{"id":"https://openalex.org/W2894495537","doi":"https://doi.org/10.1093/gerona/gly218","title":"The Impact of Reactogenicity After the First Dose of Recombinant Zoster Vaccine on the Physical Functioning and Quality of Life of Older Adults: An Open-Label, Phase III Trial","display_name":"The Impact of Reactogenicity After the First Dose of Recombinant Zoster Vaccine on the Physical Functioning and Quality of Life of Older Adults: An Open-Label, Phase III Trial","publication_year":2018,"publication_date":"2018-09-25","ids":{"openalex":"https://openalex.org/W2894495537","doi":"https://doi.org/10.1093/gerona/gly218","mag":"2894495537","pmid":"https://pubmed.ncbi.nlm.nih.gov/30256905","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6625580"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/gly218","doi":"https://doi.org/10.1093/gerona/gly218","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/gly218","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/74/8/1217/28931502/gly218.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/biomedgerontology/article-pdf/74/8/1217/28931502/gly218.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009725215","display_name":"Kenneth E. Schmader","orcid":"https://orcid.org/0000-0001-5036-2155","observed_orcids":["https://orcid.org/0000-0001-5036-2155"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E Schmader","raw_affiliation_strings":["Division of Geriatrics, Duke University Medical Center and GRECC, Durham Veterans Affairs Medical Center, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatrics, Duke University Medical Center and GRECC, Durham Veterans Affairs Medical Center, North Carolina","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051264386","display_name":"Myron J. Levin","orcid":"https://orcid.org/0000-0002-7468-106X","observed_orcids":["https://orcid.org/0000-0002-7468-106X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myron J Levin","raw_affiliation_strings":["Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora","Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061217494","display_name":"Katrijn Grupping","orcid":"https://orcid.org/0000-0002-3300-1021","observed_orcids":["https://orcid.org/0000-0002-3300-1021"]},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Katrijn Grupping","raw_affiliation_strings":["GSK, Wavre, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Wavre, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012207802","display_name":"Sean Matthews","orcid":"https://orcid.org/0000-0001-7427-7326","observed_orcids":["https://orcid.org/0000-0001-7427-7326"]},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sean Matthews","raw_affiliation_strings":["Freelance c/o GSK, Wavre, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Freelance c/o GSK, Wavre, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028867550","display_name":"David Butuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Butuk","raw_affiliation_strings":["Solaris Clinical Research, Meridian, Idaho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Solaris Clinical Research, Meridian, Idaho","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705937","display_name":"Michael Jenwei Chen","orcid":"https://orcid.org/0000-0001-7897-7733","observed_orcids":["https://orcid.org/0000-0001-7897-7733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Chen","raw_affiliation_strings":["The Corvallis Clinic, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Corvallis Clinic, Oregon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103236256","display_name":"Mohamed El Idrissi","orcid":"https://orcid.org/0000-0002-3306-3062","observed_orcids":["https://orcid.org/0000-0002-3306-3062"]},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mohamed El Idrissi","raw_affiliation_strings":["GSK, Rixensart, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Rixensart, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065562779","display_name":"Laurence A Fissette","orcid":"https://orcid.org/0000-0002-6483-6558","observed_orcids":["https://orcid.org/0000-0002-6483-6558"]},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laurence A Fissette","raw_affiliation_strings":["GSK, Wavre, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Wavre, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052604055","display_name":"Charles M. Fogarty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801349183","display_name":"Spartanburg Regional Medical Center","ror":"https://ror.org/0322mf940","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801349183","https://openalex.org/I4210133986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Fogarty","raw_affiliation_strings":["Spartanburg Medical Research, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spartanburg Medical Research, South Carolina","institution_ids":["https://openalex.org/I2801349183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109407288","display_name":"Paul Hartley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Hartley","raw_affiliation_strings":["Preferred Primary Care Physicians, Uniontown, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preferred Primary Care Physicians, Uniontown, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034478332","display_name":"Nicola