{"id":"https://openalex.org/W2894491263","doi":null,"title":"Engineering NK Cells Towards Next Generation NK Cell Immunotherapy","display_name":"Engineering NK Cells Towards Next Generation NK Cell Immunotherapy","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2894491263","mag":"2894491263"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/64770","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/64770","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/64770","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008236591","display_name":"Vincent Yi Sheng Oei","orcid":"https://orcid.org/0000-0002-9336-529X","observed_orcids":["https://orcid.org/0000-0002-9336-529X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vincent Yi Sheng Oei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008236591"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nk-cell-therapy","display_name":"NK cell therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/adaptive-nk-cells","display_name":"adaptive NK cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nk-cell-heterogeneity","display_name":"NK cell heterogeneity","score":0.746999979019165},{"id":"https://openalex.org/keywords/targeted-cell-killing","display_name":"targeted cell killing","score":0.4000000059604645},{"id":"https://openalex.org/keywords/genetically-modified-t-cells","display_name":"genetically modified T cells","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.4189999997615814},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5524793267250061},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3557860553264618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3216526508331299},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2893497347831726},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16437086462974548}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/64770","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/64770","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2894491263","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/handle/10852/64770","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/64770","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/64770","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":312,"referenced_works":["https://openalex.org/W40408739","https://openalex.org/W76522298","https://openalex.org/W1166860901","https://openalex.org/W1480489408","https://openalex.org/W1481223393","https://openalex.org/W1493661170","https://openalex.org/W1494555654","https://openalex.org/W1519518167","https://openalex.org/W1522135114","https://openalex.org/W1538826344","https://openalex.org/W1540992219","https://openalex.org/W1541594543","https://openalex.org/W1547971098","https://openalex.org/W1595178772","https://openalex.org/W1599436005","https://openalex.org/W1605872885","https://openalex.org/W1609573192","https://openalex.org/W1642873092","https://openalex.org/W1653904273","https://openalex.org/W1757602653","https://openalex.org/W1778071429","https://openalex.org/W1806981800","https://openalex.org/W1842908980","https://openalex.org/W1873760231","https://openalex.org/W1878895776","https://openalex.org/W1917682458","https://openalex.org/W1943676235","https://openalex.org/W1957901086","https://openalex.org/W1962349010","https://openalex.org/W1963684624","https://openalex.org/W1964082903","https://openalex.org/W1964742561","https://openalex.org/W1965026817","https://openalex.org/W1965779228","https://openalex.org/W1966280572","https://openalex.org/W1966379453","https://openalex.org/W1966542058","https://openalex.org/W1967229707","https://openalex.org/W1967455230","https://openalex.org/W1967517831","https://openalex.org/W1967769371","https://openalex.org/W1968063790","https://openalex.org/W1968340059","https://openalex.org/W1969814796","https://openalex.org/W1970591872","https://openalex.org/W1970848783","https://openalex.org/W1971084572","https://openalex.org/W1972452655","https://openalex.org/W1973220478","https://openalex.org/W1974308995","https://openalex.org/W1974917518","https://openalex.org/W1976101370","https://openalex.org/W1976400767","https://openalex.org/W1976772617","https://openalex.org/W1977733165","https://openalex.org/W1978479