{"id":"https://openalex.org/W2894124641","doi":"https://doi.org/10.1200/jgo.18.89300","title":"Therapeutic Potential of Cytosolic PLA2 Isoform\u2013Specific Inhibitor Arachidonyl Trifluromethyl Ketone in Cigarette Smoke Condensate\u2013Induced Pathological Conditions in Alveolar Type I and II Epithelial Cells","display_name":"Therapeutic Potential of Cytosolic PLA2 Isoform\u2013Specific Inhibitor Arachidonyl Trifluromethyl Ketone in Cigarette Smoke Condensate\u2013Induced Pathological Conditions in Alveolar Type I and II Epithelial Cells","publication_year":2018,"publication_date":"2018-09-28","ids":{"openalex":"https://openalex.org/W2894124641","doi":"https://doi.org/10.1200/jgo.18.89300","mag":"2894124641"},"language":"en","primary_location":{"id":"doi:10.1200/jgo.18.89300","doi":"https://doi.org/10.1200/jgo.18.89300","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jgo.18.89300","pdf_url":null,"source":{"id":"https://openalex.org/S2764879405","display_name":"Journal of Global Oncology","issn_l":"2378-9506","issn":["2378-9506"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Global Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1200/jgo.18.89300","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100666755","display_name":"Subodh Kumar","orcid":"https://orcid.org/0000-0003-0553-387X","observed_orcids":["https://orcid.org/0000-0003-0553-387X"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"S. Kumar","raw_affiliation_strings":["Post Graduate Institute of Medical Education and Research, Chandigarh, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research, Chandigarh, India;","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086761700","display_name":"Sheetal Sharma","orcid":"https://orcid.org/0000-0003-1818-7355","observed_orcids":["https://orcid.org/0000-0003-1818-7355"]},"institutions":[{"id":"https://openalex.org/I4210092995","display_name":"Rajiv Gandhi Cancer Institute and Research Centre","ror":"https://ror.org/00e7cvg05","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210092995"]},{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S.K. Sharma","raw_affiliation_strings":["Post Graduate Institute of Medical Education and Research, Chandigarh, India;","Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research, Chandigarh, India;","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India","institution_ids":["https://openalex.org/I4210092995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022950768","display_name":"Bikash Medhi","orcid":"https://orcid.org/0000-0002-4017-641X","observed_orcids":["https://orcid.org/0000-0002-4017-641X","https://orcid.org/0000-0003-2477-7052"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B. Medhi","raw_affiliation_strings":["Post Graduate Institute of Medical Education and Research, Chandigarh, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research, Chandigarh, India;","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111660867","display_name":"Krishan Lal KHANDUJA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K.L. Khanduja","raw_affiliation_strings":["Post Graduate Institute of Medical Education and Research, Chandigarh, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research, Chandigarh, India;","institution_ids":["https://openalex.org/I45294948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100666755"],"corresponding_institution_ids":["https://openalex.org/I45294948"],"apc_list":{"value":2400,"currency":"USD","value_usd":2400},"apc_paid":{"value":2400,"currency":"USD","value_usd":2400},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"Supplement 2","first_page":"221s","last_page":"221s"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.2393999993801117,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytosolic-phospholipase-a2","display_name":"cytosolic phospholipase A2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cigarette-smoke-condensate","display_name":"cigarette smoke condensate","score":0.9739999771118164},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8399999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/chronic-lung-inflammation","display_name":"chronic lung