{"id":"https://openalex.org/W2894042407","doi":"https://doi.org/10.1038/s41698-018-0066-x","title":"Universal cancer screening: revolutionary, rational, and realizable","display_name":"Universal cancer screening: revolutionary, rational, and realizable","publication_year":2018,"publication_date":"2018-09-24","ids":{"openalex":"https://openalex.org/W2894042407","doi":"https://doi.org/10.1038/s41698-018-0066-x","mag":"2894042407","pmid":"https://pubmed.ncbi.nlm.nih.gov/30393772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6206005"},"language":"en","primary_location":{"id":"doi:10.1038/s41698-018-0066-x","doi":"https://doi.org/10.1038/s41698-018-0066-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-018-0066-x","pdf_url":"https://www.nature.com/articles/s41698-018-0066-x.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41698-018-0066-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078991711","display_name":"David A. Ahlquist","orcid":"https://orcid.org/0000-0002-0652-0758","observed_orcids":["https://orcid.org/0000-0002-0652-0758"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A. Ahlquist","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078991711"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":0.9458,"has_fulltext":true,"cited_by_count":135,"citation_normalized_percentile":{"value":0.72457408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.2709999978542328,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.06930000334978104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multi-cancer-early-detection","display_name":"multi-cancer early detection","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6980000138282776},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.6570000052452087},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.7770000100135803},{"id":"https://openalex.org/keywords/rare-tumor","display_name":"rare tumor","score":0.5080000162124634},{"id":"https://openalex.org/keywords/exhaled-breath-biomarkers","display_name":"breath biomarkers","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cancer-mortality","display_name":"cancer mortality","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6590381264686584},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5638808608055115},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.46080541610717773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45379412174224854},{"id":"https://openalex.org/C2776463041","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer screening","level":3,"score":0.4447520077228546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2943165898323059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2494986653327942},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.1722966432571411},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s41698-018-0066-x","doi":"https://doi.org/10.1038/s41698-018-0066-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-018-0066-x","pdf_url":"https://www.nature.com/articles/s41698-018-0066-x.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5160673","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6206005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6206005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6206005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Precis Oncol","raw_type":"Text"},{"id":"pmid:30393772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30393772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ precision oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:64b24670028643e795311d0739b7b333","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/64b24670028643e795311d0739b7b333","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Precision Oncology, Vol 2, Iss 1, Pp 1-5 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41698-018-0066-x","doi":"https://doi.org/10.1038/s41698-018-0066-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-018-0066-x","pdf_url":"https://www.nature.com/articles/s41698-018-0066-x.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6800000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2894042407.pdf","grobid_xml":"https://content.openalex.org/works/W2894042407.