P. Klein","orcid":"https://orcid.org/0000-0003-1777-4814","observed_orcids":["https://orcid.org/0000-0003-1777-4814"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I2801936213","display_name":"Kaiser Permanente Oakland Medical Center","ror":"https://ror.org/05rfek682","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I2801936213"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicola P Klein","raw_affiliation_strings":["Kaiser Permanente Vaccine Study Center, Oakland, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Vaccine Study Center, Oakland, California","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I2801936213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015731103","display_name":"Max Nevarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max Nevarez","raw_affiliation_strings":["DaVita Medical Group, Colorado Springs, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DaVita Medical Group, Colorado Springs, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039067471","display_name":"Kari Uusinarkaus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kari Uusinarkaus","raw_affiliation_strings":["DaVita Medical Group, Colorado Springs, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DaVita Medical Group, Colorado Springs, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051915476","display_name":"Lidia Oostvogels","orcid":"https://orcid.org/0000-0003-1298-0360","observed_orcids":["https://orcid.org/0000-0003-1298-0360"]},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Lidia Oostvogels","raw_affiliation_strings":["GSK, Wavre, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Wavre, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084194739","display_name":"Desmond Curran","orcid":"https://orcid.org/0000-0002-7423-0111","observed_orcids":["https://orcid.org/0000-0002-7423-0111"]},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Desmond Curran","raw_affiliation_strings":["GSK, Wavre, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-7423-0111","affiliations":[{"raw_affiliation_string":"GSK, Wavre, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5051915476","https://openalex.org/A5084194739"],"corresponding_institution_ids":["https://openalex.org/I4210095529"],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":{"value":4408,"currency":"USD","value_usd":4408},"fwci":1.9488,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.85856342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"74","issue":"8","first_page":"1217","last_page":"1224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-zoster-vaccine","display_name":"recombinant zoster vaccine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/reactogenicity","display_name":"reactogenicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.7039999961853027},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9879999756813049},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9940000176429749},{"id":"https://openalex.org/keywords/herpes-zoster","display_name":"herpes zoster","score":0.7590000033378601},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.6079999804496765},{"id":"https://openalex.org/keywords/injection-site-pain","display_name":"injection site pain","score":0.7350000143051147},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.7210000157356262},{"id":"https://openalex.org/keywords/productivity-loss","display_name":"productivity loss","score":0.621999979019165},{"id":"https://openalex.org/keywords/caregiver-burden","display_name":"caregiver burden","score":0.7400000095367432},{"id":"https://openalex.org/keywords/healthcare-resource-utilization","display_name":"healthcare resource utilization","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C2777704310","wikidata":"https://www.wikidata.org/wiki/Q7300322","display_name":"Reactogenicity","level":4,"score":0.9574412107467651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7740302085876465},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.7346215844154358},{"id":"https://openalex.org/C2778616394","wikidata":"https://www.wikidata.org/wiki/Q474959","display_name":"myalgia","level":2,"score":0.6019231081008911},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4967499375343323},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48513874411582947},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35905683040618896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24387642741203308},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08907204866409302},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.07647046446800232},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006306","descriptor_name":"Health Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053061","descriptor_name":"Herpes Zoster Vaccine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/gerona/gly218","doi":"https://doi.org/10.1093/gerona/gly218","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/gly218","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/74/8/1217/28931502/gly218.