952","https://openalex.org/W1979386953","https://openalex.org/W1979862436","https://openalex.org/W1980311294","https://openalex.org/W1981137720","https://openalex.org/W1982084822","https://openalex.org/W1982933284","https://openalex.org/W1983056774","https://openalex.org/W1985579610","https://openalex.org/W1986134558","https://openalex.org/W1987504267","https://openalex.org/W1987562611","https://openalex.org/W1987631578","https://openalex.org/W1988224733","https://openalex.org/W1989273697","https://openalex.org/W1989712520","https://openalex.org/W1991890073","https://openalex.org/W1992012316","https://openalex.org/W1993072586","https://openalex.org/W1994009550","https://openalex.org/W1995515999","https://openalex.org/W1996408493","https://openalex.org/W1996787721","https://openalex.org/W1996875315","https://openalex.org/W1997996834","https://openalex.org/W1999191024","https://openalex.org/W2002307060","https://openalex.org/W2004919491","https://openalex.org/W2005765588","https://openalex.org/W2007400263","https://openalex.org/W2007542983","https://openalex.org/W2007753570","https://openalex.org/W2008919922","https://openalex.org/W2010607826","https://openalex.org/W2012392646","https://openalex.org/W2013435992","https://openalex.org/W2014562478","https://openalex.org/W2016523043","https://openalex.org/W2016979670","https://openalex.org/W2017057381","https://openalex.org/W2018447757","https://openalex.org/W2018809204","https://openalex.org/W2019813857","https://openalex.org/W2019995256","https://openalex.org/W2020234232","https://openalex.org/W2020646453","https://openalex.org/W2020709481","https://openalex.org/W2020798808","https://openalex.org/W2021759669","https://openalex.org/W2022580424","https://openalex.org/W2022609860","https://openalex.org/W2024253439","https://openalex.org/W2024981673","https://openalex.org/W2025141198","https://openalex.org/W2025912805","https://openalex.org/W2026318599","https://openalex.org/W2027053879","https://openalex.org/W2030307609","https://openalex.org/W2035313744","https://openalex.org/W2036032819","https://openalex.org/W2037036587","https://openalex.org/W2038473381","https://openalex.org/W2039638023","https://openalex.org/W2040809972","https://openalex.org/W2041901713","https://openalex.org/W2042221972","https://openalex.org/W2043570079","https://openalex.org/W2045475405","https://openalex.org/W2046947541","https://openalex.org/W2046972425","https://openalex.org/W2047187548","https://openalex.org/W2047192675","https://openalex.org/W2047205338","https://openalex.org/W2047689196","https://openalex.org/W2047819151","https://openalex.org/W2050302632","https://openalex.org/W2050752994","https://openalex.org/W2051103323","https://openalex.org/W2051452698","https://openalex.org/W2051549641","https://openalex.org/W2051885016","https://openalex.org/W2051890542","https://openalex.org/W2054326876","https://openalex.org/W2054643837","https://openalex.org/W2055417205","https://openalex.org/W2056315817","https://openalex.org/W2057389857","https://openalex.org/W2057776379","https://openalex.org/W2060096554","https://openalex.org/W2060798773","https://openalex.org/W2061630978","https://openalex.org/W2061899375","https://openalex.org/W2062581776","https://openalex.org/W2062713243","https://openalex.org/W2064272625","https://openalex.org/W2064789528","https://openalex.org/W2064800600","https://openalex.org/W2066011015","https://openalex.org/W2066082105","https://openalex.org/W2066235873","https://openalex.org/W2066302887","https://openalex.org/W2068005505","https://openalex.org/W2068173904","https://openalex.org/W2068984235","https://openalex.org/W2069680022","https://openalex.org/W2070091724","https://openalex.org/W2070120246","https://openalex.org/W2070748533","https://openalex.org/W2071453446","https://openalex.org/W2073821210","https://openalex.org/W2074165388","https://openalex.org/W2074550162","https://openalex.org/W2074746752","https://openalex.org/W2075901113","https://openalex.org/W2076162312","https://openalex.org/W2076352025","https://openalex.org/W2076991609","https://openalex.org/W2077200917","https://openalex.org/W2079683131","https://openalex.org/W2080260922","https://openalex.org/W2080945886","https://openalex.org/W2082708772","https://openalex.org/W2083289662","https://openalex.org/W2084896925","https://openalex.org/W2085404645","https://openalex.org/W2085723131","https://openalex.org/W2087055812","https://openalex.org/W2087558696","https://openalex.org/W2087580642","https://openalex.org/W2087654677","https://openalex.org/W2087857484","https://openalex.org/W2088513299","https://openalex.org/W2089684997","https://openalex.org/W2089861506","https://openalex.org/W2091675007","https://openalex.org/W2092705670","https://openalex.org/W2092792883","https://openalex.org/W2093213870","https://openalex.org/W2093670317","https://openalex.org/W2094652659","https://openalex.org/W2094668841","https://openalex.org/W2095054138","https://openalex.org/W2095213694","https://openalex.org/W2096428863","https://openalex.org/W2098749176","https://openalex.org/W2099019634","https://openalex.org/W2100412095","https://openalex.org/W2100543150","https://openalex.org/W2101206430","https://openalex.org/W2103930728","https://openalex.org/W2104794630","https://openalex.org/W2105400883","https://openalex.org/W2107446922","https://openalex.org/W2107749930","https://openalex.org/W2108395794","https://openalex.org/W2112540103","https://openalex.org/W2113802879","https://openalex.org/W2115750830","https://openalex.org/W2116171543","https://openalex.org/W2118796952","https://openalex.org/W2119236958","https://openalex.org/W2121450303","https://openalex.org/W2122459559","https://openalex.org/W2122745552","https://openalex.org/W2124416339","https://openalex.org/W2124637769","https://openalex.org/W2125163646","https://openalex.org/W2125748142","https://openalex.org/W2129278872","https://openalex.org/W2131189233","https://openalex.org/W2132268212","https://openalex.org/W2132835748","https://openalex.org/W2134571000","https://openalex.org/W2135808990","https://openalex.org/W2136000231","https://openalex.org/W2136100686","https://openalex.org/W2136631125","https://openalex.org/W2137698660","https://openalex.org/W2141470884","https://openalex.org/W2141553969","https://openalex.org/W2142548447","https://openalex.org/W2144005905","https://openalex.org/W2144436556","https://openalex.org/W2144577255","https://openalex.org/W2144680925","https://openalex.org/W2145786937","https://openalex.org/W2145794545","https://openalex.org/W2147068163","https://openalex.org/W2147267253","https://openalex.org/W2147285295","https://openalex.org/W2147787458","https://openalex.org/W2148239543","https://openalex.org/W2148330408","https://openalex.org/W2149312162","https://openalex.org/W2149516210","https://openalex.org/W2153712501","https://openalex.org/W2155813163","https://openalex.org/W2157742028","https://openalex.org/W2158513713","https://openalex.org/W2159253287","https://openalex.org/W2159571144","https://openalex.org/W2160092751","https://openalex.org/W2160579328","https://openalex.org/W2160712716","https://openalex.org/W2161165126","https://openalex.org/W2161958391","https://openalex.org/W2163828646","https://openalex.org/W2165119413","https://openalex.org/W2165144791","https://openalex.org/W2167550136","https://openalex.org/W2170106245","https://openalex.org/W2171669261","https://openalex.org/W2178995592","https://openalex.org/W2187422757","https://openalex.org/W2187957635","https://openalex.org/W2220905033","https://openalex.org/W2221432805","https://openalex.org/W2266646288","https://openalex.org/W2281040338","https://openalex.org/W2302851559","https://openalex.org/W2311158642","https://openalex.org/W2319353123","https://openalex.org/W2321321890","https://openalex.org/W2336514835","https://openalex.org/W2338392504","https://openalex.org/W2342227263","https://openalex.org/W2345009038","https://openalex.org/W2398722604","https://openalex.org/W2401536218","https://openalex.org/W2404396229","https://openalex.org/W2415443593","https://openalex.org/W2415612552","https://openalex.org/W2417124982","https://openalex.org/W2465860350","https://openalex.org/W2474402643","https://openalex.org/W2490333234","https://openalex.org/W2492270999","https://openalex.org/W2496793413","https://openalex.org/W2509359483","https://openalex.org/W2513573571","https://openalex.org/W2515679023","https://openalex.org/W2515812752","https://openalex.org/W2520496580","https://openalex.org/W2529682