","score":0.6330000162124634},{"id":"https://openalex.org/keywords/single-stranded-dna-binding","display_name":"single-stranded DNA binding","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mitochondrial-dna-deletions","display_name":"mitochondrial DNA deletions","score":0.5619999766349792},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.5479999780654907},{"id":"https://openalex.org/keywords/dna-contour-length","display_name":"DNA contour length","score":0.5199999809265137},{"id":"https://openalex.org/keywords/electrostatic-force-microscopy","display_name":"electrostatic force microscopy","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7755012512207031},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7555517554283142},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6217230558395386},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.621408998966217},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.582988440990448},{"id":"https://openalex.org/C77400797","wikidata":"https://www.wikidata.org/wiki/Q24724047","display_name":"Single-stranded binding protein","level":5,"score":0.4948992133140564},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.48181381821632385},{"id":"https://openalex.org/C5179208","wikidata":"https://www.wikidata.org/wiki/Q3782057","display_name":"HMG-box","level":5,"score":0.4714471101760864},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46885690093040466},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.4130322337150574},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.40680283308029175},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33705586194992065},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32355061173439026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2910916805267334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24111348390579224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23396450281143188},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16806957125663757},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000072760","descriptor_name":"Single Molecule Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gky875","doi":"https://doi.org/10.1093/nar/gky875","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky875","pdf_url":"https://academic.oup.com/nar/article-pdf/46/21/11287/26901630/gky875.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5244586","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6265486","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6265486","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6265486","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:30256971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30256971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gky875","doi":"https://doi.org/10.1093/nar/gky875","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky875","pdf_url":"https://academic.oup.com/nar/article-pdf/46/21/11287/26901630/gky875.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2334242146","display_name":null,"funder_award_id":"R01GM123246","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G424106435","display_name":null,"funder_award_id":"ES-065078","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7045051526","display_name":null,"funder_award_id":"P30ES025128","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G81448834","display_name":null,"funder_award_id":"R21ES027641","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G8595014448","display_name":"Mechanism of protein-mediated looping in a complex environment","funder_award_id":"R01GM107559","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8708290667","display_name":null,"funder_award_id":"R01GM107559","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G8798754312","display_name":"Sequence and structure specific DNA binding by cohesin and genome stability","funder_award_id":"R01GM123246","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000917568","display_name":"Center for Human Health and the Environment (CHHE)","funder_award_id":"P30ES025128","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337544","display_name":"Office of Extramural Research, National Institutes of Health","ror":"https://ror.org/05aq6yn88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2894544169.pdf"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W154063391","https://openalex.org/W201738796","https://openalex.org/W1501619406","https://openalex.org/W1547544053","https://openalex.org/W1554955915","https://openalex.org/W1559132509","https://openalex.org/W1576919957","https://openalex.org/W1603287594","https://openalex.org/W1806123628","https://openalex.org/W1966260649","https://openalex.org/W1971178460","https://openalex.org/W1971301795","https://openalex.org/W1971594953","https://openalex.org/W1973414360","https://openalex.org/W1973851166","https://openalex.org/W1975180512","https://openalex.org/W1981829426","https://openalex.org/W1989108993","https://openalex.org/W1989840530","https://openalex.org/W1990017624","https://openalex.org/W1991781564","https://openalex.org/W1992357330","https://openalex.org/W1997847492","https://