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1622513929","https://openalex.org/W1935731910","https://openalex.org/W1940373023","https://openalex.org/W1975475936","https://openalex.org/W1981192430","https://openalex.org/W1983466841","https://openalex.org/W1989948817","https://openalex.org/W2021794742","https://openalex.org/W2025273516","https://openalex.org/W2033491551","https://openalex.org/W2047507942","https://openalex.org/W2060650722","https://openalex.org/W2099828433","https://openalex.org/W2106768517","https://openalex.org/W2135950566","https://openalex.org/W2136806837","https://openalex.org/W2139144040","https://openalex.org/W2147798100","https://openalex.org/W2171706400","https://openalex.org/W2221837786","https://openalex.org/W2239118478","https://openalex.org/W2335651319","https://openalex.org/W2338917996","https://openalex.org/W2395483593","https://openalex.org/W2556681269","https://openalex.org/W2559221771","https://openalex.org/W2582875120","https://openalex.org/W2583699093","https://openalex.org/W2588306107","https://openalex.org/W2590954301","https://openalex.org/W2594170573","https://openalex.org/W2602657459","https://openalex.org/W2616211375","https://openalex.org/W2663574681","https://openalex.org/W2774100359","https://openalex.org/W2780615230","https://openalex.org/W2781525129","https://openalex.org/W2783674487","https://openalex.org/W2789811819","https://openalex.org/W2796153844","https://openalex.org/W2796374139","https://openalex.org/W2800670480","https://openalex.org/W2802918939","https://openalex.org/W2807164862","https://openalex.org/W2915317546","https://openalex.org/W2915804716","https://openalex.org/W2922868970","https://openalex.org/W2940139661","https://openalex.org/W2951737887","https://openalex.org/W2951934944","https://openalex.org/W2974813020","https://openalex.org/W2998668293"],"related_works":["https://openalex.org/W4392913502","https://openalex.org/W3035416333","https://openalex.org/W4200156779","https://openalex.org/W1566274562","https://openalex.org/W4399281172","https://openalex.org/W4404306084","https://openalex.org/W4412594947","https://openalex.org/W1981852029","https://openalex.org/W4400940928","https://openalex.org/W4327954480"],"abstract_inverted_index":{"Cancer":[0],"remains":[1],"the":[2,16,168,187,204],"second":[3],"leading":[4],"cause":[5],"of":[6,34,86,143,170],"mortality":[7],"worldwide,":[8],"and":[9,63,81,129,134,155,162,193,206,217,224],"overall":[10],"cancer-related":[11],"deaths":[12],"are":[13,79],"increasing.":[14],"Despite":[15],"survival":[17],"benefit":[18],"from":[19,103,186],"early":[20,164],"detection,":[21],"screening":[22,59,78,113,127,176],"has":[23],"to":[24,37,76,121,229,234],"date":[25],"targeted":[26],"only":[27],"those":[28,197],"few":[29],"organs":[30],"that":[31],"harbor":[32],"tumors":[33],"sufficient":[35],"prevalence":[36,110],"show":[38],"cost-effectiveness":[39,137],"at":[40],"population":[41,236],"levels,":[42],"leaving":[43],"most":[44],"cancer":[45,58],"types":[46,154],"unscreened.":[47],"In":[48],"this":[49,172,231],"perspective":[50],"overview,":[51],"a":[52,61,91,104,235],"case":[53],"is":[54],"made":[55],"for":[56,100],"universal":[57,77,112],"as":[60,124],"logical":[62],"more":[64],"inclusive":[65],"approach":[66],"with":[67,148],"potentially":[68,135],"high":[69],"impact.":[70],"The":[71,83,141],"centrally":[72],"important":[73],"conceptual":[74],"drivers":[75],"biological":[80],"epidemiological.":[82],"shared":[84],"biology":[85],"tumor":[87,132,145,153],"marker":[88,146],"release":[89],"into":[90,199],"common":[92,119,200],"distant":[93],"medium,":[94],"like":[95],"blood,":[96,190],"can":[97],"be":[98,122,178,227],"exploited":[99],"multi-cancer":[101],"detection":[102],"single":[105],"test.":[106],"And,":[107],"by":[108,180],"aggregating":[109],"rates,":[111],"allows":[114],"all":[115],"cancers":[116],"(including":[117,189,203],"less":[118],"ones)":[120],"included":[123],"targets,":[125],"increases":[126],"efficiency":[128],"integration":[130],"across":[131,152],"types,":[133],"improves":[136],"over":[138],"single-organ":[139],"approaches.":[140],"identification":[142],"new":[144,173],"classes":[147],"both":[149],"broad":[150],"expression":[151],"site-prediction,":[156],"remarkable":[157],"advances":[158],"in":[159,213],"assay":[160],"technologies,":[161],"compelling":[163],"clinical":[165,211],"data":[166],"increase":[167],"likelihood":[169],"actualizing":[171],"paradigm.":[174],"Multi-organ":[175],"could":[177],"achieved":[179],"targeting":[181],"markers":[182],"within":[183],"or":[184,196],"stemming":[185],"circulation":[188],"urine,":[191],"saliva,":[192],"expired":[194],"breath)":[195],"exfoliated":[198],"excretory":[201],"pathways":[202],"gastrointestinal":[205],"female":[207],"reproductive":[208],"tracts).":[209],"Rigorous":[210],"studies":[212],"intended":[214],"use":[215],"populations":[216],"collaborations":[218],"between":[219],"academia,":[220],"industry,":[221],"professional":[222],"societies,":[223],"government":[225],"will":[226],"required":[228],"bring":[230],"lofty":[232],"vision":[233],"application.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-10-05T00:00:00"}