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6625580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6625580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},{"id":"pmid:30256905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30256905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":{"id":"doi:10.1093/gerona/gly218","doi":"https://doi.org/10.1093/gerona/gly218","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/gly218","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/74/8/1217/28931502/gly218.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000899105","display_name":"Duke Claude D. Pepper Older Americans Independence Center","funder_award_id":"P30AG028716","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F8449784507","display_name":"GlaxoSmithKline Biologicals","ror":"https://ror.org/00n3pea85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2894495537.pdf","grobid_xml":"https://content.openalex.org/works/W2894495537.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1868327112","https://openalex.org/W1964914124","https://openalex.org/W1991129383","https://openalex.org/W1996464306","https://openalex.org/W2008775818","https://openalex.org/W2010207831","https://openalex.org/W2013733406","https://openalex.org/W2022877567","https://openalex.org/W2027886016","https://openalex.org/W2028419511","https://openalex.org/W2071589319","https://openalex.org/W2082084705","https://openalex.org/W2089469640","https://openalex.org/W2089973119","https://openalex.org/W2137654125","https://openalex.org/W2138068778","https://openalex.org/W2151572628","https://openalex.org/W2482786872","https://openalex.org/W2519957152","https://openalex.org/W2569903330","https://openalex.org/W2580539158","https://openalex.org/W2624880999","https://openalex.org/W2734800292","https://openalex.org/W2734980347","https://openalex.org/W2765537391","https://openalex.org/W3031436746"],"related_works":["https://openalex.org/W2897898762","https://openalex.org/W3035548283","https://openalex.org/W2981849202","https://openalex.org/W2903016637","https://openalex.org/W1488923056","https://openalex.org/W2884012554","https://openalex.org/W2966872618","https://openalex.org/W4387644030","https://openalex.org/W3216238282","https://openalex.org/W4210312979"],"abstract_inverted_index":{"BACKGROUND:":[0],"Herpes":[1],"zoster":[2,29],"and":[3,19,40,55,60,67,81,108,143,157,168,194,222,245],"its":[4],"related":[5],"complications":[6],"are":[7],"associated":[8,37,170],"with":[9,38,171,265],"significant":[10],"medical":[11],"burden,":[12],"which":[13],"negatively":[14],"affects":[15],"quality":[16,52,101,246],"of":[17,22,48,53,58,102,166,247,249],"life":[18,54,248],"daily":[20,56],"functioning":[21,57,244],"the":[23,46,51,146,242],"patients.":[24],"The":[25,115,131,260],"recently":[26],"licensed":[27],"recombinant":[28],"vaccine":[30],"(RZV)":[31],"offers":[32],"high":[33],"efficacy":[34],"but":[35],"is":[36],"local":[39,135],"systemic":[41,150],"reactions.":[42],"This":[43],"study":[44,89],"assessed":[45],"impact":[47],"RZV":[49,77,258],"on":[50,191],"participants":[59,167,231],"implications":[61],"for":[62],"caregivers.":[63],"METHODS:":[64],"Four":[65],"hundred":[66],"one":[68],"adults":[69,251],"aged":[70],"50":[71],"years":[72],"or":[73],"older":[74,250],"received":[75],"single":[76],"doses":[78],"at":[79],"0":[80],"2":[82,195],"months":[83],"in":[84,92,164,177,202],"this":[85],"open-label,":[86],"single-arm,":[87],"multicenter":[88],"(NCT02979639).":[90],"Change":[91],"mean":[93,203],"SF-36":[94,178,204],"Physical":[95,179,205],"Functioning":[96,180,206],"score":[97,181],"following":[98],"first-dose":[99],"administration,":[100],"life,":[103],"reactogenicity,":[104],"safety,":[105],"productivity":[106],"loss,":[107],"health":[109],"care":[110],"resource":[111],"utilization":[112],"was":[113,118,169,227,237,263],"assessed.":[114],"current":[116],"analysis":[117],"performed":[119],"post-vaccine":[120],"dose-1;":[121],"safety":[122],"follow-up":[123],"will":[124],"continue":[125],"until":[126],"1":[127,193],"year":[128],"post-dose-2.":[129],"RESULTS:":[130],"most":[132,147],"common":[133],"solicited":[134,149],"symptoms":[136],"were":[137,152,214,252],"injection-site":[138],"pain":[139],"(77.5%),":[140],"redness":[141],"(23.0%),":[142],"swelling":[144],"(13.3%);":[145],"frequent":[148],"reactions":[151],"fatigue":[153],"(33.5%),":[154],"headache":[155],"(28.3%),":[156],"myalgia":[158],"(26.8%).":[159],"Grade":[160],"3":[161],"reactogenicity":[162,262],"occurred":[163],"9.5%":[165],"a":[172,256],"transient":[173],"clinically":[174,199],"important":[175],"decrease":[176],"(affecting":[182],"activities":[183],"such":[184],"as":[185],"walking,":[186],"carrying":[187],"groceries,":[188],"climbing":[189],"stairs)":[190],"Days":[192],"post-first":[196],"vaccination.":[197],"No":[198],"meaningful":[200],"reductions":[201],"scale":[207],"scores":[208],"from":[209],"pre-":[210],"to":[211],"post-RZV":[212],"dose-1":[213],"observed":[215,261],"(mean":[216],"+1.9":[217],"points,":[218],"primary":[219],"end":[220],"point),":[221],"no":[223],"overall":[224],"quality-adjusted-life-year":[225],"loss":[226],"recorded":[228],"post-dose-1.":[229],"Five":[230],"reported":[232],"lost":[233],"workdays;":[234],"caregiver":[235],"workload":[236],"not":[238,253],"increased.":[239],"CONCLUSIONS:":[240],"Overall,":[241],"physical":[243],"affected":[254],"by":[255],"first":[257],"dose.":[259],"consistent":[264],"previous":[266],"studies.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-10-05T00:00:00"}