inflammation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.6399999856948853},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.47999998927116394},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6341333985328674},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5673736929893494},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5606691837310791},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5481250882148743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5291954278945923},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5249906778335571},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5039414763450623},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4313355088233948},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4029247462749481},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3779020309448242},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34012657403945923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28676652908325195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26634591817855835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19463059306144714}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jgo.18.89300","doi":"https://doi.org/10.1200/jgo.18.89300","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jgo.18.89300","pdf_url":null,"source":{"id":"https://openalex.org/S2764879405","display_name":"Journal of Global Oncology","issn_l":"2378-9506","issn":["2378-9506"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Global Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jgo.18.89300","doi":"https://doi.org/10.1200/jgo.18.89300","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jgo.18.89300","pdf_url":null,"source":{"id":"https://openalex.org/S2764879405","display_name":"Journal of Global Oncology","issn_l":"2378-9506","issn":["2378-9506"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Global Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2893515274","https://openalex.org/W2507832624","https://openalex.org/W7138360308","https://openalex.org/W1991266353","https://openalex.org/W1992569451","https://openalex.org/W2272890570","https://openalex.org/W2134159595","https://openalex.org/W2884502528","https://openalex.org/W84479134","https://openalex.org/W2144472894"],"abstract_inverted_index":{"Background:":[0],"Cigarette":[1,260],"smoking":[2],"is":[3,104],"responsible":[4],"for":[5],"various":[6,73],"lung":[7,11],"pathologies":[8],"including":[9],"chronic":[10,14,78,89],"inflammation,":[12,79],"emphysema,":[13],"obstructive":[15],"pulmonary":[16],"disease":[17],"(COPD),":[18],"cancer,":[19,110],"and":[20,55,72,82,96,161,192,198,225,237,250,269],"annually":[21],"causes":[22],"almost":[23],"10":[24],"million":[25],"deaths":[26],"globally.":[27],"During":[28],"smoke":[29,63,153,261],"exposure,":[30],"most":[31,127],"affected":[32],"cells":[33,38,231],"are":[34],"the":[35,86,113,126,139],"alveolar":[36,158,207,266],"epithelial":[37,163,208,271],"where":[39],"as":[40,77,91,93,245,254],"a":[41,246,255],"repair":[42],"mechanism,":[43],"activation":[44],"of":[45,62,69,88,99,109,116,133,142,167,206,222,227,234],"cytosolic":[46,143],"phospholipase":[47],"A2":[48],"enzymes":[49],"takes":[50],"place.":[51],"High":[52],"free":[53,217],"radicals":[54],"cPLA2":[56,117,129,168,172,215],"activity":[57,173],"due":[58],"to":[59,66],"continuous":[60,131],"exposure":[61,64,132],"leads":[65],"elevated":[67],"levels":[68,98,191,200,226],"secondary":[70,100],"metabolites":[71,101],"pathophysiologic":[74],"conditions":[75,156,264],"such":[76],"oxidative":[80,94],"stress":[81],"cancer.":[83],"To":[84,137],"reduce":[85],"burden":[87],"inflammation":[90],"well":[92,105],"stress,":[95],"higher":[97],"whose":[102],"role":[103],"defined":[106],"in":[107,151,157,203,259,265],"progression":[108],"we":[111],"checked":[112,175],"therapeutic":[114,140,248,257],"potential":[115,141,247,256],"inhibitor":[118,147,169,252],"arachidonyl":[119,148],"trifluromethyl":[120,149],"ketone":[121,150],"(ATK)":[122],"by":[123],"pharmacologically":[124],"targeting":[125],"expressible":[128],"during":[130],"cigarette":[134,152],"smoke.":[135],"Aim:":[136],"check":[138],"PLA2":[144],"isoform":[145],"specific":[146],"condensate\u2013induced":[154],"pathologic":[155],"type":[159,205,267],"I":[160,268],"II":[162,270],"cells.":[164,209,272],"Methods:":[165],"Effect":[166],"on":[170],"CSC-induced":[171,214],"were":[174],"using":[176,181,187,201],"colorimetric":[177],"assay,":[178,183],"cell":[179,235],"viability":[180,236],"MTT":[182],"FDA":[184],"uptake":[185],"assay":[186],"fluorescence":[188],"microscopy,":[189],"ROS":[190],"apoptosis":[193],"markers":[194],"through":[195],"flow":[196],"cytometry,":[197],"ERK":[199,228],"ELISA,":[202],"both":[204],"Results:":[210],"ATK":[211,253],"significantly":[212],"mimicked":[213],"activity,":[216],"radicals,":[218],"primary":[219],"apoptosis,":[220],"ratio":[221],"apoptotic/apoptotic":[223],"proteins":[224],"whereas":[229],"protected":[230],"from":[232],"loss":[233],"membrane":[238],"integrity.":[239],"Conclusion:":[240],"Current":[241],"observations":[242],"revealed":[243],"cPLA2s":[244],"target":[249],"their":[251],"agent":[258],"induced":[262],"pathological":[263]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-10-05T00:00:00"}