openalex.org/W2000106654","https://openalex.org/W2001696948","https://openalex.org/W2003850268","https://openalex.org/W2003885999","https://openalex.org/W2005928903","https://openalex.org/W2005986251","https://openalex.org/W2006705573","https://openalex.org/W2007848978","https://openalex.org/W2008159830","https://openalex.org/W2014204923","https://openalex.org/W2015912163","https://openalex.org/W2017201927","https://openalex.org/W2021078227","https://openalex.org/W2024220597","https://openalex.org/W2033319825","https://openalex.org/W2036791811","https://openalex.org/W2037145079","https://openalex.org/W2052124022","https://openalex.org/W2053619432","https://openalex.org/W2058918675","https://openalex.org/W2059453827","https://openalex.org/W2061338529","https://openalex.org/W2065571115","https://openalex.org/W2067405008","https://openalex.org/W2068464246","https://openalex.org/W2077283568","https://openalex.org/W2077517552","https://openalex.org/W2093358373","https://openalex.org/W2097812130","https://openalex.org/W2100704541","https://openalex.org/W2109291482","https://openalex.org/W2115684167","https://openalex.org/W2116541356","https://openalex.org/W2116573367","https://openalex.org/W2116711646","https://openalex.org/W2117320616","https://openalex.org/W2119472874","https://openalex.org/W2121710171","https://openalex.org/W2128923895","https://openalex.org/W2132294639","https://openalex.org/W2139539971","https://openalex.org/W2143649740","https://openalex.org/W2144634347","https://openalex.org/W2144792857","https://openalex.org/W2149682982","https://openalex.org/W2153436893","https://openalex.org/W2155949689","https://openalex.org/W2156503106","https://openalex.org/W2158750984","https://openalex.org/W2159453189","https://openalex.org/W2160001213","https://openalex.org/W2167466260","https://openalex.org/W2172617576","https://openalex.org/W2178168667","https://openalex.org/W2231683418","https://openalex.org/W2232430004","https://openalex.org/W2314225431","https://openalex.org/W2344148285","https://openalex.org/W2411506815","https://openalex.org/W2416877295","https://openalex.org/W2460708687","https://openalex.org/W2550762644","https://openalex.org/W2587980633","https://openalex.org/W2612254851","https://openalex.org/W2626352462","https://openalex.org/W2768736041","https://openalex.org/W2794170341"],"related_works":["https://openalex.org/W2116541356","https://openalex.org/W4401385506","https://openalex.org/W2425883022","https://openalex.org/W2626352462","https://openalex.org/W2612254851","https://openalex.org/W2793329416","https://openalex.org/W2156503106","https://openalex.org/W1988608516","https://openalex.org/W2052124022","https://openalex.org/W2414009180"],"abstract_inverted_index":{"Improper":[0],"maintenance":[1],"of":[2,29,60,73,80,99,114,118],"the":[3,30,40,54,115,132,179],"mitochondrial":[4,17,180],"genome":[5,181],"progressively":[6],"disrupts":[7],"cellular":[8],"respiration":[9],"and":[10],"causes":[11],"severe":[12],"metabolic":[13],"disorders":[14],"commonly":[15],"termed":[16],"diseases.":[18],"Mitochondrial":[19],"single-stranded":[20,81,111,172],"DNA":[21,47,82,107,120,127,133,150],"binding":[22,87,91,122,146],"protein":[23,51],"(mtSSB)":[24],"is":[25],"an":[26],"essential":[27],"component":[28],"mtDNA":[31,55,176],"replication":[32,56,173],"machinery.":[33],"We":[34],"utilized":[35],"single-molecule":[36],"methods":[37],"to":[38,48,77,92,104,126,183],"examine":[39],"modes":[41],"by":[42,64,88,96,188],"which":[43],"human":[44],"mtSSB":[45,62,74,101,123,156,165],"binds":[46],"help":[49],"define":[50],"interactions":[52],"at":[53,158],"fork.":[57],"Direct":[58],"visualization":[59],"individual":[61,100],"molecules":[63],"atomic":[65],"force":[66,141],"microscopy":[67],"(AFM)":[68],"revealed":[69],"a":[70,144],"random":[71],"distribution":[72],"tetramers":[75,102],"bound":[76,103],"extended":[78],"regions":[79],"(ssDNA),":[83],"strongly":[84],"suggesting":[85],"non-cooperative":[86],"mtSSB.":[89,130],"Selective":[90],"ssDNA":[93],"was":[94,124],"confirmed":[95],"AFM":[97],"imaging":[98,163],"gapped":[105,119],"plasmid":[106],"substrates":[108],"bearing":[109],"defined":[110],"regions.":[112],"Shortening":[113],"contour":[116],"length":[117],"upon":[121],"attributed":[125],"wrapping":[128],"around":[129,154],"Tracing":[131],"path":[134],"in":[135],"mtSSB-ssDNA":[136],"complexes":[137],"with":[138,148,195],"Dual-Resonance-frequency-Enhanced":[139],"Electrostatic":[140],"Microscopy":[142],"established":[143],"predominant":[145],"mode":[147],"one":[149],"strand":[151],"winding":[152],"once":[153],"each":[155],"tetramer":[157],"physiological":[159],"salt":[160],"conditions.":[161],"Single-molecule":[162],"suggests":[164],"may":[166],"not":[167],"saturate":[168],"or":[169,191],"fully":[170],"protect":[171],"intermediates":[174],"during":[175],"synthesis,":[177],"leaving":[178],"vulnerable":[182],"chemical":[184],"mutagenesis,":[185],"deletions":[186],"driven":[187],"primer":[189],"relocation":[190],"other":[192],"actions":[193],"consistent":[194],"clinically":[196],"observed":[197],"deletion":[198],"biases.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-05T00:00:00"}