758","https://openalex.org/W2532760713","https://openalex.org/W2535570660","https://openalex.org/W2537259478","https://openalex.org/W2562405204","https://openalex.org/W2564105093","https://openalex.org/W2584431542","https://openalex.org/W2588862205","https://openalex.org/W2603662360","https://openalex.org/W2738977754","https://openalex.org/W2750168879","https://openalex.org/W2752983955","https://openalex.org/W2753012794","https://openalex.org/W2753112366"],"related_works":["https://openalex.org/W3147574907","https://openalex.org/W2888919134","https://openalex.org/W3111314256","https://openalex.org/W6906472694","https://openalex.org/W2994704114","https://openalex.org/W7222458586","https://openalex.org/W7167024211","https://openalex.org/W4281396741","https://openalex.org/W7208009478","https://openalex.org/W2991379335"],"abstract_inverted_index":{"Naturlige":[0],"dreperceller":[1,6],"(NK-celler)":[2],"er":[3,12],"en":[4,30,74,97,144,255,259],"type":[5],"i":[7,33,62,121,161,241],"immunsystemet":[8],"v\u00e5rt.":[9],"Deres":[10],"funksjon":[11],"\u00e5":[13,58,83,101,244],"drepe":[14],"virusinfiserte":[15],"celler":[16],"og":[17,72,91,104,108,163,183,225],"kreftceller.":[18],"N\u00e5tidens":[19],"trend":[20],"innen":[21],"utvikling":[22],"av":[23,65,93,189,192,204,262],"immunterapi":[24,34,71,80],"foresl\u00e5r":[25],"at":[26,125,273],"NK-celler":[27,107,201,209,229],"kan":[28,230,264,270],"ha":[29,278],"essensiell":[31],"rolle":[32],"mot":[35,223],"kreft.":[36],"Tidligere":[37],"forskning":[38],"fra":[39,117],"gruppen":[40],"har":[41,51,174],"avdekket":[42],"hvordan":[43,63,177],"NK-cellene":[44,127,276],"regulerer":[45],"sin":[46],"drapsfunksjon.":[47],"I":[48],"sitt":[49],"arbeide":[50],"Vincent":[52],"Oei":[53],"benyttet":[54],"denne":[55],"kunnskapen":[56],"til":[57,142,181,198,235],"f\u00e5":[59],"\u00f8kt":[60],"innsikt":[61],"mangfoldet":[64],"NK-cellenes":[66,184],"ulike":[67,115,137,199],"undergrupper":[68,200],"p\u00e5virker":[69],"slik":[70],"utviklet":[73,95,254],"strategi":[75,98],"for":[76,99,238,272],"neste":[77],"generasjons":[78],"NK":[79],"ved":[81],"selektivt":[82,100],"dyrke":[84,102],"drepere":[85,130],"som":[86,147,150,237,257,269],"gjenkjente":[87,154],"m\u00e5l":[88],"p\u00e5":[89,157],"innsiden":[90],"utsiden":[92],"kreftcellen.\\n\\nF\u00f8rst":[94],"han":[96,124],"t\u00f8ffe":[103],"effektive":[105],"\"adaptive\"":[106],"unders\u00f8kte":[109],"hvor":[110],"effektivt":[111],"disse":[112,126],"cellene":[113],"drepte":[114,167],"blodkreftceller":[116],"pasienter.":[118],"Etter":[119],"dyrking":[120],"laboratoriet":[122],"observerte":[123],"ble":[128,134,215,251],"bedre":[129],"med":[131,218,248],"spesifikk":[132],"presisjon.\\n\\nDeretter":[133],"det":[135,252],"introduserte":[136],"genetisk":[138,216,227],"kodede":[139],"m\u00e5ls\u00f8kende":[140,220],"molekyler":[141,155,221],"T-celler,":[143],"annen":[145],"immuncelletype":[146],"ogs\u00e5":[148,175,253],"fungere":[149],"dreperceller.":[151],"Disse":[152],"missilene":[153],"enten":[156],"overflaten":[158],"eller":[159],"inne":[160],"kreftceller":[162],"slike":[164,219,226],"modifiserte":[165],"T-celler":[166,236],"et":[168,232],"overveldende":[169],"antall":[170],"kreftceller.\\n\\nOei":[171],"et.":[172],"al.":[173],"unders\u00f8kt":[176],"den":[178],"genetiske":[179,190,206],"bakgrunnen":[180],"blodgiveren":[182],"funksjonelle":[185,196],"mangfold":[186],"p\u00e5virket":[187,202],"effektiviteten":[188],"endringer":[191],"cellene.":[193],"Den":[194],"innebygde":[195],"kapasiteten":[197],"effekten":[203],"de":[205,214,274],"forandringene.":[207],"\"Adaptive\"":[208],"var":[210],"ekstremt":[211],"potente":[212],"n\u00e5r":[213],"endret":[217],"rettet":[222],"kreftcellene":[224],"endrede":[228],"v\u00e6re":[231],"fornuftig":[233],"alternativ":[234],"tiden":[239],"brukes":[240],"immunterapi.":[242],"For":[243],"kunne":[245],"velge":[246],"blodgivere":[247,268],"optimal":[249],"NK-cellesammensetning":[250],"algoritme":[256],"etter":[258],"enkel":[260],"test":[261],"NK-cellene,":[263],"peke":[265],"ut":[266],"hvilke":[267],"benyttes":[271],"dyrkede":[275],"skal":[277],"\u00f8nsket":[279],"spesifisitet.":[280]},"counts_by_year":[],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2018-10-05T00:00:00"}